Ocular Transporters and Receptors Book

Ocular Transporters and Receptors


  • Author : Ashim K Mitra
  • Publisher : Elsevier
  • Release Date : 2013-10-31
  • Genre: Science
  • Pages : 276
  • ISBN 10 : 9781908818317

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Ocular Transporters and Receptors Excerpt :

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Ocular Transporters in Ophthalmic Diseases and Drug Delivery Book

Ocular Transporters in Ophthalmic Diseases and Drug Delivery


  • Author : Joyce Tombran-Tink
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-04-09
  • Genre: Medical
  • Pages : 467
  • ISBN 10 : 9781597453752

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Ocular Transporters in Ophthalmic Diseases and Drug Delivery Excerpt :

In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.

Prodrugs and Targeted Delivery Book

Prodrugs and Targeted Delivery


  • Author : Jarkko Rautio
  • Publisher : John Wiley & Sons
  • Release Date : 2011-01-11
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9783527633180

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Prodrugs and Targeted Delivery Excerpt :

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

Drug Delivery Research Advances Book

Drug Delivery Research Advances


  • Author : Boris O. Mashkevich
  • Publisher : Nova Publishers
  • Release Date : 2007
  • Genre: Medical
  • Pages : 259
  • ISBN 10 : 160021732X

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Drug Delivery Research Advances Excerpt :

Drug delivery is a term that refers to the delivery of a pharmaceutical compound to humans or animals. Most common methods of delivery include the preferred non-invasive oral (through the mouth), nasal, pneumonial (inhalation), and rectal routes. Many medications, however, can not be delivered using these routes because they might be susceptible to degradation or are not incorporated efficiently. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunisations are based on the delivery of protein drugs and are often done by injection. Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. This new book focuses on worldwide research on drug delivery and targeting at the molecular, cellular, and higher levels.

The Biology of the Eye Book

The Biology of the Eye


  • Author : Jorge Fischbarg
  • Publisher : Elsevier
  • Release Date : 2005-12-09
  • Genre: Science
  • Pages : 406
  • ISBN 10 : 0080476090

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The Biology of the Eye Excerpt :

Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjec

Pharmacology of Ocular Therapeutics Book

Pharmacology of Ocular Therapeutics


  • Author : Thirumurthy Velpandian
  • Publisher : Springer
  • Release Date : 2016-02-29
  • Genre: Medical
  • Pages : 535
  • ISBN 10 : 9783319254982

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Pharmacology of Ocular Therapeutics Excerpt :

This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.

Drug Delivery for the Retina and Posterior Segment Disease Book

Drug Delivery for the Retina and Posterior Segment Disease


  • Author : Jayvadan K. Patel
  • Publisher : Springer
  • Release Date : 2018-10-08
  • Genre: Medical
  • Pages : 494
  • ISBN 10 : 9783319958071

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Drug Delivery for the Retina and Posterior Segment Disease Excerpt :

This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.

Ocular Periphery and Disorders Book

Ocular Periphery and Disorders


  • Author : Darlene A. Dartt
  • Publisher : Academic Press
  • Release Date : 2011
  • Genre: Medical
  • Pages : 553
  • ISBN 10 : 9780123820426

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Ocular Periphery and Disorders Excerpt :

This selection of articles from the Encyclopedia of the Eye is the first single-volume overview presenting articles on the function, biology, physiology, and pathology of the structures of the ocular periphery, as well as the related disorders and their treatment. The peripheral structures are implicated in a number of important diseases, including optic neuritis, thyroid eye disease, and strabismus. The volume offers a basic science background of these topics rather than a strictly clinical focus. The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of the ocular periphery Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers The best researchers in the field provide their conclusions in the context of the latest experimental results

Pharmacologic Therapy of Ocular Disease Book

Pharmacologic Therapy of Ocular Disease


  • Author : Scott M. Whitcup
  • Publisher : Springer
  • Release Date : 2017-06-05
  • Genre: Medical
  • Pages : 394
  • ISBN 10 : 9783319582900

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Pharmacologic Therapy of Ocular Disease Excerpt :

There have been major advancements in the pharmacologic treatment of eye diseases over the past decade. With newly discovered disease targets and novel approaches to deliver therapeutic compounds to the eye, patients are seeing improved outcomes. Not only are there better treatments for diseases where treatments existed, we now have effective therapy for previously untreatable and blinding eye disorders. This volume will cover the pharmacologic treatment of eye diseases from the front of the eye including eyelids, conjunctiva and cornea all the way back to the retina and optic nerve. The first section of the volume reviews general principles of ocular pharmacology, pharmacokinetics, pharmaceutical sciences, and drug delivery. In addition, the volume provides an up to date guide to the pharmacologic approach to the key eye diseases that threaten sight or ocular function.

Nanomedicine in Drug Delivery Book

Nanomedicine in Drug Delivery


  • Author : Arun Kumar
  • Publisher : CRC Press
  • Release Date : 2013-06-05
  • Genre: Medical
  • Pages : 469
  • ISBN 10 : 9781466506169

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Nanomedicine in Drug Delivery Excerpt :

There is a clear need for innovative technologies to improve the delivery of therapeutic and diagnostic agents in the body. Recent breakthroughs in nanomedicine are now making it possible to deliver drugs and therapeutic proteins to local areas of disease or tumors to maximize clinical benefit while limiting unwanted side effects. Nanomedicine in Drug Delivery gives an overview of aspects of nanomedicine to help readers design and develop novel drug delivery systems and devices that build on nanoscale technologies. Featuring contributions by leading researchers from around the world, the book examines: The integration of nanoparticles with therapeutic agents The synthesis and characterization of nanoencapsulated drug particles Targeted pulmonary nanomedicine delivery using inhalation aerosols The use of biological systems—bacteria, cells, viruses, and virus-like particles—as carriers to deliver nanoparticles Nanodermatology and the role of nanotechnology in the diagnosis and treatment of skin disease Nanoparticles for the delivery of small molecules, such as for gene and vaccine delivery The use of nanotechnologies to modulate and modify wound healing Nanoparticles in bioimaging, including magnetic resonance, computed tomography, and molecular imaging Nanoparticles to enhance the efficiency of existing anticancer drugs The development of nanoparticle formulations Nanoparticles for ocular drug delivery Nanoparticle toxicity, including routes of exposure and mechanisms of toxicity The use of animal and cellular models in nanoparticles safety studies With its practical focus on the design, synthesis, and application of nanomedicine in drug delivery, this book is a valuable resource for clinical researchers and anyone working to tackle the challenges of delivering drugs in a more targeted and efficient manner. It explores a wide range of promising approaches for the diagnosis and treatment of diseases using cutting-edge nanotechnologies.

Webvision Book

Webvision


  • Author : Helga Kolb
  • Publisher : Unknown
  • Release Date : 2007
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:503519994

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Webvision Excerpt :

Current Eye Research Book

Current Eye Research


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1989-07
  • Genre: Eye
  • Pages : null
  • ISBN 10 : NWU:35558001854823

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Current Eye Research Excerpt :

Drug Transporters in Drug Disposition  Effects and Toxicity Book

Drug Transporters in Drug Disposition Effects and Toxicity


  • Author : Xiaodong Liu
  • Publisher : Springer Nature
  • Release Date : 2019-09-30
  • Genre: Medical
  • Pages : 580
  • ISBN 10 : 9789811376474

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Drug Transporters in Drug Disposition Effects and Toxicity Excerpt :

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.

Cell Biology of the Eye Book

Cell Biology of the Eye


  • Author : David Mcdevitt
  • Publisher : Elsevier
  • Release Date : 2012-12-02
  • Genre: Nature
  • Pages : 584
  • ISBN 10 : 9780323145213

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Cell Biology of the Eye Excerpt :

Cell Biology of the Eye discusses the eye tissues and its role in the investigations on active transport, growth factors, receptors, and differentiation. The book is comprised of articles which discuss corneal proteoglycans; transport of ions and metabolites across the corneal endothelium; the ontogeny and localization of the crystallins in eye lens development and regeneration; the biological-physical basis of lens transparency; the chromatic organization of the retina; and the dopamine neurons in the retina. This treatise will serve as a valuable reference text for graduate and professional students, teachers, researchers, clinicians, and to all in the vision field.