Oxidative Stress and Neurodegenerative Disorders Book

Oxidative Stress and Neurodegenerative Disorders


  • Author : G. Ali Qureshi
  • Publisher : Elsevier Science Limited
  • Release Date : 2007
  • Genre: Medical
  • Pages : 772
  • ISBN 10 : 0444528091

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Oxidative Stress and Neurodegenerative Disorders Excerpt :

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Oxidative Stress and Neurodegenerative Disorders Book
Score: 5
From 1 Ratings

Oxidative Stress and Neurodegenerative Disorders


  • Author : G. Ali Qureshi
  • Publisher : Elsevier
  • Release Date : 2007-03-22
  • Genre: Science
  • Pages : 794
  • ISBN 10 : 0080489494

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Oxidative Stress and Neurodegenerative Disorders Excerpt :

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Oxidative Stress in Cancer  AIDS  and Neurodegenerative Diseases Book
Score: 5
From 1 Ratings

Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases


  • Author : Luc Montagnier
  • Publisher : CRC Press
  • Release Date : 1997-10-06
  • Genre: Medical
  • Pages : 576
  • ISBN 10 : 1420002929

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Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases Excerpt :

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Antioxidants and Functional Foods for Neurodegenerative Disorders Book

Antioxidants and Functional Foods for Neurodegenerative Disorders


  • Author : Abhai Kumar
  • Publisher : CRC Press
  • Release Date : 2021-01-07
  • Genre: Health & Fitness
  • Pages : 472
  • ISBN 10 : 9781000282740

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Antioxidants and Functional Foods for Neurodegenerative Disorders Excerpt :

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.

Novel Therapeutic Approaches Targeting Oxidative Stress Book

Novel Therapeutic Approaches Targeting Oxidative Stress


  • Author : Pawan Kumar Maurya
  • Publisher : Academic Press
  • Release Date : 2022-02-18
  • Genre: Science
  • Pages : 292
  • ISBN 10 : 9780323909068

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Novel Therapeutic Approaches Targeting Oxidative Stress Excerpt :

Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives. Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer Covers a range of therapeutic approaches to target oxidative stress Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress Features case studies illustrating the targeting of oxidative stress

Alzheimer s Disease  Cellular and Molecular Aspects of Amyloid beta Book

Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta


  • Author : J. Robin Harris
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-11-22
  • Genre: Science
  • Pages : 409
  • ISBN 10 : 9780387232263

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Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta Excerpt :

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

Inflammation  Aging  and Oxidative Stress Book

Inflammation Aging and Oxidative Stress


  • Author : Stephen C. Bondy
  • Publisher : Springer
  • Release Date : 2016-12-14
  • Genre: Science
  • Pages : 405
  • ISBN 10 : 9783319334868

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Inflammation Aging and Oxidative Stress Excerpt :

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

Oxidative Stress and Age Related Neurodegeneration Book

Oxidative Stress and Age Related Neurodegeneration


  • Author : Yuan Luo
  • Publisher : CRC Press
  • Release Date : 2005-11-21
  • Genre: Science
  • Pages : 528
  • ISBN 10 : 9781420026559

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Oxidative Stress and Age Related Neurodegeneration Excerpt :

Despite the progress being made by researchers, Alzheimer’s disease, along with other age-related neurodegenerative disorders, continues to exact a tremendous toll on our society. However, we are beginning to see a relationship that ties degenerative disorders to oxidative stress and lifestyle, suggesting the possibility for prevention and intervention through changes of individual habits, especially with regard to diet. Oxidative Stress and Age-Related Neurodegeneration brings together expert researchers involved with recent developments across a variety of fields. In looking at causation, prevention, and therapy, they offer contributions addressing these questions: What similarities and differences exist between normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress? How can oxidative stress or its effects be attenuated? Do antioxidants prevent or slow the progress of the disease? Is there any role for natural micronutrients in the attenuation of oxidative stress and prevention of age-related neurodegeneration? Some chapters look at the various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels. Other chapters focus on specific antioxidants and nutrients cited as being impactful, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract. Researchers in academia, industry, and clinical medicine, as well as students and scholars will find use for this timely collection, either as an introduction to our current understanding of neurodegeneration or as a reference for further research. Clinicians will also benefit, as this book explains the basis for many of the latest approaches to prevention and therapy.

Mitochondrial Dysfunction Book

Mitochondrial Dysfunction


  • Author : Lawrence H. Lash
  • Publisher : Unknown
  • Release Date : 1993
  • Genre: Active oxygen
  • Pages : 538
  • ISBN 10 : UOM:39015032446059

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Mitochondrial Dysfunction Excerpt :

Oxidative Stress and Redox Signalling in Parkinsons Disease Book

Oxidative Stress and Redox Signalling in Parkinsons Disease


  • Author : Rodrigo Franco
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-07-21
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9781788011914

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Oxidative Stress and Redox Signalling in Parkinsons Disease Excerpt :

Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

Glutathione System and Oxidative Stress in Health and Disease Book

Glutathione System and Oxidative Stress in Health and Disease


  • Author : Anonim
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-08-26
  • Genre: Science
  • Pages : 138
  • ISBN 10 : 9781838801250

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Glutathione System and Oxidative Stress in Health and Disease Excerpt :

The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.

Brain Aging Book

Brain Aging


  • Author : David R. Riddle
  • Publisher : CRC Press
  • Release Date : 2007-04-19
  • Genre: Medical
  • Pages : 408
  • ISBN 10 : 1420005529

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Brain Aging Excerpt :

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Oxidative Stress and Dietary Antioxidants in Neurological Diseases Book
Score: 5
From 1 Ratings

Oxidative Stress and Dietary Antioxidants in Neurological Diseases


  • Author : Colin R. Martin
  • Publisher : Academic Press
  • Release Date : 2020-06-12
  • Genre: Medical
  • Pages : 444
  • ISBN 10 : 9780128177815

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Oxidative Stress and Dietary Antioxidants in Neurological Diseases Excerpt :

Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments

Free Radicals in Human Health and Disease Book

Free Radicals in Human Health and Disease


  • Author : Vibha Rani
  • Publisher : Springer
  • Release Date : 2014-11-14
  • Genre: Science
  • Pages : 430
  • ISBN 10 : 9788132220350

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Free Radicals in Human Health and Disease Excerpt :

The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.