Proteomic And Metabolomic Approaches To Biomarker Discovery

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Proteomic and Metabolomic Approaches to Biomarker Discovery

Author : Haleem J. Issaq
Publisher : Academic Press
Release Date : 2019-10-24
Genre: Science
Pages : 504
ISBN 10 : 9780128197882

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Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Surrogate Tissue Analysis

Author : Michael E. Burczynski
Publisher : CRC Press
Release Date : 2005-11-10
Genre: Medical
Pages : 332
ISBN 10 : 9781420038095

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Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach have appeared in the scientific press. One of the first publications on this topic, Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches describes initial applications and considerations for "omic" technologies in the field of surrogate tissue analysis. Highlighting important issues to consider when conducting profiling studies to identify novel biomarkers, the first section covers transcriptional approaches in surrogate tissues. It provides a review of important issues in peripheral blood profiling, summarizes results achieved when evaluations of various blood preparation platforms are used for the purpose of transcriptional profiling, and covers the relatively novel application of transcriptional profiling in neurological and oncological disease settings. The second section focuses on proteomic and protein-based methods for identifying markers in surrogate tissues, highlighting immunoassay and mass-spectrometry approaches for assessment of proteins in serum and other fluids, with a focus on the implications of protein-based biomarkers for detecting and monitoring early stages of cancer. The third section explores metabolomic approaches along with other novel molecular screens that can be applied in surrogate tissues to find biomarkers, and examines in detail the rapid development of metabolomics into a powerful technique for biomarker identification. The authors conclude with coverage of regulatory considerations, economic impact, and pan-omic strategies which will undoubtedly impact surrogate tissue analysis in the future. They explore current concepts in pan-omic approaches during drug development where a compendium of data generated by multiple profiling approaches are assessed and evaluat

Metabolic Profiling Its Role in Biomarker Discovery and Gene Function Analysis

Author : George G. Harrigan
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Genre: Science
Pages : 335
ISBN 10 : 9781461503330

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It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

Comprehensive Biomarker Discovery and Validation for Clinical Application

Author : Péter Horvatovich
Publisher : Royal Society of Chemistry
Release Date : 2013-06-17
Genre: Science
Pages : 320
ISBN 10 : 9781849734363

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This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks.

Translational Urinomics

Author : Hugo Miguel Baptista Carreira dos Santos
Publisher : Springer
Release Date : 2022-05-21
Genre: Science
Pages : 147
ISBN 10 : 303063910X

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Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.

Biomarker Discovery in the Developing World Dissecting the Pipeline for Meeting the Challenges

Author : Sanjeeva Srivastava
Publisher : Springer
Release Date : 2016-09-30
Genre: Medical
Pages : 118
ISBN 10 : 9788132228370

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This book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker “life cycle” with emphasis on the emerging and significant role of proteomics. The book begins with a perspective on the role of biorepositories and need for biobanking practices in the developing world. The next chapter focuses on disease heterogeneity in context to geographical bias towards susceptibility to the disease and the role of multi-omics techniques to devise disruptive innovations towards biomarker discovery. Chapter 3 focuses on various omics-based platforms that are currently being used for biomarker discovery, their principles and workflow. Mass spectrometry is emerging as a powerful technology for discovery based studies and targeted validation. Chapter 4 aims at providing a glimpse of the basic workflow and considerations in mass spectrometry based studies. Rapid and aptly targeted research funding has often been deemed as one of the decisive factors enabling excellent science and path breaking innovations. With the need for sophistication required in multi-omics research, Chapter 5 focuses on innovative funding strategies such as crowdfunding and Angel philanthropy. Chapter 6 provides the latest advances in education innovation, the premise and reality of bioeconomy especially in a specific context of the developing world, not to mention the new concept of “social innovation” to link biomarkers with socially responsible and sustainable applications. Chapter 7, in ways similar to biomarkers, discusses the biosimilars as a field that has received much focus and

The Detection of Biomarkers

Author : Sibel A. Ozkan
Publisher : Academic Press
Release Date : 2021-12-05
Genre: Medical
Pages : 614
ISBN 10 : 9780128230756

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Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. Locates biomarker detection in its research context, setting out present and future prospects Allows clinical researchers to compare various biomarker assays systematically Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical Gives innovative biomarker assays that are viable alternatives to current complex methods Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

Proteomic Applications in Cancer Detection and Discovery Book

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Proteomic Applications in Cancer Detection and Discovery

Author : Timothy D. Veenstra
Publisher : John Wiley & Sons
Release Date : 2013-05-30
Genre: Science
Pages : 320
ISBN 10 : 9781118634417

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Helps researchers in proteomics and oncology work together tounderstand, prevent, and cure cancer Proteomic data is increasingly important to understanding theorigin and progression of cancer; however, most oncologicresearchers who depend on proteomics for their studies do notcollect the data themselves. As a result, there is a knowledge gapbetween scientists, who devise proteomic techniques and collect thedata, and the oncologic researchers, who are expected to interpretand apply proteomic data. Bridging the gap between proteomics andoncology research, this book explains how proteomic technology canbe used to address some of the most important questions in cancerresearch. Proteomic Applications in Cancer Detection and Discoveryenables readers to understand how proteomic data is acquired andanalyzed and how it is interpreted. Author Timothy Veenstra hasfilled the book with examples—many based on his own firsthandresearch experience—that clearly demonstrate the applicationof proteomic technology in oncology research, including thediscovery of novel biomarkers for different types of cancers. The book begins with a brief introduction to systems biology,explaining why cancer is a systems biology disease. Next, it coverssuch topics as: Mass spectrometry in cancer research Application of proteomics to global phosphorylationanalysis Search for biomarkers in biofluids Rise and fall of proteomic patterns for cancer diagnostics Emergence of protein arrays Role of proteomics in personalized medicine The final chapter is dedicated to the future prospects ofproteomics in cancer research. By guiding readers through the latest proteomic technologies andtheir applications in cancer research, Proteomic Applications inCancer Detection and Discovery enhances the ability ofresearchers in proteomics and researchers in oncology tocollaborate in order to better understand cancer and developstrategies to prevent and treat it.

Cardiovascular Biomarkers

Author : David A. Morrow
Publisher : Springer Science & Business Media
Release Date : 2010-04-28
Genre: Medical
Pages : 640
ISBN 10 : 9781597450515

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In the four pages committed to a discussion of myocardial infarction in the first edition of Harrison’s Principles of Internal Medicine, published in 1950, there was no mention of use of the laboratory for management of patients. Thirty years later, when the first edition of Braunwald’s Heart Disease, A Textbook of Cardiovascular Medicine was published, 2 out of the 1943 pages in the text contained a discussion of the laboratory examinations in acute myocardial infarction. Our knowledge base of the multitude of ways that physicians can and should use the clinical chemistry laboratory has expanded dramatically since these classic texts were published. The nomenclature has changed: terms such as “cardiac enzymes” have given way to “cardiac biomarkers. ” The number of assays has multiplied, and the operating characteristics of available assays are impr- ing at a gratifying but dizzying rate. We now use biomarkers to diagnose cardiovascular diseases and also to frame our treatment strategies. Thus, there is a clear need for a scholarly compilation of the state of the art of cardiac biomarkers. Dr. David Morrow has expertly edited an authoritative book that answers this need. The 34 chapters in Cardiovascular Biomarkers: Pathophysiology and Disease Mana- ment were written by a group of individuals who are internationally recognized thought leaders and experts in clinical and laboratory medicine.

Metabolomics for Biomedical Research

Author : Jerzy Adamski
Publisher : Academic Press
Release Date : 2020-03-20
Genre: Medical
Pages : 266
ISBN 10 : 9780128127858

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Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. Focuses on metabolomics in translational and medical research Provides basics for, and concepts of, contemporary translational personalized medicine research with metabolomics Brings the major recent progresses on design, analytics, biostatistics and bioinformatics relating to the success of metabolomics research

Proteomic Methods in Neuropsychiatric Research Book

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Proteomic Methods in Neuropsychiatric Research

Author : Paul C. Guest
Publisher : Springer
Release Date : 2017-03-28
Genre: Science
Pages : 370
ISBN 10 : 9783319524795

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Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care. The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine. It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.

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Metabolome Analyses

Author : Seetharaman Vaidyanathan
Publisher : Springer Science & Business Media
Release Date : 2006-03-20
Genre: Science
Pages : 390
ISBN 10 : 9780387252407

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Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.

Reviews on Biomarker Studies of Metabolic and Metabolism Related Disorders

Author : Paul C. Guest
Publisher : Springer
Release Date : 2019-03-27
Genre: Science
Pages : 303
ISBN 10 : 9783030126681

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The book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders. The early identification of those at risk of developing obesity will help to place these individuals on the best treatment course as early as possible for improved treatment outcomes. This will also help to cut costs incurred by the healthcare services. For all of this to occur, new research efforts are needed to identify novel biomarkers that can be used to predict the disease in the presymptomatic stage, for disease monitoring and for prediction of treatment response. It is also possible that new drug targets can be identified using these approaches which, in turn, can lead to the development of new treatment approaches. This volume also includes a series of reviews on biomarker discovery and usage in the study of diseases marked by perturbations in metabolism. It will describe the pros and cons of the various approaches and cover the successes and failures in this important research field.

Radiation Proteomics

Author : Dariusz Leszczynski
Publisher : Springer Science & Business Media
Release Date : 2013-02-03
Genre: Medical
Pages : 130
ISBN 10 : 9789400758964

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Methods of proteomics have been shown to be powerful tools in search of target proteins – proteins that respond in cells to an internal or an external stimulus. Proteomics is widely used in biomedical research. However, in radiation biology research, following exposures of living matter to low doses of either ionizing or non-ionizing radiation, proteomics approach is only very slowly gaining support. This book, by presenting the current status of the use of proteomics in radiation biology, will help to attract attention to the field of radiation proteomics.

Advancing Mass Spectrometry based Metabolomics and Proteomics

Author : Ling Hao
Publisher : Unknown
Release Date : 2017
Genre: Uncategoriezed
Pages : 439
ISBN 10 : OCLC:1105928119

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Quantitative analysis of endogenous biomolecules offers a wealth of clues to understand cell biology and disease mechanisms. Mass spectrometry (MS) has become a foremost technology for the study of biomolecules and their dynamic alterations involved in disease processes. This dissertation is devoted to the development of novel and improved MS-based metabolomic and proteomic methodologies and the application to human disease studies. Specifically, both label-free and stable isotope labeling strategies have been developed for the analysis of metabolites, peptides, and proteins in various biological systems. Label-free methods provide straightforward measurements of biomolecules and are combined with advanced bioinformatics tools for biomarker discovery. Stable isotope labeling, particularly custom DiLeu, iDiLeu, and mdDiLeu tags, offers high-throughput and accurate quantification of biomolecules. Novel online software platform has also been developed for automated omics data analysis. The advancements of analytical methodologies in this work have been mainly achieved on standard flow liquid chromatography (LC)-MS, nanoflow LC-MS, and capillary electrophoresis (CE)-MS platforms. Comprehensive metabolomic and proteomic studies have been successfully applied to disease biomarker discovery for human Preclinical Alzheimer's Disease and Lower Urinary Tract Symptoms in human and mouse models.