Pyrazole Based Drug Discovery Book

Pyrazole Based Drug Discovery


  • Author : Nachiket S. Dighe
  • Publisher : Elsevier
  • Release Date : 2021-06-15
  • Genre: Science
  • Pages : 370
  • ISBN 10 : 0128241403

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Pyrazole Based Drug Discovery Excerpt :

Pyrazole-Based Drug Discovery outlines the complexities of the pyrazole scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Designed as a guide for both experts and students working in this and related areas, this volume will facilitate the continued design and development of novel pharmaceuticals based on pyrazole and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. Pyrazole is a novel heterocycle with anti-fungal, antimicrobial, anti-tubercular, and antipsychotic pharmacological activities, proving to be a promising agent for medicinal chemists to synthesize various new chemical entities with desired biological activities. This book is ideal for researchers working in organic and medicinal chemistry both in academia and industry. Explores this extremely important heterocycle in a high level of detail Describes synthesis methods for current drugs based on pyrazole scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing pyrazole Provides pharmacologists a solid overview of the chemical background of existing pyrazole-based drugs

Pyrazole  Preparation and Uses Book

Pyrazole Preparation and Uses


  • Author : Dilipkumar Pal
  • Publisher : Nova Science Publishers
  • Release Date : 2020-08-11
  • Genre: Uncategoriezed
  • Pages : 563
  • ISBN 10 : 1536182508

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Pyrazole Preparation and Uses Excerpt :

This book has comprehensively reviewed the latest information on pyrazoles, their preparations and uses. It provides extended ideas on pyrazole and its derivatives including their synthesis, chemistry, structure activity relationship (SAR) and therapeutic applications. The health promoting properties of these pyrazoles are discussed in this book with different therapeutic applications of pyrazole scaffold. Topics related to pyrazole and its analogues as potential anticancer, anti-angiogenesis, antiviral, antioxidative, anti-convulsive, anthelmintic, anti-inflammatory, antidiabetic agents are described in this book in detail. Furthermore, current status and future prospects of pyrazole moiety in drug discovery, importance of it in plant systems, its relevance in neurological drug discovery, its potency as herbicidal and antimicrobial agents have been enumerated through different chapters. In a summary, this book is a valuable resource for research scholars, academics, students, industrialists and subject experts working in the multidisciplinary fields like medicinal chemistry, synthetic chemistry, biochemistry, pharmacology, natural product chemistry and other related areas in the field of pyrazole derivatives drug discovery and research.

Structure based Drug Discovery Book

Structure based Drug Discovery


  • Author : Harren Jhoti
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-24
  • Genre: Science
  • Pages : 250
  • ISBN 10 : 9781402044076

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Structure based Drug Discovery Excerpt :

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

Privileged Scaffolds in Medicinal Chemistry Book

Privileged Scaffolds in Medicinal Chemistry


  • Author : Stefan Bräse
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-20
  • Genre: Drug development
  • Pages : 468
  • ISBN 10 : 9781782620303

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Privileged Scaffolds in Medicinal Chemistry Excerpt :

One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of a discarded flask found during a lab clean-up. Some years later, scientists discovered that benzodiazepine derivatives were also effective in treating other diseases. This class of molecules was the first to be described as privileged in the sense that it is especially effective at altering the course of disease. Other privileged molecular structures have since been discovered, and since these compounds are so effective at interacting with numerous classes of proteins, they may be an effective starting point to look for new drugs against the supposedly "undruggable" proteins. Following introductory chapters presenting an overview, a historical perspective and the theoretical background and findings, main chapters describe the structure of privileged structures in turn and discuss major drug classes associated with them and their syntheses. This book provides comprehensive coverage of the subject through chapters contributed by expert authors from both academia and industry and will be an excellent reference source for medicinal chemists of a range of disciplines and experiences.

Privileged Structures in Drug Discovery Book

Privileged Structures in Drug Discovery


  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-07
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9781118686355

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Privileged Structures in Drug Discovery Excerpt :

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic syn

Synthetic Methods in Drug Discovery Book

Synthetic Methods in Drug Discovery


  • Author : David C. Blakemore
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-05-30
  • Genre: Uncategoriezed
  • Pages : 474
  • ISBN 10 : 9781849738033

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Synthetic Methods in Drug Discovery Excerpt :

The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Heterocyclic Chemistry in Drug Discovery Book
Score: 5
From 1 Ratings

Heterocyclic Chemistry in Drug Discovery


  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release Date : 2013-04-26
  • Genre: Science
  • Pages : 720
  • ISBN 10 : 9781118354438

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Heterocyclic Chemistry in Drug Discovery Excerpt :

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Drug Discovery for Leishmaniasis Book

Drug Discovery for Leishmaniasis


  • Author : Carmen Gil
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-10-26
  • Genre: Science
  • Pages : 402
  • ISBN 10 : 9781788012584

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Drug Discovery for Leishmaniasis Excerpt :

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.

Drug Discovery and Drug Development Book

Drug Discovery and Drug Development


  • Author : Madhu Dikshit
  • Publisher : Springer Nature
  • Release Date : 2021-02-10
  • Genre: Medical
  • Pages : 376
  • ISBN 10 : 9789811580024

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Drug Discovery and Drug Development Excerpt :

Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR.

Drug Discovery with Privileged Building Blocks Book

Drug Discovery with Privileged Building Blocks


  • Author : Jie Jack Li
  • Publisher : CRC Press
  • Release Date : 2021-10-21
  • Genre: Medical
  • Pages : 320
  • ISBN 10 : 9781000416015

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Drug Discovery with Privileged Building Blocks Excerpt :

Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists, and veteran medicinal chemists will find it useful as well. Key Feature The book covers privileged building blocks appearing most frequently on patents for novel drugs. The latest relevant tactics are explained in the context of drug design and medicinal chemistry. Key synthesis, especially large-scale synthesis, is described. The most recent literature references are cited.

Analogue based Drug Discovery III Book

Analogue based Drug Discovery III


  • Author : János Fischer
  • Publisher : John Wiley & Sons
  • Release Date : 2012-10-15
  • Genre: Medical
  • Pages : 404
  • ISBN 10 : 9783527651108

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Analogue based Drug Discovery III Excerpt :

Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and -- together with the previous volumes -- constitutes the first systematic approach to drug analogue development.

Imidazole Based Drug Discovery Book

Imidazole Based Drug Discovery


  • Author : Shikha Agarwal
  • Publisher : Elsevier
  • Release Date : 2021-12-10
  • Genre: Science
  • Pages : 372
  • ISBN 10 : 9780323903639

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Imidazole Based Drug Discovery Excerpt :

Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications of imidazole derivatives that are useful to researchers working on designing more promising clinical lead compounds with this scaffold. It also includes information on past decades of research on the synthesis and biological applications of imidazole derivatives. This is an ideal resource for researchers in organic chemistry both in academic and industrial settings, as well as postgraduates in chemistry and medicinal chemistry. Reviews the most current developments and future perspectives of imidazole on different disease therapies to achieve the ultimate goal of disease eradication Discusses the role of imidazole in contemporary science, technological innovation, drug development, critical challenges and future research directions Covers emerging trends on different eco-benign pathways to synthesize imidazole derivatives for the development of simpler synthetic protocols

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book

Green Approaches in Medicinal Chemistry for Sustainable Drug Design


  • Author : Bimal K. Banik
  • Publisher : Elsevier
  • Release Date : 2020-03-27
  • Genre: Medical
  • Pages : 1044
  • ISBN 10 : 9780128175934

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design Excerpt :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Protein Crystallography in Drug Discovery  Volume 20 Book

Protein Crystallography in Drug Discovery Volume 20


  • Author : Robert E. Babine
  • Publisher : John Wiley & Sons
  • Release Date : 2004-02-13
  • Genre: Science
  • Pages : 262
  • ISBN 10 : 3527306781

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Protein Crystallography in Drug Discovery Volume 20 Excerpt :

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

Frontiers in Drug Design and Discovery Book

Frontiers in Drug Design and Discovery


  • Author : Atta-ur- Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2010-12-13
  • Genre: Medical
  • Pages : 644
  • ISBN 10 : 9781608052011

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Frontiers in Drug Design and Discovery Excerpt :

"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu