Sialic Acids and Sialoglycoconjugates in the Biology of Life  Health and Disease Book

Sialic Acids and Sialoglycoconjugates in the Biology of Life Health and Disease


  • Author : Shyamasree Ghosh
  • Publisher : Academic Press
  • Release Date : 2020-01-08
  • Genre: Science
  • Pages : 362
  • ISBN 10 : 9780128161272

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Sialic Acids and Sialoglycoconjugates in the Biology of Life Health and Disease Excerpt :

Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease enables the reader to understand the role of sialylation as a post translational modification. The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations have been associated with several diseases including cancer. In the post genomics and proteomics era, sialoglybiology has become more and more important in deciphering health and disease conditions. Discusses the sialic acids and their role in different diseases (other than cancer) Provides an understanding of sialylations as post translational modifications (PTM) Demonstrates the impact sialylation has on infectious diseases, the autoimmune system and health Gives insights on the importance of sialic acid biology through animal models

Essentials of Glycobiology Book
Score: 4
From 1 Ratings

Essentials of Glycobiology


  • Author : Ajit Varki
  • Publisher : CSHL Press
  • Release Date : 1999
  • Genre: Science
  • Pages : 694
  • ISBN 10 : 0879696818

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Essentials of Glycobiology Excerpt :

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Organelle and Molecular Targeting Book

Organelle and Molecular Targeting


  • Author : Lara Scheherazade Milane
  • Publisher : CRC Press
  • Release Date : 2021-12-29
  • Genre: Science
  • Pages : 510
  • ISBN 10 : 9781000505931

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Organelle and Molecular Targeting Excerpt :

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies

Immunogenetics  A Molecular and Clinical Overview Book

Immunogenetics A Molecular and Clinical Overview


  • Author : Muneeb U. Rehman
  • Publisher : Academic Press
  • Release Date : 2021-11-30
  • Genre: Medical
  • Pages : 410
  • ISBN 10 : 9780323903356

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Immunogenetics A Molecular and Clinical Overview Excerpt :

A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology. Contains exclusive information about research on immunogenetics from around the globe Includes minute and recent details that will be the prerequisite requirement for any researcher who wants to work on immunogenetics and its applications Comes fully-equipped with pictures, illustrations and tables that deliver information in a meticulous manner

Stem Cells Book

Stem Cells


  • Author : Suchandra Chowdhury
  • Publisher : Springer Nature
  • Release Date : 2021-07-24
  • Genre: Science
  • Pages : 266
  • ISBN 10 : 9789811616389

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Stem Cells Excerpt :

Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.

Green Synthesis  Characterization and Applications of Nanoparticles Book

Green Synthesis Characterization and Applications of Nanoparticles


  • Author : Ashutosh Kumar Shukla
  • Publisher : Elsevier
  • Release Date : 2018-11-26
  • Genre: Technology & Engineering
  • Pages : 548
  • ISBN 10 : 9780081025802

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Green Synthesis Characterization and Applications of Nanoparticles Excerpt :

Green Synthesis, Characterization and Applications of Nanoparticles shows how eco-friendly nanoparticles are engineered and used. In particular, metal nanoparticles, metal oxide nanoparticles and other categories of nanoparticles are discussed. The book outlines a range of methodologies and explores the appropriate use of each. Characterization methods include spectroscopic, microscopic and diffraction methods, but magnetic resonance methods are also included as they can be used to understand the mechanism of nanoparticle synthesis using organisms. Applications covered include targeted drug delivery, water purification and hydrogen generation. This is an important research resource for those wishing to learn more about how eco-efficient nanoparticles can best be used. Theoretical details and mathematical derivations are kept to a necessary minimum to suit the need of interdisciplinary audiences and those who may be relatively new to the field. Explores recent trends in growth, characterization, properties and applications of nanoparticles Gives readers an understanding on how they are applied through the use of case studies and examples Assesses the advantages and disadvantages of a variety of synthesis and characterization techniques for green nanoparticles in different situations

Bioactive Components in Milk and Dairy Products Book

Bioactive Components in Milk and Dairy Products


  • Author : Young W. Park
  • Publisher : John Wiley & Sons
  • Release Date : 2009-06-30
  • Genre: Technology & Engineering
  • Pages : 440
  • ISBN 10 : 9780813819822

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Bioactive Components in Milk and Dairy Products Excerpt :

Although bioactive compounds in milk and dairy products have been extensively studied during the last few decades – especially in human and bovine milks and some dairy products – very few publications on this topic are available, especially in other dairy species’ milk and their processed dairy products. Also, little is available in the areas of bioactive and nutraceutical compounds in bovine and human milks, while books on other mammalian species are non-existent. Bioactive Components in Milk and Dairy Products extensively covers the bioactive components in milk and dairy products of many dairy species, including cows, goats, buffalo, sheep, horse, camel, and other minor species. Park has assembled a group of internationally reputed scientists in the forefront of functional milk and dairy products, food science and technology as contributors to this unique book. Coverage for each of the various dairy species includes: bioactive proteins and peptides; bioactive lipid components; oligosaccharides; growth factors; and other minor bioactive compounds, such as minerals, vitamins, hormones and nucleotides, etc. Bioactive components are discussed for manufactured dairy products, such as caseins, caseinates, and cheeses; yogurt products; koumiss and kefir; and whey products. Aimed at food scientists, food technologists, dairy manufacturers, nutritionists, nutraceutical and functional foods specialists, allergy specialists, biotechnologists, medical and health professionals, and upper level students and faculty in dairy and food sciences and nutrition, Bioactive Components in Milk and Dairy Products is an important resource for those who are seeking nutritional, health, and therapeutic values or product technology information on milk and dairy products from the dairy cow and speciesbeyond. Areas featured are: Unique coverage of bioactive compounds in milks of the dairy cow and minor species, including goat, sheep, buffalo, camel, and mare Identifies bioactive componen

Receptor Binding Book

Receptor Binding


  • Author : Alan A. Boulton
  • Publisher : Neuromethods
  • Release Date : 1986-06-20
  • Genre: Medical
  • Pages : 616
  • ISBN 10 : UOM:39015011657742

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Receptor Binding Excerpt :

Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientists and 1s written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routinely across the widest range of s- drsciplines. Collecting these general techniques together in a single volume stnkes us not only as a service, but will no doubt prove of exceptional utilitarian value as well. Volumes 2 and 3 describe all current procedures for the analyses of ammes and theirmetabolites and of amino acrds, respectively. These collections will clearly be of value to all neuroscientists working in or contemplating research in these fields. Similar reasons exist for Volume 4 on receptor binding techniques since experimental details are provided for many types of ligand-receptor binding, including chapters on general prin- ples, drug discovery and development, and a most useful app- dix on computer programs for Scatchard, nonlinear, and compe- tive displacement analyses. Volume 5 provides procedures for the assessment of enzymes involved in biogenic amine synthesis and catabolism. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physrologists, -anatomists, psychopharmacologists, psychiatrists, neurologists, and chemists (organic, analytical, pharmaceutical, medicinal); in fact, everyone involved in the neurosciences, both basic and clinical.

Food Proteins and Bioactive Peptides Book

Food Proteins and Bioactive Peptides


  • Author : Maria Hayes
  • Publisher : MDPI
  • Release Date : 2018-06-01
  • Genre: Electronic books
  • Pages : 179
  • ISBN 10 : 9783038428633

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Food Proteins and Bioactive Peptides Excerpt :

This book is a printed edition of the Special Issue "Food Proteins and Bioactive Peptides" that was published in Foods

Biology of Trypanosoma cruzi Book

Biology of Trypanosoma cruzi


  • Author : Wanderley De Souza
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-12-18
  • Genre: Medical
  • Pages : 236
  • ISBN 10 : 9781839682032

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Biology of Trypanosoma cruzi Excerpt :

Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective stages are able to penetrate into a mammalian host cell, where they multiply several times and thus amplify the infection; and (3) evasion from the immune system, using several mechanisms. This book, with 13 chapters, has been organized in four major sections: 1. "Basic Biology," 2. "Biochemistry and Molecular Biology," 3. "Parasite"Host Cell Interaction," and 4 "Chemotherapy." The chapters include basic biological information on the protozoan lifecycle, including new information on parasite genomics and proteomics. In addition, they analyze the interaction with host cells as well the immune response and evasion, ending with information on experimental chemotherapy against Chagas disease.

New Insights Into Retinal Degenerative Diseases Book

New Insights Into Retinal Degenerative Diseases


  • Author : Robert E. Anderson
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 355
  • ISBN 10 : 9781461513551

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New Insights Into Retinal Degenerative Diseases Excerpt :

Since 1984, we have organized satellite symposia on retinal degenerations that are held in conjunction with the biennial International Congress of Eye Research. The timing and location of our Retinal Degeneration Symposia have allowed scientists and clinicians from around the world to convene and present their exciting new findings. The symposia have been arranged to allow ample time for discussions and one-on-one interactions in a relaxed atmosphere, where international friendships and collaborations could be established. The IXth International Symposium on Retinal Degeneration was held on October 9-14, 2000 in Durango, Colorado and was attended by over 100 scientists from six continents. This book contains many of their presentations. Several events of note occurred at this meeting. First, thanks to the generous support of the Foundation Fighting Blindness, we were able to sponsor the travel of 11 young scientists from six countries. Most of them have contributed chapters to this volume. The response to the travel program was so overwhelming that we will make it regular feature of our meeting. This will allow other bright, young investigators to be introduced to the world experts who study retinal degenerations. Second, about 40% of the scientists who attended this meeting were there for the first time. We believe that this indicates a growing interest in retinal degeneration research and ensures that new talent will be attracted to this important area of investigation. The symposium received support from several organizations.

Biology of the Sialic Acids Book

Biology of the Sialic Acids


  • Author : A. Rosenberg
  • Publisher : Springer Science & Business Media
  • Release Date : 1995-07-31
  • Genre: Science
  • Pages : 398
  • ISBN 10 : 0306449749

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Biology of the Sialic Acids Excerpt :

Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables.

Biochemistry and Cell Biology of Ageing  Part I Biomedical Science Book

Biochemistry and Cell Biology of Ageing Part I Biomedical Science


  • Author : J. Robin Harris
  • Publisher : Springer
  • Release Date : 2019-02-18
  • Genre: Medical
  • Pages : 526
  • ISBN 10 : 9789811328350

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Biochemistry and Cell Biology of Ageing Part I Biomedical Science Excerpt :

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Antibody Fc  Book

Antibody Fc


  • Author : Margaret Ackerman
  • Publisher : Academic Press
  • Release Date : 2013-08-06
  • Genre: Medical
  • Pages : 358
  • ISBN 10 : 9780123948182

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Antibody Fc Excerpt :

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system