Ocular Transporters and Receptors Book

Ocular Transporters and Receptors


  • Author : Ashim K Mitra
  • Publisher : Elsevier
  • Release Date : 2013-10-31
  • Genre: Science
  • Pages : 276
  • ISBN 10 : 9781908818317

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Ocular Transporters and Receptors Excerpt :

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Prodrugs and Targeted Delivery Book

Prodrugs and Targeted Delivery


  • Author : Jarkko Rautio
  • Publisher : John Wiley & Sons
  • Release Date : 2011-01-11
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9783527633180

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Prodrugs and Targeted Delivery Excerpt :

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

Ocular Transporters in Ophthalmic Diseases and Drug Delivery Book

Ocular Transporters in Ophthalmic Diseases and Drug Delivery


  • Author : Joyce Tombran-Tink
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-04-09
  • Genre: Medical
  • Pages : 467
  • ISBN 10 : 9781597453752

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Ocular Transporters in Ophthalmic Diseases and Drug Delivery Excerpt :

In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.

The Biology of the Eye Book

The Biology of the Eye


  • Author : Jorge Fischbarg
  • Publisher : Elsevier
  • Release Date : 2005-12-09
  • Genre: Science
  • Pages : 406
  • ISBN 10 : 0080476090

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The Biology of the Eye Excerpt :

Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjec

Pharmacology of Ocular Therapeutics Book

Pharmacology of Ocular Therapeutics


  • Author : Thirumurthy Velpandian
  • Publisher : Springer
  • Release Date : 2016-02-29
  • Genre: Medical
  • Pages : 535
  • ISBN 10 : 9783319254982

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Pharmacology of Ocular Therapeutics Excerpt :

This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.

Drug Delivery Research Advances Book

Drug Delivery Research Advances


  • Author : Boris O. Mashkevich
  • Publisher : Nova Publishers
  • Release Date : 2007
  • Genre: Medical
  • Pages : 259
  • ISBN 10 : 160021732X

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Drug Delivery Research Advances Excerpt :

Drug delivery is a term that refers to the delivery of a pharmaceutical compound to humans or animals. Most common methods of delivery include the preferred non-invasive oral (through the mouth), nasal, pneumonial (inhalation), and rectal routes. Many medications, however, can not be delivered using these routes because they might be susceptible to degradation or are not incorporated efficiently. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunisations are based on the delivery of protein drugs and are often done by injection. Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. This new book focuses on worldwide research on drug delivery and targeting at the molecular, cellular, and higher levels.

Transporters in Drug Discovery and Development Book

Transporters in Drug Discovery and Development


  • Author : Yurong Lai
  • Publisher : Woodhead Publishing
  • Release Date : 2014-08-22
  • Genre: Medical
  • Pages : 780
  • ISBN 10 : 9781908818287

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Transporters in Drug Discovery and Development Excerpt :

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity

Polysaccharide Carriers for Drug Delivery Book

Polysaccharide Carriers for Drug Delivery


  • Author : Sabyasachi Maiti
  • Publisher : Woodhead Publishing
  • Release Date : 2019-06-14
  • Genre: Medical
  • Pages : 802
  • ISBN 10 : 9780081025543

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Polysaccharide Carriers for Drug Delivery Excerpt :

Polysaccharide Carriers for Drug Delivery presents the latest information on the selection of safe materials. Due to reported safety profiles on polysaccharides; they have been the natural choice for investigation. A wide variety of drug delivery and biomedical systems have been studied, however, the related information either concept-wise or application-oriented is scattered, therefore becoming difficult for readers and researchers to digest in a concise manner. This gathering of information will help readers easily comprehend the subject matter. Focuses on biopolysaccharide-based, distinct approaches for drug delivery applications Illustrates new concepts and highlights future scope for clinical development Provides comprehensive, up-to-date information on different aspects of drug delivery technology

Peptide and Protein Delivery Book

Peptide and Protein Delivery


  • Author : Chris Van Der Walle
  • Publisher : Academic Press
  • Release Date : 2011-05-12
  • Genre: Science
  • Pages : 380
  • ISBN 10 : 0123849365

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Peptide and Protein Delivery Excerpt :

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Chitin Chitosan Book

Chitin Chitosan


  • Author : Rajendra Dongre
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-07-18
  • Genre: Science
  • Pages : 382
  • ISBN 10 : 9781789234060

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Chitin Chitosan Excerpt :

Chitin is the second most abundant biopolymer after cellulose and is a resourceful copious and cheap biomaterial discovered in 1859 owing to significant industrial and technological utility. Raw chitin-chitosan resembles keratin in its biological functions. Chitin chemistry vastly developed via innate unparalleled biological features and exceptional physicochemical characters. Chitosan endures assorted chemical/physical modifications easily at free proactive functionalities, yet intact bulk properties are achieved through processing, viz., film, membrane, composite, hybrid, nanofibre, nanoparticle, hydrogel and scaffolds. Rapidly lessen bioresources signify chitosan as an option due to renewable eco-friendliness and drive embryonic myriad applications in S

Drug Delivery for the Retina and Posterior Segment Disease Book

Drug Delivery for the Retina and Posterior Segment Disease


  • Author : Jayvadan K. Patel
  • Publisher : Springer
  • Release Date : 2018-10-08
  • Genre: Medical
  • Pages : 494
  • ISBN 10 : 9783319958071

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Drug Delivery for the Retina and Posterior Segment Disease Excerpt :

This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.

Ocular Periphery and Disorders Book

Ocular Periphery and Disorders


  • Author : Darlene A. Dartt
  • Publisher : Academic Press
  • Release Date : 2011
  • Genre: Medical
  • Pages : 553
  • ISBN 10 : 9780123820426

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Ocular Periphery and Disorders Excerpt :

This selection of articles from the Encyclopedia of the Eye is the first single-volume overview presenting articles on the function, biology, physiology, and pathology of the structures of the ocular periphery, as well as the related disorders and their treatment. The peripheral structures are implicated in a number of important diseases, including optic neuritis, thyroid eye disease, and strabismus. The volume offers a basic science background of these topics rather than a strictly clinical focus. The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of the ocular periphery Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers The best researchers in the field provide their conclusions in the context of the latest experimental results

Mucosal Delivery of Drugs and Biologics in Nanoparticles Book

Mucosal Delivery of Drugs and Biologics in Nanoparticles


  • Author : Pavan Muttil
  • Publisher : Springer Nature
  • Release Date : 2020-03-18
  • Genre: Medical
  • Pages : 277
  • ISBN 10 : 9783030359102

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Mucosal Delivery of Drugs and Biologics in Nanoparticles Excerpt :

Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Computer Aided Applications in Pharmaceutical Technology Book

Computer Aided Applications in Pharmaceutical Technology


  • Author : Jelena Djuris
  • Publisher : Elsevier
  • Release Date : 2013-04-10
  • Genre: Medical
  • Pages : 300
  • ISBN 10 : 9781908818324

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Computer Aided Applications in Pharmaceutical Technology Excerpt :

Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

Webvision Book

Webvision


  • Author : Helga Kolb
  • Publisher : Unknown
  • Release Date : 2007
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:503519994

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Webvision Excerpt :