Reproductive and Developmental Toxicology Book

Reproductive and Developmental Toxicology


  • Author : Ramesh C. Gupta
  • Publisher : Academic Press
  • Release Date : 2011-04-04
  • Genre: Medical
  • Pages : 1220
  • ISBN 10 : 0123820332

DOWNLOAD BOOK
Reproductive and Developmental Toxicology Excerpt :

Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. Provides a complete, integrated source of information on the key risk stages during reproduction and development Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Developmental and Reproductive Toxicology Book

Developmental and Reproductive Toxicology


  • Author : Ronald D. Hood
  • Publisher : CRC Press
  • Release Date : 2005-08-30
  • Genre: Medical
  • Pages : 1168
  • ISBN 10 : 9781420040548

DOWNLOAD BOOK
Developmental and Reproductive Toxicology Excerpt :

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers evaluating and interpreting data. Originally titled Handbook of Developmental Toxicology, the second edition's new name reflects significant changes in its content and scope. New coverage in the Second Edition: Genomics and proteomics Tests for endocrine disruptors Testing for male and female reproductive toxicity Extensive treatment of the significance, reliability, and interpretation of developmental and reproductive toxicity data Toxicity testing in neonatal and juvenile animals Postnatal developmental milestones FDA perspective on risk assessment Extensive glossaries of developmental defect terminology Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies.

Oligonucleotide Based Drugs and Therapeutics Book

Oligonucleotide Based Drugs and Therapeutics


  • Author : Nicolay Ferrari
  • Publisher : John Wiley & Sons
  • Release Date : 2018-06-06
  • Genre: Medical
  • Pages : 576
  • ISBN 10 : 9781119070306

DOWNLOAD BOOK
Oligonucleotide Based Drugs and Therapeutics Excerpt :

A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970's, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. • Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics • Examines the principles, practices, and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides • Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candi

Reproductive Toxicology  Third Edition Book

Reproductive Toxicology Third Edition


  • Author : Robert W. Kapp
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Medical
  • Pages : 512
  • ISBN 10 : 9781420073447

DOWNLOAD BOOK
Reproductive Toxicology Third Edition Excerpt :

Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology’s contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research. This ground-breaking resource includes: New and important critical mechanistic topics such as epigenetics and omics The first significant compilation of epigenetic mechanisms An in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction New guidelines with respect to the latest research applications in the field

Male Reproductive Toxicology Book

Male Reproductive Toxicology


  • Author : Robert E. Chapin
  • Publisher : Elsevier
  • Release Date : 2013-10-22
  • Genre: Medical
  • Pages : 402
  • ISBN 10 : 9781483270951

DOWNLOAD BOOK
Male Reproductive Toxicology Excerpt :

Methods in Toxicology, Volume 3: Male Reproductive Toxicology, Part A, deals with the male reproductive system and discusses methods that will help identify toxicant-induced changes at all levels in living organisms. It is important to realize that a toxic effect does not occur in a vacuum. All work in toxicology must be predicated on a demonstrated adverse effect in vivo. If good toxicology cannot exist in a vacuum, then there must be a structure. Thus, the book begins by presenting a few models as examples of the ways experiments could be grouped to define the toxicity of a chemical. This is followed by separate chapters on methods such as male mouse sexual behavior test; in vitro techniques for assessing pituitary secretory function; histological methods for preservation of the rat testis; procedures for assessing testicular sperm head counts in mice, rats, and dogs; and guidelines for conducting rodent dominant lethal tests. Subsequent chapters cover topics such as methods for the isolation and purification of Leydig cells from rat and mouse testes, and techniques used in semen analysis and fertility assessment in the rabbit.

Test No  421  Reproduction Developmental Toxicity Screening Test Book

Test No 421 Reproduction Developmental Toxicity Screening Test


  • Author : OECD
  • Publisher : OECD Publishing
  • Release Date : 1995-07-27
  • Genre: Uncategoriezed
  • Pages : 10
  • ISBN 10 : 9789264070967

DOWNLOAD BOOK
Test No 421 Reproduction Developmental Toxicity Screening Test Excerpt :

The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...

Male Mediated Developmental Toxicity Book

Male Mediated Developmental Toxicity


  • Author : Andrew F. Olshan
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 406
  • ISBN 10 : 9781461518778

DOWNLOAD BOOK
Male Mediated Developmental Toxicity Excerpt :

The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.

Reproductive and Developmental Toxicology Book

Reproductive and Developmental Toxicology


  • Author : Ramesh C. Gupta
  • Publisher : Academic Press
  • Release Date : 2022-03-31
  • Genre: Medical
  • Pages : 1556
  • ISBN 10 : 9780323915601

DOWNLOAD BOOK
Reproductive and Developmental Toxicology Excerpt :

Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more

Toxicology for the Health and Pharmaceutical Sciences Book

Toxicology for the Health and Pharmaceutical Sciences


  • Author : Antonio Peña-Fernández
  • Publisher : Unknown
  • Release Date : 2021-09
  • Genre: Chemicals
  • Pages : null
  • ISBN 10 : 1032100222

DOWNLOAD BOOK
Toxicology for the Health and Pharmaceutical Sciences Excerpt :

"There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry, public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal to address and manage emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current, toxicology-related subjects for any undergraduate/postgraduate health programmes, as well as aiding with the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading, and reference for policy makers, and others that influence, and decide regulations that have an impact on the environment, and human health"--

OECD Guidelines for the Testing of Chemicals  Section 4 Test No  443  Extended One Generation Reproductive Toxicity Study Book

OECD Guidelines for the Testing of Chemicals Section 4 Test No 443 Extended One Generation Reproductive Toxicity Study


  • Author : OECD
  • Publisher : OECD Publishing
  • Release Date : 2018-06-27
  • Genre: Uncategoriezed
  • Pages : 25
  • ISBN 10 : 9789264185371

DOWNLOAD BOOK
OECD Guidelines for the Testing of Chemicals Section 4 Test No 443 Extended One Generation Reproductive Toxicity Study Excerpt :

This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...

Human Risk Assessment Book

Human Risk Assessment


  • Author : M V Roloff
  • Publisher : CRC Press
  • Release Date : 2020-10-29
  • Genre: Medical
  • Pages : 300
  • ISBN 10 : 9781000162875

DOWNLOAD BOOK
Human Risk Assessment Excerpt :

This book explores the factors which are critical in the selection of an appropriate animal species for toxicology studies and the subsequent extrapolation of the data to humans. It provides some future directions for risk assessment activities at the Environmental Protection Agency.

Nutraceuticals Book
Score: 4.5
From 2 Ratings

Nutraceuticals


  • Author : Ramesh C. Gupta
  • Publisher : Academic Press
  • Release Date : 2016-01-28
  • Genre: Medical
  • Pages : 1040
  • ISBN 10 : 9780128021651

DOWNLOAD BOOK
Nutraceuticals Excerpt :

Nutraceuticals: Efficacy, Safety and Toxicity brings together all current knowledge regarding nutraceuticals and their potential toxic effects as written by the scientists at the forefront of their study. Users will find an introduction to nutraceuticals, herbal medicines, ayurvedic medicines, prebiotics, probiotics, and adaptogens, along with their use and specific applications. This essential reference then discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and their interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered, providing a comprehensive overview of the most effective tools for the evaluation, safety, and toxicity of nutraceuticals, prebiotics, probiotics, and alternative medicines. Grants an overview of the current state-of-the-science of nutraceuticals, their use and applications, and known adverse effects Provides effective tools to evaluate the potential toxicity of any nutraceutical Includes details of regulatory issues as written by international experts

Male mediated Developmental Toxicity Book

Male mediated Developmental Toxicity


  • Author : Diana Anderson
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007
  • Genre: Medical
  • Pages : 318
  • ISBN 10 : 9780854048472

DOWNLOAD BOOK
Male mediated Developmental Toxicity Excerpt :

Male germ line mutagenesis and the effects on developmental defects in the next generation.

Barile   s Clinical Toxicology Book

Barile s Clinical Toxicology


  • Author : Frank A. Barile
  • Publisher : CRC Press
  • Release Date : 2019-04-24
  • Genre: Medical
  • Pages : 584
  • ISBN 10 : 9781498765381

DOWNLOAD BOOK
Barile s Clinical Toxicology Excerpt :

As with the two previous editions, Barile’s Clinical Toxicology: Principles and Mechanisms, Third edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. With special emphasis placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs, the new edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. The new edition presents the latest, up-to-date protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology. In addition, the effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered. KEY FEATURES • Discusses source of the drug or chemical, pharmacological and toxicological mechanisms of action, detection, identification, and treatment • Examines the complex interactions associated with clinical toxicological events • Emphasizes the signs and symptoms of diseases and pathology caused by toxins and clinical drugs • Covers effect of toxins on body systems and drug-induced adverse reactions • Offers a unique perspective for toxicology, pharmacology, pharmacy and health professions students The target audience for this book is undergraduate and graduate toxicology students, clinical pharmacy (Pharm.D.) students, emergency medical personnel, regulatory agencies, and other related health science professionals. It satisfies an essential need for a concise yet detailed authoritative, fundamental text addressing the current principles of clinical toxicology.

Biomarkers in Toxicology Book

Biomarkers in Toxicology


  • Author : Ramesh C. Gupta
  • Publisher : Academic Press
  • Release Date : 2014-01-25
  • Genre: Medical
  • Pages : 1152
  • ISBN 10 : 9780124046498

DOWNLOAD BOOK
Biomarkers in Toxicology Excerpt :

Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more