Personalized Immunosuppression in Transplantation Book

Personalized Immunosuppression in Transplantation


  • Author : Michael Oellerich
  • Publisher : Elsevier
  • Release Date : 2015-08-08
  • Genre: Medical
  • Pages : 316
  • ISBN 10 : 9780128011331

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Personalized Immunosuppression in Transplantation Excerpt :

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Personalized Immunosuppression in Transplantation Book

Personalized Immunosuppression in Transplantation


  • Author : Michael Oellerich
  • Publisher : Elsevier
  • Release Date : 2015-09-17
  • Genre: Medical
  • Pages : 316
  • ISBN 10 : 0128008857

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Personalized Immunosuppression in Transplantation Excerpt :

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Textbook of Personalized Medicine Book

Textbook of Personalized Medicine


  • Author : Kewal K. Jain
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-08-29
  • Genre: Medical
  • Pages : 430
  • ISBN 10 : 9781441907691

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Textbook of Personalized Medicine Excerpt :

Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic. There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine, summarizes the author’s efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.

Gastrointestinal Transplantation  An Issue of Gastroenterology Clinics of North America  E Book Book

Gastrointestinal Transplantation An Issue of Gastroenterology Clinics of North America E Book


  • Author : Enrico Benedetti
  • Publisher : Elsevier Health Sciences
  • Release Date : 2018-05-16
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9780323584029

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Gastrointestinal Transplantation An Issue of Gastroenterology Clinics of North America E Book Excerpt :

The Guest Editors have put together a concise monograph on the latest advances in transplantation of the liver, intestine, and pancreas. Expert authors have written comprehensive reviews on the following topics: Living donor liver transplantation: Technical innovations; Liver transplantation for cholangiocarcinoma; Immunological monitoring to personalize immunosuppression after liver transplantation; Status of adult LDLT in US based on A2ALL; Pediatric liver transplantation; Modern treatment of fulminant liver failure; Intestinal failure and rehabilitation; Adult intestinal transplantation; Pediatric intestinal transplantation; Living donor intestinal transplantation; Endoscopic follow-up of intestinal transplant recipients; Multivisceral transplantation; Pancreas transplantation for DM1 and DM2; and Robotic pancreas transplantation. Readers will come away with the clinical information they need to stay current on issues surrounding gastrointestinal transplantations.

Frontiers in Transplantology Book

Frontiers in Transplantology


  • Author : Hesham Abdeldayem
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-09-07
  • Genre: Medical
  • Pages : 312
  • ISBN 10 : 9789535125235

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Frontiers in Transplantology Excerpt :

This book is addressed to researchers, practicing physicians, and surgeons in the field of organ transplantation, as well as the medical students, residents, and fellows. The topics covered include the religious concepts in organ transplantation, embryonic organ transplantation, tolerance, normothermic graft perfusion, pharmacogenetics of immunosuppressors, viral transmission in organ transplantation, pediatric and split-liver transplantation, portopulmonary hypertension, mechanical circulatory support, ex vivo lung perfusion, and ABO-incompatible kidney transplantation.

Organ Donation and Transplantation Book

Organ Donation and Transplantation


  • Author : Georgios Tsoulfas
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-07-25
  • Genre: Medical
  • Pages : 454
  • ISBN 10 : 9781789233407

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Organ Donation and Transplantation Excerpt :

One of the most interesting and at the same time most challenging fields of medicine and surgery has been that of organ donation and transplantation. It is a field that has made tremendous strides during the last few decades through the combined input and efforts of scientists from various specialties. What started as a dream of pioneers has become a reality for the thousands of our patients whose lives can now be saved and improved. However, at the same time, the challenges remain significant and so do the expectations. This book will be a collection of chapters describing these same challenges involved including the ethical, legal, and medical issues in organ donation and the technical and immunological problems the experts are facing involved in the care of these patients.The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of organ donation and transplantation.

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology Book

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology


  • Author : Seth Kwabena Amponsah
  • Publisher : Springer Nature
  • Release Date : 2022-10-25
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9783031123986

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology Excerpt :

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Disease Recurrence After Liver Transplantation Book

Disease Recurrence After Liver Transplantation


  • Author : Paul J. Thuluvath
  • Publisher : Springer
  • Release Date : 2015-11-11
  • Genre: Medical
  • Pages : 269
  • ISBN 10 : 9781493929474

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Disease Recurrence After Liver Transplantation Excerpt :

As there is a high incidence of disease recurrence after liver transplantation, this volume is designed around the need for a reference text dealing exclusively with this problem. The book places special emphasis on pre- and post-transplant predictors of recurrence, severity assessment, prophylaxis, and treatment. Pathobiology of disease recurrence is discussed in detail where applicable. Issues including quality of life and cost burden are also covered in the text. Written by well-known authorities in each field, Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival serves as a comprehensive reference for physicians and surgeons who take care of liver transplant recipients and a major addition to the literature detailing the current understanding of disease recurrence.

Pharmacogenomics in Precision Medicine Book

Pharmacogenomics in Precision Medicine


  • Author : Weimin Cai
  • Publisher : Springer Nature
  • Release Date : 2020-06-12
  • Genre: Medical
  • Pages : 289
  • ISBN 10 : 9789811538957

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Pharmacogenomics in Precision Medicine Excerpt :

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Drug Benefits and Risks Book

Drug Benefits and Risks


  • Author : Christoffel Jos van Boxtel
  • Publisher : IOS Press
  • Release Date : 2008
  • Genre: Medical
  • Pages : 847
  • ISBN 10 : 9781586038809

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Drug Benefits and Risks Excerpt :

Explores the scientific basis and practice of drug therapy. This book examines the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world. It covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases.

Transplantation  An Issue of Anesthesiology Clinics Book

Transplantation An Issue of Anesthesiology Clinics


  • Author : Aman Mahajan
  • Publisher : Elsevier Health Sciences
  • Release Date : 2017-08-31
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9780323552677

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Transplantation An Issue of Anesthesiology Clinics Excerpt :

This issue of Anesthesiology Clinics focuses on Transplantation. Editors Aman Mahajan and Christopher Wray have assembled an expert team of authors on topics such as: Immunology and Pharmacology of Transplantation; Infectious Diseases and Malignancies in Transplantation; Anesthesia Management of the Organ Donor; Transfusion Medicine and Coagulation Management in Organ Transplantation; Pediatric Transplantation; Anesthesia for Kidney and Pancreas Transplantation; Anesthesia for Heart Transplantation; Anesthesia for Lung Transplantation; Anesthesia for Liver Transplantation; Anesthesia for Small Bowel and Multivisceral Transplantation; Anesthesia for hand and face transplantation; Anesthesia considerations in Transplant recipients for Non-transplant surgery.

Intercellular Signaling Peptides and Proteins   Advances in Research and Application  2013 Edition Book

Intercellular Signaling Peptides and Proteins Advances in Research and Application 2013 Edition


  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-06-21
  • Genre: Science
  • Pages : 645
  • ISBN 10 : 9781481688994

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Intercellular Signaling Peptides and Proteins Advances in Research and Application 2013 Edition Excerpt :

Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Agouti-Related Protein. The editors have built Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Agouti-Related Protein in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Pediatric Liver Transplantation Book

Pediatric Liver Transplantation


  • Author : Nedim Hadzic
  • Publisher : Elsevier Health Sciences
  • Release Date : 2020-11-13
  • Genre: Medical
  • Pages : 512
  • ISBN 10 : 9780323636728

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Pediatric Liver Transplantation Excerpt :

Written and edited by global leaders in the field, Pediatric Liver Transplantation: A Clinical Guide covers all aspects of treatment and management regarding this multifaceted procedure and unique patient population. This practical reference offers detailed, focused guidance in a highly templated, easy-to-consult format, covering everything from pre-transplantation preparation to surgical techniques to post-operative complications. Provides an in-depth understanding of all aspects of pediatric liver transplantation, ideal for pediatric hepatologists, pediatric transplant surgeons, and others on the pediatric transplant team. Covers all surgical techniques in detail, including split graft, living related, auxiliary, and domino. Discusses pediatric liver transplantation consideration for an increasing number of additional metabolic, hematologic and renal conditions; breakthroughs in grafting and stem cell therapy; and techniques and present role of hepatocyte transplantation. Uses a quick-reference templated format; each chapter includes an overview, pathophysiology, conventional management, controversies, and bulleted summary of key take-aways. Includes state-of-the-art mini-reviews based on updated references and author experience throughout the text. Features a full-color design with numerous algorithms, figures, and radiological and histopathological photos.

Clinical Guide to Heart Transplantation Book

Clinical Guide to Heart Transplantation


  • Author : Jon Kobashigawa
  • Publisher : Springer
  • Release Date : 2017-03-29
  • Genre: Medical
  • Pages : 258
  • ISBN 10 : 9783319437736

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Clinical Guide to Heart Transplantation Excerpt :

This is a concise review of up-to-date concepts and techniques in the discipline of heart transplantation. It is a review and reference for practitioners managing patients with advanced heart disease, including patients with end-stage heart failure, mechanical circulatory support or transplant recipients. Heart failure is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing heart failure is one in five. Heart failure carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. As heart transplantation remains the best treatment option for patients with end stage heart failure, this primer will provide valuable information and management strategies for physicians caring for these patients. Also, due to continued shortage in donor organs, heart transplantation is a limited resource – which further underscores the importance of appropriately evaluating patients for transplant candidacy and managing their pre, peri- and post-transplant care for maximum benefit and best outcomes.​

Cytochromes P450  Drug Metabolism  Bioactivation and Biodiversity 2 0 Book

Cytochromes P450 Drug Metabolism Bioactivation and Biodiversity 2 0


  • Author : Patrick M. Dansette
  • Publisher : MDPI
  • Release Date : 2021-08-31
  • Genre: Science
  • Pages : 286
  • ISBN 10 : 9783036502564

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Cytochromes P450 Drug Metabolism Bioactivation and Biodiversity 2 0 Excerpt :

This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor.