Nucleic Acids in Chemistry and Biology Book

Nucleic Acids in Chemistry and Biology


  • Author : G Michael Blackburn
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-09
  • Genre: Science
  • Pages : null
  • ISBN 10 : 9781782625773

GET BOOK
Nucleic Acids in Chemistry and Biology Excerpt :

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Spherical Nucleic Acids Book

Spherical Nucleic Acids


  • Author : Chad A. Mirkin
  • Publisher : CRC Press
  • Release Date : 2020-09-01
  • Genre: Medical
  • Pages : 1806
  • ISBN 10 : 9780429578069

GET BOOK
Spherical Nucleic Acids Excerpt :

Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation. It is a reprint volume that compiles 101 key papers from high-impact journals in this research area published by the Mirkin Group at Northwestern University, Illinois, USA, within the International Institute for Nanotechnology, and collaborators. Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.

The Chemical Biology of Nucleic Acids Book

The Chemical Biology of Nucleic Acids


  • Author : Günter Mayer
  • Publisher : Wiley
  • Release Date : 2010-04-22
  • Genre: Science
  • Pages : 478
  • ISBN 10 : 9780470664018

GET BOOK
The Chemical Biology of Nucleic Acids Excerpt :

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book

Nucleic Acids as Gene Anticancer Drug Delivery Therapy


  • Author : Loutfy H. Madkour
  • Publisher : Academic Press
  • Release Date : 2019-08-27
  • Genre: Business & Economics
  • Pages : 650
  • ISBN 10 : 9780128197783

GET BOOK
Nucleic Acids as Gene Anticancer Drug Delivery Therapy Excerpt :

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Book

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids


  • Author : Surendra Nimesh
  • Publisher : Woodhead Publishing
  • Release Date : 2017-04-04
  • Genre: Science
  • Pages : 256
  • ISBN 10 : 9780081005637

GET BOOK
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Excerpt :

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies

Proteins and Nucleic Acids Book

Proteins and Nucleic Acids


  • Author : Abraham Marcus
  • Publisher : Elsevier
  • Release Date : 2014-05-10
  • Genre: Science
  • Pages : 672
  • ISBN 10 : 9781483220369

GET BOOK
Proteins and Nucleic Acids Excerpt :

The Biochemistry of Plants: A Comprehensive Treatise, Volume 6: Proteins and Nucleic Acids provides information pertinent to the nucleic acids and the regulation of the expression of this information. This book presents the processes by which the nucleic acids are finally expressed as proteins. Organized into 14 chapters, this volume begins with an overview of the overall structure of eukaryotic genomes, with emphasis on higher-plant DNA. This text then examines the enzymes involved in the cleavage and degradation of DNA. Other chapters provide a critical assessment of eukaryotic nucleic acid polymerases. This book discusses as well some examples from plant mitochondrial systems. The final chapter deals with two special areas of plant biology where the expression of the nucleic acids is seen in striking relief, the formation of plant tumors, and the growth and expression of plant viruses. This book is a valuable resource for plant biochemists, molecular biologists, senior graduate students, and research workers.

Nanotechnology for the Delivery of Therapeutic Nucleic Acids Book

Nanotechnology for the Delivery of Therapeutic Nucleic Acids


  • Author : Dan Peer
  • Publisher : CRC Press
  • Release Date : 2013-03-27
  • Genre: Medical
  • Pages : 240
  • ISBN 10 : 9789814411059

GET BOOK
Nanotechnology for the Delivery of Therapeutic Nucleic Acids Excerpt :

Nucleic acid (NA) therapeutics has been extensively studied both in the academia and in the pharmaceutical industry and is still considered the promise for new therapeutic modalities, especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to the new therapeutic modality is the lack of efficient and safe delivery strategies. Nanotechnology for the Delivery of Therapeutic Nucleic Acids, written by world experts in the field of nanotechnology for NA delivery, the contributing authors bring together the state of the art in delivery strategies with strong emphasis on aspects that are of essence to the pharmaceutical industry, such as stability, general toxicity, immune-toxicity, pharmacokinetics, efficacy, and validation of new drug targets using unique approaches based on exquisite nanotechnology strategies.

Nucleic Acids Book

Nucleic Acids


  • Author : Marcelo Larramendy
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-03-16
  • Genre: Science
  • Pages : 220
  • ISBN 10 : 9789535122647

GET BOOK
Nucleic Acids Excerpt :

This edited book, "Nucleic Acids - From Basic Aspects to Laboratory Tools", contains a series of chapters that highlight the development and status of the various aspects of the nucleic acids related to DNA chemistry and biology and the molecular application of these small DNA molecules and related synthetic analogues within biological systems. Furthermore, it is hoped that the information in the present book will be of value to those directly engaged in the handling and use of nucleic acids, and that this book will continue to meet the expectations and needs of all who are interested in the different fascinating aspects of molecular biology.

Advanced Organic Chemistry of Nucleic Acids Book

Advanced Organic Chemistry of Nucleic Acids


  • Author : Zoe A. Shabarova
  • Publisher : John Wiley & Sons
  • Release Date : 2008-07-11
  • Genre: Science
  • Pages : 603
  • ISBN 10 : 9783527615926

GET BOOK
Advanced Organic Chemistry of Nucleic Acids Excerpt :

Sequencing, cloning, transcription - these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations between sequence, structure and functionality of nucleic acids are presented. The first edition of this book, which was published in Russian, has immediately become a recognized standard reference. This second, thoroughly revised and updated edition, now published in English, is likely to achieve a similar position in the international scientific community.

Quadruplex Nucleic Acids Book

Quadruplex Nucleic Acids


  • Author : Stephen Neidle
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007-10-31
  • Genre: Science
  • Pages : 301
  • ISBN 10 : 9781847555298

GET BOOK
Quadruplex Nucleic Acids Excerpt :

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability. The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered. Surveying the current state of knowledge, and with contributions from leading experts, this is the first comprehensive review of this rapidly growing area. Quadruplex Nucleic Acids is ideal for researchers interested in areas related to chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Photochemistry and Photobiology of Nucleic Acids Book

Photochemistry and Photobiology of Nucleic Acids


  • Author : Shih-Yi Wang
  • Publisher : Elsevier
  • Release Date : 2012-12-02
  • Genre: Science
  • Pages : 612
  • ISBN 10 : 9780323141697

GET BOOK
Photochemistry and Photobiology of Nucleic Acids Excerpt :

Photochemistry and Photobiology of Nucleic Acids, Volume I: Chemistry covers the historical developments in the study of photobiology and photochemistry of nucleic acid components. This volume is divided into 12 chapters that deal with the isolation and characterization of ultraviolet photoproducts of pyrimidines. After briefly covering the concepts of photochemistry of nucleic acids, this volume goes on describing the UV-induced physical and chemical alterations in nucleic acid components, such as pyrimidines, purines, their nucleosides and nucleotides, and related compounds. Significant chapters are devoted to mass and nuclear magnetic resonance spectrometry and crystal and molecular structure determinations by X-ray diffraction. Together with the pertinent examples, a short discussion on the theory and techniques is also presented in each chapter. This volume also includes a chapter on radiation chemistry to examine the close relationship between the chemical effects of UV-light and X- or gamma-radiation. This volume is of value to researchers who are active in the study of photochemistry and photobiology in nucleic acids as well as to advanced undergraduate and graduate students interested in this field.

The Chemistry of Nucleic Acids Book

The Chemistry of Nucleic Acids


  • Author : Denis Oswald Jordan
  • Publisher : Unknown
  • Release Date : 1960
  • Genre: Nucleic acids
  • Pages : 358
  • ISBN 10 : UOM:39015065775994

GET BOOK
The Chemistry of Nucleic Acids Excerpt :

Dynamics of Proteins and Nucleic Acids Book

Dynamics of Proteins and Nucleic Acids


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2013-08-14
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 9780124116276

GET BOOK
Dynamics of Proteins and Nucleic Acids Excerpt :

Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Essentials of Nucleic Acid Analysis Book
Score: 4
From 1 Ratings

Essentials of Nucleic Acid Analysis


  • Author : Jacquie T. Keer
  • Publisher : Royal Society of Chemistry
  • Release Date : 2008-01-01
  • Genre: Science
  • Pages : 248
  • ISBN 10 : 9780854043675

GET BOOK
Essentials of Nucleic Acid Analysis Excerpt :

An indispensable handbook of the highest standard for those working in the fields of food analysis and forensic applications.

Dynamics of Proteins and Nucleic Acids Book

Dynamics of Proteins and Nucleic Acids


  • Author : J. Andrew McCammon
  • Publisher : Cambridge University Press
  • Release Date : 1988-04-29
  • Genre: Science
  • Pages : 234
  • ISBN 10 : 0521356520

GET BOOK
Dynamics of Proteins and Nucleic Acids Excerpt :

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.