Single Molecule Biology Book

Single Molecule Biology


  • Author : Alexander E. Knight
  • Publisher : Academic Press
  • Release Date : 2009-02-26
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 008092123X

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Single Molecule Biology Excerpt :

Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective. The contents are organized by biological system or molecule. Each chapter discusses insights that have been revealed about their mechanism, structure or function by single molecule techniques. Among the topics covered are enzymes, motor proteins, membrane channels, DNA, ribozymes, cytoskeletal proteins, and other key molecules of current interest. An introduction by the editor provides a concise review of key principles and an historical overview. The last section discusses applications in molecular diagnostics and drug discovery. * Organized by biological system or molecule. * Each chapter discusses insights into mechanism of action, structure, and function * Covers enzymes, motor proteins, membrane channels, DNA, ribozymes, etc. * Includes an introduction to key principles and an historical overview. * Discusses applications in molecular diagnostics and drug discovery. * Provides an expert's perspective on future developments.

Single Molecule Cellular Biophysics Book

Single Molecule Cellular Biophysics


  • Author : Mark C. Leake
  • Publisher : Cambridge University Press
  • Release Date : 2013-01-31
  • Genre: Science
  • Pages : null
  • ISBN 10 : 9781139619349

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Single Molecule Cellular Biophysics Excerpt :

Recent advances in single molecule science have presented a new branch of science: single molecule cellular biophysics, combining classical cell biology with cutting-edge single molecule biophysics. This textbook explains the essential elements of this new discipline, from the state-of-the-art single molecule techniques to real-world applications in unravelling the inner workings of the cell. Every effort has been made to ensure the text can be easily understood by students from both the physical and life sciences. Mathematical derivations are kept to a minimum whilst unnecessary biological terminology is avoided and text boxes provide readers from either background with additional information. 100 end-of-chapter exercises are divided into those aimed at physical sciences students, those aimed at life science students and those that can be tackled by students from both disciplines. The use of case studies and real research examples make this textbook indispensable for undergraduate students entering this exciting field.

Single Molecule Science Book

Single Molecule Science


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2020-12
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 1108525903

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Single Molecule Spectroscopy in Chemistry  Physics and Biology Book

Single Molecule Spectroscopy in Chemistry Physics and Biology


  • Author : Astrid Graslund
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-04-17
  • Genre: Molecular spectroscopy
  • Pages : 570
  • ISBN 10 : 9783642025983

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Single Molecule Spectroscopy in Chemistry Physics and Biology Excerpt :

Written by the leading experts in the field, this book describes the development and current state of the art in single molecule spectroscopy. The application of this technique, which started 1989, in physics, chemistry and biosciences is displayed.

Handbook of Single Molecule Biophysics Book

Handbook of Single Molecule Biophysics


  • Author : Peter Hinterdorfer
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-12-24
  • Genre: Science
  • Pages : 626
  • ISBN 10 : 0387764976

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Handbook of Single Molecule Biophysics Excerpt :

This handbook describes experimental techniques to monitor and manipulate individual biomolecules, including fluorescence detection, atomic force microscopy, and optical and magnetic trapping. It includes single-molecule studies of physical properties of biomolecules such as folding, polymer physics of protein and DNA, enzymology and biochemistry, single molecules in the membrane, and single-molecule techniques in living cells.

Single Molecule Analysis Book

Single Molecule Analysis


  • Author : Erwin J. G. Peterman
  • Publisher : Humana Press
  • Release Date : 2011-09-15
  • Genre: Science
  • Pages : 317
  • ISBN 10 : 1617792810

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Single Molecule Analysis Excerpt :

Life scientists believe that life is driven, directed, and shaped by biomolecules working on their own or in concert. It is only in the last few decades that technological breakthroughs in sensitive fluorescence microscopy and single-molecule manipulation techniques have made it possible to observe and manipulate single biomolecules and measure their individual properties. The methodologies presented in Single Molecule Techniques: Methods and Protocols are being applied more and more to the study of biologically relevant molecules, such as DNA, DNA-binding proteins, and motor proteins, and are becoming commonplace in molecular biophysics, biochemistry, and molecular and cell biology. The aim of Single Molecule Techniques: Methods and Protocols is to provide a broad overview of single-molecule approaches applied to biomolecules on the basis of clear and concise protocols, including a solid introduction to the most widely used single-molecule techniques, such as optical tweezers, single-molecule fluorescence tools, atomic force microscopy, magnetic tweezers, and tethered particle motion. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Single Molecule Techniques: Methods and Protocols serves as an ideal guide to scientists of all backgrounds and provides a broad and thorough overview of the exciting and still-emerging field of single-molecule biology.

Single Molecule Biophysics Book

Single Molecule Biophysics


  • Author : Tamiki Komatsuzaki
  • Publisher : Wiley
  • Release Date : 2011-11-16
  • Genre: Science
  • Pages : 512
  • ISBN 10 : 1118131398

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Single Molecule Biophysics Excerpt :

Discover the experimental and theoretical developments in optical single-molecule spectroscopy that are changing the ways we think about molecules and atoms The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. This latest volume explores the advent of optical single-molecule spectroscopy, and how atomic force microscopy has empowered novel experiments on individual biomolecules, opening up new frontiers in molecular and cell biology and leading to new theoretical approaches and insights. Organized into two parts—one experimental, the other theoretical—this volume explores advances across the field of single-molecule biophysics, presenting new perspectives on the theoretical properties of atoms and molecules. Single-molecule experiments have provided fresh perspectives on questions such as how proteins fold to specific conformations from highly heterogeneous structures, how signal transductions take place on the molecular level, and how proteins behave in membranes and living cells.This volume is designed to further contribute to the rapid development of single-molecule biophysics research. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics.

Single molecule Techniques Book
Score: 5
From 2 Ratings

Single molecule Techniques


  • Author : Paul R. Selvin
  • Publisher : CSHL Press
  • Release Date : 2008
  • Genre: Science
  • Pages : 511
  • ISBN 10 : 9780879697754

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Single molecule Techniques Excerpt :

Geared towards research scientists in structural and molecular biology, biochemistry, and biophysics, this manual will be useful to all who are interested in observing, manipulating and elucidating the molecular mechanisms and discrete properties of macromolecules.

Single Molecule Enzymology  Fluorescence Based and High Throughput Methods Book

Single Molecule Enzymology Fluorescence Based and High Throughput Methods


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2016-10-28
  • Genre: Medical
  • Pages : 616
  • ISBN 10 : 9780128095478

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Single Molecule Enzymology Fluorescence Based and High Throughput Methods Excerpt :

Single-Molecule Enzymology, Part A, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in single-molecule enzymology, and includes sections on such topics as force-based and hybrid approaches, fluorescence, high-throughput sm enzymology, nanopores, and tethered particle motion. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in single-molecule enzymology Contains sections on such topics as force-based and hybrid approaches, fluorescence, high-throughput sm enzymology, nanopores, and tethered particle motion

Single Molecule and Single Cell Sequencing Book

Single Molecule and Single Cell Sequencing


  • Author : Yutaka Suzuki
  • Publisher : Springer
  • Release Date : 2019-04-09
  • Genre: Medical
  • Pages : 150
  • ISBN 10 : 9789811360374

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Single Molecule and Single Cell Sequencing Excerpt :

This book presents an overview of the recent technologies in single molecule and single cell sequencing. These sequencing technologies are revolutionizing the way of the genomic studies and the understanding of complex biological systems. The PacBio sequencer has enabled extremely long-read sequencing and the MinION sequencer has made the sequencing possible in developing countries. New developments and technologies are constantly emerging, which will further expand sequencing applications. In parallel, single cell sequencing technologies are rapidly becoming a popular platform. This volume presents not only an updated overview of these technologies, but also of the related developments in bioinformatics. Without powerful bioinformatics software, where rapid progress is taking place, these new technologies will not realize their full potential. All the contributors to this volume have been involved in the development of these technologies and software and have also made significant progress on their applications. This book is intended to be of interest to a wide audience ranging from genome researchers to basic molecular biologists and clinicians.

Single Molecule Detection in Solution Book

Single Molecule Detection in Solution


  • Author : Jörg Enderlein
  • Publisher : Wiley-VCH
  • Release Date : 2002-05-06
  • Genre: Science
  • Pages : 398
  • ISBN 10 : UOM:39015055895729

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Single Molecule Detection in Solution Excerpt :

The detection of single molecules opens up new horizons in analytical chemistry, biology and medicine. This discipline, which belongs to the expanding field of nanoscience, has been rapidly emerging over the last ten years. This handbook provides a thorough overview of the field. It begins with basics of single molecule detection in solution, describes methods and devices (fluorescense correlation spectroscopy, surface enhanced Raman scattering, sensors, especially dyes, screening techniques, especially confocal laser scanning microscopy). In the second part, various applications in life sciences and medicine provide the latest research results. This modern handbook is a highly accessible reference for a broad community from advanced researchers, specialists and company professionals in physics, spectroscopy, biotechnology, analytical chemistry, and medicine. Written by leading authorities in the field, it is timely and fills a gap - up to now there exists no handbook concerning this theme.

Single Molecule Chemistry and Physics Book

Single Molecule Chemistry and Physics


  • Author : Chen Wang
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-09-22
  • Genre: Technology & Engineering
  • Pages : 303
  • ISBN 10 : 9783540395027

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Single Molecule Chemistry and Physics Excerpt :

Single-molecule studies constitute a distinguishable category of focused - search in nanoscience and nanotechnology. This book is dedicated to the - troduction of recent advances on single-molecule studies. It will be illustrated that studying single molecules is both intellectually and technologically ch- lenging, and also o?ers vast potential in opening up new scienti?c frontiers. We wish to present the readers with several di?erent techniques for studying single molecules, such as electron-tunneling methods, interaction-force m- surement techniques, optical spectroscopy, plus a number of directions where further progress could be pursued. We hope the work may assist the readers, especially graduate students and those who wish to explore single molecules, to become familiarized with the pace of the progress in this ?eld and the relevant primary techniques. Due to limitation of space, we are not able to elaborate on the technical details of all of the experimental methods that are vital in single molecule studies, so introductions to only selected experimental methods are touched in the context. Since the technical details and theoretical analysis of these techniqueshavealreadybeenthoroughlycoveredinmanyliteratures,weonly provide introductions to the basic principles of the detection techniques here, and focus on their experimental achievements in the area of single-molecule studies. These techniques have proven to be highly e?ective when indep- dently used. The combinationof those techniques could lead to further - vances in the detection capabilities.

Molecular Biology of the Cell Book
Score: 4.5
From 5 Ratings

Molecular Biology of the Cell


  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0815332181

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Single Molecule Enzymology Book

Single Molecule Enzymology


  • Author : Gregory I. Mashanov
  • Publisher : Humana Press
  • Release Date : 2011-08-04
  • Genre: Science
  • Pages : 294
  • ISBN 10 : 1617792608

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Single Molecule Enzymology Excerpt :

The last fifteen years have witnessed the birth and maturation of many original methods and the development of protocols specific to single molecule measurements and their analysis, including techniques involving optical imaging, electron microscopy, optical and magnetic trapping, and developments in atomic force microscopy. In Single Molecule Enzymology: Methods and Protocols, experts in the field provide procedures which enable the extraction of detailed information about enzyme work cycles, their static and kinetic properties, and information about their location and activity within cells. The detailed volume offers practical advice on many aspects of single molecule enzymology and includes strategic overviews of interconnected methods involved in sample preparation, single molecule measurements, and data analysis. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Single Molecule Enzymology: Methods and Protocols is intended for use within the diverse community of molecular biologists, biochemists, and biophysicists studying enzymes in detail and can be used by researchers planning their first single molecule study or to aid more experienced researchers in further developing their existing studies.

Fundamentals of Molecular Structural Biology Book

Fundamentals of Molecular Structural Biology


  • Author : Subrata Pal
  • Publisher : Academic Press
  • Release Date : 2019-08-13
  • Genre: Science
  • Pages : 518
  • ISBN 10 : 9780128148563

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Fundamentals of Molecular Structural Biology Excerpt :

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease