Drug Discovery and Development  Third Edition Book

Drug Discovery and Development Third Edition


  • Author : James J. O'Donnell
  • Publisher : CRC Press
  • Release Date : 2019-12-13
  • Genre: Medical
  • Pages : 860
  • ISBN 10 : 9781351625135

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Drug Discovery and Development Third Edition Excerpt :

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Translational Neuroscience Book

Translational Neuroscience


  • Author : James E. Barrett
  • Publisher : Cambridge University Press
  • Release Date : 2012-06-28
  • Genre: Medical
  • Pages : 379
  • ISBN 10 : 9780521519762

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Translational Neuroscience Excerpt :

A comprehensive and authoritative analysis of translational neuroscience, covering all major areas of psychiatry, neurology and neurodevelopmental disorders.

Drug Discovery and Development Book

Drug Discovery and Development


  • Author : Vishwanath Gaitonde
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-03-11
  • Genre: Medical
  • Pages : 166
  • ISBN 10 : 9781789239751

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Drug Discovery and Development Excerpt :

The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.

Regenerative Pharmacology Book

Regenerative Pharmacology


  • Author : George J. Christ
  • Publisher : Cambridge University Press
  • Release Date : 2013-04-15
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9781107354739

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Regenerative Pharmacology Excerpt :

Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.

Autoimmune Neurology Book

Autoimmune Neurology


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2016-03-11
  • Genre: Science
  • Pages : 568
  • ISBN 10 : 9780444634467

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Autoimmune Neurology Excerpt :

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Sharing Clinical Trial Data Book

Sharing Clinical Trial Data


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2015-04-20
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9780309316323

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Sharing Clinical Trial Data Excerpt :

Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research--from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Translational Medicine in CNS Drug Development Book

Translational Medicine in CNS Drug Development


  • Author : George G. Nomikos
  • Publisher : Academic Press
  • Release Date : 2019-06-18
  • Genre: Medical
  • Pages : 458
  • ISBN 10 : 9780128031643

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Translational Medicine in CNS Drug Development Excerpt :

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Practical Guide To Scientific And Technical Translation  A  Publishing  Style And Terminology Book

Practical Guide To Scientific And Technical Translation A Publishing Style And Terminology


  • Author : James Brian Alexander Mitchell
  • Publisher : World Scientific
  • Release Date : 2022-01-25
  • Genre: Education
  • Pages : 188
  • ISBN 10 : 9789811241574

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Practical Guide To Scientific And Technical Translation A Publishing Style And Terminology Excerpt :

Are you a non-native English speaker? Are you often confronted with manuscript rejections because of poor language impeding comprehension of your paper? A Practical Guide to Scientific and Technical Translation is your solution. In this one-stop guide, two authors with extensive experience as reviewers and translators in a vast medley of scientific fields assist you to produce professional quality documents, whether through direct authoring in a language foreign to you or translation from an existing text. The book is not intended as a text on English grammar but as a troubleshooting guide to linguistic and style errors. We will help you overcome at least the most common problems here. Technical terminology searching and choice will also be covered with examples from a number of scientific (physics, chemistry) and engineering disciplines (aviation, transport, nuclear, environment, etc.), with advice on how to choose the right term for the right job. While the emphasis is on producing documents in English (the lingua franca of modern scientific literature), general translation concepts are also discussed. Hence, this book will also be useful to translators, and scientists who need to present their work in languages other than English.

APA Handbook of Psychopharmacology Book

APA Handbook of Psychopharmacology


  • Author : Suzette M. Evans
  • Publisher : APA Handbooks in Psychology(r)
  • Release Date : 2019
  • Genre: Medical
  • Pages : 776
  • ISBN 10 : 1433830752

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APA Handbook of Psychopharmacology Excerpt :

The APA Handbook of Psychopharmacology provides working knowledge of basic pharmacology and psychopharmacology, examines psychopharmacology for treatment of various emotional and behavioral conditions, and discusses related professional and social issues.

Leucine Rich Repeat Kinase 2  LRRK2  Book

Leucine Rich Repeat Kinase 2 LRRK2


  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release Date : 2017-03-28
  • Genre: Medical
  • Pages : 271
  • ISBN 10 : 9783319499697

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Leucine Rich Repeat Kinase 2 LRRK2 Excerpt :

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Drug Repurposing Book

Drug Repurposing


  • Author : Farid A. Badria
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-12-02
  • Genre: Medical
  • Pages : 236
  • ISBN 10 : 9781839685200

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Drug Repurposing Excerpt :

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Brain Neurotrauma Book

Brain Neurotrauma


  • Author : Firas H. Kobeissy
  • Publisher : CRC Press
  • Release Date : 2015-02-25
  • Genre: Science
  • Pages : 725
  • ISBN 10 : 9781466565999

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Brain Neurotrauma Excerpt :

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Emerging Cognitive Neuroscience and Related Technologies Book

Emerging Cognitive Neuroscience and Related Technologies


  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 2008-12-06
  • Genre: Medical
  • Pages : 215
  • ISBN 10 : 9780309118941

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Emerging Cognitive Neuroscience and Related Technologies Excerpt :

Emerging Cognitive Neuroscience and Related Technologies, from the National Research Council, identifies and explores several specific research areas that have implications for U.S. national security, and should therefore be monitored consistently by the intelligence community. These areas include: neurophysiological advances in detecting and measuring indicators of psychological states and intentions of individuals the development of drugs or technologies that can alter human physical or cognitive abilities advances in real-time brain imaging breakthroughs in high-performance computing and neuronal modeling that could allow researchers to develop systems which mimic functions of the human brain, particularly the ability to organize disparate forms of data. As these fields continue to grow, it will be imperative that the intelligence community be able to identify scientific advances relevant to national security when they occur. To do so will require adequate funding, intelligence analysts with advanced training in science and technology, and increased collaboration with the scientific community, particularly academia. A key tool for the intelligence community, this book will also be a useful resource for the health industry, the military, and others with a vested interest in technologies such as brain imaging and cognitive or physical enhancers.

Trials of War Criminals Before the Nuernberg Military Tribunals Under Control Council Law No  10  Nuremberg  October 1946 April  1949  Case 1  U S  v  Brandt  cont   Case 2  U S  v  Milch  Milch case  Book

Trials of War Criminals Before the Nuernberg Military Tribunals Under Control Council Law No 10 Nuremberg October 1946 April 1949 Case 1 U S v Brandt cont Case 2 U S v Milch Milch case


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1949
  • Genre: Government publications
  • Pages : 912
  • ISBN 10 : UIUC:30112106554907

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Trials of War Criminals Before the Nuernberg Military Tribunals Under Control Council Law No 10 Nuremberg October 1946 April 1949 Case 1 U S v Brandt cont Case 2 U S v Milch Milch case Excerpt :