Stress and Epigenetics in Suicide Book

Stress and Epigenetics in Suicide


  • Author : Vsevolod Rozanov
  • Publisher : Academic Press
  • Release Date : 2017-02-13
  • Genre: Medical
  • Pages : 236
  • ISBN 10 : 9780128052860

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Stress and Epigenetics in Suicide Excerpt :

Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention. Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment Integrates social, psychological, and existential influences, giving readers a better understanding of the interdisciplinary nature of suicide risk factors Presents future directions for suicide-prevention strategies that incorporate recent research on genomics and stress resilience

The Neurobiological Basis of Suicide Book

The Neurobiological Basis of Suicide


  • Author : Yogesh Dwivedi
  • Publisher : CRC Press
  • Release Date : 2012-06-25
  • Genre: Medical
  • Pages : 482
  • ISBN 10 : 9781439838815

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The Neurobiological Basis of Suicide Excerpt :

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Epigenetics of Stress and Stress Disorders Book

Epigenetics of Stress and Stress Disorders


  • Author : Nagy Youssef
  • Publisher : Academic Press
  • Release Date : 2022-02-25
  • Genre: Medical
  • Pages : 420
  • ISBN 10 : 9780128230626

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Epigenetics of Stress and Stress Disorders Excerpt :

Epigenetics of Stress and Stress Disorders, Volume 31 in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA or gene expression following prolonged stress and/or trauma. Sections introduce both genetic and psychiatric foundations, including modes of epigenetic modification and gene expression that result from stress, as well as the medical knowledge required to understand stress related disorders and resilience. From here, chapters discuss epigenetic research techniques applied in recent studies, including epigenome-wide association studies (EWAS) of PTSD and resilience, the possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PSTD. The book concludes by examining the possible effects of transgenerational stress-induced epigenetic alterations on the resilience of future offspring, the potential for epigenetic therapeutics, and public health implications. Examines the epigenetics of stress, trauma and related stress disorders Includes methods (e.g. EWAS), protocols and directions for further studies Connects new research to clinical practice and highlights implications for patient care, drug discovery and public health

The Epigenetics of Suicide Book

The Epigenetics of Suicide


  • Author : Benoit Labonté
  • Publisher : Unknown
  • Release Date : 2013
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:922058836

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The Epigenetics of Suicide Excerpt :

"Suicide is a problem resulting from the interaction between several factors. Among these factors, early-life adversity, characterized by child sexual and physical abuse as well as parental neglect, is one of the strongest risk factors for depression and suicidal behaviors. While it is clear that child abuse increases the risk for depression and suicide, the mechanisms mediating these effects are still unknown. Recent evidences suggest that epigenetic mechanisms may be involved in mediating the effects of early-life adversity on behavior. Early-life stress in animals has been shown to alter DNA methylation in genes regulatory regions what, in turn, has been associated with changes in gene expression and behavioral modifications. Importantly, similar changes have been reported in several genes in the human brain. However, although epigenetic modifications have been found in several genes, the extent of epigenetic changes induced by early-life adversity is still unknown and their impacts on increasing suicide risk are unclear. This thesis aims at expanding our understanding of suicide by investigating one potential mechanism by which early-life adversity may increase vulnerability to mood disorders and suicide, namely epigenetic regulation of gene expression. We first expanded our characterization of DNA methylation alterations induced by early and adult-life stress in the regulatory regions of the glucocorticoid receptor gene which is one of the most consistent alterations associated with stress, depression and suicidal behaviors. We then opted for a genome-wide characterization of DNA methylation alterations found in the brains of suicide completers with and without a history of child abuse using microarray analyses focusing on gene promoters throughout the genome. Our findings revealed several DNA methylation alterations in genes with known roles on behavioral regulation and identified several new genes and networks which may be specifically altered by early-life a

Epigenetics in Psychiatry Book

Epigenetics in Psychiatry


  • Author : Jacob Peedicayil
  • Publisher : Academic Press
  • Release Date : 2021-08-16
  • Genre: Science
  • Pages : 846
  • ISBN 10 : 9780128235782

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Epigenetics in Psychiatry Excerpt :

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Early Life Stress and Depression Book

Early Life Stress and Depression


  • Author : Fushun Wang
  • Publisher : Frontiers Media SA
  • Release Date : 2020-02-13
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889634743

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Early Life Stress and Depression Excerpt :

Epigenetics and Psychiatric Disease Book

Epigenetics and Psychiatric Disease


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-06-22
  • Genre: Science
  • Pages : 450
  • ISBN 10 : 9780128135662

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Epigenetics and Psychiatric Disease Excerpt :

Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic regulation in schizophrenia, Progress in the epigenetics of depression, the epigenetics of circadian rhythms in imprinted neurodevelopmental disorders, DNA methylation mediating substance abuse, mechanisms and therapeutic opportunities, DNA methylation in animals model of psychosis, Epigenetics of early life stress, Epigenetic drugs for mood disorders, and more. Accessible to students and researchers alike, with content that appeals to a variety of readers Written by leading authorities in their respective fields of molecular biology

Suicide by Self Immolation Book

Suicide by Self Immolation


  • Author : César A. Alfonso
  • Publisher : Springer Nature
  • Release Date : 2021
  • Genre: Electronic books
  • Pages : 264
  • ISBN 10 : 9783030626136

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Suicide by Self Immolation Excerpt :

This book addresses biopsychosocial and transcultural determinants of suicide by self-immolation, populations at risk throughout the world and prevention strategies specifically designed for young women in fragile environments. Self-immolation, the act of burning oneself as a means of suicide, is rare in high-income countries, and is usually a symbolic display of political protest among men that generally receives international media coverage. In contrast, in low- and-middle-income countries it is highly prevalent, primarily affects women, and may be one of the most common suicide methods in regions of Central and South Asia and parts of Africa. Psychiatric conditions, like adjustment disorders, traumatic stress disorders, and major depression, and family dynamics that include intimate partner violence, forced marriages, the threat of honor killings, and interpersonal family conflicts in a cultural context of war-related life events, poverty, forced migration and ethnic conflicts are important contributing factors. Written by over 40 academic psychiatrists from all continents, sociologists, and historians, the book covers topics such as region-specific cultural and historical factors associated with suicide; the role of religion and belief systems; marginalization, oppression, retraumatization and suicide risk; countertransference aspects of working in burn centers; responsible reporting and the media; and suicide prevention strategies to protect those at risk.

Behavioral Neurobiology of Suicide and Self Harm Book

Behavioral Neurobiology of Suicide and Self Harm


  • Author : Enrique Baca-Garcia
  • Publisher : Springer Nature
  • Release Date : 2020-12-21
  • Genre: Medical
  • Pages : 245
  • ISBN 10 : 9783030575748

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Behavioral Neurobiology of Suicide and Self Harm Excerpt :

This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide. Suicidal behavior, perhaps, is the most complex behavior that combines biological, social, and psychological factors. A new frontier and new opportunities are opening with the technologies of data acquisition and data analysis. Personalized models based on digital phenotype could provide promising strategies for preventing suicide.

Biological Aspects of Suicidal Behavior Book

Biological Aspects of Suicidal Behavior


  • Author : W. P. Kaschka
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2016
  • Genre: Medical
  • Pages : 169
  • ISBN 10 : 9783318055832

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Biological Aspects of Suicidal Behavior Excerpt :

Suicide is one of the most important causes of death in modern societies. To develop more effective preventive measures, we have to be aware of and learn more about its neurobiological foundations. In recent years, the tools of modern neurosciences have increasingly been utilized to characterize the pathophysiology of complex human behaviors such as suicide. To improve suicide risk assessment and suicide prevention, a better understanding of its pathophysiology is crucial. This includes research from a variety of disciplines such as neuropsychological, psychosocial and cultural studies but also findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. Important results have, for example, been obtained in the field of gene-environment interaction and suicidal behavior. We have just begun to understand how early-life adversity may increase suicide risk by epigenetic mechanisms. Based on such insights, novel therapeutic interventions and preventive measures can be developed. Furthermore, a better understanding of the pathophysiological mechanisms involved in suicidal behavior could reveal the mechanism of compounds like lithium salts. In this book, suicidal behavior and its prevention is discussed by international experts in the light of the most recent results from a broad spectrum of neurosciences.

Stress  Genetics  Epigenetics and Genomics Book

Stress Genetics Epigenetics and Genomics


  • Author : George Fink
  • Publisher : Academic Press
  • Release Date : 2020-10-24
  • Genre: Science
  • Pages : 344
  • ISBN 10 : 9780128131572

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Stress Genetics Epigenetics and Genomics Excerpt :

This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences. Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter includes a boxed “Key points call out section Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series

Understanding Suicide Book

Understanding Suicide


  • Author : Philippe Courtet
  • Publisher : Springer
  • Release Date : 2016-03-05
  • Genre: Medical
  • Pages : 457
  • ISBN 10 : 9783319262826

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Understanding Suicide Excerpt :

In this book international experts address a range of key current issues relating to suicide. The opening chapters discuss nosology, definitions, clinical determinants, and conceptual models of the suicide process and consider the evidence regarding potential biomarkers of suicide risk based on neuroscientific research. Adopting a neo-Durkheimian perspective, the role of various social factors in the genesis of suicidal behavior is then explored in depth. Practical user-friendly tools that facilitate risk assessment by clinicians are provided, and detailed consideration is given to efficient and innovative strategies for the prevention of suicide and the treatment of suicidal behavior, such as psychotherapy, psychopharmacological approaches, and effective organization of care, including surveillance and the use of online tools. The final part of the book focuses on the need for and development of a personalized approach within the field of suicide prevention.

Oxford Textbook of Suicidology and Suicide Prevention Book

Oxford Textbook of Suicidology and Suicide Prevention


  • Author : Danuta Wasserman
  • Publisher : Oxford University Press, USA
  • Release Date : 2021-01-08
  • Genre: Medical
  • Pages : 856
  • ISBN 10 : 9780198834441

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Oxford Textbook of Suicidology and Suicide Prevention Excerpt :

Part of the authoritative Oxford Textbooks in Psychiatry series, the new edition of the Oxford Textbook of Suicidology and Suicide Prevention remains a key text in the field of suicidology, fully updated with new chapters devoted to major psychiatric disorders and their relation to suicide.

Environmental Epigenetics Book

Environmental Epigenetics


  • Author : L. Joseph Su
  • Publisher : Springer
  • Release Date : 2015-05-18
  • Genre: Medical
  • Pages : 321
  • ISBN 10 : 9781447166788

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Environmental Epigenetics Excerpt :

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Handbook of Epigenetics Book

Handbook of Epigenetics


  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release Date : 2017-07-10
  • Genre: Science
  • Pages : 682
  • ISBN 10 : 9780128054772

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Handbook of Epigenetics Excerpt :

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials