Retrovirus Cell Interactions Book

Retrovirus Cell Interactions


  • Author : Leslie Parent
  • Publisher : Academic Press
  • Release Date : 2018-08
  • Genre: Medical
  • Pages : 528
  • ISBN 10 : 0128111852

DOWNLOAD BOOK
Retrovirus Cell Interactions Excerpt :

Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems

Retrovirus Cell Interactions Book

Retrovirus Cell Interactions


  • Author : Leslie Parent
  • Publisher : Academic Press
  • Release Date : 2018-08-09
  • Genre: Medical
  • Pages : 528
  • ISBN 10 : 9780128111932

DOWNLOAD BOOK
Retrovirus Cell Interactions Excerpt :

Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems

Cellular Factors Involved in Early Steps of Retroviral Replication Book

Cellular Factors Involved in Early Steps of Retroviral Replication


  • Author : John A.T. Young
  • Publisher : Springer Science & Business Media
  • Release Date : 2003-07-23
  • Genre: Medical
  • Pages : 266
  • ISBN 10 : 3540008446

DOWNLOAD BOOK
Cellular Factors Involved in Early Steps of Retroviral Replication Excerpt :

The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.

Retroviruses Book

Retroviruses


  • Author : John M. Coffin
  • Publisher : CSHL Press
  • Release Date : 1997
  • Genre: Medical
  • Pages : 856
  • ISBN 10 : 0879695714

DOWNLOAD BOOK
Retroviruses Excerpt :

For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.

Retroviral Proteases Book

Retroviral Proteases


  • Author : Lawrence C. Kuo
  • Publisher : Gulf Professional Publishing
  • Release Date : 1994-09-22
  • Genre: Medical
  • Pages : 494
  • ISBN 10 : 0121821420

DOWNLOAD BOOK
Retroviral Proteases Excerpt :

Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Interactions Between Retroviruses and Herpesviruses Book

Interactions Between Retroviruses and Herpesviruses


  • Author : Hsing-Jien Kung
  • Publisher : World Scientific
  • Release Date : 1994
  • Genre: Medical
  • Pages : 138
  • ISBN 10 : 9810216254

DOWNLOAD BOOK
Interactions Between Retroviruses and Herpesviruses Excerpt :

Retroviruses and herpesviruses are two important human pathogens. Together, they occupy one of the most important places in modern Medical Virology. Coinfections of these two viruses in the same individuals are frequently observed, especially in patients afflicted with AIDS. Potential consequences of such interactions include the exacerbation of the disease, changing of the disease courses and the release of new viruses, etc. An understanding of the underlying mechanism is important, but, thus far, few insights have been gained. The present monograph, arranged in eight chapters, is intended to provide an updated and concise review of recent works regarding the molecular and cellular mechanisms of such interactions. The topics covered range from transcriptional regulation, receptor modulation, genetic recombination, to AIDS and oncogenesis. Human immunodeficiency virus, avian leukosis virus, reticuloendotheliosis virus, herpes simplex virus, cytomegalovirus, herpesvirus-6 and Marek's disease virus are among the viruses discussed. The contributing authors are among the leaders in this field and are responsible for many of the original discoveries presented. This should serve as a valuable research and teaching reference for both beginning and advanced researchers in virology and oncology.

Molecular and Cellular Biology of Viruses Book

Molecular and Cellular Biology of Viruses


  • Author : Phoebe Lostroh
  • Publisher : Garland Science
  • Release Date : 2019-05-06
  • Genre: Science
  • Pages : 971
  • ISBN 10 : 9780429664304

DOWNLOAD BOOK
Molecular and Cellular Biology of Viruses Excerpt :

Viruses interact with host cells in ways that uniquely reveal a great deal about general aspects of molecular and cellular structure and function. Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as HIV, influenza, and poliovirus. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as anti-viral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research. Key selling feature: Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups, including plant viruses and bacteriophages, illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors Extensive questions and answers for each chapter

Viral Envelope Proteins and the HIV 1 Accessory Gene Vpu Mediate Selectivity of Viral and Host Proteins in Retroviral Assembly Book

Viral Envelope Proteins and the HIV 1 Accessory Gene Vpu Mediate Selectivity of Viral and Host Proteins in Retroviral Assembly


  • Author : Tiffany M. Lucas
  • Publisher : Unknown
  • Release Date : 2012
  • Genre: CD antigens
  • Pages : 188
  • ISBN 10 : OCLC:864760878

DOWNLOAD BOOK
Viral Envelope Proteins and the HIV 1 Accessory Gene Vpu Mediate Selectivity of Viral and Host Proteins in Retroviral Assembly Excerpt :

Retroviruses are enveloped RNA viruses that assemble primarily at the plasma membrane of the host cell. During budding from the membrane, they acquire their own glycoproteins as well as a lipid bilayer derived from the cell. The assembly process is complex and involves protein:protein, protein:RNA, and, likely, protein:lipid interactions between viral components and the cell. These interactions appear to be specific and retroviruses are selective in acquisition of proteins. Compatibility during retrovirus assembly appears to be mediated by multiple factors: physical compatibility between glycoproteins and viral structural proteins, trafficking of proteins to appropriate locations, lipid interactions between Gag, Env and the plasma membrane, and microdomain association. In addition to mediating coalescence of appropriate factors, retroviruses appear equally equipped at excluding select host cell proteins and have evolved a number of genes to do so. Surprisingly, retrovirus assembly has remained enigmatic and there are no anti-retroviral drugs that target the assembly stage of HIV replication. Much of the knowledge we have garnered on retrovirus assembly has been through a process known as pseudotyping, where the core structural proteins will accept the glycoproteins of an unrelated virus. Here we present work outlining contributions of the envelope protein from murine leukemia virus to assembly with the lentiviral vector human immunodeficiency virus-1 (HIV-1). We subsequently observed an interesting phenotype, where an HIV-1 accessory gene known as Vpu restricts the envelope protein from gibbon ape leukemia virus (GaLV Env) from assembling with HIV-1. Further studies from our lab demonstrated that Vpu recognizes GaLV Env in a manner almost identical to CD4, the natural cellular target of Vpu, and that GaLV Env is essentially a CD4 analogue. Interestingly, we have found that Vpu restricts both target proteins in a manner that does not fit with the previously described

Cell Interactions in Atherosclerosis Book

Cell Interactions in Atherosclerosis


  • Author : Horst Robenek
  • Publisher : CRC Press
  • Release Date : 1992-09-25
  • Genre: Medical
  • Pages : 342
  • ISBN 10 : 0849355052

DOWNLOAD BOOK
Cell Interactions in Atherosclerosis Excerpt :

Cell Interactions in Atherosclerosis covers the scientific foundations of the most important disease inflicting the developed world today. It presents a collection of topical aspects on the general theme of cell interactions in atherosclerosis, providing authoritative, up-to-the-minute accounts of how new developments in cell biology have advanced our understanding of these cellular interactions. The book is amply illustrated with electron micrographs and light micrographs incorporating modern cytochemical procedures. Cell Interactions in Atherosclerosis will interest all medical and scientific professionals dealing with atherosclerosis and heart disease.

Encyclopedia of AIDS Book

Encyclopedia of AIDS


  • Author : Thomas J. Hope
  • Publisher : Springer
  • Release Date : 2018-02-22
  • Genre: Medical
  • Pages : 2192
  • ISBN 10 : 149397100X

DOWNLOAD BOOK
Encyclopedia of AIDS Excerpt :

For the first time, the world’s experts in HIV-AIDS have come together to publish the Encyclopedia of AIDS. The work features over 4000 A-Z entries including medical, cultural, social, and pharmacological essays. The Pathology entries cover the various types of HIV-related illnesses, including those that are and are not AIDS-defining. Many of the conditions that are AIDS-defining illnesses have their own entries or are cross-referenced to a generic entry in which several related conditions are discussed (such as enteric diseases and fungal infections). Typically, the treatment of any given form of pathology is briefly discussed in the entry that covers that illness. The reference is a must-read for Infectious Disease specialists, Immunologists, Public Health researchers, Virologists, Microbiologists, Pharmacologists, and Physicians.

HIV 1 Integrase Book

HIV 1 Integrase


  • Author : Nouri Neamati
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-10
  • Genre: Science
  • Pages : 520
  • ISBN 10 : 9781118015360

DOWNLOAD BOOK
HIV 1 Integrase Excerpt :

This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.