Platelets Book
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Platelets


  • Author : Alan D. Michelson
  • Publisher : Elsevier
  • Release Date : 2011-08-29
  • Genre: Medical
  • Pages : 1376
  • ISBN 10 : 0080465862

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Platelets Excerpt :

PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. · First edition won Best Book in Medical Science Award from the Association of American Publishers · Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias · A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Platelets Book

Platelets


  • Author : Orhan N. Ulutin
  • Publisher : Unknown
  • Release Date : 1975
  • Genre: Blood platelet disorders
  • Pages : 524
  • ISBN 10 : UOM:39015000281512

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Platelets Excerpt :

Platelets Book

Platelets


  • Author : Alan D. Michelson
  • Publisher : Academic Press
  • Release Date : 2019-03-15
  • Genre: Science
  • Pages : 1400
  • ISBN 10 : 0128134569

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Platelets Excerpt :

Experts from all areas of academic and medical research in hematology, oncology, cardiology, and pathology, take readers from the bench research through the role of platelets in disease, to new therapeutic approaches. Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 125 world experts from 14 countries. This award-winning reference provides clear presentations by basic scientists of the cellular, molecular, and genetic mechanisms of platelets and the subsequent pathophysiological processes such as thrombosis, hemorrhage, inflammation, and cancer. It also provides clear presentations by hematologists, oncologists, cardiologists, pathologists, and other clinicians on how antiplatelet therapy, gene therapy, and platelet transfusion can lead to new therapeutic approaches to diagnose and treat thrombosis and other cardiovascular diseases. Since the publication of the third edition, there continues to be a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. This Fourth Edition of Platelets will continue to draw all this information into a single, comprehensive and authoritative resource. Presents a comprehensive, translational source for all aspects of platelet biology, pathophysiology, and clinical manifestations in one reference work Contains new chapters on topics such as the regulators of GPVI signaling, in vivo thrombosis evaluations, pharmaco genomics of platelets, interplay between anti-platelets and anti-coagulants in clinical practice, and redox regulation of platelet function Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of platelets Provides a full color reference with 250 illustrations and over 12,000 references

Platelets  Drugs and Thrombosis Book

Platelets Drugs and Thrombosis


  • Author : Joseph Hirsh
  • Publisher : Basel ; New York : S. Karger
  • Release Date : 1975
  • Genre: Medical
  • Pages : 322
  • ISBN 10 : UOM:39015002418849

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Platelets Drugs and Thrombosis Excerpt :

Platelets in Thrombotic and Non Thrombotic Disorders Book

Platelets in Thrombotic and Non Thrombotic Disorders


  • Author : Paolo Gresele
  • Publisher : Springer
  • Release Date : 2017-03-08
  • Genre: Medical
  • Pages : 1445
  • ISBN 10 : 9783319474625

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Platelets in Thrombotic and Non Thrombotic Disorders Excerpt :

This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

Platelets in Thrombotic and Non Thrombotic Disorders Book

Platelets in Thrombotic and Non Thrombotic Disorders


  • Author : Paolo Gresele
  • Publisher : Cambridge University Press
  • Release Date : 2002-05-30
  • Genre: Medical
  • Pages : 1144
  • ISBN 10 : 052180261X

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Platelets in Thrombotic and Non Thrombotic Disorders Excerpt :

An essential reference for biomedical scientists and clinicians in hematology, cardiology, thrombosis and related disciplines.

Platelets in Hematologic and Cardiovascular Disorders Book

Platelets in Hematologic and Cardiovascular Disorders


  • Author : Paolo Gresele
  • Publisher : Cambridge University Press
  • Release Date : 2007-12-13
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9781139468763

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Platelets in Hematologic and Cardiovascular Disorders Excerpt :

A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

Clinical Decisions in Platelet Therapy Book

Clinical Decisions in Platelet Therapy


  • Author : American Association of Blood Banks
  • Publisher : Amer Assn of Blood Banks
  • Release Date : 1992
  • Genre: Medical
  • Pages : 127
  • ISBN 10 : UOM:39015032182126

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Clinical Decisions in Platelet Therapy Excerpt :

Platelets and Megakaryocytes Book

Platelets and Megakaryocytes


  • Author : Jonathan M. Gibbins
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-02-04
  • Genre: Medical
  • Pages : 385
  • ISBN 10 : 9781592597826

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Platelets and Megakaryocytes Excerpt :

12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

Platelet Function in Basset Hound Hereditary Thrombopathy Book

Platelet Function in Basset Hound Hereditary Thrombopathy


  • Author : Wayne Robert Patterson
  • Publisher : Unknown
  • Release Date : 1986
  • Genre: Basset hound
  • Pages : 124
  • ISBN 10 : MSU:31293031038122

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Platelet Function in Basset Hound Hereditary Thrombopathy Excerpt :

An inherited intrinsic platelet aggregation defect has been identified in Basset Hounds which clinically resembles the human disease, Glanzmann's thrombasthenia. The defect was named Basset Hound Hereditary Thrombopathy (BHT) and initial studies revealed variably prolonged bleeding times, normal blood coagulation parameters, normal platelet count and morphology, normal whole blood clot retraction, and an abnormal platelet aggregation response to adenosine diphosphate (ADP). An evaluation of the specific platelet defect included simultaneous measurement of dense granule release and aggregation, two dimensional electrophoretic and crossed immunoelectrophoretic techniques in order to determine if the defect was associated with platelet membrane glycoprotein abnormalities, and measurement of radiolabeled fibrinogen binding to ADP stimulated platelets. An analysis of two-dimensional and crossed-immunoelectrophoretic gels revealed no abnormalities in platelet protein/glycoprotein content when affected Basset Hound platelets were compared to normal dog platelets.

The Circulating Platelet Book

The Circulating Platelet


  • Author : Shirley A. Johnson
  • Publisher : Elsevier
  • Release Date : 2012-12-02
  • Genre: Medical
  • Pages : 622
  • ISBN 10 : 9780323144322

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The Circulating Platelet Excerpt :

The Circulating Platelet focuses on the biochemistry and physiology of platelets. Composed of contributions of authors, the compilation starts with the discussions on the origin, discovery, production, and life span of blood platelets. The discussions continue with the morphology of platelets. Concerns include peripheral, sol-gel, and organelle zones and the membrane systems. The book also looks at the energy metabolism of thrombocytes and highlights the presence of glycoproteins in blood platelets. These include polysaccharides, glucosaminoglycans, and glycoproteins. The text also discusses the properties, functions, and the physiological value of thrombosthenin. The compilation further discusses platelet aggregation and functions of platelets. Concerns include collection and processing of platelets; preparation of homogenates; and the agents that influence platelet aggregation. The role of platelets in blood clots and fibrinolysis is emphasized. The selection ends with discussions on the immunological reactions of platelets; the clinical diseases related to blood platelets; and blood transfusion and preservation. The text is vital for researchers interested in studying blood platelets.

Platelet vessel Wall Interactions in Hemostasis and Thrombosis Book

Platelet vessel Wall Interactions in Hemostasis and Thrombosis


  • Author : Rolando Enrique Rumbaut
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2010
  • Genre: Medical
  • Pages : 67
  • ISBN 10 : 9781615040391

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Platelet vessel Wall Interactions in Hemostasis and Thrombosis Excerpt :

Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions.