Neuroinflammation  Resolution  and Neuroprotection in the Brain Book

Neuroinflammation Resolution and Neuroprotection in the Brain


  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2021-10-01
  • Genre: Medical
  • Pages : 332
  • ISBN 10 : 9780323884617

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Neuroinflammation Resolution and Neuroprotection in the Brain Excerpt :

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects. Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection Examines the role of diet and exercise on neuroinflammatory diseases Provides cutting-edge research on signal transduction processes Explores the treatment of neurological disorders caused by neuroinflammation

Mechanisms of Innate Neuroprotection Book

Mechanisms of Innate Neuroprotection


  • Author : Giuseppe Pignataro
  • Publisher : Frontiers Media SA
  • Release Date : 2016-07-27
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889199297

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Mechanisms of Innate Neuroprotection Excerpt :

As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.

New Insight into Cerebrovascular Diseases Book

New Insight into Cerebrovascular Diseases


  • Author : Patricia Bozzetto Ambrosi
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-05-13
  • Genre: Medical
  • Pages : 356
  • ISBN 10 : 9781789853599

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New Insight into Cerebrovascular Diseases Excerpt :

“Brain circulation is a true road map that consists of large extended navigation territories and a number of unimagined and undiscovered routes.” Dr. Patricia Bozzetto Ambrosi This book combines an update on the review of cerebrovascular diseases in the form of textbook chapters, which has been carefully reviewed by Dr. Patricia Bozzetto Ambrosi, Drs. Rufai Ahmad and Auwal Abdullahi and Dr. Amit Agrawal, high-performance academic editors with extensive experience in neurodisciplines, including neurology, neurosurgery, neuroscience, and neuroradiology, covering the best standards of neurological practice involving basic and clinical aspects of cerebrovascular diseases. Each topic was carefully revised and prepared using smooth, structured vocabulary, plus superb graphics and scientific illustrations. In emphasizing the most common aspects of cerebrovascular diseases: stroke burden, pathophysiology, hemodynamics, diagnosis, management, repair, and healing, the book is comprehensive but concise and should become the standard reference guide for this neurological approach.

Natural Products and Neuroprotection Book

Natural Products and Neuroprotection


  • Author : Cristina Angeloni
  • Publisher : MDPI
  • Release Date : 2020-06-17
  • Genre: Science
  • Pages : 338
  • ISBN 10 : 9783039362165

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Natural Products and Neuroprotection Excerpt :

Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.

The Role of Bioactive Lipids in Cancer  Inflammation and Related Diseases Book

The Role of Bioactive Lipids in Cancer Inflammation and Related Diseases


  • Author : Kenneth V. Honn
  • Publisher : Springer Nature
  • Release Date : 2019-09-27
  • Genre: Medical
  • Pages : 257
  • ISBN 10 : 9783030217358

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The Role of Bioactive Lipids in Cancer Inflammation and Related Diseases Excerpt :

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.

Diet  Inflammation  and Health Book

Diet Inflammation and Health


  • Author : James R. Hebert
  • Publisher : Academic Press
  • Release Date : 2022-04-28
  • Genre: Health & Fitness
  • Pages : 926
  • ISBN 10 : 9780128221655

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Diet Inflammation and Health Excerpt :

Diet, Inflammation, and Health introduces concepts of inflammation, the role of acute inflammatory responses in good health, and the association of chronic systemic inflammation with mental distress, cognitive decline, and chronic diseases, ranging from diabetes to cardiovascular diseases, stroke, and cancer. The book also describes the pathophysiology of inflammation and its effects on insulin insensitivity and blunted immune response to carcinogenesis. Researchers and allied health care professionals working in dietetics and medicine, as well as students studying related fields will benefit from this reference and its recommendations on areas where future research is needed. Addresses the role of acute inflammatory responses in achieving and maintaining good health Covers the association of chronic system inflammation with various conditions and diseases Describes the effect of inflammation on mechanisms ranging from insulin insensitivity and immune response to carcinogenesis

The Brain and Host Defense Book

The Brain and Host Defense


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2009-12-24
  • Genre: Science
  • Pages : 358
  • ISBN 10 : 0444535454

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The Brain and Host Defense Excerpt :

It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Neuroprotection Book

Neuroprotection


  • Author : Matilde Otero-Losada
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-11-26
  • Genre: Medical
  • Pages : 348
  • ISBN 10 : 9781838804398

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Neuroprotection Excerpt :

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Marine Anti inflammatory Agents 2020 Book

Marine Anti inflammatory Agents 2020


  • Author : Donatella Degl’Innocenti
  • Publisher : MDPI
  • Release Date : 2021-05-18
  • Genre: Medical
  • Pages : 112
  • ISBN 10 : 9783036507880

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Marine Anti inflammatory Agents 2020 Excerpt :

This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations of acute and chronic inflammation in both in vitro and in vivo experimental models.

Update on Dementia Book

Update on Dementia


  • Author : Davide Moretti
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-09-28
  • Genre: Medical
  • Pages : 558
  • ISBN 10 : 9789535126546

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Update on Dementia Excerpt :

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Neuroinflammation Book

Neuroinflammation


  • Author : Samuel David
  • Publisher : John Wiley & Sons
  • Release Date : 2015-03-10
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9781118732779

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Neuroinflammation Excerpt :

Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field. neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both th

Neuroprotection in Alzheimer s Disease Book

Neuroprotection in Alzheimer s Disease


  • Author : Illana Gozes
  • Publisher : Academic Press
  • Release Date : 2016-12-30
  • Genre: Medical
  • Pages : 342
  • ISBN 10 : 9780128037126

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Neuroprotection in Alzheimer s Disease Excerpt :

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Inflammation and Oxidative Stress in Neurological Disorders Book

Inflammation and Oxidative Stress in Neurological Disorders


  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-01-27
  • Genre: Medical
  • Pages : 355
  • ISBN 10 : 9783319041117

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Inflammation and Oxidative Stress in Neurological Disorders Excerpt :

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Neuroinflammation and Neurodegeneration Book

Neuroinflammation and Neurodegeneration


  • Author : Phillip K. Peterson
  • Publisher : Springer
  • Release Date : 2014-07-11
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 1493910701

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Neuroinflammation and Neurodegeneration Excerpt :

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.