Oxidative Stress and Neurodegenerative Disorders Book
Score: 5
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Oxidative Stress and Neurodegenerative Disorders


  • Author : G. Ali Qureshi
  • Publisher : Elsevier
  • Release Date : 2007-03-22
  • Genre: Science
  • Pages : 794
  • ISBN 10 : 0080489494

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Oxidative Stress and Neurodegenerative Disorders Book Description :

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Mitochondria and Oxidative Stress in Neurodegenerative Disorders  Volume 1147 Book

Mitochondria and Oxidative Stress in Neurodegenerative Disorders Volume 1147


  • Author : Gary E. Gibson
  • Publisher : Wiley-Blackwell
  • Release Date : 2008-12-30
  • Genre: Science
  • Pages : 414
  • ISBN 10 : STANFORD:36105131906716

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Mitochondria and Oxidative Stress in Neurodegenerative Disorders Volume 1147 Book Description :

Our understanding of how mitochondria functionally interact with other cellular organelles and the process of transcription, and how mitochondria detect oxidative modification of macromolecules has improved significantly in the past decade. Importantly, the roles of mitochondria and oxidative stress are also better defined in the pathophysiology of neurodegenerative disorders. This volume combines basic, clinical, and translational research in a forum designed to provide the most current information on aspects of mitochondrial function and its relationship to age-related neurodegenerative diseases and their treatment. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Oxidative Stress and Age Related Neurodegeneration Book

Oxidative Stress and Age Related Neurodegeneration


  • Author : Yuan Luo
  • Publisher : CRC Press
  • Release Date : 2005-11-21
  • Genre: Science
  • Pages : 528
  • ISBN 10 : 9781420026559

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Oxidative Stress and Age Related Neurodegeneration Book Description :

Despite the progress being made by researchers, Alzheimer’s disease, along with other age-related neurodegenerative disorders, continues to exact a tremendous toll on our society. However, we are beginning to see a relationship that ties degenerative disorders to oxidative stress and lifestyle, suggesting the possibility for prevention and intervention through changes of individual habits, especially with regard to diet. Oxidative Stress and Age-Related Neurodegeneration brings together expert researchers involved with recent developments across a variety of fields. In looking at causation, prevention, and therapy, they offer contributions addressing these questions: What similarities and differences exist between normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress? How can oxidative stress or its effects be attenuated? Do antioxidants prevent or slow the progress of the disease? Is there any role for natural micronutrients in the attenuation of oxidative stress and prevention of age-related neurodegeneration? Some chapters look at the various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels. Other chapters focus on specific antioxidants and nutrients cited as being impactful, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract. Researchers in academia, industry, and clinical medicine, as well as students and scholars will find use for this timely collection, either as an introduction to our current understanding of neurodegeneration or as a reference for further research. Clinicians will also benefit, as this book explains the basis for many of the latest approaches to prevention and therapy.

Oxidative Stress in Cancer  AIDS  and Neurodegenerative Diseases Book
Score: 5
From 1 Ratings

Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases


  • Author : Luc Montagnier
  • Publisher : CRC Press
  • Release Date : 1997-10-06
  • Genre: Medical
  • Pages : 576
  • ISBN 10 : 1420002929

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Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases Book Description :

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Mitochondria and Oxidative Stress in Neurodegenerative Disorders Book

Mitochondria and Oxidative Stress in Neurodegenerative Disorders


  • Author : Gary E. Gibson
  • Publisher : Wiley-Blackwell
  • Release Date : 2008-12-30
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 1573317136

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Mitochondria and Oxidative Stress in Neurodegenerative Disorders Book Description :

Our understanding of how mitochondria functionally interact with other cellular organelles and the process of transcription, and how mitochondria detect oxidative modification of macromolecules has improved significantly in the past decade. Importantly, the roles of mitochondria and oxidative stress are also better defined in the pathophysiology of neurodegenerative disorders. This volume combines basic, clinical, and translational research in a forum designed to provide the most current information on aspects of mitochondrial function and its relationship to age-related neurodegenerative diseases and their treatment. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Oxidative Stress in Vertebrates and Invertebrates Book

Oxidative Stress in Vertebrates and Invertebrates


  • Author : Tahira Farooqui
  • Publisher : John Wiley & Sons
  • Release Date : 2011-12-06
  • Genre: Science
  • Pages : 416
  • ISBN 10 : 9781118001943

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Oxidative Stress in Vertebrates and Invertebrates Book Description :

This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Metal Ions and Neurodegenerative Disorders Book

Metal Ions and Neurodegenerative Disorders


  • Author : Paolo Zatta
  • Publisher : World Scientific
  • Release Date : 2003
  • Genre: Medical
  • Pages : 511
  • ISBN 10 : 981279669X

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Metal Ions and Neurodegenerative Disorders Book Description :

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease

Oxidative Stress and Redox Signalling in Parkinsons Disease Book

Oxidative Stress and Redox Signalling in Parkinsons Disease


  • Author : Rodrigo Franco
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-07-21
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9781788011914

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Oxidative Stress and Redox Signalling in Parkinsons Disease Book Description :

Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

Inflammation and Oxidative Stress in Neurological Disorders Book

Inflammation and Oxidative Stress in Neurological Disorders


  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-01-27
  • Genre: Medical
  • Pages : 355
  • ISBN 10 : 9783319041117

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Inflammation and Oxidative Stress in Neurological Disorders Book Description :

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Free Radicals and Diseases Book

Free Radicals and Diseases


  • Author : Rizwan Ahmad
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-10-26
  • Genre: Medical
  • Pages : 386
  • ISBN 10 : 9789535127468

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Free Radicals and Diseases Book Description :

The current volume entitled, "Free Radicals and Diseases" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions.

Handbook of Research on Critical Examinations of Neurodegenerative Disorders Book

Handbook of Research on Critical Examinations of Neurodegenerative Disorders


  • Author : Uddin, Md. Sahab
  • Publisher : IGI Global
  • Release Date : 2018-07-31
  • Genre: Medical
  • Pages : 597
  • ISBN 10 : 9781522552833

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Handbook of Research on Critical Examinations of Neurodegenerative Disorders Book Description :

Neurodegeneration is a key feature of several diseases that are referred to as neurodegenerative diseases. The process of neurodegeneration is not well-understood so the diseases that stem from it have, as yet, no cures. As such, studying the effects of these disorders can provide insight into the treatment, prevention, and future opportunities and challenges in this growing field. The Handbook of Research on Critical Examinations of Neurodegenerative Disorders is a critical scholarly resource that provides an extensive explanation of various neurodegenerative disorders based on existing studies to clarify etiology, pathological mechanisms, diagnosis, therapeutic interventions, as well as current status and future opportunities and challenges. Featuring coverage on a broad range of topics such as dementia, mitochondrial dysfunction, and risk factors, this book is geared towards neurobiologists, neuropsychologists, neurophysiologists, neuropathologists, medical professionals, academicians, and researchers seeking research on the complexity of neurodegenerative disorders.

Role of Oxidative Stress in Chronic Diseases Book

Role of Oxidative Stress in Chronic Diseases


  • Author : Isaias Dichi
  • Publisher : CRC Press
  • Release Date : 2014-03-14
  • Genre: Medical
  • Pages : 720
  • ISBN 10 : 9781482216820

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Role of Oxidative Stress in Chronic Diseases Book Description :

This book presents recent findings on the role of oxidative stress in chronic diseases. Understanding the mechanisms behind it enables readers to comprehend the rationale which underlies intervention in such conditions. The book places special emphasis on genetic polymorphism—an important issue related to this field of study. It covers the role of oxidative stress in transmissible disorders as well as non-transmissible chronic conditions with chapters on metabolic diseases, autoimmune and neurodegenerative diseases, and cancer and cachexia. Each chapter covers a different disorder and the efficacy of interventional procedures.

A Master Regulator of Oxidative StressThe Transcription Factor Nrf2 Book

A Master Regulator of Oxidative StressThe Transcription Factor Nrf2


  • Author : Jose Antonio Morales-Gonzalez
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-12-21
  • Genre: Science
  • Pages : 210
  • ISBN 10 : 9789535128373

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A Master Regulator of Oxidative StressThe Transcription Factor Nrf2 Book Description :

Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.

Molecular Aspects of Neurodegeneration and Neuroprotection Book

Molecular Aspects of Neurodegeneration and Neuroprotection


  • Author : Akhlaq A. Farooqui
  • Publisher : Bentham Science Publishers
  • Release Date : 2011-01-26
  • Genre: Science
  • Pages : 146
  • ISBN 10 : 9781608050925

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Molecular Aspects of Neurodegeneration and Neuroprotection Book Description :

"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Alzheimer s Disease  Cellular and Molecular Aspects of Amyloid beta Book

Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta


  • Author : J. Robin Harris
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-11-22
  • Genre: Science
  • Pages : 409
  • ISBN 10 : 9780387232263

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Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta Book Description :

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

Advances in Dementia Research Book

Advances in Dementia Research


  • Author : Kurt A. Jellinger
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-07
  • Genre: Medical
  • Pages : 339
  • ISBN 10 : 9783709167816

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Advances in Dementia Research Book Description :

Dementia is a major health problem that becomes increasingly common with advancing age. Despite recent progress in neurobiology and molecular genetics, the aetiology and pathogenesis of most dementia disorders are still poorly understood, and early exact diagnosis as a prerequisite of effective treatment needs to be improved. The present volume includes the contributions of renowned experts in the field of neurodegeneration presented at the International Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging techniques, and the role of vascular, immunological and other mechanisms including oxidative stress and estrogens in the development of neurodegeneration and dementia. Recent developments in diagnosis and therapy of Alzheimer disease and related disorders are reviewed and future therapeutic approaches are discussed. Thus, this volume provides a timely overview of most recent developments in dementia research and treatment strategies of dementia disorders.

Neuroinflammation and Neurodegeneration Book

Neuroinflammation and Neurodegeneration


  • Author : Phillip K. Peterson
  • Publisher : Springer
  • Release Date : 2014-07-08
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 9781493910717

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Neuroinflammation and Neurodegeneration Book Description :

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

DJ 1 PARK7 Protein Book

DJ 1 PARK7 Protein


  • Author : Hiroyoshi Ariga
  • Publisher : Springer
  • Release Date : 2017-11-16
  • Genre: Medical
  • Pages : 222
  • ISBN 10 : 9789811065835

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DJ 1 PARK7 Protein Book Description :

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.

Inflammation  Aging  and Oxidative Stress Book

Inflammation Aging and Oxidative Stress


  • Author : Stephen C. Bondy
  • Publisher : Springer
  • Release Date : 2016-12-14
  • Genre: Science
  • Pages : 405
  • ISBN 10 : 9783319334868

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Inflammation Aging and Oxidative Stress Book Description :

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

Oxidative Stress  Inflammation  and Health Book

Oxidative Stress Inflammation and Health


  • Author : Young-Joon Surh
  • Publisher : CRC Press
  • Release Date : 2005-05-24
  • Genre: Science
  • Pages : 660
  • ISBN 10 : 9781420028256

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Oxidative Stress Inflammation and Health Book Description :

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.