Recent Advances in Medicinal Chemistry Book

Recent Advances in Medicinal Chemistry


  • Author : Atta-ur-Rahman
  • Publisher : Elsevier
  • Release Date : 2015-06-16
  • Genre: Science
  • Pages : 486
  • ISBN 10 : 9780128039625

GET BOOK
Recent Advances in Medicinal Chemistry Excerpt :

Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more. Edited and written by leading experts in medicinal chemistry research Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health

Advances in Medicinal Chemistry Book

Advances in Medicinal Chemistry


  • Author : B.E. Maryanoff
  • Publisher : Elsevier
  • Release Date : 1999-04-01
  • Genre: Science
  • Pages : 321
  • ISBN 10 : 0080526373

GET BOOK
Advances in Medicinal Chemistry Excerpt :

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

Advances in Medicinal Chemistry Research Book

Advances in Medicinal Chemistry Research


  • Author : Edeildo Ferreira Da Silva, Jr.
  • Publisher : Unknown
  • Release Date : 2019-10-15
  • Genre: Uncategoriezed
  • Pages : 366
  • ISBN 10 : 1536163686

GET BOOK
Advances in Medicinal Chemistry Research Excerpt :

Advances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide. Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer's agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great updat

Handbook of Research on Medicinal Chemistry Book

Handbook of Research on Medicinal Chemistry


  • Author : Debarshi Kar Mahapatra
  • Publisher : Taylor & Francis
  • Release Date : 2017-11-20
  • Genre: Medical
  • Pages : 626
  • ISBN 10 : 9781771885454

GET BOOK
Handbook of Research on Medicinal Chemistry Excerpt :

This valuable new book, Handbook of Research on Medicinal Chemistry: Innovations and Methodologies, presents some of the latest advancements in the various fields of combinatorial chemistry, drug discovery, biochemical aspects, pharmacology of medicinal agents, current practical problems, and nutraceuticals. The editors keep the drug molecule as the central component of the volume and aim to explain the associated features essential to exhibiting pharmacological activity. With a unique combination of chapters in biology, clinical aspects, biochemistry, synthetic chemistry, medicine and technology, the volume provides broad exposure to the essential aspect of pharmaceuticals. The volume many important aspects of medicinal chemistry, including techniques in drug discovery pharmacological aspects of natural products chemical mediators: druggable targets advances in medicinal chemistry The field of medicinal chemistry is growing at an unprecedented pace, and this volume takes an interdisciplinary approach, covering a range of new research and new practices in the field. The volume takes into account the latest therapeutic guidelines put forward by the World Health Organization and the U.S Food and Drug Administration.. Topics include: drug design drug discovery natural products and supplements and nutraceuticals pharmaceutical approaches to sexual dysfunction drug resistance parasites new natural compounds and identification of new targets stereochemistry aspects in medicinal chemistry common drug interactions in daily practices Handbook of Research on Medicinal Chemistry: Innovations and Methodologies will be a valuable addition to the bookshelves of pharmaceutical scientists and faculty as well as for industry professionals.

Recent Advances in Medicinal Chemistry Book

Recent Advances in Medicinal Chemistry


  • Author : Mark Bamford (Fellow of the association for the advancement of science)
  • Publisher : Unknown
  • Release Date : 2013
  • Genre: Pharmaceutical chemistry
  • Pages : 320
  • ISBN 10 : 9382220453

GET BOOK
Recent Advances in Medicinal Chemistry Excerpt :

Medicinal Chemistry of Neglected and Tropical Diseases Book

Medicinal Chemistry of Neglected and Tropical Diseases


  • Author : Venkatesan Jayaprakash
  • Publisher : CRC Press
  • Release Date : 2019-08-15
  • Genre: Medical
  • Pages : 374
  • ISBN 10 : 9781351011648

GET BOOK
Medicinal Chemistry of Neglected and Tropical Diseases Excerpt :

Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.

The Practice of Medicinal Chemistry Book

The Practice of Medicinal Chemistry


  • Author : Camille Georges Wermuth
  • Publisher : Elsevier
  • Release Date : 2015-07-01
  • Genre: Science
  • Pages : 902
  • ISBN 10 : 9780124172135

GET BOOK
The Practice of Medicinal Chemistry Excerpt :

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

New Developments in Medicinal Chemistry Book

New Developments in Medicinal Chemistry


  • Author : Carlton Anthony Taft
  • Publisher : Bentham Science Publishers
  • Release Date : 2014-10-10
  • Genre: Medical
  • Pages : 250
  • ISBN 10 : 9781608059546

GET BOOK
New Developments in Medicinal Chemistry Excerpt :

This e-book series is recommended for readers who are interested in or work with current theoretical and experimental research in medicinal chemistry, with an emphasis on computer aided-drug design and organic synthesis for therapeutic purposes. The e-book series encompasses the multidisciplinary field of medicinal chemistry which overlaps the knowledge of chemistry, physics, biochemistry, biology and pharmacology. The second volume of the series contains the following topics: -Current State-of-the-Art for Virtual Screening and Docking Methods -Estimating Protein-Ligand Binding Affinity by NMR -ADME/Tox Predictions in Drug Design -Bioisosteric Replacements in Drug Design

Platform Technologies in Drug Discovery and Validation Book

Platform Technologies in Drug Discovery and Validation


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-11-21
  • Genre: Medical
  • Pages : 690
  • ISBN 10 : 9780128130704

GET BOOK
Platform Technologies in Drug Discovery and Validation Excerpt :

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique for its treatment of platform technologies for medicinal chemistry and target validation Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field Presents state-of-the-art summaries of platform technologies

Annual Reports in Medicinal Chemistry Book

Annual Reports in Medicinal Chemistry


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2014-09-24
  • Genre: Science
  • Pages : 636
  • ISBN 10 : 9780128003725

GET BOOK
Annual Reports in Medicinal Chemistry Excerpt :

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. Reviews on hot topics of interest in small molecule drug discovery heavily pursued by industrial research organizations Provides preclinical information in the context of chemical structures Knowledgeable section editors who evaluate invited reviews for scientific rigor

Progress in Medicinal Chemistry Book

Progress in Medicinal Chemistry


  • Author : F. ... D. ... King
  • Publisher : Unknown
  • Release Date : 2002
  • Genre: Uncategoriezed
  • Pages : 274
  • ISBN 10 : 0720474000

GET BOOK
Progress in Medicinal Chemistry Excerpt :

Advances in Metallodrugs Book

Advances in Metallodrugs


  • Author : Shahid Ul-Islam
  • Publisher : John Wiley & Sons
  • Release Date : 2020-07-08
  • Genre: Science
  • Pages : 432
  • ISBN 10 : 9781119640424

GET BOOK
Advances in Metallodrugs Excerpt :

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Recent Advances in the Science of Cannabis Book

Recent Advances in the Science of Cannabis


  • Author : Robert M. Strongin
  • Publisher : CRC Press
  • Release Date : 2021-11-18
  • Genre: Medical
  • Pages : 292
  • ISBN 10 : 9781000467710

GET BOOK
Recent Advances in the Science of Cannabis Excerpt :

Recent Advances in the Science of Cannabis describes progress in a variety of significant areas of cannabis science. This unique book covers topics in cultivation and secondary metabolites, aroma and chemotypes, cannabinoid structures, physiology and pharmacology, as well as the development of unique topical products. State-of-the-art analytical methods and instrumentation are covered, including current developments in mass spectrometry and chromatography, as well as microbial testing. Given the popularity of smoking and vaporizing cannabis, the chemistry of vaping cannabinoid and terpene concentrates is also presented, along with emerging regulatory issues. Key Features: A guide to emerging modern cannabis technology in a dynamic regulatory climate and appealing to both novices and specialists. Building upon pioneering studies of terpene and cannabinoid chemistry, this distinctive volume describes current best practices, technological breakthroughs and historical context. Written by researchers in industry and academia, a greater understanding of the risks of exposure to emissions from vaping or dabbing cannabis concentrates is provided here. A selection of the book content reviewing Thermal Degradation of Cannabinoids and Cannabis Terpenes has been included in “Hot 2021” RSC Advances.