Non Canonical Autophagy Book

Non Canonical Autophagy


  • Author : Giulia Petroni
  • Publisher : Academic Press
  • Release Date : 2021-05-01
  • Genre: Science
  • Pages : 182
  • ISBN 10 : 9780128209110

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Non Canonical Autophagy Excerpt :

Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

Membrane Biogenesis Book

Membrane Biogenesis


  • Author : Jos A.F. Op den Kamp
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • Genre: Science
  • Pages : 477
  • ISBN 10 : 9783642731846

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Membrane Biogenesis Excerpt :

Many individual aspects of the dynamics and assembly of biological membranes have been studied in great detail. Cell biological approaches, advanced genetics, biophysics and biochemistry have greatly contributed to an increase in our knowledge in this field.lt is obvious however, that the three major membrane constituents - lipids, proteins and carbohydrates- are studied, in most cases separately and that a coherent overview of the various aspects of membrane biogenesis is not readily available. The NATO Advanced Study Institute on "New Perspectives in the Dynamics of Assembly of Biomembranes" intended to provide such an overview: it was set up to teach students and specialists the achievements obtained in the various research areas and to try and integrate the numerous aspects of membrane assembly into a coherent framework. The articles in here reflect this. Statting with detailed contributions on phospholipid structure, dynamics, organization and biogenesis, an up to date overview of the basic, lipidic backbone of biomembranes is given. Extensive progress is made in the research on membrane protein biosynthesis. In particular the post- and co-translational modification processes of proteins, the mechanisms of protein translocation and the sorting mechanisms which are necessary to direct proteins to their final, intra - or extracellular destination have been characterized in detail. Modern genetic approaches were indispensable in this research area: gene cloning, hybrid protein construction, site directed mutagenesis and sequencing techniques elucidated many functional aspects of specific nucleic acid and amino acid sequences.

Autophagy in Health and Disease Book

Autophagy in Health and Disease


  • Author : Roberta A. Gottlieb
  • Publisher : Academic Press
  • Release Date : 2012-10-16
  • Genre: Medical
  • Pages : 227
  • ISBN 10 : 9780123851017

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Autophagy in Health and Disease Excerpt :

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Autophagy in Autoimmunity Book

Autophagy in Autoimmunity


  • Author : Xu-jie Zhou
  • Publisher : Frontiers Media SA
  • Release Date : 2019-05-15
  • Genre: Uncategoriezed
  • Pages : 161
  • ISBN 10 : 9782889458127

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Autophagy in Autoimmunity Excerpt :

Autophagy Book

Autophagy


  • Author : Nicholas Ktistakis
  • Publisher : Humana Press
  • Release Date : 2019-01-05
  • Genre: Science
  • Pages : 741
  • ISBN 10 : 1493988727

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Autophagy Excerpt :

This volume details a comprehensive and extensive set of protocols for the study of autophagy in vitro and in vivo. Chapters focus on mammals, various model organisms, and provide protocols for the study of autophagy-related processes outside of the canonical autophagy pathways. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Autophagy: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Autophagy of the Nervous System Book

Autophagy of the Nervous System


  • Author : Zhenyu Yue
  • Publisher : World Scientific
  • Release Date : 2012
  • Genre: Medical
  • Pages : 426
  • ISBN 10 : 9789814350440

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Autophagy of the Nervous System Excerpt :

What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provide an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons. Current experimental evidence for both evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented. Advances in our understanding of the complex interplay of autophagy induction and downregulation will be discussed in relation to the critical balance needed to modulate neuroprotection versus neurodegeneration in the context of neurological diseases including Alzheimer's, Parkinson's, Huntington's, ischemic-hypoxic and lysosomal diseases.

The Non canonical Role of Autophagy Components in the Secretion of Neural Peptide Hormones Book

The Non canonical Role of Autophagy Components in the Secretion of Neural Peptide Hormones


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2016
  • Genre: Electronic books
  • Pages : 47
  • ISBN 10 : OCLC:976434208

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The Non canonical Role of Autophagy Components in the Secretion of Neural Peptide Hormones Excerpt :

The canonical autophagy pathway has primarily been described as a degradative mechanism, which clears the cell of old damaged organelles, protein aggregates and pathogens. Central to the pathway is the de novo formation of a vesicle structure called the autophagosome, which fuses with lysosomes to degrade its content. The Atg8a/MAP1-LC3 protein family is essential for the formation of the autophagosome, and Atg8a mutations result in a variety of defects related to decreased autophagic function. Recently, we have observed a phenotype in Atg8a mutant Drosophila that is consistent with secretory defects of the peptide hormone Bursicon, which is responsible for wing expansion and cuticle hardening upon eclosion. This observation is in accordance with other recent findings which show that components of the autophagy pathway are also involved in the secretion of bioactive molecules. However, the intersection of autophagy and secretory pathways is not yet fully understood. Here, we show that along with Bursicon two additional peptide hormones are differentially secreted and show impaired hemolymph profiles when autophagic function is lowered in the fly nervous system. This includes the release of the pigment dispersing factor (PDF, circadian cycle) and the mesencephalic astrocyte-derived neurotrophic factor (dMANF, stress response), which is highlighted by the aberrant sleep-circadian behaviors (PDF) and trauma-mediated sensitivity (MANF) associated with Atg8a1 mutant flies. Based on the Bursicon wing phenotype, we conducted a secretion-based screen using the GAL4/UAS-dsRNAi knockdown system and identified Atg8a and other autophagy components involved with organelle initiation and membrane expansion that show impaired Bursicon release upon knockdown. Furthermore, this did not include genes involved with selective autophagy (aggrephagy) or endosomal-lysosomal trafficking. Findings from this research will have broad implications toward understanding complex secretory defects

Autophagy in Current Trends in Cellular Physiology and Pathology Book

Autophagy in Current Trends in Cellular Physiology and Pathology


  • Author : Nikolai Gorbunov
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-11-10
  • Genre: Science
  • Pages : 526
  • ISBN 10 : 9789535127260

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Autophagy in Current Trends in Cellular Physiology and Pathology Excerpt :

Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.