Neuroprotection in Alzheimer s Disease Book

Neuroprotection in Alzheimer s Disease

  • Author : Illana Gozes
  • Publisher : Academic Press
  • Release Date : 2016-12-30
  • Genre: Medical
  • Pages : 342
  • ISBN 10 : 9780128037126
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Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Neuroprotection in Autism Schizophrenia and Alzheimer s disease Book

Neuroprotection in Autism Schizophrenia and Alzheimer s disease

  • Author : Illana Gozes
  • Publisher : Academic Press
  • Release Date : 2019-10-16
  • Genre: Medical
  • Pages : 322
  • ISBN 10 : 9780128140383
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Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer’s disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. Offers an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders Helps the reader become familiar with novel neuroprotective mechanisms and experimental treatment modalities in these difficult to treat disorders Written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry

Neuroprotection Book

Neuroprotection

  • Author : Matilde Otero-Losada
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-11-26
  • Genre: Medical
  • Pages : 350
  • ISBN 10 : 9781838804398
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Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection Book

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

  • Author : Shun Shimohama
  • Publisher : Unknown
  • Release Date : 2020-10-08
  • Genre: Medical
  • Pages : 196
  • ISBN 10 : 1013269756
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This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Alzheimer s Disease Book

Alzheimer s Disease

  • Author : Ralph W. Richter
  • Publisher : Springer Science & Business Media
  • Release Date : 2003-10-10
  • Genre: Medical
  • Pages : 773
  • ISBN 10 : 9781592596614
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Alzheimer’s disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic. Alzheimer’s Disease: A Physician’s Guide to Practical Management was written by selected clinicians and scientists who represent some of the world’s leading centers of excellence in AD research. The editors are proud and grateful for their profound contributions. This book is particularly designed to assist physicians and other health-care professionals in the evaluation, assessment, and treatment of individuals with AD. At the same time, by illuminating the basic scientific background, we hope to provide state-of-the art information about the disease and possible future therapeutic strategies. The recent psychiatric treatment aspects of AD are also clearly presented. Because the early diagnosis of the dementia process is now considered of increasing importance, we focus particularly in several chapters on early changes and preclinical conditions, such as mild cognitive impairment and predementia AD.

New Perspectives of Central Nervous System Injury and Neuroprotection Book

New Perspectives of Central Nervous System Injury and Neuroprotection

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2012-10-22
  • Genre: Medical
  • Pages : 424
  • ISBN 10 : 9780123870162
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Central nervous system (CNS) diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis affect a large number of populations worldwide for which no suitable cure is currently available. In addition, stroke, nanoparticle intoxication, diabetes, hypertension, and psychostimulant abuse either alone or in combination are capable of inducing potential brain damage. Thus, there is an urgent need to expand our knowledge to find suitable therapeutic strategies to enhance neurorepair processes in such diseases. This volume presents neuroprotection and novel therapeutic strategies developed in the last 5 years by 12 world leaders in the field. The term neuroprotection means rescuing neuronal and non-neuronal cells together. The cerebral endothelium that constitutes the anatomical and physiological site of the blood-brain barrier (BBB) is one of the most important non-neural cells in the CNS. Any distortion of the BBB leads to brain diseases and restoration of the barrier results in neuroprotection. Thus, the BBB appears to be the "gateway" for neurological diseases and neurorepair. However, to treat brain tumors or infarcts, new therapeutic strategies are needed to enhance brain drug delivery using nanotechnology. In addition, apart from conventional drugs, restoration of BBB function could also be achieved by means of antibodies directed against specific proteins, neurotransmitters or exogenous supplement of neurotrophic factors. Since co-morbidity factors e.g., hypertension, diabetes, and exposure of nanoparticles could complicate the pathogenesis of neurological disorders either an enhanced dose of the drug or nanodelivery of a combination of several drugs is needed to achieve neuroprotection. This volume of International Review of Neurobiology is the first to discuss novel therapeutic strategies in situations of neurological disorders in combination with different co-morbidity factors. Reviews written by experts in such a way that pro

Nanomedicine and Neuroprotection in Brain Diseases Book

Nanomedicine and Neuroprotection in Brain Diseases

  • Author : Hari Shanker Sharma
  • Publisher : Elsevier
  • Release Date : 2021-09-22
  • Genre: Psychology
  • Pages : 442
  • ISBN 10 : 9780323901635
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Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Brain Research series Updated release includes the latest information on the Neuropharmacology of Neuroprotection

Molecular Mechanisms and Therapeutic Strategies in Alzheimer s Disease Book

Molecular Mechanisms and Therapeutic Strategies in Alzheimer s Disease

  • Author : Veer Gupta
  • Publisher : LAP Lambert Academic Publishing
  • Release Date : 2012
  • Genre: Uncategoriezed
  • Pages : 240
  • ISBN 10 : 3844385843
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This book provides an insight into the mechanism on the role of amino acid stereospecificity based amyloid beta aggregation pattern; non-apoptotic amyloid beta peptide induced DNA nicking and neuro-neutraceutical property of garlic and curcumin derivatives. These findings provide a molecular understanding of the neurodegeneration and neuroprotection in Alzheimers Disease brain. Novel neuroprotective strategies to treat various neurodegenrative disorders are discussed.

Neuroprotective Natural Products Book

Neuroprotective Natural Products

  • Author : Goutam Brahmachari
  • Publisher : John Wiley & Sons
  • Release Date : 2017-03-01
  • Genre: Medical
  • Pages : 376
  • ISBN 10 : 9783527803804
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Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

Alzheimer s Disease Drug Development Book

Alzheimer s Disease Drug Development

  • Author : Jeffrey Cummings
  • Publisher : Cambridge University Press
  • Release Date : 2022-03-31
  • Genre: Business & Economics
  • Pages : 575
  • ISBN 10 : 9781108838665
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Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

The Management of Alzheimer s Disease Book

The Management of Alzheimer s Disease

  • Author : Gordon K. Wilcock
  • Publisher : Routledge
  • Release Date : 1993-01-01
  • Genre: Medical
  • Pages : 220
  • ISBN 10 : 1871816203
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Cinquiesme livre contenant xxviii chansons...(Lyons 1539]) and Le parangon des chanson. Sixiesme livre contenant xxv chansons nouvelles...(Lyons, 1540)

Genetically Modified Organisms and Genetic Engineering in Research and Therapy Book

Genetically Modified Organisms and Genetic Engineering in Research and Therapy

  • Author : Pascale Piguet
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2012
  • Genre: Science
  • Pages : 138
  • ISBN 10 : 9783805590655
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Genetically modified organisms (GMO) raise societal, political and ethical concerns. They inspire strong resistance or, conversely, enthusiastic assent. The aim of this publication is to give an overview of genetic engineering, starting with the history of the discovery of restriction enzymes continuing with technical aspects of transgenesis to its applications in research and ethical considerations. Be it the use of single engineered cells or GMO, these applications cover a broad array, ranging from disease-oriented research (but not only), to the promising perspectives of gene therapy. Historical and technical aspects give insights into the problems inherent to the creation of GMO, and illustrate the links and limits between genetic engineering, GMOs and gene therapy. A summary article in English and French structures the links between the different chapters and concepts. Scientists interested in genetic engineering of single cells or animal models, as well as in gene therapy, will find an up-to-date review on the use and perspectives of transgenesis. However, this publication is also recommended to the public interested in the definition of GMO, which encompasses a much broader array than the genetically modified crops covered by media.

Phytochemical Omics in Medicinal Plants Book

Phytochemical Omics in Medicinal Plants

  • Author : Jen-Tsung Chen
  • Publisher : MDPI
  • Release Date : 2021-08-18
  • Genre: Medical
  • Pages : 542
  • ISBN 10 : 9783036512945
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Medicinal plants are used to treat diseases and provide health benefits, and their applications are increasing around the world. A huge array of phytochemicals have been identified from medicinal plants, belonging to carotenoids, flavonoids, lignans, and phenolic acids, and so on, with a wide range of biological activities. In order to explore our knowledge of phytochemicals with the assistance of modern molecular tools and high-throughput technologies, this book collects recent innovative original research and review articles on subtopics of mechanistic insights into bioactivities, treatment of diseases, profiling, extraction and identification, and biotechnology.

Frontiers in Alzheimer s Disease Research Book

Frontiers in Alzheimer s Disease Research

  • Author : Eileen M. Welsh
  • Publisher : Nova Publishers
  • Release Date : 2006
  • Genre: Alzheimer's disease
  • Pages : 376
  • ISBN 10 : 159454929X
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Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. The most common form of dementia among older people is Alzheimer's Disease (AD), which involves the parts of the brain that control memory, thought and language. Age is the most important known risk factor for AD. The number of people with the disease doubles every 5 years beyond age 65. AD is a slow disease, starting with mild memory loss and ending with severe brain damage. The course the disease takes and how fast changes occur vary from person to person. On average, AD patients live from 8 to 10 years after they are diagnosed, though the disease can last for as many as 20 years. Current research is aimed at understanding why AD occurs and who is at greatest risk for developing it, improving the accuracy of diagnosis and ability to identify who is at risk, developing, discovering and testing new treatments for behavioural problems in patients with AD. This book gathers state-of-the-art research from leading scientists throughout the world which offers important information on understanding the underlying causes and discovering the most effective treatments for Alzheimer's Disease.