PARP Inhibitors for Cancer Therapy Book

PARP Inhibitors for Cancer Therapy


  • Author : Nicola J. Curtin
  • Publisher : Humana Press
  • Release Date : 2015-06-13
  • Genre: Medical
  • Pages : 591
  • ISBN 10 : 9783319141510

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PARP Inhibitors for Cancer Therapy Excerpt :

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

PARP Inhibitors for Cancer Therapy Book

PARP Inhibitors for Cancer Therapy


  • Author : Nicola J. Curtin
  • Publisher : Unknown
  • Release Date : 2015
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 331914152X

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PARP Inhibitors for Cancer Therapy Excerpt :

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP--poly ADP ribose polymerase--in cancer therapy. The volume covers the history of the discovery of PARP and its role in DNA repair. Additionally, it describes the discovery of the PARP family, and includes a discussion of other DNA maintenance-associated PARPs. As well, the volume features a section on the accessible chemistry behind the development of inhibitors. PARP inhibitors--PARPi--are a group of pharmacological inhibitors that are particularly good targets for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA-damaging agents used to treat cancer. Researchers have learned a great deal about the biology of PARP and how tumor-specific defects in DNA repair can be exploited by PARPi. The "synthetic lethality" of PARPi is an exciting concept for cancer therapy, and has led to heightened activity in this area.

Inhibiting PARP as a Strategic Target in Cancer Book

Inhibiting PARP as a Strategic Target in Cancer


  • Author : Christina Annunziata
  • Publisher : Frontiers Media SA
  • Release Date : 2016-08-05
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889199556

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Inhibiting PARP as a Strategic Target in Cancer Excerpt :

Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.

Translational Advances in Gynecologic Cancers Book

Translational Advances in Gynecologic Cancers


  • Author : Michael Birrer
  • Publisher : Academic Press
  • Release Date : 2017-01-25
  • Genre: Medical
  • Pages : 354
  • ISBN 10 : 9780128037980

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Translational Advances in Gynecologic Cancers Excerpt :

Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included. Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus. Provides a comprehensive description of all evolving translational gynecologic cancer research for clinicians Identifies knowledge gaps to inform the next research direction Ties together clinical research and patient needs to help both the researcher and clinician Addresses genomics, new target therapies, novel tools, and more for ovarian, endometrial, and cervical cancer

DNA Repair in Cancer Therapy Book

DNA Repair in Cancer Therapy


  • Author : Mark R. Kelley
  • Publisher : Academic Press
  • Release Date : 2016-06-07
  • Genre: Medical
  • Pages : 464
  • ISBN 10 : 9780128035993

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DNA Repair in Cancer Therapy Excerpt :

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Targeted Therapies in Oncology  Second Edition Book

Targeted Therapies in Oncology Second Edition


  • Author : Giuseppe Giaccone
  • Publisher : CRC Press
  • Release Date : 2013-10-21
  • Genre: Medical
  • Pages : 498
  • ISBN 10 : 9781842145456

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Targeted Therapies in Oncology Second Edition Excerpt :

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

Ovarian Cancer Book

Ovarian Cancer


  • Author : Omer Devaja
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-10-24
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9781789843330

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Ovarian Cancer Excerpt :

Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy Book

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-03-28
  • Genre: Medical
  • Pages : 308
  • ISBN 10 : 9780128137543

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Targeting Cell Survival Pathways to Enhance Response to Chemotherapy Excerpt :

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials

Breast Cancer Metastasis and Drug Resistance Book

Breast Cancer Metastasis and Drug Resistance


  • Author : Aamir Ahmad
  • Publisher : Springer Nature
  • Release Date : 2019-08-27
  • Genre: Medical
  • Pages : 427
  • ISBN 10 : 9783030203016

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Breast Cancer Metastasis and Drug Resistance Excerpt :

Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Targeting the DNA Damage Response for Anti Cancer Therapy Book

Targeting the DNA Damage Response for Anti Cancer Therapy


  • Author : John Pollard
  • Publisher : Springer
  • Release Date : 2018-05-26
  • Genre: Medical
  • Pages : 401
  • ISBN 10 : 9783319758367

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Targeting the DNA Damage Response for Anti Cancer Therapy Excerpt :

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR. In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.

Handbook of Therapeutic Biomarkers in Cancer Book
Score: 5
From 1 Ratings

Handbook of Therapeutic Biomarkers in Cancer


  • Author : Sherry X. Yang
  • Publisher : CRC Press
  • Release Date : 2013-06-21
  • Genre: Medical
  • Pages : 518
  • ISBN 10 : 9789814364669

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Handbook of Therapeutic Biomarkers in Cancer Excerpt :

In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.

Poly ADP Ribosyl ation Book

Poly ADP Ribosyl ation


  • Author : Alexander Bürkle
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-01-11
  • Genre: Medical
  • Pages : 246
  • ISBN 10 : 9780387360058

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Poly ADP Ribosyl ation Excerpt :

This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.

Cancer Drug Design and Discovery Book

Cancer Drug Design and Discovery


  • Author : Stephen Neidle
  • Publisher : Elsevier
  • Release Date : 2011-04-28
  • Genre: Medical
  • Pages : 496
  • ISBN 10 : 0080554954

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Cancer Drug Design and Discovery Excerpt :

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories

New Research Directions in DNA Repair Book

New Research Directions in DNA Repair


  • Author : Clark Chen
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-05-22
  • Genre: Medical
  • Pages : 674
  • ISBN 10 : 9789535111146

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New Research Directions in DNA Repair Excerpt :

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Targeted Therapies in Breast Cancer Book

Targeted Therapies in Breast Cancer


  • Author : George W. Sledge, Jr.
  • Publisher : Unknown
  • Release Date : 2013-04-15
  • Genre: Medical
  • Pages : 100
  • ISBN 10 : 1846920663

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Targeted Therapies in Breast Cancer Excerpt :

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.