Spinal Cord Injury  SCI  Repair Strategies Book

Spinal Cord Injury SCI Repair Strategies


  • Author : Giuseppe Perale
  • Publisher : Woodhead Publishing
  • Release Date : 2019-10-30
  • Genre: Medical
  • Pages : 346
  • ISBN 10 : 9780081028087

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Spinal Cord Injury SCI Repair Strategies Excerpt :

Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Promoting Neuroplasticity to Repair the Injured Spinal Cord Book

Promoting Neuroplasticity to Repair the Injured Spinal Cord


  • Author : Nina Weishaupt
  • Publisher : Unknown
  • Release Date : 2013
  • Genre: Neuroplasticity
  • Pages : 272
  • ISBN 10 : OCLC:871700569

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Promoting Neuroplasticity to Repair the Injured Spinal Cord Excerpt :

This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay pathways to re-establish communication with target regions below the injury level. In chapter 2, I attempted to promote a detour for the cervically injured corticospinal tract (CST) via spared reticulospinal tract (RtST) axons with a combined treatment including the neurotrophins BDNF, NT-3 and rehabilitative training. Although anatomical evidence for the desired rewiring was not obtained, I found a synergistic effect of BDNF treatment and training on recovery of skilled forelimb reaching. No effect of NT-3 administered rostral to the SCI was evident. The experiment in chapter 3 was designed to answer the question whether NT-3-induced CST collateral growth rostral to an SCI can be facilitated by systemic immune activation. Results indicate that NT-3 expression can promote collateral growth from the injured CST, irrespective of immune activation. Since results from chapter 2 did not shed light on the previously suggested role of the RtST in recovery of hand/paw function after cervical SCI, I next examined whether the mostly spared RtST responds to SCI with changes in its anatomical projection pattern. While collateral projections were unchanged rostral to the SCI, I observed a marked withdrawal of collaterals from grey matter regions directly caudal to the SCI. Results from chapter 2 combined with previous reports indicate that task-specific training does often not translate into untrained tasks and may even result in undesired side effects. To elucidate the functional relationship between trained tasks further, I next investigated how training the primarily affected forelimb (PAF) and/or the less affected forelimb (LAF) after unilateral cervical SCI influences performance outcom

Spinal Cord Injury Book

Spinal Cord Injury


  • Author : Joost Verhaagen
  • Publisher : Newnes
  • Release Date : 2012-12-31
  • Genre: Medical
  • Pages : 656
  • ISBN 10 : 9780444535078

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Spinal Cord Injury Excerpt :

Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists. Comprehensive coverage of the latest scientific understanding of spinal cord injuries Detailed coverage of current treatment best practices and potential future treatments Connects leading edge research programs to future treatment opportunities

Biomimetic Materials And Design Book

Biomimetic Materials And Design


  • Author : Angela Dillow
  • Publisher : CRC Press
  • Release Date : 2002-08-28
  • Genre: Medical
  • Pages : 696
  • ISBN 10 : 020390897X

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Biomimetic Materials And Design Excerpt :

Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

Neurobiology of Spinal Cord Injury Book

Neurobiology of Spinal Cord Injury


  • Author : Robert G. Kalb
  • Publisher : Springer Science & Business Media
  • Release Date : 1999-10-22
  • Genre: Medical
  • Pages : 284
  • ISBN 10 : 9781592592005

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Neurobiology of Spinal Cord Injury Excerpt :

Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Spinal Cord Injury Rehabilitation Book

Spinal Cord Injury Rehabilitation


  • Author : Edelle Field-Fote
  • Publisher : F.A. Davis
  • Release Date : 2009-03-26
  • Genre: Medical
  • Pages : 500
  • ISBN 10 : 9780803623194

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Spinal Cord Injury Rehabilitation Excerpt :

One of the world’s leading authorities in spinal cord injury, and a participant in the Human Brain Project brings you an evidenced-based guide to the state-of-the-art in spinal cord rehabilitation. She has assembled an expert team of clinicians, each with expertise in the content areas they address. Their work encompasses all of the new scientific knowledge and technological advances practitioners need to know to determine the most effective rehabilitation interventions for each patient and to attain maximum restoration of function in individuals with SCI.

Neuroprotection Book

Neuroprotection


  • Author : Matilde Otero-Losada
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-11-26
  • Genre: Medical
  • Pages : 348
  • ISBN 10 : 9781838804398

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Neuroprotection Excerpt :

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

The Neuroscience of Spinal Cord Injury Book

The Neuroscience of Spinal Cord Injury


  • Author : Rajkumar Rajendram
  • Publisher : Academic Press
  • Release Date : 2022-05-27
  • Genre: Medical
  • Pages : 1200
  • ISBN 10 : 9780323995764

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The Neuroscience of Spinal Cord Injury Excerpt :

Diagnosis and Treatment of Spinal Cord Injury will enhance readers’ understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries. Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Diagnosis and Treatment of Spinal Cord Injury: Covers both the diagnosis and treatment of spinal cord injury Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on epidemiology and pain Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury Discusses pain reduction, drug delivery, and rehabilitation Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury: Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on signaling and hormonal e

Diagnosis and Treatment of Spinal Cord Injury Book

Diagnosis and Treatment of Spinal Cord Injury


  • Author : Rajkumar Rajendram
  • Publisher : Academic Press
  • Release Date : 2022-05-10
  • Genre: Medical
  • Pages : 626
  • ISBN 10 : 9780128224991

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Diagnosis and Treatment of Spinal Cord Injury Excerpt :

Diagnosis and Treatment of Spinal Cord Injury will enhance readers’ understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries. Covers both the diagnosis and treatment of spinal cord injury Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on epidemiology and pain Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury Discusses pain reduction, drug delivery, and rehabilitation

Spinal Cord Injury  New Insights for the Healthcare Professional  2013 Edition Book

Spinal Cord Injury New Insights for the Healthcare Professional 2013 Edition


  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-07-22
  • Genre: Medical
  • Pages : 196
  • ISBN 10 : 9781481662185

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Spinal Cord Injury New Insights for the Healthcare Professional 2013 Edition Excerpt :

Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Therapeutic Strategies to Spinal Cord Injury Book

Therapeutic Strategies to Spinal Cord Injury


  • Author : Pavla Jendelova
  • Publisher : MDPI
  • Release Date : 2018-11-29
  • Genre: Uncategoriezed
  • Pages : 238
  • ISBN 10 : 9783038974062

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Therapeutic Strategies to Spinal Cord Injury Excerpt :

This book is a printed edition of the Special Issue "Therapeutic Strategies to Spinal Cord Injury" that was published in IJMS

Handbook of Innovations in Central Nervous System Regenerative Medicine Book

Handbook of Innovations in Central Nervous System Regenerative Medicine


  • Author : Antonio Salgado
  • Publisher : Elsevier
  • Release Date : 2020-06-10
  • Genre: Medical
  • Pages : 710
  • ISBN 10 : 9780128180853

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Handbook of Innovations in Central Nervous System Regenerative Medicine Excerpt :

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma Book

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma


  • Author : Michael Fehlings
  • Publisher : Academic Press
  • Release Date : 2022-02-17
  • Genre: Medical
  • Pages : 644
  • ISBN 10 : 9780128198360

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Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma Excerpt :

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples

Spinal Trauma Book

Spinal Trauma


  • Author : Eric D. Schwartz
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2007
  • Genre: Medical
  • Pages : 419
  • ISBN 10 : 9780781762489

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Spinal Trauma Excerpt :

Written by recognized experts, this volume is a comprehensive reference on the use of advanced imaging techniques in the diagnosis and management of spinal trauma. In one cohesive source, the book brings together information on state-of-the-art clinical imaging—including multidetector CT and high-field MRI techniques—and the pathophysiology, neurologic evaluation, medical management, surgical treatment, and postoperative assessment of spine trauma and spinal cord injury. Also included are cutting-edge reviews of experimental imaging techniques and their applications and experimental therapies such as neurotransplantation. More than 700 illustrations—including 180 in full color—complement the text.