Precision Medicine in Stroke Book

Precision Medicine in Stroke


  • Author : Ana Catarina Fonseca
  • Publisher : Springer Nature
  • Release Date : 2021-05-04
  • Genre: Medical
  • Pages : 339
  • ISBN 10 : 9783030707613

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Precision Medicine in Stroke Excerpt :

This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area. Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.

Broken Movement Book

Broken Movement


  • Author : John W. Krakauer
  • Publisher : MIT Press
  • Release Date : 2017-11-03
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 9780262037228

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Broken Movement Excerpt :

An account of the neurobiology of motor recovery in the arm and hand after stroke by two experts in the field. Stroke is a leading cause of disability in adults and recovery is often difficult, with existing rehabilitation therapies largely ineffective. In Broken Movement, John Krakauer and S. Thomas Carmichael, both experts in the field, provide an account of the neurobiology of motor recovery in the arm and hand after stroke. They cover topics that range from behavior to physiology to cellular and molecular biology. Broken Movement is the only accessible single-volume work that covers motor control and motor learning as they apply to stroke recovery and combines them with motor cortical physiology and molecular biology. The authors cast a critical eye at current frameworks and practices, offer new recommendations for promoting recovery, and propose new research directions for the study of brain repair. Krakauer and Carmichael discuss such subjects as the behavioral phenotype of hand and arm paresis in human and non-human primates; the physiology and anatomy of the motor system after stroke; mechanisms of spontaneous recovery; the time course of early recovery; the challenges of chronic stroke; and pharmacological and stem cell therapies. They argue for a new approach in which patients are subjected to higher doses and intensities of rehabilitation in a more dynamic and enriching environment early after stroke. Finally they review the potential of four areas to improve motor recovery: video gaming and virtual reality, invasive brain stimulation, re-opening the sensitive period after stroke, and the application of precision medicine.

Genomic and Precision Medicine Book

Genomic and Precision Medicine


  • Author : Geoffrey S. Ginsburg
  • Publisher : Academic Press
  • Release Date : 2017-11-17
  • Genre: Science
  • Pages : 336
  • ISBN 10 : 9780128018255

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Genomic and Precision Medicine Excerpt :

Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders. Each chapter is organized for the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Presents a comprehensive volume written and edited by cardiovascular genomic specialists Covers succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine into practice Provides an overview on major opportunities for genomic and personalized medicine in practice Includes case studies that highlight the practical use of genomics in the management of patients

Precision Medicine in Cancers and Non Communicable Diseases Book

Precision Medicine in Cancers and Non Communicable Diseases


  • Author : Debmalya Barh
  • Publisher : CRC Press
  • Release Date : 2018-09-03
  • Genre: Medical
  • Pages : 326
  • ISBN 10 : 9781498775625

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Precision Medicine in Cancers and Non Communicable Diseases Excerpt :

The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of "Precision Medicine". This book aims to provide a readily available resource on all the important developments achieved so far in the field of oncology. All recent developments have been explained along with epidemiology, technologies and approaches to manage the included diseases. Therefore, readers will get the up to date information on the next-generation approach in tackling all kinds of cancer. Key Features • Presents the latest trend of cancer management based on precision/predictive medicine approach • Reviews the latest and up to date literature in the field of Precision Medicine • Highlights the next generation approach in tackling malignant diseases • Discusses how a life-threatening disease like cancer can be managed with the help of Precision Medicine • Encapsulates a global prospective

Precision Medicine in Cancers and Non Communicable Diseases Book

Precision Medicine in Cancers and Non Communicable Diseases


  • Author : Debmalya Barh
  • Publisher : CRC Press
  • Release Date : 2018-09-03
  • Genre: Medical
  • Pages : 326
  • ISBN 10 : 9781351650786

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Precision Medicine in Cancers and Non Communicable Diseases Excerpt :

The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of "Precision Medicine". This book aims to provide a readily available resource on all the important developments achieved so far in the field of oncology. All recent developments have been explained along with epidemiology, technologies and approaches to manage the included diseases. Therefore, readers will get the up to date information on the next-generation approach in tackling all kinds of cancer. Key Features • Presents the latest trend of cancer management based on precision/predictive medicine approach • Reviews the latest and up to date literature in the field of Precision Medicine • Highlights the next generation approach in tackling malignant diseases • Discusses how a life-threatening disease like cancer can be managed with the help of Precision Medicine • Encapsulates a global prospective

Genomic and Precision Medicine Book

Genomic and Precision Medicine


  • Author : Geoffrey S. Ginsburg
  • Publisher : Academic Press
  • Release Date : 2022-04-09
  • Genre: Science
  • Pages : 378
  • ISBN 10 : 9780128006535

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Genomic and Precision Medicine Excerpt :

Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice Covers case studies that highlight the practical use of genomics in the management of patients

XPOMET   Book

XPOMET


  • Author : Ulrich H. Pieper
  • Publisher : MWV
  • Release Date : 2020-02-17
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 9783954664986

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XPOMET Excerpt :

As modern healthcare becomes increasingly personalized and data-driven, traditional healthcare is being transformed into a dynamic, multi-layered and highly connected global ecosystem. New players, such as medical entrepreneurs and tech giants like Apple, Amazon, Google and IBM Watson are continuing to expose and challenge the current healthcare market by providing innovative digital products and know-how. Digital health offers both—a suite of new capabilities and new approaches that unlock health(care) from constraints of time, place, distance and knowledge. It opens up entirely new ways to address and understand people and their health needs. This is how XPOMET© was born, and has been continuously growing as a platform, that is dedicated to innovative trends in medicine and care and at the same time creates a community that promotes cultural change in the healthcare industry. In 2019, the XPOMET© Medicinale has become an international event to showcase best practice, highlight trends in global healthcare and forecast future developments in health and tech. The book offers a broad collection of the extensive knowledge of contributors to the XPOMET© Medicinale 2019. International experts share their novel ideas, challenges and achievements in the global healthcare market. The reader is invited to join in the XPOMET© community’s vision and to be inspired by the latest discoveries and technological know-how in healthcare.

1   USE OF ARTIFICIAL INTELLIGENCE TO PREDICT VOLUME OF BRAIN AND INFARCTION GROWTH RATE  A STEP TOWARDS PRECISION MEDICINE Book

1 USE OF ARTIFICIAL INTELLIGENCE TO PREDICT VOLUME OF BRAIN AND INFARCTION GROWTH RATE A STEP TOWARDS PRECISION MEDICINE


  • Author : Saadat Kamran
  • Publisher : Unknown
  • Release Date : 2017
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:1163808084

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1 USE OF ARTIFICIAL INTELLIGENCE TO PREDICT VOLUME OF BRAIN AND INFARCTION GROWTH RATE A STEP TOWARDS PRECISION MEDICINE Excerpt :

Background: Background. The final human brain infarction volume [IV] and infarction growth rate [IGR] are strong predictors of clinical outcome. IGR is dynamic with wide variations in speed of growth. The conventional mathematical techniques are unable to predict IV and IGR.Patients and Methods: In this, single-center, prospective study data was collected on all acute stroke patients treated by intravenous thrombolysis and/or mechanical thrombectomy between January 2014 and December 2016.Infarct Growth Rate calculation [IGR]. Infarct volumes were measured on the baseline and 24-hour CT. For IGR calculation we assumed the stroke volume to be zero prior to stroke onset.Infarct growth rate 1[IGR1] = u0394 volume (IV CT1u20130)/u0394 time (time CT1- stroke onset time)Second infarct growth rate [IGR2] was measured on second CT [CT2]IGR2 = u0394 volume/ u0394 time = (IV CT2- IV CT1)/ (time CT2-time CT1).To quantify the difference between the estimated IGR and actual IGR mean square error [MSE] was usedufffdufffdufffdufffdufffdufffd=1/ufffdufffd u2211128_(ufffdufffd=0)^(ufffdufffdu22121)u2592(u3016ufffdufffdufffdufffdufffdufffdu3017_(u3016ufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdu3017_ufffdufffd )u2212u3016ufffdufffdufffdufffdufffdufffdu3017_(u3016ufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdufffdu3017_ufffdufffd ) )^2ResultsA total of 134 consecutive patients with an acute ischemic infarction secondary to middle cerebral artery occlusion were treated with a mean time to treatment from symptom onset of 213.27 +/- 227.12 minutes. A bivariate analysis showed the clot burden score [p=0.003], and time to treatment [p=0.78] was negatively/inversely correlated with IGR, while IGR 1 positively correlated with IGR2 [p=0.067]. The IGR2 was significantly higher when the collateral circulation score was low compared to a high score [p=0.001]. An unfavourable modified treatment in cerebral infarction (mTICI) score had a signif

Brainlesion  Glioma  Multiple Sclerosis  Stroke and Traumatic Brain Injuries Book

Brainlesion Glioma Multiple Sclerosis Stroke and Traumatic Brain Injuries


  • Author : Alessandro Crimi
  • Publisher : Springer
  • Release Date : 2019-02-08
  • Genre: Computers
  • Pages : 477
  • ISBN 10 : 9783030117238

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Brainlesion Glioma Multiple Sclerosis Stroke and Traumatic Brain Injuries Excerpt :

This two-volume set LNCS 11383 and 11384 constitutes revised selected papers from the 4th International MICCAI Brainlesion Workshop, BrainLes 2018, as well as the International Multimodal Brain Tumor Segmentation, BraTS, Ischemic Stroke Lesion Segmentation, ISLES, MR Brain Image Segmentation, MRBrainS18, Computational Precision Medicine, CPM, and Stroke Workshop on Imaging and Treatment Challenges, SWITCH, which were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI, in Granada, Spain, in September 2018. The 92 papers presented in this volume were carefully reviewed and selected from 95 submissions. They were organized in topical sections named: brain lesion image analysis; brain tumor image segmentation; ischemic stroke lesion image segmentation; grand challenge on MR brain segmentation; computational precision medicine; stroke workshop on imaging and treatment challenges.

Handbook of Biomarkers and Precision Medicine Book

Handbook of Biomarkers and Precision Medicine


  • Author : Claudio Carini
  • Publisher : CRC Press
  • Release Date : 2019-04-16
  • Genre: Mathematics
  • Pages : 631
  • ISBN 10 : 9780429574627

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Handbook of Biomarkers and Precision Medicine Excerpt :

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Pharmacogenomics in Precision Medicine Book

Pharmacogenomics in Precision Medicine


  • Author : Weimin Cai
  • Publisher : Springer Nature
  • Release Date : 2020-06-12
  • Genre: Medical
  • Pages : 289
  • ISBN 10 : 9789811538957

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Pharmacogenomics in Precision Medicine Excerpt :

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

The Foundation of Precision Medicine  Integration of Electronic Health Records with Genomics Through Basic  Clinical  and Translational Research Book

The Foundation of Precision Medicine Integration of Electronic Health Records with Genomics Through Basic Clinical and Translational Research


  • Author : Mariza de Andrade
  • Publisher : Frontiers Media SA
  • Release Date : 2016-06-30
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889198726

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The Foundation of Precision Medicine Integration of Electronic Health Records with Genomics Through Basic Clinical and Translational Research Excerpt :

This eBook contains the 19 articles that were part of a Special Topic in Frontiers in Genetics entitled “Genetics Research in Electronic Health Records Linked to DNA Biobanks”. The Special Issue was published on-line in 2014-2015 and contained papers representing the diverse research ongoing in the integration of electronic health records (EHR) with genomics through basic, clinical, and translational research. We have divided the eBook into four Chapters. Chapter 1 describes the Electronic Medical Records and Genomics (eMERGE) network and its contri-bution to genomics. It highlights methodological questions related to large data sets such as imputation and population stratification. Chapter 2 describes the results of genetic studies on different diseases for which all the phenotypic information was extracted from the EHR with highly specific ePhenotyping algorithms. Chapter 3 focuses on more complex analyses of the genome including copy number variants (CNV), pleiotropy com-bined with phenome-wide association studies (PheWAS), and epistasis (gene-gene interactions). Chapter 4 discusses the use of genetic data together with EHR-derived clinical data in clinical settings, and how to return genetic results to patients and providers. It also contains a comprehensive review on genetic risk scores. We have included mostly Original Research Articles in the eBook, but also Reviews and Methods papers on the relevant topics of analyzing and integrating genomic data. The release of this eBook is timely, since several countries are launching Precision Medicine initiatives. Precision Medicine is a new concept in patient care taking into account individual variability in genetic, environmental and lifestyle factors, when treating diseases or trying to prevent them from developing. It has become an important focus for biomedical, clinical and translational informatics. The papers presented in this eBook are well positioned to educate the readers about Precision Medicine and to

Stroke Genetics Book

Stroke Genetics


  • Author : Hugh S. Markus
  • Publisher : Oxford Medical Publications
  • Release Date : 2003
  • Genre: Medical
  • Pages : 346
  • ISBN 10 : 9780198515869

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Stroke Genetics Excerpt :

Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

Progress and Challenges in Precision Medicine Book

Progress and Challenges in Precision Medicine


  • Author : Mukesh Verma
  • Publisher : Academic Press
  • Release Date : 2016-12-22
  • Genre: Medical
  • Pages : 344
  • ISBN 10 : 9780128095027

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Progress and Challenges in Precision Medicine Excerpt :

Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development