The Epigenome and Developmental Origins of Health and Disease Book

The Epigenome and Developmental Origins of Health and Disease


  • Author : Cheryl S Rosenfeld
  • Publisher : Academic Press
  • Release Date : 2015-10-10
  • Genre: Science
  • Pages : 560
  • ISBN 10 : 9780128016725

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The Epigenome and Developmental Origins of Health and Disease Excerpt :

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Perinatal and Developmental Epigenetics Book

Perinatal and Developmental Epigenetics


  • Author : Garima Singh
  • Publisher : Academic Press
  • Release Date : 2022-03-15
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 0128217855

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Perinatal and Developmental Epigenetics Excerpt :

Increasing evidence shows the perinatal periods see intense epigenetic activity, enabling the fine-tuning of developmental processes in response to changing environment conditions. Perinatal and Developmental Epigenetics, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development, opening with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility, while concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood. Examines disease onset stemming from epigenetic changes during the perinatal periods Features contributions from international experts in the field, across basic biology, disease research, and drug discovery Offers intervention strategies to mitigate adverse developmental programming to improve health outcomes

Hypoxia and Human Diseases Book

Hypoxia and Human Diseases


  • Author : Jing Zheng
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-02-01
  • Genre: Medical
  • Pages : 454
  • ISBN 10 : 9789535128953

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Hypoxia and Human Diseases Excerpt :

This book contains a total of 21 chapters, each of which was written by experts in the corresponding field. The objective of this book is to provide a comprehensive and updated overview of cellular and molecular mechanisms underlying hypoxia's impacts on human health, as well as current advances and future directions in the detection, recognition, and management of hypoxia-related disorders. This collection of articles provides a clear update in the area of hypoxia research for biomedical researchers, medical students, nurse practitioners, and practicing clinicians in the fields of high altitude biology, cardiovascular biology and medicine, tumor oncology, obstetrics, pediatrics, and orthodontics and for others who may be interested in hypoxia.

Prenatal Stress and Child Development Book

Prenatal Stress and Child Development


  • Author : Ashley Wazana
  • Publisher : Springer Nature
  • Release Date : 2021-04-19
  • Genre: Psychology
  • Pages : 643
  • ISBN 10 : 9783030601591

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Prenatal Stress and Child Development Excerpt :

This book examines the complex impact of prenatal stress and the mechanism of its transmission on children’s development and well-being, including prenatal programming, epigenetics, infl ammatory processes, and the brain-gut microbiome. It analyzes current findings on prenatal stressors affecting pregnancy, including preconception stress, prenatal maternal depression, anxiety, and pregnancy-specific anxieties. Chapters explore how prenatal stress affects cognitive, affective, behavioral, and neurobiological development in children while pinpointing core processes of adaptation, resilience, and interventions that may reduce negative behaviors and promote optimal outcomes in children. Th is complex perspective on mechanisms by which early environmental influences interact with prenatal programming of susceptibility aims to inform clinical strategies and future research targeting prenatal stress and its cyclical impact on subsequent generations. Key areas of coverage include: The developmental effects of prenatal maternal stress on children. Epigenetic effects of prenatal stress. Intergenerational transmission of parental early life stress. The microbiome-gut-brain axis and the effects of prenatal stress on early neurodevelopment. The effect of prenatal stress on parenting. Gestational stress and resilience. Prenatal stress and children’s sleeping behavior. Prenatal, perinatal, and population-based interventions to prevent psychopathology. Prenatal Stress and Child Development is an essential resource for researchers, professors and graduate students as well as clinicians, therapists, and related professionals in infancy and early childhood development, maternal and child health, developmental psychology, pediatrics, social work, child and adolescent psychiatry, developmental neuroscience, and related behavioral and social sciences and medical disciplines. Excerpt from the foreword: “I would make the plea that in addition to anyone with an interest in child devel

Epigenetics  the Environment  and Children   s Health Across Lifespans Book

Epigenetics the Environment and Children s Health Across Lifespans


  • Author : David Hollar
  • Publisher : Springer
  • Release Date : 2016-02-08
  • Genre: Medical
  • Pages : 386
  • ISBN 10 : 9783319253251

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Epigenetics the Environment and Children s Health Across Lifespans Excerpt :

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker γH2AX: from bench science to clinical trials What’s the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children’s exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children’s Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

Developmental Origins of Health and Disease Book

Developmental Origins of Health and Disease


  • Author : Peter Gluckman
  • Publisher : Cambridge University Press
  • Release Date : 2006-04-20
  • Genre: Medical
  • Pages : 542
  • ISBN 10 : 0521847435

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Developmental Origins of Health and Disease Excerpt :

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Adaptive and Maladaptive Aspects of Developmental Stress Book

Adaptive and Maladaptive Aspects of Developmental Stress


  • Author : Giovanni Laviola
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-01-31
  • Genre: Medical
  • Pages : 281
  • ISBN 10 : 9781461456056

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Adaptive and Maladaptive Aspects of Developmental Stress Excerpt :

Since the very early stages of life, we all experience some form of stress. Stressors can be mild to severe and can range from unsuccessfully longing for maternal milk in infancy, to recklessly wiggling on a motorbike to be on time to watch the NBA finals on TV, to breaking up a relationship. All those events that we call “stress” have the capability of perturbing a given state of psychological and physiological equilibrium and moving it to a different level. The transition from crawling to walking has to be considered a form of stress as much as losing a job. It is through a continuous cross-talk between environmental stressors and individual adaptations that we build our personalities and our ways to cope with daily hassles. External challenges should not necessarily be regarded as “bad”, but instead seen as constructive forces forming our ability to navigate a changing world. What is stress good for? What is stress bad for? When and why do we need to be “stressed”? Should we worry about stress? When does stress equate to “normality”? When does it turn into pathology? We hope with this book to provide some answers to these fundamental questions.

Handbook of Prenatal and Perinatal Psychology Book

Handbook of Prenatal and Perinatal Psychology


  • Author : Klaus Evertz
  • Publisher : Springer Nature
  • Release Date : 2020-10-27
  • Genre: Psychology
  • Pages : 817
  • ISBN 10 : 9783030417161

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Handbook of Prenatal and Perinatal Psychology Excerpt :

The handbook synthesizes the comprehensive interdisciplinary research on the psychological and behavioral dimensions of life before, during, and immediately after birth. It examines how experiences during the prenatal period are associated with basic physiological and psychological imprints that last a lifetime and explores the ways in which brain networks reflect these experiences. Chapters offer findings on prenatal development, fetal programming, fetal stress, and epigenetics. In addition, chapters discuss psychotherapy for infants – before, during, and after birth – as well as prevention to promote positive health and well-being outcomes. Topics featured in this handbook include: Contemporary environmental stressors and adverse pregnancy outcomes The psychology of newborn intensive care. Art therapy and its use in treating prenatal trauma. The failures and successes of Cathartic Regression Therapy. Prenatal bonding and its positive effects on postnatal health and well-being. The role of family midwives and early prevention. The cultural meaning of prenatal psychology. The Handbook of Prenatal and Perinatal Psychology is an essential resource for researchers, clinicians and related professionals, as well as graduate students in a wide range of interrelated disciplines, including developmental psychology, pediatric and obstetrical medicine, neuroscience, infancy and early child development, obstetrics and gynecology, nursing, social work, and early childhood education.

Perinatal Growth and Nutrition Book

Perinatal Growth and Nutrition


  • Author : Ian J. Griffin
  • Publisher : CRC Press
  • Release Date : 2014-05-13
  • Genre: Medical
  • Pages : 342
  • ISBN 10 : 9781466558540

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Perinatal Growth and Nutrition Excerpt :

Preterm infants grow poorly after birth and very commonly develop ex utero growth restriction (EUGR). However, the risks and benefits of catch-up growth in preterm infants must be weighed, and evidence addressing this warrants examination. Perinatal Growth and Nutrition explores the reasons for EUGR and the long-term effects on developmental outcom

Developmental Human Behavioral Epigenetics Book

Developmental Human Behavioral Epigenetics


  • Author : Livio Provenzi
  • Publisher : Academic Press
  • Release Date : 2020-11-12
  • Genre: Science
  • Pages : 188
  • ISBN 10 : 9780128192634

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Developmental Human Behavioral Epigenetics Excerpt :

Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. Enables more effective study design and methods application in behavioral epigenetics research across human and animal models Examines findings in human behavioral epigenetics to-date Features contributions from leading international researchers in behavioral epigenetics

Examining a Developmental Approach to Childhood Obesity Book

Examining a Developmental Approach to Childhood Obesity


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2015-09-08
  • Genre: Medical
  • Pages : 170
  • ISBN 10 : 9780309376983

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Examining a Developmental Approach to Childhood Obesity Excerpt :

Recent scientific evidence points to the origins of childhood obesity as an outcome of the dynamic interplay of genetic, behavioral, and environmental factors throughout early development, with a compelling body of evidence suggesting that both maternal and paternal nutritional and other exposures affect a child's risk of later obesity. The burgeoning field of epigenetics has led researchers to speculate that many of the observed associations between early developmental exposures and later risk of childhood obesity are mediated, at least in part, through epigenetic mechanisms. To explore the body of evolving science that examines the nexus of biology, environment, and developmental stage on risk of childhood obesity, the Institute of Medicine and the National Research Council convened a workshop in February 2015. The workshop focused on the prenatal period, infancy, and early childhood and addressed evidence from both animal and human studies. Workshop objectives were to (1) identify epigenetic-mediated relationships between exposure to risk factors during sensitive periods of development (gestation through age 3) and subsequent obesity-related outcomes; (2) explore the science around periods of plasticity and potential reversibility of obesity risk in the context of early childhood development; and (3) examine the translation of epigenetic science to guide early childhood obesity prevention and intervention to reduce obesity risk. This report summarizes the information presented and discussed at the workshop.

Fanaroff and Martin s Neonatal Perinatal Medicine E Book Book
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Fanaroff and Martin s Neonatal Perinatal Medicine E Book


  • Author : Richard J. Martin
  • Publisher : Elsevier Health Sciences
  • Release Date : 2010-10-04
  • Genre: Medical
  • Pages : 2008
  • ISBN 10 : 9780323081115

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Fanaroff and Martin s Neonatal Perinatal Medicine E Book Excerpt :

Fanaroff and Martin’s Neonatal-Perinatal Medicine covers everything you need to improve the quality of life and long-term outcomes of your patients. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh, along with a multi-disciplinary team of contributors guide you through the sweeping developments in diagnosis and treatment of the mother fetus, and neonate. The completely updated 9th edition keeps you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. See nuances and details in over 800 illustrations that depict disorders in the clinical setting and explain complex information. Find the information you need easily with indexing in both volumes that provides quick access to specific guidance. Spot genetic problems early and advise parents of concerns thanks to completely new section on this topic. Tackle the health problems associated with preterm births through a new chapter on The Late Preterm Infant. Understand the fetal origins of adult disease through a new chapter that focuses on conditions that originate in the womb. Stay current on the developments and research surrounding neonatal anemia from the entirely new chapter on Blood and Hematopoietic System highlights. Obtain more global perspectives and best practices from an increased number of international contributions in this edition.

Pregnancy Disorders and Perinatal Outcomes Book

Pregnancy Disorders and Perinatal Outcomes


  • Author : Cathy Vaillancourt
  • Publisher : Bentham Science Publishers
  • Release Date : 2012-06-08
  • Genre: Medical
  • Pages : 161
  • ISBN 10 : 9781608053728

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Pregnancy Disorders and Perinatal Outcomes Excerpt :

Pregnancy Disorders and Perinatal Outcomes offers readers insights into knowledge related to maternal habits or disorders that could affect fetal development and lead to disability later in childhood and adulthood. It contains chapters on the role of plac

Fetal and Neonatal Physiology E Book Book
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Fetal and Neonatal Physiology E Book


  • Author : Richard A. Polin
  • Publisher : Elsevier Health Sciences
  • Release Date : 2016-05-11
  • Genre: Medical
  • Pages : 2050
  • ISBN 10 : 9780323352321

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Fetal and Neonatal Physiology E Book Excerpt :

Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highl