Neurobiology of Disease Book

Neurobiology of Disease


  • Author :
  • Publisher : Elsevier
  • Release Date : 2011-09-06
  • Genre: Science
  • Pages : 1104
  • ISBN 10 : 0080466389

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Neurobiology of Disease Book Description :

Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields. Provides cutting edge information about fundamental mechanisms underlying neurological diseases Amply supplied with tables, illustrations and references Includes supporting clinical information putting the mechanisms of disease into perspective

Cingulate Neurobiology and Disease Book

Cingulate Neurobiology and Disease


  • Author : Brent Vogt
  • Publisher : Oxford University Press
  • Release Date : 2009-06-04
  • Genre: Medical
  • Pages : 829
  • ISBN 10 : 9780198566960

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Cingulate Neurobiology and Disease Book Description :

One of the major neuroscience publications of the past few years, Cingulate Neurobiology and Disease presents the definitive review of the cingulate cortex, explaining its critical role in a host of diseases and illnesses.

Neurobiology of Disease Book

Neurobiology of Disease


  • Author : Alan L. Pearlman
  • Publisher : Oxford University Press, USA
  • Release Date : 1990
  • Genre: Art
  • Pages : 482
  • ISBN 10 : 0195053192

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Neurobiology of Disease Book Description :

The study of the mechanisms by which diseases alter the function of the nervous system was once well described by the appellation "Neurological Pathophysiology," the title of the previous editions of this book. But when disciplines as diverse as molecular genetics and radiation biophysics converge on the analysis of the nervous system and its disorders, a title with broader meaning is required to encompass them. The change in the book's title reflects a change in its scope, as it includes much more information on functional and anatomical systems than the early editions. New to this edition are three chapters on Memory, Genetic Disorders, and Brain Tumors. Infections are given more extensive treatment, the original chapter being divided into two, the first on bacteria, fungi and parasites, the second on viruses. All other chapters have been updated. For medical students and physicians it offers an introduction to the scientific basis of clinical neurology--the framework on which diagnosis and treatment are based. For graduate students and scientists in the field of neurobiology, it describes the expression of fundamental mechanisms gone awry, and provides clues for elucidating those mechanisms.

The Neurobiology of Disease Book

The Neurobiology of Disease


  • Author : H. Bostock
  • Publisher :
  • Release Date : 1996
  • Genre: Nervous system
  • Pages : 443
  • ISBN 10 : OCLC:1176311745

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The Neurobiology of Disease Book Description :

Neurobiology of Brain Disorders Book

Neurobiology of Brain Disorders


  • Author : Michael J. Zigmond
  • Publisher : Elsevier
  • Release Date : 2014-12-03
  • Genre: Science
  • Pages : 824
  • ISBN 10 : 9780123982803

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Neurobiology of Brain Disorders Book Description :

Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Neurobiology of Disease Book

Neurobiology of Disease


  • Author : Michael V Johnston
  • Publisher : Oxford University Press
  • Release Date : 2016-08-18
  • Genre: Medical
  • Pages : 1488
  • ISBN 10 : 9780199937844

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Neurobiology of Disease Book Description :

The second edition of Neurobiology of Disease includes nearly 200 articles surveying all major disorders of the nervous system in both adults and children, focusing on relevant diagnosis and treatments from the perspective of cutting edge clinical and basic neurobiological research. Akin to an encyclopedia of every neurologic disorder, this comprehensive work is ideal for graduate and medical school students, residents, and candidates preparing for their board certification examinations. Each chapter is illustrated with detailed figures, supplemented with descriptive and diagnostic tables, and thoroughly referenced for further investigations. The book's editors, Michael V. Johnston, Harold P. Adams Jr., and Ali Fatemi bring their unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this new edition, the following Section Editors provided oversight of their respective sections: · Movement Disorders-Joel Perlmutter, Washington University · Dementias-David Knopman, Mayo Clinic · Motorneuron Diseases-Merit Cudkowicz, Massachusetts General Hospital · Paroxysmal Disorders-Solomon Moshe, Albert Einstein College of Medicine · Pediatric Neurology and Developmental Disorders-Tanjala Gipson and Deepa Menon, Kennedy Krieger Institute and Johns Hopkins University · Neuroimmunological Diseases-Carlos Pardo-Villamizar, Johns Hopkins University · Cerebrovascular Diseases-Harold P. Adams Jr., University of Iowa · Peripheral and Autonomic Nervous System Disorders and Pain-Nicholas Maragakis, Johns Hopkins University · Neoplastic and Paraneoplastic Diseases-Lisa DeAngelis, Memorial Sloan-Kettering Cancer Center · Infectious Diseases of the Nervous System-Karen L. Roos, Indiana University · Sleep Disturbances-Mark Dyken, University of Iowa · Substance Abuse and Toxicology Disorders-Barry E. Kosofsky, Weill-Cornell University Medical Center · Neurologic Manifestations of Medical Disorders-John C.

The Neurobiology of Disease Book

The Neurobiology of Disease


  • Author : Hugh Bostock
  • Publisher : Cambridge University Press
  • Release Date : 1996-04-18
  • Genre: Medical
  • Pages : 443
  • ISBN 10 : 0521451329

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The Neurobiology of Disease Book Description :

Combining the knowledge of distinguished clinicians and scientists, this valuable reference seeks to inspire further understanding of neurological disease.

Neurobiology of Huntington   s Disease Book

Neurobiology of Huntington s Disease


  • Author : Donald C. Lo
  • Publisher : CRC Press
  • Release Date : 2010-07-02
  • Genre: Science
  • Pages : 338
  • ISBN 10 : 9781420008258

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Neurobiology of Huntington s Disease Book Description :

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Diseases of the Nervous System Book

Diseases of the Nervous System


  • Author : Harald Sontheimer
  • Publisher : Academic Press
  • Release Date : 2015-03-06
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9780128004036

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Diseases of the Nervous System Book Description :

The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. 2016 PROSE Award winner of the Best Textbook Award in Biological & Life Sciences Provides a focused tutorial introduction to the core diseases of the nervous system Includes comprehensive introductions to Stroke, Epilepsy, Alzheimer

Neurobiology of the Axon in Health and Disease Book

Neurobiology of the Axon in Health and Disease


  • Author : Maren Engelhardt
  • Publisher : Frontiers Media SA
  • Release Date : 2019-11-04
  • Genre: Electronic book
  • Pages : 134
  • ISBN 10 : 9782889194889

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Neurobiology of the Axon in Health and Disease Book Description :

Ever since Santiago Ramón y Cajal sketched his captivating panels of the microscopic structure of the brain with its vast diversity of neuronal morphology over a century ago, scientists have been drawn to this seemingly chaotic network of neurites and processes to uncover how structure relates to function. During the course of a century, we have moved from merely describing neuronal and glial morphology to furthering our understanding of such intricate processes as organelle and factor transport, cellular compartmentalization, neuronal polarity, cytoskeleton dynamics, neurite pathfinding, and the impact of pathophysiological insult on these structures and events. Yet to this day, and likely for the foreseeable future, much work remains to be done to fully grasp the exceptional role of neurites for the function of larger neuronal ensembles and networks. While the somatodendritic domain of neurons has been in the focus of attention for many years, mostly because of its great dynamic remodeling capacity during events of plasticity (e.g. learning), the axonal domain has somehow remained in the background despite the fact that especially recent comprehensive studies from various fields of research underline the axon’s contribution to dynamic plasticity processes. Consequently, this Research Topic focuses on the many exciting aspects of axonal neurobiology – ranging from membrane composition and molecular determination during development to axonal domain specialization and physiology in health and disease. In Chapter 1 “Axons in the PNS”, Bombeiro et al. use immunodeficient mice to study the role of lymphocytes during the regeneration of peripheral nerves, showing that the modulation of immune responses after injury can be an efficient approach to enhance nerve regeneration in the PNS. Using a DRG model, Berbusse et al. identify the onset of damage to mitochondrial structure and dynamics as a key event during early axon degeneration and provide evidence that Nmna

Tau oligomers Book

Tau oligomers


  • Author : Jesus Avila
  • Publisher : Frontiers E-books
  • Release Date : 2014-08-18
  • Genre:
  • Pages :
  • ISBN 10 : 9782889192618

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Tau oligomers Book Description :

Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the ta

Parkinsonism Beyond Parkinson s Disease Book

Parkinsonism Beyond Parkinson s Disease


  • Author :
  • Publisher : Academic Press
  • Release Date : 2019-11-26
  • Genre: Medical
  • Pages : 468
  • ISBN 10 : 9780128177310

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Parkinsonism Beyond Parkinson s Disease Book Description :

Parkinsonism beyond Parkinson's Disease, Volume 149, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including How to approach a patient with parkinsonism – red flags for atypical parkinsonism, The ‘classic’ atypical parkinsonian disorders, Classification of atypical parkinsonism per pathology vs. phenotypes, Progressive supranuclear palsy, Corticobasal degeneration, Multiple system atrophy, Atypical parkinsonism in other sporadic and genetic neurodegenerative diseases, Sporadic ‘Atypical’ Parkinson’s disease, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology series Updated release includes the latest information on Parkinson's Disease

The Benefits of Natural Products for Neurodegenerative Diseases Book

The Benefits of Natural Products for Neurodegenerative Diseases


  • Author : M. Mohamed Essa
  • Publisher : Springer
  • Release Date : 2016-09-20
  • Genre: Medical
  • Pages : 496
  • ISBN 10 : 9783319283838

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The Benefits of Natural Products for Neurodegenerative Diseases Book Description :

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Functional Neurobiology of Aging Book

Functional Neurobiology of Aging


  • Author : Patrick R. Hof
  • Publisher : Academic Press
  • Release Date : 2001-01-11
  • Genre: Science
  • Pages : 960
  • ISBN 10 : 008052558X

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Functional Neurobiology of Aging Book Description :

Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. Organized by function, making it easy to find and understand the material Addresses impairments both associated with diseases and not associated with diseases Written by leading researchers in the field Most comprehensive source of information on the neurobiology of aging

Neurobiology of Alzheimer s Disease Book

Neurobiology of Alzheimer s Disease


  • Author : David Dawbarn
  • Publisher : Oxford University Press, USA
  • Release Date : 2007
  • Genre: Medical
  • Pages : 468
  • ISBN 10 : 0198566611

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Neurobiology of Alzheimer s Disease Book Description :

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Behavioral Neurobiology of Huntington s Disease and Parkinson s Disease Book

Behavioral Neurobiology of Huntington s Disease and Parkinson s Disease


  • Author : Hoa Huu Phuc Nguyen
  • Publisher : Springer
  • Release Date : 2015-05-23
  • Genre: Medical
  • Pages : 397
  • ISBN 10 : 9783662463444

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Behavioral Neurobiology of Huntington s Disease and Parkinson s Disease Book Description :

Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease  Treating Neurodegenerative Diseases as Metabolic Diseases Book

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases


  • Author :
  • Publisher : Academic Press
  • Release Date : 2020-09-01
  • Genre: Medical
  • Pages : 322
  • ISBN 10 : 9780128231227

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Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases Book Description :

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases.

Imaging of the Human Brain in Health and Disease Book

Imaging of the Human Brain in Health and Disease


  • Author : Philip Seeman
  • Publisher : Elsevier
  • Release Date : 2013-11-15
  • Genre: Medical
  • Pages : 532
  • ISBN 10 : 9780124186842

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Imaging of the Human Brain in Health and Disease Book Description :

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. A focused introduction to imaging healthy and diseased brains Focuses on the primary neurotransmitter release Includes sigma, acetylcholine, opioid, and dopamine receptors Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease

Phosphodiesterases  CNS Functions and Diseases Book

Phosphodiesterases CNS Functions and Diseases


  • Author : Han-Ting Zhang
  • Publisher : Springer
  • Release Date : 2017-09-26
  • Genre: Medical
  • Pages : 471
  • ISBN 10 : 9783319588117

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Phosphodiesterases CNS Functions and Diseases Book Description :

PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.