Nitric Oxide Donors Book

Nitric Oxide Donors

  • Author : Amedea Seabra
  • Publisher : Academic Press
  • Release Date : 2017-03-17
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9780128134597

Nitric Oxide Donors Excerpt :

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval

Nitric Oxide Donors Book

Nitric Oxide Donors

  • Author : Peng George Wang
  • Publisher : John Wiley & Sons
  • Release Date : 2005-08-16
  • Genre: Science
  • Pages : 407
  • ISBN 10 : 9783527603848

Nitric Oxide Donors Excerpt :

Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.

Nitric Oxide  Donor Induced  in Chemosensitization Book

Nitric Oxide Donor Induced in Chemosensitization

  • Author : Benjamin Bonavida
  • Publisher : Academic Press
  • Release Date : 2017-06-28
  • Genre: Medical
  • Pages : 250
  • ISBN 10 : 9780128110218

Nitric Oxide Donor Induced in Chemosensitization Excerpt :

Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders Book

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

  • Author : Lucia Morbidelli
  • Publisher : Academic Press
  • Release Date : 2019-02-09
  • Genre: Medical
  • Pages : 372
  • ISBN 10 : 9780128172797

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders Excerpt :

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

Organic Nitrates Book

Organic Nitrates

  • Author : P. Needleman
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 198
  • ISBN 10 : 9783642660245

Organic Nitrates Excerpt :

Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.

Functionalised Cardiovascular Stents Book

Functionalised Cardiovascular Stents

  • Author : Gerard Wall
  • Publisher : Woodhead Publishing
  • Release Date : 2018-02-06
  • Genre: Medical
  • Pages : 368
  • ISBN 10 : 9780081004982

Functionalised Cardiovascular Stents Excerpt :

Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo. Provides a specific focus on cardiovascular stents Includes a range of topics covering the fundamentals, surface modification and biofunctionalization Provides essential knowledge for researchers on advances in the field

Katzung   Trevor s Pharmacology Examination and Board Review  Thirteenth Edition Book

Katzung Trevor s Pharmacology Examination and Board Review Thirteenth Edition

  • Author : Bertram G. Katzung
  • Publisher : McGraw Hill Professional
  • Release Date : 2021-06-25
  • Genre: Medical
  • Pages : 608
  • ISBN 10 : 9781260117134

Katzung Trevor s Pharmacology Examination and Board Review Thirteenth Edition Excerpt :

Score your highest on medical pharmacology courses and board exams with the world’s bestselling pharmacology review book! More than 1,000 Q&A! This authoritative resource from the authors of pharmacology’s most trusted textbook delivers a clear, concise review of fundamental concepts backed by more than 1,000 review questions and answers. With fully up-to-date content, the chapter-based approach facilitates use with course notes or larger texts. Everything you need to excel: 1,000+ board-review type questions Concise discussion of the major concepts that underlie basic principles or specific drug groups in every chapter Two comprehensive 100-question practice exams with answer keys and explanations for correct answers List of high-yield terms and definitions Skill Keeper Questions that help you understand the connections of related topics 180 photos and illustrations―including explanatory figures and tables, and overview diagrams that visually organize drug groups and concepts Checklist of tasks you should be able to perform upon completion of the chapter Summary tables that provide key information about specific drug mechanisms of action and effects, clinical uses, pharmacokinetics, drug interactions, and toxicities Test-taking strategies for improving your test performance

Pharmacology Book


  • Author : Bertram G. Katzung
  • Publisher : McGraw-Hill/Appleton & Lange
  • Release Date : 1993
  • Genre: Pharmacology
  • Pages : 436
  • ISBN 10 : UOM:39015013819522

Pharmacology Excerpt :

Nitric Oxide Synthase Book

Nitric Oxide Synthase

  • Author : Seyed Soheil Saeedi Saravi
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-05-17
  • Genre: Science
  • Pages : 250
  • ISBN 10 : 9789535131632

Nitric Oxide Synthase Excerpt :

Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.

Chemical Tools for Imaging  Manipulating  and Tracking Biological Systems  Diverse Methods for Optical Imaging and Conjugation Book

Chemical Tools for Imaging Manipulating and Tracking Biological Systems Diverse Methods for Optical Imaging and Conjugation

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-05-29
  • Genre: Science
  • Pages : 430
  • ISBN 10 : 9780128211526

Chemical Tools for Imaging Manipulating and Tracking Biological Systems Diverse Methods for Optical Imaging and Conjugation Excerpt :

Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Optical Imaging and Conjugation, Volume 639, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Fluorogenic detection of protein aggregates in live cells using the AggTag method, Synthesis and Application of Ratiometric Probes for Hydrogen Peroxide Detection, Chemical Tools for Multicolor Protein FRET with Tryptophan, Fluorescing Isofunctional Ribonucleosides for Adenosine Deaminase Activity and Inhibition, Temporal profiling establishes a dynamic S-palmitoylation cycle, Solvation-guided design of fluorescent probes for discrimination of amyloids, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways

Ruthenium Complexes Book

Ruthenium Complexes

  • Author : Alvin A. Holder
  • Publisher : John Wiley & Sons
  • Release Date : 2017-11-01
  • Genre: Science
  • Pages : 344
  • ISBN 10 : 9783527695249

Ruthenium Complexes Excerpt :

Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.

Principles of Bone Biology Book

Principles of Bone Biology

  • Author : John P. Bilezikian
  • Publisher : Academic Press
  • Release Date : 2008-09-29
  • Genre: Medical
  • Pages : 1900
  • ISBN 10 : 0080568750

Principles of Bone Biology Excerpt :

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

Globins and Other Nitric Oxide Reactive Proteins Book
Score: 5
From 1 Ratings

Globins and Other Nitric Oxide Reactive Proteins

  • Author : Robert K. Poole
  • Publisher : Elsevier
  • Release Date : 2011-09-02
  • Genre: Science
  • Pages : 672
  • ISBN 10 : 008056044X

Globins and Other Nitric Oxide Reactive Proteins Excerpt :

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: This volume features methods for the study of globin and other nitric oxide-reactive proteins.

Nitric Oxide Book

Nitric Oxide

  • Author : Paul Kubes
  • Publisher : Austin, Texas : R.G. Landes
  • Release Date : 1995
  • Genre: Medical
  • Pages : 171
  • ISBN 10 : WISC:89057502460

Nitric Oxide Excerpt :