Successes and Challenges of NK Immunotherapy Book

Successes and Challenges of NK Immunotherapy


  • Author : Benjamin Bonavida
  • Publisher : Academic Press
  • Release Date : 2021-06-23
  • Genre: Science
  • Pages : 538
  • ISBN 10 : 9780128243961

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Successes and Challenges of NK Immunotherapy Excerpt :

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer Book

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer


  • Author : Loredana Cifaldi
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-31
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889638765

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Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer Excerpt :

In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.

NK Cell Based Cancer Immunotherapy Book

NK Cell Based Cancer Immunotherapy


  • Author : Francisco Borrego
  • Publisher : Frontiers Media SA
  • Release Date : 2016-09-08
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889199341

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NK Cell Based Cancer Immunotherapy Excerpt :

Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK c

NK Cells in Cancer Immunotherapy Book

NK Cells in Cancer Immunotherapy


  • Author : Lynda Addou-Klouche
  • Publisher : Unknown
  • Release Date : 2017
  • Genre: Medicine
  • Pages : null
  • ISBN 10 : OCLC:1154268044

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NK Cells in Cancer Immunotherapy Excerpt :

Natural killer (NK) cells are crucial components of the innate immune system and play critical roles in host immunity against viral infections and cancer. NK cells' activity is controlled by the interaction of a wide range of receptors expressed on their surfaces with cell surface ligands. Opposite signals delivered by inhibitory and activating receptors tightly regulate NK cells' cytotoxicity. Natural killer cells can discriminate between normal and cancer cells. NK cells are known to directly recognize and kill malignant cells or induce apoptosis. However, tumor cells have the ability to evade those attacks. The main mechanisms involve the lack of expression or downregulation of the expression of major histocompatibility complex (MHC) class I molecules and secretion of soluble NKG2D ligands by tumor cells. Furthermore, tumors harbor a population of cancer stem cells (CSCs), which can drive tumor progression and therapeutical resistance. This chapter highlights the roles of NK cells in tumor immunosurveillance and their applications for cancer immunotherapy. NK cell biology and function as well as the role of their receptor interactions will be described. We will discuss the therapeutic applications of NK cells in cancer and NK cells targeting CSCs as a promising strategy for cancer therapy.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Sarah S. Donatelli
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059050

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Cancer Immunotherapy Excerpt :

Natural Killer (NK) cells are a unique subset of lymphocytes genetically programmed to locate and destroy cellular malignancies. They accomplish this through unique cell surface receptors that, upon contacting a target cell, transmit either inhibitory or activating intracellular signals, ultimately determining whether the target cell will be killed or spared. Acquisition of the capacity to kill comes only after the NK cell is rendered tolerant to healthy self cells through interaction with naturally expressed MHC I molecules. The resulting functional NK cell is endowed with both repressive and stimulatory receptors that recognize MHC I or MHC I-related proteins, and stress-induced proteins that are not normally expressed by healthy cells, respectively. The respective signaling pathways are generally conserved among receptors; consequently, mechanisms that dysregulate NK-cell surface receptor density may directly impair NK responsiveness towards cancerous cells by affecting the ratio of inhibitory-to-activating signals. Furthermore, activating receptors can be downregulated, suggesting a targeted evasion strategy that specifically converts the NK cell towards an inhibitory phenotype.

Tumor Progression and Therapeutic Resistance Book

Tumor Progression and Therapeutic Resistance


  • Author : Wafik S. El-Deiry
  • Publisher : Unknown
  • Release Date : 2005
  • Genre: Medical
  • Pages : 198
  • ISBN 10 : UVA:X030000978

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Tumor Progression and Therapeutic Resistance Excerpt :

This volume presents the entire breadth of translational cancer research and brings together members of academia and industry in the expectation of accelerating interactions and progress in the field. A variety of key topics are presented, beginning with discovery of molecular targets and pathways (oncogene, cell survival, tumor suppression, cell death), host-neoplasm interactions (cell adhesion, matrix proteases), early detection, monitoring progression, understanding tumor progression and metastasis, immune surveillance, in vivo molecular imaging, animal models, drug discovery including chemistry, high-throughput assays, mechanism determination, target validation, therapeutic window and some progress in clinical trials for more advanced agents and targets.

Natural Killer Cells Book

Natural Killer Cells


  • Author : Michael T. Lotze
  • Publisher : Academic Press
  • Release Date : 2009-11-12
  • Genre: Medical
  • Pages : 660
  • ISBN 10 : 0080919294

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Natural Killer Cells Excerpt :

Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells

Immune Surveillance Book

Immune Surveillance


  • Author : Richard T. Smith
  • Publisher : Elsevier
  • Release Date : 2012-12-02
  • Genre: Nature
  • Pages : 552
  • ISBN 10 : 9780323146265

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Immune Surveillance Excerpt :

Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

Immunotherapy Book

Immunotherapy


  • Author : Krassimir Metodiev
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-04-26
  • Genre: Medical
  • Pages : 414
  • ISBN 10 : 9789535131052

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Immunotherapy Excerpt :

This is another attempt of InTechOpen to continue the dissemination of international knowledge and experience in the field of immunology. The present book includes a number of modern concepts of specialists and experts in the field of immunotherapy, covering the major topics and analyzing the history, current stage, and future ideas of application of modern immunomodulation. It is always a benefit, but also a compliment, to gather a team of internationally distinguished authors and to motivate them to reveal their expertise for the benefit of medical science and health practice. On behalf of all readers, immunologists, immunogeneticists, biologists, oncologists, microbiologists, virologists, hematologists, chemotherapists, health-care experts, as well as students and medical specialists, also on my personal behalf, I would like to extend my gratitude and highest appreciation to InTechOpen for giving me the unique chance to be the editor of this exclusive book.

Cancer Immunology Book

Cancer Immunology


  • Author : Nima Rezaei
  • Publisher : Springer
  • Release Date : 2014-12-29
  • Genre: Medical
  • Pages : 485
  • ISBN 10 : 9783662449462

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Cancer Immunology Excerpt :

This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.

Cancer Immunotherapy and Biological Cancer Treatments Book

Cancer Immunotherapy and Biological Cancer Treatments


  • Author : Hilal Arnouk
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-11-13
  • Genre: Medical
  • Pages : 112
  • ISBN 10 : 9781789848625

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Cancer Immunotherapy and Biological Cancer Treatments Excerpt :

In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy.

Critical Issues in Head and Neck Oncology Book

Critical Issues in Head and Neck Oncology


  • Author : Jan B. Vermorken
  • Publisher : Springer Nature
  • Release Date : 2021-06-02
  • Genre: Medical
  • Pages : 373
  • ISBN 10 : 9783030632342

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Critical Issues in Head and Neck Oncology Excerpt :

This open access book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck cancers. Readers will learn about the latest drug developments and epidemiological aspects in cancers ranging from Head and Neck Squamous Cell Cancer to Nasopharynx cancer. Edited by a team of world leaders in Head and Neck Cancer, this volume serves as an easy reference to the head and neck oncology practitioner and provides a contemporary overview for specialists the field. The chapters are based on the latest data presented at the 7th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field.

Immunotherapy in Translational Cancer Research Book

Immunotherapy in Translational Cancer Research


  • Author : Laurence J. N. Cooper
  • Publisher : John Wiley & Sons
  • Release Date : 2018-05-01
  • Genre: Medical
  • Pages : 312
  • ISBN 10 : 9781118123225

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Immunotherapy in Translational Cancer Research Excerpt :

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.