Principles of Asymmetric Synthesis Book
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Principles of Asymmetric Synthesis


  • Author : R.E. Gawley
  • Publisher : Elsevier
  • Release Date : 1996-11-21
  • Genre: Science
  • Pages : 394
  • ISBN 10 : 9780080514772

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Principles of Asymmetric Synthesis Excerpt :

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented

Principles and Applications of Asymmetric Synthesis Book
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Principles and Applications of Asymmetric Synthesis


  • Author : Guo-Qiang Lin
  • Publisher : John Wiley & Sons
  • Release Date : 2003-05-29
  • Genre: Science
  • Pages : 536
  • ISBN 10 : 9780471465249

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Principles and Applications of Asymmetric Synthesis Excerpt :

Asymmetric synthesis remains a challenge to practicing scientistsas the need for enantiomerically pure or enriched compoundscontinues to increase. Over the last decade, a large amount ofliterature has been published in this field. Principles andApplications of Asymmetric Synthesis consolidates and evaluates themost useful methodologies into a one-volume resource for theconvenience of practicing scientists and students. Authored by internationally renowned scientists in the field, thisreliable reference covers more than 450 reactions and includesimportant stoichiometric as well as catalytic asymmetric reactions.The first chapter reviews the basic principles, commonnomenclature, and analytical methods, and the remainder of the bookis organized according to reaction type. The text examines suchtopics as: Carbon-carbon bond formations involving carbonyls, enamines,imines, and enolates Asymmetric C-O bond formations including epoxidation,dihydroxylation, and aminohydroxylation Asymmetric synthesis using the Diels-Alder reaction and othercyclizations Applications to the total synthesis of natural products Use of enzymes in asymmetric synthesis Practicing chemists in the pharmaceutical, fine chemical, andagricultural professions as well as graduate students will findthat Principles and Applications of Asymmetric Synthesis affordscomprehensive and current coverage.

Principles of Asymmetric Synthesis Book

Principles of Asymmetric Synthesis


  • Author : Robert E. Gawley
  • Publisher : Elsevier
  • Release Date : 2012-07-16
  • Genre: Science
  • Pages : 569
  • ISBN 10 : 9780080448602

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Principles of Asymmetric Synthesis Excerpt :

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented

Dynamic Stereochemistry of Chiral Compounds Book

Dynamic Stereochemistry of Chiral Compounds


  • Author : Christian Wolf
  • Publisher : Royal Society of Chemistry
  • Release Date : 2008
  • Genre: Science
  • Pages : 534
  • ISBN 10 : 9780854042463

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Dynamic Stereochemistry of Chiral Compounds Excerpt :

A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.

Asymmetric Synthesis Book

Asymmetric Synthesis


  • Author : Alan Aitken
  • Publisher : CRC Press
  • Release Date : 1992-12-30
  • Genre: Science
  • Pages : 256
  • ISBN 10 : 0751401900

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Asymmetric Synthesis Excerpt :

Asymmetric synthesis is one of the most important areas of research and development in synthetic organic chemistry, and has wide-ranging industrial applications. This introduction to the subject covers chirality, nomenclature and analytical methods of resolution. The main body of the text describes the principal methods available to the organic chemist wishing to synthesize chiral compounds. Case studies are included, and reference sections allow access to the relevant review and research literature. This book is written for organic chemists at postgraduate and advanced undergraduate level.

Stereochemistry and Organic Reactions Book

Stereochemistry and Organic Reactions


  • Author : Dipak Kumar Mandal
  • Publisher : Academic Press
  • Release Date : 2021-04-21
  • Genre: Science
  • Pages : 638
  • ISBN 10 : 9780128240939

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Stereochemistry and Organic Reactions Excerpt :

Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for the origin of stereoelectronic effects, and an introduction to the principles of stereoselectivity and hierarchical levels of asymmetric synthesis. Each chapter includes problems that reinforce main themes, making it valuable to students, teachers and researchers working in organic, biological and medicinal chemistry, as well as biologists, pharmacologists, polymer chemists and chemists. Presents a holistic and unified approach to stereochemical understanding and predictions, covering reactions of all mechanistic classes Includes two background chapters on perturbation theory and stereoselective principles, along with asymmetric designs Features novel rules and mnemonics to delineate product stereochemistry Includes up-to-date coverage with over 1300 selective references

Asymmetric Catalysis In Organic Synthesis Book

Asymmetric Catalysis In Organic Synthesis


  • Author : Ryoji Noyori
  • Publisher : Wiley-Interscience
  • Release Date : 1994-02-03
  • Genre: Science
  • Pages : 404
  • ISBN 10 : MINN:31951D01091644G

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Asymmetric Catalysis In Organic Synthesis Excerpt :

Deals with basic principles of asymmetric catalysis focusing on its synthetic significance. Covers homogeneous asymmetric hydrogenation, asymmetric catalysis via chiral metal complexes, heterogeneous catalysis and non-organometallic catalysis. The collection of a range of stereoselective reactions illustrate various strategies and methodologies as well as their general utility.

Asymmetric Synthesis Book

Asymmetric Synthesis


  • Author : Y. Vatsala
  • Publisher : Unknown
  • Release Date : 2014-03-01
  • Genre: Science
  • Pages : 178
  • ISBN 10 : 1781830134

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Asymmetric Synthesis Excerpt :

Deals with stereochemistry of specialised topics. This book provides a comprehensive account of concepts of Asymmetric Synthesis. It is based on three important principles: concepts and terminology used in asymmetric synthesis, the four types of asymmetric synthesis, and applications of asymmetric synthesis.

Advances in Asymmetric Autocatalysis and Related Topics Book

Advances in Asymmetric Autocatalysis and Related Topics


  • Author : Gyula Palyi
  • Publisher : Academic Press
  • Release Date : 2017-05-18
  • Genre: Science
  • Pages : 408
  • ISBN 10 : 9780128128251

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Advances in Asymmetric Autocatalysis and Related Topics Excerpt :

Advances in Asymmetric Autocatalysis and Related Topics provides various viewpoints on the important developments in asymmetric autocatalysis that have occurred in the past few years, also including brand new information in the field. Asymmetric autocatalysis is a chemical reaction which leads from achiral starting materials to chiral products, and in which the product accelerates its own formation reaction (conventional catalysis) and promotes the prevalence of its own chiral configuration (asymmetric induction). The combination of these two effects in the same reaction was unprecedented before 1995 when it was first described by Kenso SOAI at the Tokyo University of Science. Since then, several new combinations of this effect have been found, most intriguingly the possibility of absolute asymmetric synthesis, which is the spontaneous formation of the excess of one of the enantiomers of the product, a dream of organic chemists for more than a century. The book contains expert-contributed chapters that describe the most exciting recent developments in the field of the Soai reaction and in related topics, ranging from mechanistic studies and theoretical research, to very practical problems in chiral syntheses and products. Features contributions from global experts, including several chapters from Kenso Soai and expert colleagues Focuses on recent developments in the field of asymmetric autocatalysis and newly reported findings Explores the Soai reaction, new developments, and the light it sheds on homochirality in certain biomolecules

Asymmetric Organo Metal Catalysis Book

Asymmetric Organo Metal Catalysis


  • Author : Liu-Zhu Gong
  • Publisher : John Wiley & Sons
  • Release Date : 2022-03-14
  • Genre: Science
  • Pages : 354
  • ISBN 10 : 9783527345922

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Asymmetric Organo Metal Catalysis Excerpt :

Explore the latest advances involving organo/metal combined catalysts from leading contributors in the field In Asymmetric Organo-Metal Catalysis: Concepts, Principles, and Applications, accomplished chemist Liu-Zhu Gong delivers a comprehensive discussion of how to design efficient organo/metal combined catalyst systems, new cooperatively catalyzed asymmetric reactions, relay catalytic cascades, and multicomponent reactions. The distinguished author covers critical topics, like the combined catalysis of chiral phase transfer catalysts, enamine, iminium, nucleophilic Lewis base, or Bronsted acids with metal complexes, while also covering the cooperative catalysis of photocatalysts and organocatalysts. The book offers readers an exploration of the general concepts and principles of bond activation and reorganization, together with a comprehensive introduction to the historical developments and recent advances in the field. Readers will also benefit from the descriptions of new chemistry and new synthetic methods included within. Asymmetric Organo-Metal Catalysis also provides: Thorough introductions to chiral PTC-metal cooperative catalysis and enamine-metal cooperative catalysis Comprehensive explorations of iminum-metal relay catalysis and cooperative catalysis of bronsted acids and transition metals Practical discussions of metal-bronsted acid relay catalysis and Lewis base–Lewis acid cooperative catalysis In-depth examinations of Lewis base-transition metal cooperative catalysis and photocatalysis combined with organocatalysis Perfect for organic, catalytic, and pharmaceutical chemists, Asymmetric Organo-Metal Catalysis: Concepts, Principles, and Applications is also an invaluable resource for chemists working with or on organometallics.

Organic Chemistry from Retrosynthesis to Asymmetric Synthesis Book

Organic Chemistry from Retrosynthesis to Asymmetric Synthesis


  • Author : Vitomir Šunjić
  • Publisher : Springer
  • Release Date : 2016-04-30
  • Genre: Science
  • Pages : 211
  • ISBN 10 : 9783319299266

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Organic Chemistry from Retrosynthesis to Asymmetric Synthesis Excerpt :

This book connects a retrosynthetic or disconnection approach with synthetic methods in the preparation of target molecules from simple, achiral ones to complex, chiral structures in the optically pure form. Retrosynthetic considerations and asymmetric syntheses are presented as closely related topics, often in the same chapter, underlining the importance of retrosynthetic consideration of target molecules neglecting stereochemistry and equipping readers to overcome the difficulties they may encounter in the planning and experimental implementation of asymmetric syntheses. This approach prepares students in advanced organic chemistry courses, and in particular young scientists working at academic and industrial laboratories, for independently solving synthetic problems and creating proposals for the synthesis of complex structures.

Fundamentals of Asymmetric Catalysis Book
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Fundamentals of Asymmetric Catalysis


  • Author : Patrick J. Walsh
  • Publisher : University Science Books
  • Release Date : 2009-01-02
  • Genre: Science
  • Pages : 692
  • ISBN 10 : 1891389548

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Fundamentals of Asymmetric Catalysis Excerpt :

This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept in Fundamentals of Asymmetric Catalysis is supported by carefully selected examples of a wide range of catalysts, reactions and reaction mechanisms.

Chiral Auxiliaries and Ligands in Asymmetric Synthesis Book

Chiral Auxiliaries and Ligands in Asymmetric Synthesis


  • Author : Jacqueline Seyden-Penne
  • Publisher : Wiley-Interscience
  • Release Date : 1995-10-23
  • Genre: Science
  • Pages : 744
  • ISBN 10 : UOM:39015034927643

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Chiral Auxiliaries and Ligands in Asymmetric Synthesis Excerpt :

Table of Contents Preface Abbreviations Introduction 1 1 Enantiomerically Pure Chiral Auxiliaries 43 2 Chiral Reagents 87 3 Chiral Catalysis and Catalysts Bearing Chiral Ligands 117 4 Asymmetric Deprotonations and Protonations 143 5 Alkylations and Related Reactions 157 6 Additions to C=O and C=N Double Bonds 209 7 Additions to Carbon-Carbon Double Bonds 367 8 Additions to Double Bonds Bearing Heteroatoms. Oxidations of Sulfides and Selenides 503 9 Cycloadditions 513 10 Sigmatropic Rearrangements 593 11 Transition Metal Catalyzed Reactions 619 References 637 Index 707.

Asymmetric Catalysis Book

Asymmetric Catalysis


  • Author : B. Bosnich
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 172
  • ISBN 10 : 9789400951778

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Asymmetric Catalysis Excerpt :

The rate of advance in areas of science is seldom constant. Usually certain fields effloresce with activity because of the ~ealization that solutions are possible to long standing important problems. So it is now with asymmetric catalysis, a field which promises to change profoundly the strategic thinking of synthetic chemists. As this Report will show, reagents which can induce catalytic enantiocontrol of chemical transformations could represent the ultimate synthetic method. Nearly all synthetic strategies of complex molecules involve steps which require enantiocontrol and, in many cases, a specific catalytic transformation embodying enan tiocontrol has enormous advantages in terms of the rate and economy of the reaction. Because asymmetric catalysis is in a formative stage, workers with different backgrounds have joined the field. This Workshop had representatives with organometallic, organic, structural, kinetic, enzymatic, microbiological and industrial backgrounds. Each had his own perspective and this Report represents a consensus of this group of eleven people. The result is probably as compre hensive and balanced a view of the subject as is possible at present. It is hoped that those who have until now had but a glancing interest in asymmetric catalysis will find this Report a useful indication of its present state. We believe that asymmetric catalysis will have an increasing impact on the development of chemistry and will eventually dominate much of synthetic and industrial chemistry.

Asymmetric Synthesis of Drugs and Natural Products Book

Asymmetric Synthesis of Drugs and Natural Products


  • Author : Ahindra Nag
  • Publisher : CRC Press
  • Release Date : 2018-01-12
  • Genre: Medical
  • Pages : 770
  • ISBN 10 : 9781315302294

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Asymmetric Synthesis of Drugs and Natural Products Excerpt :

This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds.