PAKs  RAC CDC42  p21  activated Kinases Book

PAKs RAC CDC42 p21 activated Kinases


  • Author : Hiroshi Maruta
  • Publisher : Newnes
  • Release Date : 2013-01-23
  • Genre: Science
  • Pages : 276
  • ISBN 10 : 9780124072107

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PAKs RAC CDC42 p21 activated Kinases Excerpt :

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.

EJB Reviews 1996 Book

EJB Reviews 1996


  • Author : P. Christen
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 285
  • ISBN 10 : 9783642606595

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EJB Reviews 1996 Excerpt :

In the mid-1980s the European Journal of Biochemistry set out to publish review articles. The enterprise proved successful, resulting in high-level reviews written by well-known scientists appearing in the Journal. The reviews represent emerging and rapidly growing fields of research in fundamental as well as applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. The authors of the reviews are explicitely asked to be critical, selective, evaluative and interdisciplinary oriented. The reviews should encourage young scientists to think independently and creatively, and inform active investigators about the state of the art in a given field.

ARF Family GTPases Book

ARF Family GTPases


  • Author : Richard A. Kahn
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-04-11
  • Genre: Science
  • Pages : 350
  • ISBN 10 : 9781402025938

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ARF Family GTPases Excerpt :

For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.

EJB Reviews Book

EJB Reviews


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1996
  • Genre: Biochemistry
  • Pages : null
  • ISBN 10 : UOM:39015051255001

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EJB Reviews Excerpt :

Handbook of Cell Signaling Book

Handbook of Cell Signaling


  • Author : Ralph A. Bradshaw
  • Publisher : Academic Press
  • Release Date : 2009-11-03
  • Genre: Science
  • Pages : 3048
  • ISBN 10 : 9780080920917

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Handbook of Cell Signaling Excerpt :

Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

Leucine Rich Repeat Kinase 2  LRRK2  Book

Leucine Rich Repeat Kinase 2 LRRK2


  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release Date : 2017-03-28
  • Genre: Medical
  • Pages : 271
  • ISBN 10 : 9783319499697

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Leucine Rich Repeat Kinase 2 LRRK2 Excerpt :

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Rho Family GTPases Book

Rho Family GTPases


  • Author : Edward J. Manser
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-03-30
  • Genre: Science
  • Pages : 298
  • ISBN 10 : 9781402034626

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Rho Family GTPases Excerpt :

Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted. The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases. The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.

Scientific Report Book

Scientific Report


  • Author : Scripps Research Institute
  • Publisher : Unknown
  • Release Date : 2002
  • Genre: Medicine
  • Pages : null
  • ISBN 10 : UOM:39015053077346

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Scientific Report Excerpt :

Microvascular Research  Biology and Pathology  Two Volume Set Book

Microvascular Research Biology and Pathology Two Volume Set


  • Author : David Shepro
  • Publisher : Elsevier
  • Release Date : 2005-11-17
  • Genre: Medical
  • Pages : 1296
  • ISBN 10 : 9780126395105

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Microvascular Research Biology and Pathology Two Volume Set Excerpt :

The microvasculature refers to the smallest blood vessels, arterial and venous, that nurture the tissues of each organ. Apart from transport, they also contribute to the systematic regulation of the body. In everyday terminology, the microcirculation is "where the action is." Microcirculation is directly involved in such disease states as Alzheimers, inflammation, tumor growth, diabetic retinopathy, and wound healing- plus cardiovascular fitness is directly related to the formation of new capillaries in large muscles. Microvascular Research is the first book devoted exclusively to this vital systemic component of the cardiovascular system and provides up to date mini-reviews of normal functions and clinical states. The contributing authors are senior scientists with international reputation in their given disciplines. This two-volume set is a broad, interdisciplinary work that encompasses basic research and clinical applications equally. * Broad coverage of both basic and clinical aspects of microvasculature research * Contains 167 chapters from over 300 international authors * Each chapter includes key figures and annotated references

Protein Phosphatases Book

Protein Phosphatases


  • Author : Joaquín Arino
  • Publisher : Springer Science & Business Media
  • Release Date : 2003-12-16
  • Genre: Science
  • Pages : 378
  • ISBN 10 : 3540205608

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Protein Phosphatases Excerpt :

This book provides an up-to-date and comprehensive overview of protein phosphatase research, a rapidly evolving field with increasing importance in our understanding of the molecular basis of cell biology and of pathological processes. The book covers dephosphorylation processes involving serine/threonine, as well as tyrosine and histidine residues, and aims to be a useful resource for both the advanced reader as well as the newcomer to the field. It is also valuable for those working in the pharmaceutical and Biotech industries.

Nucleic Acids Abstracts Book

Nucleic Acids Abstracts


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1997
  • Genre: Nucleic acids
  • Pages : null
  • ISBN 10 : UVA:X006074589

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Nucleic Acids Abstracts Excerpt :

Cumulated Index Medicus Book
Score: 3.5
From 2 Ratings

Cumulated Index Medicus


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1999
  • Genre: Medicine
  • Pages : null
  • ISBN 10 : OSU:32436010790853

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Cumulated Index Medicus Excerpt :

Molecular Biology of the Cell Book

Molecular Biology of the Cell


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2005
  • Genre: Cells
  • Pages : null
  • ISBN 10 : UOM:39015058967426

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Molecular Biology of the Cell Excerpt :

Breast Cancer Book

Breast Cancer


  • Author : Phuc Van Pham
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-04-05
  • Genre: Medical
  • Pages : 568
  • ISBN 10 : 9789535129998

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Breast Cancer Excerpt :

Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.