Neurobiology of Disease Book

Neurobiology of Disease

  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2011-09-06
  • Genre: Science
  • Pages : 1104
  • ISBN 10 : 0080466389

Neurobiology of Disease Excerpt :

Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields. Provides cutting edge information about fundamental mechanisms underlying neurological diseases Amply supplied with tables, illustrations and references Includes supporting clinical information putting the mechanisms of disease into perspective

The Neurobiology of Disease Book

The Neurobiology of Disease

  • Author : Hugh Bostock
  • Publisher : Cambridge University Press
  • Release Date : 2011-06-30
  • Genre: Medical
  • Pages : 464
  • ISBN 10 : 0521342384

The Neurobiology of Disease Excerpt :

Demonstrating the value of interactions between neurology and the basic sciences that underpin it, this volume considers a range of topics from the points of view of both neurobiologist and clinician and reveals how advances in our understanding have been and continue to be made. The coverage boasts an excellent section on the physiology and pathophysiology of central and peripheral nerve fibers and an in-depth view of motor control including the often ignored but vital respiratory movements. Also notable are the chapters on neuronal plasticity, and cell death and axonal regeneration: active areas in neuroscience, where new knowledge will almost certainly revolutionize neurological treatments in years to come.

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome Book

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

  • Author : Elizabeth Head
  • Publisher : Academic Press
  • Release Date : 2021-08-31
  • Genre: Medical
  • Pages : 352
  • ISBN 10 : 9780128188460

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome Excerpt :

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Functional Neurobiology of Aging Book

Functional Neurobiology of Aging

  • Author : Patrick R. Hof
  • Publisher : Academic Press
  • Release Date : 2001-01-11
  • Genre: Science
  • Pages : 960
  • ISBN 10 : 008052558X

Functional Neurobiology of Aging Excerpt :

Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. Organized by function, making it easy to find and understand the material Addresses impairments both associated with diseases and not associated with diseases Written by leading researchers in the field Most comprehensive source of information on the neurobiology of aging

Cingulate Neurobiology and Disease Book

Cingulate Neurobiology and Disease

  • Author : Brent Vogt
  • Publisher : Oxford University Press
  • Release Date : 2009-06-04
  • Genre: Medical
  • Pages : 829
  • ISBN 10 : 9780198566960

Cingulate Neurobiology and Disease Excerpt :

One of the major neuroscience publications of the past few years, Cingulate Neurobiology and Disease presents the definitive review of the cingulate cortex, explaining its critical role in a host of diseases and illnesses.

Neurobiology of Huntington   s Disease Book

Neurobiology of Huntington s Disease

  • Author : Donald C. Lo
  • Publisher : CRC Press
  • Release Date : 2010-07-02
  • Genre: Science
  • Pages : 338
  • ISBN 10 : 9781420008258

Neurobiology of Huntington s Disease Excerpt :

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Neurobiology of Brain Disorders Book

Neurobiology of Brain Disorders

  • Author : Michael J. Zigmond
  • Publisher : Academic Press
  • Release Date : 2022-05-27
  • Genre: Science
  • Pages : 1134
  • ISBN 10 : 9780323898256

Neurobiology of Brain Disorders Excerpt :

Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more. Links basic, translational and clinical research on disorders of the nervous system Covers a vast array of neurological and psychiatric disorders, including Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson's, Huntington's, Alzheimer's, OCD, PTSD, schizophrenia, depression and pain Features new chapters on the effects of aging and isolation on brain health Expands coverage on disorders, including new chapters on fibromyalgia, chronic fatigue, and restless legs syndrome Features in-text summary points, special feature boxes and research questions

Neurobiology of Alzheimer s Disease Book

Neurobiology of Alzheimer s Disease

  • Author : David Dawbarn
  • Publisher : Oxford University Press
  • Release Date : 2007-05-03
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9780191034589

Neurobiology of Alzheimer s Disease Excerpt :

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associated proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Guide for the Care and Use of Laboratory Animals Book

Guide for the Care and Use of Laboratory Animals

  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 2011-01-27
  • Genre: Science
  • Pages : 246
  • ISBN 10 : 9780309154000

Guide for the Care and Use of Laboratory Animals Excerpt :

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional ad

Omic Studies of Neurodegenerative Disease   Book

Omic Studies of Neurodegenerative Disease

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2015-08-25
  • Genre: Science
  • Pages : 214
  • ISBN 10 : 9780128016213

Omic Studies of Neurodegenerative Disease Excerpt :

Omic Studies of Neurodegenerative Disease: Part A is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research. Provides the expertise of leading contributors in the field Demonstrates how findings in the fields of genomics, proteomics, and metabolomic studies can combined for further insights Informs the reader on the current state of the studies used to study the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research

Parkinson s Disease Book

Parkinson s Disease

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-05-26
  • Genre: Medical
  • Pages : 540
  • ISBN 10 : 9780128098509

Parkinson s Disease Excerpt :

Parkinson's Disease, Volume 132 addresses new developments in the F33 study of this disease, highlighting how the lives of people with Parkinson’s have undergone dramatic changes in the last decade. New to this edition are chapters on the Hallmarks of clinical aspects PD throughout centuries, The motor syndrome of Parkinson disease, The non-motor features of Parkinson’s disease, The New Diagnostic Criteria for Parkinson's disease, Advances in the Clinical Differential diagnosis, Clinical assessments in PD : Scales and monitoring, Biomarkers of Parkinson’s disease: an Introduction, and the Genetics of Parkinson’s Disease: Genotype-Phenotype Correlations. The topics discussed in this comprehensive series provide a clearer understanding of the prodromal stage, genetics, strategies, routes of treatment, and development of non-dopaminergic therapies in Parkinson's Disease, both medical and surgical. Contains cutting-edge developments in the field Presents both motor and non-motor coverage

The Benefits of Natural Products for Neurodegenerative Diseases Book

The Benefits of Natural Products for Neurodegenerative Diseases

  • Author : M. Mohamed Essa
  • Publisher : Springer
  • Release Date : 2016-09-20
  • Genre: Medical
  • Pages : 496
  • ISBN 10 : 9783319283838

The Benefits of Natural Products for Neurodegenerative Diseases Excerpt :

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

The Clinical Neurobiology of the Hippocampus Book

The Clinical Neurobiology of the Hippocampus

  • Author : Thorsten Bartsch
  • Publisher : OUP Oxford
  • Release Date : 2012-07-26
  • Genre: Medical
  • Pages : 336
  • ISBN 10 : 9780191628962

The Clinical Neurobiology of the Hippocampus Excerpt :

The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. Its recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical and neurocomputational literature that presents basic mechanisms, theoretical models and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented in current literature, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. The Clinical Neurobiology of the Hippocampus explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural and psychiatric symptoms and surpasses the ability to encode, store and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia. The first part of the book covers the basic and integrative features of the hippocampus, such as the anatomy and imaging of this structure, and the basic mechanisms of hippocampal function, including the principles of hippocampus-dependent memory processing in amnesia and sleep, the mechanisms of vulnerability and adult neurogenesis as well as the effects of stress. The second part covers the various clinical manifestations in which the hippocampus is

Neurochemical Mechanisms in Disease Book

Neurochemical Mechanisms in Disease

  • Author : John P. Blass
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-01
  • Genre: Medical
  • Pages : 844
  • ISBN 10 : 9781441971043

Neurochemical Mechanisms in Disease Excerpt :

This newest volume of Advances in Neurobiology deals with the Neurochemistry of disease, with chapters covering both human diseases and animal “model” diseases.

The Neuropathology of Dementia Book
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The Neuropathology of Dementia

  • Author : Margaret M. Esiri
  • Publisher : Cambridge University Press
  • Release Date : 2004-07-22
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 0521819156

The Neuropathology of Dementia Excerpt :

This completely rewritten, updated new edition, now illustrated in colour, is almost twice the size of its predecessor.