Post Genomic Cardiology Book
Score: 5
From 1 Ratings

Post Genomic Cardiology


  • Author : José Marín-García
  • Publisher : Academic Press
  • Release Date : 2014-05-09
  • Genre: Science
  • Pages : 944
  • ISBN 10 : 9780124046429

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Post Genomic Cardiology Excerpt :

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Aging and the Heart Book
Score: 5
From 1 Ratings

Aging and the Heart


  • Author : José Marín-García
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-07
  • Genre: Medical
  • Pages : 568
  • ISBN 10 : 9780387740720

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Aging and the Heart Excerpt :

In this book, the genetic and molecular basis of cardiovascular aging is examined in detail and a comprehensive assessment given of the bioenergetics changes occurring in human and animal models of cardiac aging. Both current diagnostic and future therapeutic modalities are presented, giving this book a dual-pronged approach. Cardiac aging, like aging in general, is a complex process involving numerous cellular and molecular changes. This book sheds new light on the phenomenon.

Heart Failure Book
Score: 5
From 1 Ratings

Heart Failure


  • Author : José Marín-García
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-06-23
  • Genre: Medical
  • Pages : 470
  • ISBN 10 : 9781607611479

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Heart Failure Excerpt :

Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.

Signaling in the Heart Book

Signaling in the Heart


  • Author : José Marín-García
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-06-21
  • Genre: Medical
  • Pages : 507
  • ISBN 10 : 9781441994615

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Signaling in the Heart Excerpt :

Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.

Cardiovascular Genomics Book

Cardiovascular Genomics


  • Author : Mohan K. Raizada
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-02-24
  • Genre: Medical
  • Pages : 362
  • ISBN 10 : 9781592598830

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Cardiovascular Genomics Excerpt :

Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.

Proteomic and Genomic Analysis of Cardiovascular Disease Book

Proteomic and Genomic Analysis of Cardiovascular Disease


  • Author : Jennifer E. Van Eyk
  • Publisher : Wiley-Blackwell
  • Release Date : 2003-04-10
  • Genre: Science
  • Pages : 396
  • ISBN 10 : UOM:39015061093830

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Proteomic and Genomic Analysis of Cardiovascular Disease Excerpt :

This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.

Signaling in the Heart Book

Signaling in the Heart


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2011-10-05
  • Genre: Uncategoriezed
  • Pages : 528
  • ISBN 10 : 1441994629

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Signaling in the Heart Excerpt :

Epigenetics in Precision Medicine Book

Epigenetics in Precision Medicine


  • Author : Jose Luis Garcia-Gimenez
  • Publisher : Elsevier
  • Release Date : 2021-11-22
  • Genre: Medical
  • Pages : 614
  • ISBN 10 : 9780323858052

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Epigenetics in Precision Medicine Excerpt :

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Principles of Gender Specific Medicine Book
Score: 5
From 1 Ratings

Principles of Gender Specific Medicine


  • Author : Marianne J. Legato
  • Publisher : Academic Press
  • Release Date : 2017-05-15
  • Genre: Medical
  • Pages : 792
  • ISBN 10 : 9780128035429

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Principles of Gender Specific Medicine Excerpt :

The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation. This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness. Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols

The Genome Odyssey Book
Score: 4
From 3 Ratings

The Genome Odyssey


  • Author : Dr. Euan Angus Ashley
  • Publisher : Celadon Books
  • Release Date : 2021-02-23
  • Genre: Science
  • Pages : 352
  • ISBN 10 : 9781250234971

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The Genome Odyssey Excerpt :

In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the gen

Inherited Cardiac Disease Book

Inherited Cardiac Disease


  • Author : Perry Elliott
  • Publisher : Oxford University Press
  • Release Date : 2011-05-26
  • Genre: Medical
  • Pages : 424
  • ISBN 10 : 9780199559688

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Inherited Cardiac Disease Excerpt :

Containing summaries of inherited cardiovascular disorders with a focus on aetiology, presentation and management, this handbook covers the fundamentals of molecular biology and genetic testing, and the detailed clinical information relevant to patient management.

Biocode Book
Score: 4
From 3 Ratings

Biocode


  • Author : Dawn Field
  • Publisher : American Chemical Society
  • Release Date : 2015
  • Genre: Science
  • Pages : 209
  • ISBN 10 : 9780199687756

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Biocode Excerpt :

The living world runs on genomic software - what Dawn Field and Neil Davies call the 'biocode' - the sum of all DNA on Earth. In Biocode, they tell the story of a new age of scientific discovery: the growing global effort to read and map the biocode, and what that might mean for the future. The structure of DNA was identified in 1953, and the whole human genome was mapped by 2003. Since then the new field of genomics has mushroomed and is now operating on an industrial scale. Genomes can now be sequenced rapidly and increasingly cheaply. The genomes of large numbers of organisms from mammals to microbes, have been mapped. Getting your genome sequenced is becoming affordable for many. You too can check paternity, find out where your ancestors came from, or whether you are at risk of some diseases. Some check out the pedigree of their pets, while others turn genomes into art. A stray hair is enough to crudely reconstruct the face of the owner. From reading to constructing: the first steps to creating artificial life have already been taken. Some may find the rapidity of developments, and the potential for misuse, alarming. But they also open up unprecedented possibilities. The ability to read DNA has changed how we view ourselves and understand our place in nature. From the largest oceans, to the insides of our guts, we are able to explore the biosphere as never before, from the genome up. Sequencing technology has made the invisible world of microbes visible, and biodiversity genomics is revealing whole new worlds within us and without. The findings are transformational: we are all ecosystems now. Already the first efforts at 'barcoding' entire ecological communities and creating 'genomic observatories' have begun. The future, the authors argue, will involve biocoding the entire planet.