Nuclear Architecture and Dynamics Book

Nuclear Architecture and Dynamics


  • Author : Christophe Lavelle
  • Publisher : Academic Press
  • Release Date : 2017-10-27
  • Genre: Medical
  • Pages : 618
  • ISBN 10 : 9780128035030

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Nuclear Architecture and Dynamics Excerpt :

Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. Highlights the link between the (bio)chemistry and the (bio)physics of chromatin Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds

Nuclear Dynamics Book

Nuclear Dynamics


  • Author : K. Nagata
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-03
  • Genre: Science
  • Pages : 279
  • ISBN 10 : 9784431301301

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Nuclear Dynamics Excerpt :

The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

Genomic Imprinting Book

Genomic Imprinting


  • Author : Rolf Ohlsson
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • Genre: Science
  • Pages : 330
  • ISBN 10 : 9783540691112

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Genomic Imprinting Excerpt :

The form and function of every living organism on the earth depends on the complex regulation of gene expression. This is carried out by controlling and interdigitating spatial and temporal patterns of gene activity during the life time of eukaryotic organisms. This is most dramatically apparent during early stages of development, when new types of cells and organs are being formed, often during very short time spans. To achieve this, it is vital that developmentally important genes can be kept in inactive or active states which are stably inherited in the soma. Indeed, it is now wellknown that the propen sity for a gene to be transcribed or silenced is stably propagated through many cell generations, even from parent to progeny. This phenomenon constitutes a type of extragenetic or epigenetic memory of cell identity and developmental potential which has been fundamental to the evolution of complex lifeforms, such as the reader of this book. This monograph focuses on a particular aspect of the epigenetic control of gene function: genomic imprinting. This defines a phenomenon where some genes or whole chromosomes can be silenced, activated, or even deleted depending on their parental origin. The impact of genomic imprinting is most clearly seen in the areas of cancer, clinical genetics, and development. Many of the processes associated with genomic imprinting can be observed in plants, yeast and man, for example, and may constitute, therefore, principles which are very conserved on an evolutionary scale.

Chromatin Regulation and Dynamics Book

Chromatin Regulation and Dynamics


  • Author : Anita Göndör
  • Publisher : Academic Press
  • Release Date : 2016-10-25
  • Genre: Science
  • Pages : 496
  • ISBN 10 : 9780128034026

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Chromatin Regulation and Dynamics Excerpt :

Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Advances in Nuclear Architecture Book

Advances in Nuclear Architecture


  • Author : Niall M. Adams
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-10-17
  • Genre: Medical
  • Pages : 210
  • ISBN 10 : 9789048198993

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Advances in Nuclear Architecture Excerpt :

This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.

Nuclear Envelope Dynamics in Embryos and Somatic Cells Book

Nuclear Envelope Dynamics in Embryos and Somatic Cells


  • Author : Philippe Collas
  • Publisher : Springer
  • Release Date : 2012-11-01
  • Genre: Science
  • Pages : 174
  • ISBN 10 : 1461349370

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Nuclear Envelope Dynamics in Embryos and Somatic Cells Excerpt :

This volume provides an exhaustive review of the most current knowledge of the composition, architecture and dynamics of the nuclear envelope. In contrast to other comprehensive works on cellular membranes in general, this book is the first to specifically address the nuclear envelope. Experts in the field relate the different domains of the nuclear envelope, their biogenesis, their composition, their mode of targeting to chromosomes and how they dissociate from chromosomes upon cell division. A wealth of information from several experimental systems is provided, such as dividing somatic cells, embryos and nuclear assembly assays in cell-free extracts, in a wide range of vertebrate and invertebrate organisms ranging from humans to yeast. The book also contains up-to-date reviews on the relationship between mutations in proteins of the nuclear envelope and Emery-Dreifuss muscular dystrophy. The breadth of topics covered in what may seem to be a field as narrow as the nuclear envelope makes this volume a valuable reference.

RNA Trafficking and Nuclear Structure Dynamics Book

RNA Trafficking and Nuclear Structure Dynamics


  • Author : Philippe Jeanteur
  • Publisher : Springer
  • Release Date : 2007-11-03
  • Genre: Science
  • Pages : 153
  • ISBN 10 : 9783540742661

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RNA Trafficking and Nuclear Structure Dynamics Excerpt :

This volume explores nuclear structure and trafficking involving or relevant to RNA and RNPs. Topics include advances and current problems in the structural organization of different subnuclear compartments, Cajal bodies and gems, speckles containing splicing factors, and PML bodies characteristic of ProMyelocytic leukemia. The book also describes the dynamic aspects of RNA trafficking and the latest technologies for live cell imaging of mRNA.

Nuclear Dynamics of Radiation induced Foci in Euchromatin and Heterochromatin Book

Nuclear Dynamics of Radiation induced Foci in Euchromatin and Heterochromatin


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2013
  • Genre: Uncategoriezed
  • Pages : 11
  • ISBN 10 : OCLC:1066378847

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Nuclear Dynamics of Radiation induced Foci in Euchromatin and Heterochromatin Excerpt :

Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity. While much is known about the molecular mechanisms involved in DSB repair and checkpoint activation, the roles of nuclear dynamics of radiation-induced foci (RIF) in DNA repair are just beginning to emerge. Here, we summarize results from recent studies that point to distinct features of these dynamics in two different chromatin environments: heterochromatin and euchromatin. We also discuss how nuclear architecture and chromatin components might control these dynamics, and the need of novel quantification methods for a better description and interpretation of these phenomena. These studies are expected to provide new biomarkers for radiation risk and new strategies for cancer detection and treatment.

Nuclear Architecture and Chromatin Dynamics in Development and Regeneration Book

Nuclear Architecture and Chromatin Dynamics in Development and Regeneration


  • Author : Hannah E. Arbach
  • Publisher : Unknown
  • Release Date : 2021
  • Genre: Uncategoriezed
  • Pages : 102
  • ISBN 10 : OCLC:1302728780

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Nuclear Architecture and Chromatin Dynamics in Development and Regeneration Excerpt :

The nucleus and its contents are not just static entities which offer a location and template for transcription. In both development and disease alterations in nuclear structure and/or chromatin architecture can contribute to normal or impaired function. In this study I used Xenopus tropicalis to study two processes that alter nuclear structure or chromatin architecture. Fist, to study the impact of nuclear compartment shape I characterized cells with branched nuclei in the tail fin. We found that despite an extreme nuclear shape, cell with branched nuclei had active cell cycles, and marks of active transcription, as well as transcriptional repression. Our characterization also determined that actin and laminb1 were necessary for maintaining branched nuclear structure. Second, I studied how dynamic changes in chromatin structure facilitated by epigenetic modifications enabled tail regeneration. Using ATAC-seq (An Assay for Transposase Accessible Chromatin) we queried changes in chromatin accessibility upon inhibition of Histone deacetylases (HDACs), and the enzymatic component of the polycomb repressive 2 complex, enhancer of zeste 2 (EZH2), both of which serve to close chromatin. We found that HDACs and EZH2 had distinct targets in the first 24 hours post amputation (hpa). Early inhibition of HDAC activity impairs tail regeneration and promoter regions are particularly sensitive. Our analysis uncovered a role for HDAC activity in regulation of neural regeneration. EZH2 inhibition during the first 24 hpa also impairs regeneration, however gene bodies were much more susceptible to be more accessible upon EZH2 inhibition. We also uncovered a role in early EZH2 activity in regulating the immune response that occurs after injury. Overall, we leveraged the powerful model system Xenopus tropicalis to establish a new model for extreme nuclear morphology and identify alterations in chromatin structure that regulate regenerative processes.

Annual Plant Reviews  Plant Nuclear Structure  Genome Architecture and Gene Regulation Book

Annual Plant Reviews Plant Nuclear Structure Genome Architecture and Gene Regulation


  • Author : David Evans
  • Publisher : John Wiley & Sons
  • Release Date : 2013-03-27
  • Genre: Science
  • Pages : 296
  • ISBN 10 : 9781118472484

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Annual Plant Reviews Plant Nuclear Structure Genome Architecture and Gene Regulation Excerpt :

This timely volume brings together expert reviews of the recentsignificant advances in our knowledge and understanding of theorganisation of the higher plant nucleus, and in particular in therelationship between nuclear organisation and the regulation ofgene expression. Rapid progress has been made in a number of keyareas over the last five years, including description andcharacterization of proteins of the nuclear envelope and nuclearpore complex, novel insights into nucleoskeletal structures, aswell as developments related to chromatin organization, functionand gene expression. These advances open the way for new researchinto areas such as stress tolerance, plant-pathogen interactionsand ultimately crop improvement and food security. Continuedresearch into plant nuclear structure, genome architecture and generegulation also enriches our understanding of the origin andevolution of the nucleus and its envelope. Edited by world-class researchers in plant cell biology, andcomprising contributions from internationally-renowned academics,this latest volume in the prestigious Annual Plant Reviews seriesbrings together a wealth of knowledge in the burgeoning field ofplant nuclear structure and genetics. Annual Plant Reviews, Volume 46: Plant Nuclear Structure,Genome Architecture and Gene Regulation is a vitalresource for advanced students, researchers and professionals inplant science and related disciplines. Libraries in all researchestablishments where plant science, biochemistry, molecularbiology, genetics and genomics and agricultural science are taughtand studied will find this excellent volume an essential additionto their shelf.