Neuropsychiatric Disorders and Epigenetics Book

Neuropsychiatric Disorders and Epigenetics


  • Author : Dag Yasui
  • Publisher : Academic Press
  • Release Date : 2016-11-15
  • Genre: Science
  • Pages : 444
  • ISBN 10 : 9780128005279

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Neuropsychiatric Disorders and Epigenetics Excerpt :

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

Pharmacoepigenetics Book

Pharmacoepigenetics


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-06-04
  • Genre: Medical
  • Pages : 983
  • ISBN 10 : 9780128139400

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Pharmacoepigenetics Excerpt :

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Neuropsychiatric Disorders and Epigenetics Book

Neuropsychiatric Disorders and Epigenetics


  • Author : Dag Yasui
  • Publisher : Academic Press
  • Release Date : 2016-10-15
  • Genre: Uncategoriezed
  • Pages : 400
  • ISBN 10 : 0128002263

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Neuropsychiatric Disorders and Epigenetics Excerpt :

"Neurobehavioral Disorders and Epigenetics" is a comprehensive reference for the epigenetic basis of most common neurobehavioral disorders. The volume is organized into 22 chapters representing individual neurological disorders, from Addiction to Stress. The epigenetic aspects of each disorder are addressed by at least two scientists with expertise in that research area. Particular emphasis is placed by each contributing author on potential epigenetic interventions. In an effort to cover a broad range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA, author contributions were selected accordingly. In addition the effects of environmental stimuli on epigenetic states is addressed in some chapters based on relevance to disease induction. Recent discoveries in epigenetic research enabled by advances in genomic technologies, have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders. Clearly neurobehavioral disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with high costs to society. Thus, these collected works will define epigenetics as a key player in neurobehavioral disorders, highlight the full spectrum of epigenetic mechanisms underlying such disorders and introduce the vast range of epigenetic therapies under development. Relates the effects of environmental stimuli on epigenetic states to neurological disease inductionAnalysis of the epigenetic basis for common neuropsychiatric disorders and how it guides treatment, providing insight and perspective to both clinicians and basic scientistsExtensive use of diagrams, illustrations and tables, and graphical abstracts for each subsection permits rapid review

Epigenetics in Psychiatry Book

Epigenetics in Psychiatry


  • Author : Jacob Peedicayil
  • Publisher : Academic Press
  • Release Date : 2021-08-16
  • Genre: Science
  • Pages : 846
  • ISBN 10 : 9780128235782

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Epigenetics in Psychiatry Excerpt :

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Epigenetic Regulation in the Nervous System Book

Epigenetic Regulation in the Nervous System


  • Author : J. David Sweatt
  • Publisher : Academic Press
  • Release Date : 2012-12-31
  • Genre: Science
  • Pages : 374
  • ISBN 10 : 9780123944054

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Epigenetic Regulation in the Nervous System Excerpt :

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making

Neuropsychiatric Disorders Book

Neuropsychiatric Disorders


  • Author : Koho Miyoshi
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-08-09
  • Genre: Medical
  • Pages : 351
  • ISBN 10 : 9784431538714

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Neuropsychiatric Disorders Excerpt :

Around the world societies are facing growing aging populations with the concomitant increase in neuropsychiatric disorders. Neuropsychiatric disorders are organic brain diseases with psychiatric symptoms, as in Alzheimer’s and Parkinson’s diseases, that cause cognitive impairment, including dementia, amnesic syndrome, and personality–behavioral changes. As a clinical science, neuropsychiatry aims to explore the complex interrelationship between behavior and brain function from a variety of perspectives, including those of psychology, neurology, and psychiatry. This concise and updated monograph comprises the latest findings in the field and includes chapters on delusional symptoms, mood disorders and neurotic symptoms, cognitive impairment, behavioral and personality changes, and recently, cerebral alterations revealed in PTSD patients and in endogenous psychoses through neuroimaging and neuropathology. These findings will certainly widen the realm of neuropsychiatry going forward and will prove of great value to specialists as well as to academics and trainees in neurology, psychiatry, neuropsychology, neuroradiology, neuropathology, neurophysiology, neurochemistry, and clinical genetics. Ultimately, neuropsychiatry aims to prevent and reduce the suffering of individuals with the psychiatric symptoms of cerebral disorders.

Epigenetics of Stress and Stress Disorders Book

Epigenetics of Stress and Stress Disorders


  • Author : Nagy Youssef
  • Publisher : Elsevier
  • Release Date : 2022-02-18
  • Genre: Medical
  • Pages : 420
  • ISBN 10 : 9780128230398

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Epigenetics of Stress and Stress Disorders Excerpt :

Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or "epidrugs.” Examines the epigenetics of stress, trauma, and related stress disorders Connects new research to clinical practice and highlights implications for patient care, drug discovery, and public health Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigenetic alterations Features chapter contributions from international experts in the field

Neurodegenerative Diseases Book

Neurodegenerative Diseases


  • Author : Uday Kishore
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-05-15
  • Genre: Medical
  • Pages : 642
  • ISBN 10 : 9789535110880

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Neurodegenerative Diseases Excerpt :

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Psychotic Disorders Book

Psychotic Disorders


  • Author : Federico Durbano
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-06-27
  • Genre: Medical
  • Pages : 174
  • ISBN 10 : 9781789233247

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Psychotic Disorders Excerpt :

In this book, with the involvement not only of clinical psychiatrists but also of neurobiologists, specific issues of psychotic disorders (mainly schizophrenia and mood disorders) are reviewed. The focus of attention ranges from therapeutics to the new frontiers of epigenetics. A special focus is on the individual reactions to psychosis (ranging from psychological ones to treatments and neurobiological basis). Because of the rapid development of neurosciences, which are showing common underling factors to different phenotypical expressions of mental illness, we are facing an enormous growth of biological data, which is not always easy to interpret. The risk is to forget that we are relating to other individuals, with their stories, and, most of all, with their environmental resources and interactions. The contributions to this book will range from individual experience (a personal history of illness) through some aspects of individual management of illness (insight), from correct use of available psychosocial resources to the environment-gene relationships (epigenetics).

Genomics  Circuits  and Pathways in Clinical Neuropsychiatry Book

Genomics Circuits and Pathways in Clinical Neuropsychiatry


  • Author : Thomas Lehner
  • Publisher : Academic Press
  • Release Date : 2016-06-07
  • Genre: Science
  • Pages : 796
  • ISBN 10 : 9780128005309

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Genomics Circuits and Pathways in Clinical Neuropsychiatry Excerpt :

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Principles of Psychiatric Genetics Book

Principles of Psychiatric Genetics


  • Author : John I. Nurnberger, Jr
  • Publisher : Cambridge University Press
  • Release Date : 2012-09-13
  • Genre: Medical
  • Pages : 415
  • ISBN 10 : 9780521896498

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Principles of Psychiatric Genetics Excerpt :

A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.

Chromatin Signaling and Neurological Disorders Book

Chromatin Signaling and Neurological Disorders


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-05-24
  • Genre: Medical
  • Pages : 378
  • ISBN 10 : 9780128137970

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Chromatin Signaling and Neurological Disorders Excerpt :

Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases. In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research. Examines specific chromatin signaling factors that regulate spinal muscular atrophy, ulbospinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, Angelman syndrome, Rader-Willi syndrome, and more Contains chapter contributions from international experts who speak to the clinical significance of recent findings and the implications for the development of epigenetics-based therapeutics Provides researchers, students and clinicians with approaches to better interpret and employ new diagnostic studies for treating neurological disorders

Anxiety Disorders Book

Anxiety Disorders


  • Author : Nese Kocabasoglu
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-02-27
  • Genre: Medical
  • Pages : 140
  • ISBN 10 : 9781789854817

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Anxiety Disorders Excerpt :

In this book, we focus on children with anxiety disorders and the children whose parents were diagnosed with anxiety disorders in their lifetime. The aim is to investigate the different types of anxiety disorders with different underlying mechanisms. The developmental perspective will support a better understanding of the development of anxiety disorders and transition from childhood to adulthood. We believe this book will appeal to a wide audience of practicing psychiatrists, psychologists, psychiatric nurses, social workers and mental health professionals. It is our hope that many will find this book useful for training mental health professionals to give them the newest developmental point of view about prototype anxiety disorders. We dedicate this book to our lovely families, patients, and their families.

Neuroepigenomics in Aging and Disease Book

Neuroepigenomics in Aging and Disease


  • Author : Raul Delgado-Morales
  • Publisher : Springer
  • Release Date : 2017-05-18
  • Genre: Science
  • Pages : 525
  • ISBN 10 : 9783319538891

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Neuroepigenomics in Aging and Disease Excerpt :

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Histone Modifications in Therapy Book

Histone Modifications in Therapy


  • Author : Pedro Castelo-Branco
  • Publisher : Academic Press
  • Release Date : 2020-08-21
  • Genre: Science
  • Pages : 490
  • ISBN 10 : 9780128167403

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Histone Modifications in Therapy Excerpt :

Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists