Overflow Metabolism Book

Overflow Metabolism


  • Author : Alexei Vazquez
  • Publisher : Academic Press
  • Release Date : 2017-10-27
  • Genre: Medical
  • Pages : 84
  • ISBN 10 : 9780128123355

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Overflow Metabolism Excerpt :

Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Includes examples of overflow metabolism and major phenomenological features Features a critical view of proposed theories to explain overflow metabolism Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results

Overflow Metabolism Book

Overflow Metabolism


  • Author : Alexei Vazquez
  • Publisher : Academic Press
  • Release Date : 2017-10-16
  • Genre: Metabolism
  • Pages : 84
  • ISBN 10 : 0128122080

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Overflow Metabolism Excerpt :

Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Includes examples of overflow metabolism and major phenomenological features Features a critical view of proposed theories to explain overflow metabolism Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results

Insect Plant Interactions Book

Insect Plant Interactions


  • Author : Elizabeth A. Bernays
  • Publisher : CRC Press
  • Release Date : 2019-10-01
  • Genre: Science
  • Pages : 176
  • ISBN 10 : 9781000697551

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Insect Plant Interactions Excerpt :

First Published in 1989, this book explores the relationship between plants and insects and the ways in which they interact with each other. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.

Physiological Stress Responses in Bioprocesses Book

Physiological Stress Responses in Bioprocesses


  • Author : Sven-Olof Enfors
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-05-06
  • Genre: Science
  • Pages : 264
  • ISBN 10 : 3540203117

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Physiological Stress Responses in Bioprocesses Excerpt :

This review series covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated. Electronic version available at http://link.springer.de/series/abe/

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production Book

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production


  • Author : Kazuyuki Shimizu
  • Publisher : CRC Press
  • Release Date : 2017-07-12
  • Genre: Science
  • Pages : 477
  • ISBN 10 : 9781351650106

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Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production Excerpt :

The global warming problem is becoming critical year by year, causing climate disaster all over the world, where it has been believed that the CO2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. Moreover, the global stock of fossil fuels is limited, and may run out soon within several tens of years. Although wind, geo-thermal, and tide energies have been considered as clean energy sources, those depend on the land or sea locations and subject to the climate change. Biofuel and biochemical production from renewable bio-resources has thus been paid recent attention from environmental protection and energy production points of view, where the current chemical and energy producing plants can be also utilized with slight modification. The so-called 1st generation biofuels have been produced from corn starch and sugarcane in particular in USA and Brazil. However, this causes the problem of the so-called "food and energy issues" as the production scale increases. The 2nd generation biofuel production from lingo-cellulosic biomass or wastes has thus been paid recent attention. However, it requires energy intensive pretreatment for the degradation of lingo-cellulosic biomass, and the fermentation is slow due to low growth rate, and thus the productivity of biofuels and bio-chemicals is low. The 3rd generation biofuel production from photosynthetic organisms such as cyanobacteria and algae has been also paid attention, because such organisms can grow with only sun light and CO2 in the air, but the cell growth rate and thus the productivity of the fuels is significantly low. The main part or core of such production processes is the fermentation by micro-organisms. In particular, it is critical to properly understand the cell metabolism followed by the efficient metabolic engineering. The book gives comprehensive explanation of the cell metabolism and the metabolic regulation mechanisms of a variety of micro-organisms.

Amino Acid Biosynthesis     Pathways  Regulation and Metabolic Engineering Book

Amino Acid Biosynthesis Pathways Regulation and Metabolic Engineering


  • Author : Volker F. Wendisch
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-03-24
  • Genre: Science
  • Pages : 413
  • ISBN 10 : 9783540485964

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Amino Acid Biosynthesis Pathways Regulation and Metabolic Engineering Excerpt :

This book presents the current knowledge of fundamental as well as applied microbiology of amino acids. Coverage details the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The book also examines the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and as food and feed additives.

Microbial Life History Book

Microbial Life History


  • Author : Steven A. Frank
  • Publisher : Princeton University Press
  • Release Date : 2022-08-16
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 9780691231198

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Microbial Life History Excerpt :

A powerful framework for understanding how natural selection shapes adaptation and biological design Design and diversity are the two great challenges in the study of life. Microbial Life History draws on the latest advances in microbiology to describe the fundamental forces of biological design and apply these evolutionary processes to a broad diversity of traits in microbial metabolism and biochemistry. Emphasizing how to formulate and test hypotheses of adaptation, Steven Frank provides a new foundation for exploring the evolutionary forces of design. He discusses the economic principles of marginal valuations, trade-offs, and payoffs in risky and random environments; the social aspects of conflict and cooperation; the demographic aspects of age and spatial heterogeneity; and the engineering control theory principles by which systems adjust to environments. Frank then applies these evolutionary principles to the biochemistry of microbial metabolism, providing the first comprehensive link between the forces that shape biological design and cellular energetics. Tracing how natural selection sculpts metabolism, Microbial Life History provides new perspectives on the life histories of organisms, from growth rate and survival to dispersal and defense against attack. Along the way, this incisive book addresses the conceptual and philosophical challenges confronting evolutionary biologists and other practitioners who study biological design and seek to apply its lessons.

Metabolism and Bacterial Pathogenesis Book

Metabolism and Bacterial Pathogenesis


  • Author : Tyrrell Conway
  • Publisher : John Wiley & Sons
  • Release Date : 2020-07-24
  • Genre: Science
  • Pages : 382
  • ISBN 10 : 9781555818883

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Metabolism and Bacterial Pathogenesis Excerpt :

Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments. Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future. Beginning with overviews, Metabolism and Bacterial Pathogenesis covers a wide range of diseases and both Gram-positive and -negative bacteria that serve as model systems for in vitro and in vivo investigations intracellular, respiratory, and enteric pathogens pathogen-specific nutrient acquisition in hosts mechanisms of host-driven metabolic adaptation by pathogens metabolic regulation of virulence gene expression Useful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, Metabolism and Bacterial Pathogenesis is also essential reading for scientists studying the microbiome.

Basic Biotechnology Book
Score: 3
From 3 Ratings

Basic Biotechnology


  • Author : Colin Ratledge
  • Publisher : Cambridge University Press
  • Release Date : 2006-05-25
  • Genre: Medical
  • Pages : 683
  • ISBN 10 : 9780521840316

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Basic Biotechnology Excerpt :

Biotechnology is one of the major technologies of the twenty-first century. Its wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and the application of microbiology to the production of goods from bread to antibiotics. In this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology. The fundamental principles that underpin all biotechnology are explained and a full range of examples are discussed to show how these principles are applied; from starting substrate to final product. A distinctive feature of this text are the discussions of the public perception of biotechnology and the business of biotechnology, which set the science in a broader context. This comprehensive textbook is essential reading for all students of biotechnology and applied microbiology, and for researchers in biotechnology industries.

Secondary Metabolism in Plant Cell Cultures Book

Secondary Metabolism in Plant Cell Cultures


  • Author : International Association of Plant Cell and Tissue Culture
  • Publisher : CUP Archive
  • Release Date : 1986-09-25
  • Genre: Science
  • Pages : 296
  • ISBN 10 : 0521328896

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Secondary Metabolism in Plant Cell Cultures Excerpt :

This 1986 book, derived from the meeting held by the International Association of Plant Cell and Tissue Culture in Sheffield in July 1985, describes the state of research in the area of secondary metabolism in plant cell and tissue culture. Such cultures are a major tool in horticulture and agriculture, and in the chemical industry.

The Metabolic Pathway Engineering Handbook Book

The Metabolic Pathway Engineering Handbook


  • Author : Christina Smolke
  • Publisher : CRC Press
  • Release Date : 2009-07-28
  • Genre: Medical
  • Pages : 678
  • ISBN 10 : 1439802971

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The Metabolic Pathway Engineering Handbook Excerpt :

This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction

The Metabolic Pathway Engineering Handbook  Two Volume Set Book

The Metabolic Pathway Engineering Handbook Two Volume Set


  • Author : Christina Smolke
  • Publisher : CRC Press
  • Release Date : 2009-08-18
  • Genre: Medical
  • Pages : 1259
  • ISBN 10 : 9781420005622

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The Metabolic Pathway Engineering Handbook Two Volume Set Excerpt :

Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metab