Precision Medicine and the Reinvention of Human Disease Book

Precision Medicine and the Reinvention of Human Disease


  • Author : Jules J. Berman
  • Publisher : Academic Press
  • Release Date : 2018-01-26
  • Genre: Business & Economics
  • Pages : 398
  • ISBN 10 : 9780128143940

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Precision Medicine and the Reinvention of Human Disease Excerpt :

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Evolution s Clinical Guidebook Book

Evolution s Clinical Guidebook


  • Author : Jules J. Berman
  • Publisher : Academic Press
  • Release Date : 2019-04-25
  • Genre: Science
  • Pages : 357
  • ISBN 10 : 9780128171271

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Evolution s Clinical Guidebook Excerpt :

Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data. Offers an innovative approach, focusing on how disease-associated pathways evolved Explains how the fields of phylogeny and embryology have become closely tied to the fields of genetics and bioinformatics Demonstrates how students and biomedical professionals can apply the knowledge obtained in this book to the theory and practice of precision medicine

Taxonomic Guide to Infectious Diseases Book

Taxonomic Guide to Infectious Diseases


  • Author : Jules J. Berman
  • Publisher : Academic Press
  • Release Date : 2019-05-31
  • Genre: Medical
  • Pages : 399
  • ISBN 10 : 9780128175774

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Taxonomic Guide to Infectious Diseases Excerpt :

Taxonomic Guide to Infectious Diseases: Understanding the Biologic Classes of Pathogenic Organisms, Second Edition tackles the complexity of clinical microbiology by assigning every infectious organism to one of 40+ taxonomic classes and providing a description of the defining traits that apply to all the organisms within each class. This edition is an updated, revised and greatly expanded guide to the classes of organisms that infect humans. This book will provide students and clinicians alike with a simplified way to understand the complex fields of clinical microbiology and parasitology. Focuses on human disease processes and includes numerous clinical tips for healthcare providers Describes the principles of classification and explains why the science of taxonomy is vital to the fields of bioinformatics and modern disease research Provides images of prototypical organisms for taxonomic classes Includes a section that lists common taxonomic pitfalls and how they can be avoided

Logic and Critical Thinking in the Biomedical Sciences Book

Logic and Critical Thinking in the Biomedical Sciences


  • Author : Jules J. Berman
  • Publisher : Academic Press
  • Release Date : 2020-07-08
  • Genre: Business & Economics
  • Pages : 290
  • ISBN 10 : 9780128213629

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Logic and Critical Thinking in the Biomedical Sciences Excerpt :

All too often, individuals engaged in the biomedical sciences assume that numeric data must be left to the proper authorities (e.g., statisticians and data analysts) who are trained to apply sophisticated mathematical algorithms to sets of data. This is a terrible mistake. Individuals with keen observational skills, regardless of their mathematical training, are in the best position to draw correct inferences from their own data and to guide the subsequent implementation of robust, mathematical analyses. Volume 2 of Logic and Critical Thinking in the Biomedical Sciences provides readers with a repertoire of deductive non-mathematical methods that will help them draw useful inferences from their own data. Volumes 1 and 2 of Logic and Critical Thinking in the Biomedical Sciences are written for biomedical scientists and college-level students engaged in any of the life sciences, including bioinformatics and related data sciences. Demonstrates that a great deal can be deduced from quantitative data, without applying any statistical or mathematical analyses Provides readers with simple techniques for quickly reviewing and finding important relationships hidden within large and complex sets of data Using examples drawn from the biomedical literature, discusses common pitfalls in data interpretation and how they can be avoided

Logic and Critical Thinking in the Biomedical Sciences Book

Logic and Critical Thinking in the Biomedical Sciences


  • Author : Jules J. Berman
  • Publisher : Academic Press
  • Release Date : 2020-07-03
  • Genre: Business & Economics
  • Pages : 306
  • ISBN 10 : 9780128213711

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Logic and Critical Thinking in the Biomedical Sciences Excerpt :

Science is not a collection of facts. Science is the process by which we draw inferences from facts. Volume I of Logic and Critical Thinking in the Biomedical Sciences invites readers to linger over a collection of common observations to see what inferences can be drawn, when one applies a bit of deductive logic. If we just think about what we observe, it is often possible to discover profound biomedical insights. Volumes 1 and 2 of Logic and Critical Thinking in the Biomedical Sciences are written for biomedical scientists and college-level students engaged in any of the life sciences, including bioinformatics and related data sciences. Provides a strong introduction to deductive methods that can be directly applied to the biomedical sciences Using hundreds of examples, shows how creative scientists draw important inferences from observations that are often ignored by their peers Discusses complex biological and medical concepts in a relaxed manner, intended to focus the reader’s attention on the deductive process, without dwelling excessively on details

Classification Made Relevant Book

Classification Made Relevant


  • Author : Jules J. Berman
  • Publisher : Academic Press
  • Release Date : 2022-01-25
  • Genre: Computers
  • Pages : 444
  • ISBN 10 : 9780323972581

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Classification Made Relevant Excerpt :

Classification Made Relevant explains how classifications and ontologies are designed, and how they are used to analyze scientific information. It is through our description of the relationships among classes of objects that we are able to simplify knowledge and explore the ways in which individual classified objects behave. The book begins by describing the fundamentals of classification and leads up to a description of how computer scientists use object-oriented programming languages to model classifications and ontologies. Numerous examples are chosen from the Classification of Life, the Periodic Table of the Elements, and the symmetry relationships contained within the Classification Theorem of Finite Simple Groups. When these three classifications are tied together, they provide a relational hierarchy connecting all of the natural sciences. This book is intended to reach a multidisciplinary audience of students and professionals working in the data sciences, the library sciences, and all of the STEM sciences. The chapters introduce and describe general concepts that can be understood by any intelligent reader. With each new concept, there follow practical examples selected from various scientific disciplines. In these cases, technical points and specialized vocabulary are linked to glossary items, where the item is clarified and expanded. Technical terms in the data sciences often have different meanings, depending on the reader's specific discipline. The word “ontology has so many meanings, it has become meaningless. Skeptics can google on the word “ontology to quickly confirm the inchoate status of this subject. In such cases, the glossary describes the different way the term has been used and will clarify its meaning within the book's context. For the benefit of computer scientists, the glossary contains short scripts written in Perl or Python or Ruby. Non-programmers will be spared from reading computer code, without missing out on the concepts covered

Complex Systems in Medicine Book

Complex Systems in Medicine


  • Author : David C. Aron
  • Publisher : Springer Nature
  • Release Date : 2019-08-30
  • Genre: Medical
  • Pages : 255
  • ISBN 10 : 9783030245931

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Complex Systems in Medicine Excerpt :

This unique title explores complex systems in clinical medicine and the subsequent implementation of that knowledge into practice. Written conversationally and as a reflection on the journey of learning about complex systems, the book explores how knowledge of these systems can be applied to four key roles in academic medicine: clinical practice, education, research, and administration. Further, this title emphasizes how gaining an understanding of complex systems can greatly help a physician deal with the many challenges found in academic medicine. Unlike other books on complexity in medicine, which tend to focus on only one aspect of the management of patients, Complex Systems in Medicine deals with the multifaceted roles of a physician. The approach in this book is uniquely qualitative rather than mathematical, and is written to make it not only of interest to physicians, trainees, and allied health providers, but also to make it more accessible to a non-medical audience. The inclusion of personal anecdotes by the author provides concrete examples of the application of knowledge of complex systems in academic medicine. A first-of-its-kind contribution to the literature, Complex Systems in Medicine: A Hedgehog’s Tale of Complexity in Clinical Practice, Research, Education, and Management is not only a novel reference for medical professionals, it is an accessible tool for the non-medical audience hoping to learn more about complex systems and their direct relevance to medicine, a field that deals with the infinite variety of humans and their ills. It illustrates the consequences of the interactive elements of patient care that make medicine both a science and an art.

Lifestyle Psychiatry Book

Lifestyle Psychiatry


  • Author : Douglas L. Noordsy, M.D.
  • Publisher : American Psychiatric Pub
  • Release Date : 2019-04-08
  • Genre: Medical
  • Pages : 416
  • ISBN 10 : 9781615371662

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Lifestyle Psychiatry Excerpt :

Exercise, a healthy diet, stress management, sound sleep: Most practitioners would agree that living well can mitigate the impact of mental disorders. Yet many are unprepared to address lifestyle factors in their care of patients. Lifestyle Psychiatry seeks to instill confidence by collating and analyzing the impressive emerging body of evidence that supports the efficacy of healthy lifestyle practices -- both as the primary intervention and in conjunction with traditional treatments such as psychopharmacology or psychotherapy -- in preventing and managing psychiatric disorders. This volume examines the impact of lifestyle interventions -- from exercise, yoga, and tai chi to mindfulness and meditation, diet and nutrition, and sleep management -- on psychiatric disorders, including depression, anxiety, posttraumatic stress disorder, schizophrenia, and addiction. Readers can readily find data to support the use of specific lifestyle interventions for a patient presenting with a specific disorder. Detailed descriptions of the mechanisms of each lifestyle intervention also prepare practitioners to educate their patients on the specific neurobiological and psychological effects of these interventions to support their recovery. With chapters that focus on developing a robust therapeutic alliance and inspiring patients to assume responsibility for their own well-being, this guide provides a framework for lasting, sustainable lifestyle changes. Additionally, the book discusses the impact of the provider's lifestyle on clinical behavior and the implications of lifestyle medicine and psychiatry for health care systems and population health, offering a broader examination of the important role this new field can play in leading a sophisticated, holistic approach to optimizing wellness.

Principles and Practice of Big Data Book

Principles and Practice of Big Data


  • Author : Jules J Berman
  • Publisher : Academic Press
  • Release Date : 2018-07-23
  • Genre: Computers
  • Pages : 480
  • ISBN 10 : 9780128156100

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Principles and Practice of Big Data Excerpt :

Principles and Practice of Big Data: Preparing, Sharing, and Analyzing Complex Information, Second Edition updates and expands on the first edition, bringing a set of techniques and algorithms that are tailored to Big Data projects. The book stresses the point that most data analyses conducted on large, complex data sets can be achieved without the use of specialized suites of software (e.g., Hadoop), and without expensive hardware (e.g., supercomputers). The core of every algorithm described in the book can be implemented in a few lines of code using just about any popular programming language (Python snippets are provided). Through the use of new multiple examples, this edition demonstrates that if we understand our data, and if we know how to ask the right questions, we can learn a great deal from large and complex data collections. The book will assist students and professionals from all scientific backgrounds who are interested in stepping outside the traditional boundaries of their chosen academic disciplines. Presents new methodologies that are widely applicable to just about any project involving large and complex datasets Offers readers informative new case studies across a range scientific and engineering disciplines Provides insights into semantics, identification, de-identification, vulnerabilities and regulatory/legal issues Utilizes a combination of pseudocode and very short snippets of Python code to show readers how they may develop their own projects without downloading or learning new software

Genomics and the Reimagining of Personalized Medicine Book

Genomics and the Reimagining of Personalized Medicine


  • Author : Richard Tutton
  • Publisher : Routledge
  • Release Date : 2016-04-15
  • Genre: Medical
  • Pages : 214
  • ISBN 10 : 9781317129400

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Genomics and the Reimagining of Personalized Medicine Excerpt :

Drawing on insights from work in medical history and sociology, this book analyzes changing meanings of personalized medicine over time, from the rise of biomedicine in the twentieth century, to the emergence of pharmacogenomics and personal genomics in the 1990s and 2000s. In the past when doctors championed personalization they did so to emphasize that patients had unique biographies and social experiences in the name of caring for their patients as individuals. However, since the middle of the twentieth century, geneticists have successfully promoted the belief that genes are implicated in why some people develop diseases and why some have adverse reactions to drugs when others do not. In doing so, they claim to offer a new way of personalizing the prediction, prevention and treatment of disease. As this book shows, the genomic reimagining of personalized medicine centres on new forms of capitalization and consumption of genetic information. While genomics promises the ultimate individualization of medicine, the author argues that personalized medicine exists in the imaginative gap between the problems and limits of current scientific practices and future prospects to individualize medical interventions. A rigorous, critical examination of the promises of genomics to transform the economics and delivery of medicine, Genomics and the Reimagining of Personalized Medicine examines the consequences of the shift towards personalization for the way we think about and act on health and disease in society. As such, it will be of interest to scholars and students of the sociology of medicine and health, science and technology studies, and health policy.

Principles of Big Data Book

Principles of Big Data


  • Author : Jules J. Berman
  • Publisher : Newnes
  • Release Date : 2013-05-20
  • Genre: Computers
  • Pages : 288
  • ISBN 10 : 9780124047242

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Principles of Big Data Excerpt :

Principles of Big Data helps readers avoid the common mistakes that endanger all Big Data projects. By stressing simple, fundamental concepts, this book teaches readers how to organize large volumes of complex data, and how to achieve data permanence when the content of the data is constantly changing. General methods for data verification and validation, as specifically applied to Big Data resources, are stressed throughout the book. The book demonstrates how adept analysts can find relationships among data objects held in disparate Big Data resources, when the data objects are endowed with semantic support (i.e., organized in classes of uniquely identified data objects). Readers will learn how their data can be integrated with data from other resources, and how the data extracted from Big Data resources can be used for purposes beyond those imagined by the data creators. Learn general methods for specifying Big Data in a way that is understandable to humans and to computers Avoid the pitfalls in Big Data design and analysis Understand how to create and use Big Data safely and responsibly with a set of laws, regulations and ethical standards that apply to the acquisition, distribution and integration of Big Data resources

MoneyBall Medicine Book
Score: 5
From 1 Ratings

MoneyBall Medicine


  • Author : Harry Glorikian
  • Publisher : Taylor & Francis
  • Release Date : 2017-11-20
  • Genre: Business & Economics
  • Pages : 252
  • ISBN 10 : 9781351984331

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MoneyBall Medicine Excerpt :

How can a smartwatch help patients with diabetes manage their disease? Why can’t patients find out prices for surgeries and other procedures before they happen? How can researchers speed up the decade-long process of drug development? How will "Precision Medicine" impact patient care outside of cancer? What can doctors, hospitals, and health systems do to ensure they are maximizing high-value care? How can healthcare entrepreneurs find success in this data-driven market? A revolution is transforming the $10 trillion healthcare landscape, promising greater transparency, improved efficiency, and new ways of delivering care. This new landscape presents tremendous opportunity for those who are ready to embrace the data-driven reality. Having the right data and knowing how to use it will be the key to success in the healthcare market in the future. We are already starting to see the impacts in drug development, precision medicine, and how patients with rare diseases are diagnosed and treated. Startups are launched every week to fill an unmet need and address the current problems in the healthcare system. Digital devices and artificial intelligence are helping doctors do their jobs faster and with more accuracy. MoneyBall Medicine: Thriving in the New Data-Driven Healthcare Market, which includes interviews with dozens of healthcare leaders, describes the business challenges and opportunities arising for those working in one of the most vibrant sectors of the world’s economy. Doctors, hospital administrators, health information technology directors, and entrepreneurs need to adapt to the changes effecting healthcare today in order to succeed in the new, cost-conscious and value-based environment of the future. The authors map out many of the changes taking place, describe how they are impacting everyone from patients to researchers to insurers, and outline some predictions for the healthcare industry in the years to come.

Taxonomic Guide to Infectious Diseases Book

Taxonomic Guide to Infectious Diseases


  • Author : Jules J. Berman
  • Publisher : Academic Press
  • Release Date : 2012
  • Genre: HEALTH & FITNESS
  • Pages : 355
  • ISBN 10 : 9780124158955

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Taxonomic Guide to Infectious Diseases Excerpt :

In the past few decades, there have been great advances in the phylogenetic classification of infectious diseases of man. Taxonomic Guide to Infectious Diseases organizes this information into a standard biological classification and provides a short, clinically-oriented description of every genus (class) of infectious organism. It covers an overview of modern taxonomy, including a description of the kingdoms of life and the evolutionary principles underlying the class hierarchy, and each following chapter will describe one phylum and the genera that contain infectious species. Taxonomic Guide to Infectious Diseases is written in an engaging, narrative style, providing the reader with an easy to digest yet clinically-oriented story of the pathogenic features of each genus. Designed for researchers, clinicians and students of infectious diseases, medical microbiology and pathology. Offers genus-by-genus classification of infectious diseases along with short, clinically-oriented descriptions of each genus Presents comprehensive lists of infectious species for each genera and identifies diseases caused by each species Compiled and written by a well-known pathologist with extensive experience in diagnosing human infectious diseases

Brugada Phenocopy Book

Brugada Phenocopy


  • Author : Adrian Baranchuk
  • Publisher : Academic Press
  • Release Date : 2018-03-28
  • Genre: Medical
  • Pages : 154
  • ISBN 10 : 9780128111529

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Brugada Phenocopy Excerpt :

Brugada Phenocopy: The Art of Recognizing the Brugada ECG Pattern details all aspects associated with alternative diagnosis to Brugada Syndrome (BrS). Coverage includes how to identify the proper ECG pattern, what to do to investigate for BrP, and how to avoid misinterpretations and the use of unnecessary and expensive treatments. Chapters are written by experienced professionals, many of whom are colleagues that initially described this condition. This easy to use volume is a must have reference for researchers of cardiology, cardiologists, electrocardiologists, internists, emergency care doctors and students, residents and fellows. Assists in the proper recognition of the Brugada ECG patterns and how to distinguish true BrS from other conditions with identical ECG Expands understanding on how to properly recognize the ECG of Brugada patterns Contains access to a companion website with video to enhance understanding of proper measurement of the beta angle (Chevallier) and the base of the triangle (Serra)

Graphic Medicine Manifesto Book

Graphic Medicine Manifesto


  • Author : MK Czerwiec
  • Publisher : Penn State Press
  • Release Date : 2020-05-18
  • Genre: Comics & Graphic Novels
  • Pages : 208
  • ISBN 10 : 9780271089362

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Graphic Medicine Manifesto Excerpt :

This inaugural volume in the Graphic Medicine series establishes the principles of graphic medicine and begins to map the field. The volume combines scholarly essays by members of the editorial team with previously unpublished visual narratives by Ian Williams and MK Czerwiec, and it includes arresting visual work from a wide range of graphic medicine practitioners. The book’s first section, featuring essays by Scott Smith and Susan Squier, argues that as a new area of scholarship, research on graphic medicine has the potential to challenge the conventional boundaries of academic disciplines, raise questions about their foundations, and reinvigorate literary scholarship—and the notion of the literary text—for a broader audience. The second section, incorporating essays by Michael Green and Kimberly Myers, demonstrates that graphic medicine narratives can engage members of the health professions with literary and visual representations and symbolic practices that offer patients, family members, physicians, and other caregivers new ways to experience and work with the complex challenges of the medical experience. The final section, by Ian Williams and MK Czerwiec, focuses on the practice of creating graphic narratives, iconography, drawing as a social practice, and the nature of comics as visual rhetoric. A conclusion (in comics form) testifies to the diverse and growing graphic medicine community. Two valuable bibliographies guide readers to comics and scholarly works relevant to the field.