PAKs  RAC CDC42  p21  activated Kinases Book

PAKs RAC CDC42 p21 activated Kinases


  • Author : Hiroshi Maruta
  • Publisher : Newnes
  • Release Date : 2013-01-23
  • Genre: Science
  • Pages : 276
  • ISBN 10 : 9780124072107

GET BOOK
PAKs RAC CDC42 p21 activated Kinases Excerpt :

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.

Cytoskeleton and Small G Proteins Book

Cytoskeleton and Small G Proteins


  • Author : Ph Jeanteur
  • Publisher : Springer Science & Business Media
  • Release Date : 1999-01-21
  • Genre: Medical
  • Pages : 234
  • ISBN 10 : 3540648089

GET BOOK
Cytoskeleton and Small G Proteins Excerpt :

The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

Leucine Rich Repeat Kinase 2  LRRK2  Book

Leucine Rich Repeat Kinase 2 LRRK2


  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release Date : 2017-03-28
  • Genre: Medical
  • Pages : 271
  • ISBN 10 : 9783319499697

GET BOOK
Leucine Rich Repeat Kinase 2 LRRK2 Excerpt :

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Interaction Between a Novel P21 Activated Kinase  PAK6  and Androgen Receptor in Prostate Cancer Book

Interaction Between a Novel P21 Activated Kinase PAK6 and Androgen Receptor in Prostate Cancer


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2003
  • Genre: Uncategoriezed
  • Pages : 24
  • ISBN 10 : OCLC:74248357

GET BOOK
Interaction Between a Novel P21 Activated Kinase PAK6 and Androgen Receptor in Prostate Cancer Excerpt :

The androgen-signaling pathway is important for the growth and progression of prostate cancer. The cell cycle signaling regulated by the mitogen activated protein/extracellular-signal-regulated kinase (MAPK/ERK) have been linked to tumorigenesis and tumor progression. The p2l-activated kinases (PAKs) are members of a growing class of Rac/Cdc42-associated Ste20-like ser/thr protein kinases. Recent studies have shown that MAPK/ERK signaling can be mediated via Cdc42/Rac-stimulation of PAK activity. Recently, we demonstrated a specific interaction between a novel PAK protein, PAK6, and AR. This finding provided the first link between I PAK-mediated signaling to the steroid hormone receptor pathway. In this study, we propose to assess the biological roles of PAK6 in prostate cancer cells, and to examine the expression of PAK6 in prostate tissues. We anticipate that by completing the objectives proposed in this grant, we will obtain fresh insight into the regulatory processes of AR and PAK6 that may contribute to the development of new targets for the treatment of prostate cancer.

Cellular Signal Processing Book

Cellular Signal Processing


  • Author : Friedrich Marks
  • Publisher : Garland Science
  • Release Date : 2017-05-17
  • Genre: Medical
  • Pages : 640
  • ISBN 10 : 9781351677226

GET BOOK
Cellular Signal Processing Excerpt :

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

Regulation of Gene Expression in the Tumor Environment Book

Regulation of Gene Expression in the Tumor Environment


  • Author : Menashe Bar-Eli
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-08-25
  • Genre: Medical
  • Pages : 148
  • ISBN 10 : 9781402083419

GET BOOK
Regulation of Gene Expression in the Tumor Environment Excerpt :

It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.

EJB Reviews 1996 Book

EJB Reviews 1996


  • Author : P. Christen
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 285
  • ISBN 10 : 9783642606595

GET BOOK
EJB Reviews 1996 Excerpt :

In the mid-1980s the European Journal of Biochemistry set out to publish review articles. The enterprise proved successful, resulting in high-level reviews written by well-known scientists appearing in the Journal. The reviews represent emerging and rapidly growing fields of research in fundamental as well as applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. The authors of the reviews are explicitely asked to be critical, selective, evaluative and interdisciplinary oriented. The reviews should encourage young scientists to think independently and creatively, and inform active investigators about the state of the art in a given field.

Cytoskeleton and Small G Proteins Book

Cytoskeleton and Small G Proteins


  • Author : Philippe Jeanteur
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 234
  • ISBN 10 : 9783642585913

GET BOOK
Cytoskeleton and Small G Proteins Excerpt :

The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

Handbook of Cell Signaling Book

Handbook of Cell Signaling


  • Author : Ralph A. Bradshaw
  • Publisher : Academic Press
  • Release Date : 2009-11-03
  • Genre: Science
  • Pages : 3048
  • ISBN 10 : 9780080920917

GET BOOK
Handbook of Cell Signaling Excerpt :

Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

Regulators and Effectors of Small GTPases  Part G  Ras Family II Book
Score: 5
From 1 Ratings

Regulators and Effectors of Small GTPases Part G Ras Family II


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2001-06-05
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 0080522564

GET BOOK
Regulators and Effectors of Small GTPases Part G Ras Family II Excerpt :

The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences. This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325, 329, and 332) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in the above-mentioned aspects of cell biology at the molecular level.

The JNK Signaling Pathway Book

The JNK Signaling Pathway


  • Author : Anning Lin
  • Publisher : CRC Press
  • Release Date : 2006-02-15
  • Genre: Science
  • Pages : 97
  • ISBN 10 : 9781498713344

GET BOOK
The JNK Signaling Pathway Excerpt :

Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecul

Proteomics of Spermatogenesis Book

Proteomics of Spermatogenesis


  • Author : G. S. Gupta
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-07-02
  • Genre: Science
  • Pages : 855
  • ISBN 10 : 9780387276557

GET BOOK
Proteomics of Spermatogenesis Excerpt :

Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine.

Advances in Cancer Research Book

Advances in Cancer Research


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 1998-02-09
  • Genre: Science
  • Pages : 242
  • ISBN 10 : 008056254X

GET BOOK
Advances in Cancer Research Excerpt :

The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that tumors develop in a series of steps and the effect that this 40-year-old hypothesis has had on cancer research. The second Foundations article by L.A. Loeb presents the historical significance of increased mutagenesis and clonal selection on tumor progression. The first regular article, by R. Khosravi-Far and colleagues, analyzes the functional role of Ras in signal transduction and the involvement that Rho family proteins have on Ras. Mark Saville and Roger Watson review supporting evidence that B-Myb may be a critical regulator of the cell cycle. S. Baylin and co-authors compare DNA methylation in normal cells with that in cancerous cells and discuss the specific consequences associated with tumor progression. Last, Steven Grant discusses the use of ara-C as a treatment for various types of cancer and summarizes its cellular metabolism, mode of action and resistance, and the molecular events involved in apoptosis.

The Biochemistry of Cell Signalling Book

The Biochemistry of Cell Signalling


  • Author : Ernst J. M. Helmreich
  • Publisher : Oxford University Press, USA
  • Release Date : 2001
  • Genre: Science
  • Pages : 328
  • ISBN 10 : 0198508204

GET BOOK
The Biochemistry of Cell Signalling Excerpt :

The Biochemistry of Cell Signalling is a comprehensive yet concise study of the principles of cell signalling, concentrating on the structural and mechanistic aspects.