Proteomic and Metabolomic Approaches to Biomarker Discovery Book

Proteomic and Metabolomic Approaches to Biomarker Discovery


  • Author : Haleem J. Issaq
  • Publisher : Academic Press
  • Release Date : 2019-10-24
  • Genre: Science
  • Pages : 504
  • ISBN 10 : 9780128197882

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Proteomic and Metabolomic Approaches to Biomarker Discovery Excerpt :

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

The Detection of Biomarkers Book

The Detection of Biomarkers


  • Author : Sibel A. Ozkan
  • Publisher : Academic Press
  • Release Date : 2021-12-05
  • Genre: Medical
  • Pages : 614
  • ISBN 10 : 9780128230756

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The Detection of Biomarkers Excerpt :

Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. Locates biomarker detection in its research context, setting out present and future prospects Allows clinical researchers to compare various biomarker assays systematically Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical Gives innovative biomarker assays that are viable alternatives to current complex methods Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

Metabolomics for Biomedical Research Book

Metabolomics for Biomedical Research


  • Author : Jerzy Adamski
  • Publisher : Academic Press
  • Release Date : 2020-03-20
  • Genre: Medical
  • Pages : 266
  • ISBN 10 : 9780128127858

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Metabolomics for Biomedical Research Excerpt :

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. Focuses on metabolomics in translational and medical research Provides basics for, and concepts of, contemporary translational personalized medicine research with metabolomics Brings the major recent progresses on design, analytics, biostatistics and bioinformatics relating to the success of metabolomics research

Emerging Sample Treatments in Proteomics Book

Emerging Sample Treatments in Proteomics


  • Author : José-Luis Capelo-Martínez
  • Publisher : Springer
  • Release Date : 2019-06-24
  • Genre: Science
  • Pages : 222
  • ISBN 10 : 9783030122980

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Emerging Sample Treatments in Proteomics Excerpt :

Proteomics is a well-established area of Science; yet with a strong area in constant evolution, namely sample treatment. There few books that currently cover the field of emerging sample treatments in proteomics, this new volume will be the first to cover all emerging and existing studies. This unique book presents the latest advances in the field focusing on emerging trends linked to high-resolution mass spectrometry, technology addressed to treat samples faster and to attempts to simplify the proteome for the reader.

Biomarker Discovery in the Developing World  Dissecting the Pipeline for Meeting the Challenges Book

Biomarker Discovery in the Developing World Dissecting the Pipeline for Meeting the Challenges


  • Author : Sanjeeva Srivastava
  • Publisher : Springer
  • Release Date : 2016-09-30
  • Genre: Medical
  • Pages : 118
  • ISBN 10 : 9788132228370

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Biomarker Discovery in the Developing World Dissecting the Pipeline for Meeting the Challenges Excerpt :

This book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker “life cycle” with emphasis on the emerging and significant role of proteomics. The book begins with a perspective on the role of biorepositories and need for biobanking practices in the developing world. The next chapter focuses on disease heterogeneity in context to geographical bias towards susceptibility to the disease and the role of multi-omics techniques to devise disruptive innovations towards biomarker discovery. Chapter 3 focuses on various omics-based platforms that are currently being used for biomarker discovery, their principles and workflow. Mass spectrometry is emerging as a powerful technology for discovery based studies and targeted validation. Chapter 4 aims at providing a glimpse of the basic workflow and considerations in mass spectrometry based studies. Rapid and aptly targeted research funding has often been deemed as one of the decisive factors enabling excellent science and path breaking innovations. With the need for sophistication required in multi-omics research, Chapter 5 focuses on innovative funding strategies such as crowdfunding and Angel philanthropy. Chapter 6 provides the latest advances in education innovation, the premise and reality of bioeconomy especially in a specific context of the developing world, not to mention the new concept of “social innovation” to link biomarkers with socially responsible and sustainable applications. Chapter 7, in ways similar to biomarkers, discusses the biosimilars as a field that has received much focus and

Proteomic Applications in Cancer Detection and Discovery Book
Score: 5
From 1 Ratings

Proteomic Applications in Cancer Detection and Discovery


  • Author : Timothy D. Veenstra
  • Publisher : John Wiley & Sons
  • Release Date : 2013-05-30
  • Genre: Science
  • Pages : 320
  • ISBN 10 : 9781118634417

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Proteomic Applications in Cancer Detection and Discovery Excerpt :

Helps researchers in proteomics and oncology work together tounderstand, prevent, and cure cancer Proteomic data is increasingly important to understanding theorigin and progression of cancer; however, most oncologicresearchers who depend on proteomics for their studies do notcollect the data themselves. As a result, there is a knowledge gapbetween scientists, who devise proteomic techniques and collect thedata, and the oncologic researchers, who are expected to interpretand apply proteomic data. Bridging the gap between proteomics andoncology research, this book explains how proteomic technology canbe used to address some of the most important questions in cancerresearch. Proteomic Applications in Cancer Detection and Discoveryenables readers to understand how proteomic data is acquired andanalyzed and how it is interpreted. Author Timothy Veenstra hasfilled the book with examples—many based on his own firsthandresearch experience—that clearly demonstrate the applicationof proteomic technology in oncology research, including thediscovery of novel biomarkers for different types of cancers. The book begins with a brief introduction to systems biology,explaining why cancer is a systems biology disease. Next, it coverssuch topics as: Mass spectrometry in cancer research Application of proteomics to global phosphorylationanalysis Search for biomarkers in biofluids Rise and fall of proteomic patterns for cancer diagnostics Emergence of protein arrays Role of proteomics in personalized medicine The final chapter is dedicated to the future prospects ofproteomics in cancer research. By guiding readers through the latest proteomic technologies andtheir applications in cancer research, Proteomic Applications inCancer Detection and Discovery enhances the ability ofresearchers in proteomics and researchers in oncology tocollaborate in order to better understand cancer and developstrategies to prevent and treat it.

AGO Driven Non Coding RNAs Book

AGO Driven Non Coding RNAs


  • Author : Bibekanand Mallick
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • Genre: Science
  • Pages : 387
  • ISBN 10 : 9780128156704

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AGO Driven Non Coding RNAs Excerpt :

The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics

Brain Connectivity in Autism Book

Brain Connectivity in Autism


  • Author : Rajesh K. Kana
  • Publisher : Frontiers E-books
  • Release Date : 2014-09-23
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889192823

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Brain Connectivity in Autism Excerpt :

Novel Biomarkers in Alzheimer rsquo s Disease Book

Novel Biomarkers in Alzheimer rsquo s Disease


  • Author : Chiara Villa
  • Publisher : MDPI
  • Release Date : 2021-02-05
  • Genre: Science
  • Pages : 442
  • ISBN 10 : 9783039439034

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Novel Biomarkers in Alzheimer rsquo s Disease Excerpt :

Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders Book

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders


  • Author : Paul C. Guest
  • Publisher : Springer
  • Release Date : 2019-02-12
  • Genre: Science
  • Pages : 328
  • ISBN 10 : 9783030055424

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Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders Excerpt :

This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

Multi omic Data Integration Book

Multi omic Data Integration


  • Author : Paolo Tieri
  • Publisher : Frontiers Media SA
  • Release Date : 2015-09-17
  • Genre: Science (General)
  • Pages : null
  • ISBN 10 : 9782889196487

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Multi omic Data Integration Excerpt :

Stable, predictive biomarkers and interpretable disease signatures are seen as a significant step towards personalized medicine. In this perspective, integration of multi-omic data coming from genomics, transcriptomics, glycomics, proteomics, metabolomics is a powerful strategy to reconstruct and analyse complex multi-dimensional interactions, enabling deeper mechanistic and medical insight. At the same time, there is a rising concern that much of such different omic data –although often publicly and freely available- lie in databases and repositories underutilised or not used at all. Issues coming from lack of standardisation and shared biological identities are also well-known. From these considerations, a novel, pressing request arises from the life sciences to design methodologies and approaches that allow for these data to be interpreted as a whole, i.e. as intertwined molecular signatures containing genes, proteins, mRNAs and miRNAs, able to capture inter-layers connections and complexity. Papers discuss data integration approaches and methods of several types and extents, their application in understanding the pathogenesis of specific diseases or in identifying candidate biomarkers to exploit the full benefit of multi-omic datasets and their intrinsic information content. Topics of interest include, but are not limited to: • Methods for the integration of layered data, including, but not limited to, genomics, transcriptomics, glycomics, proteomics, metabolomics; • Application of multi-omic data integration approaches for diagnostic biomarker discovery in any field of the life sciences; • Innovative approaches for the analysis and the visualization of multi-omic datasets; • Methods and applications for systematic measurements from single/undivided samples (comprising genomic, transcriptomic, proteomic, metabolomic measurements, among others); • Multi-scale approaches for integrated dynamic modelling and simulation; • Implementation of application

Metabolic Interaction in Infection Book

Metabolic Interaction in Infection


  • Author : Ricardo Silvestre
  • Publisher : Springer
  • Release Date : 2018-04-06
  • Genre: Science
  • Pages : 476
  • ISBN 10 : 9783319749327

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Metabolic Interaction in Infection Excerpt :

This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.

Methodologies for Metabolomics Book

Methodologies for Metabolomics


  • Author : Norbert W. Lutz
  • Publisher : Cambridge University Press
  • Release Date : 2013-01-21
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9781139619059

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Methodologies for Metabolomics Excerpt :

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Role of Biomarkers in Medicine Book

Role of Biomarkers in Medicine


  • Author : Mu Wang
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-08-17
  • Genre: Medical
  • Pages : 260
  • ISBN 10 : 9789535125051

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Role of Biomarkers in Medicine Excerpt :

The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.