Modern Supercritical Fluid Chromatography Book

Modern Supercritical Fluid Chromatography


  • Author : Larry M. Miller
  • Publisher : John Wiley & Sons
  • Release Date : 2019-11-05
  • Genre: Science
  • Pages : 416
  • ISBN 10 : 9781119625995

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Modern Supercritical Fluid Chromatography Excerpt :

Explains why modern supercritical fluid chromatography (SFC) is the leading "green" analytical and purification separations technology. Modern supercritical fluid chromatography (SFC) is the leading method used to analyze and purify chiral and achiral chemical compounds, many of which are pharmaceuticals, pharmaceutical candidates, and natural products including cannabis-related compounds. This book covers current SFC instrumentation as it relates to greater robustness, better reproducibility, and increased analytical sensitivity. Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases covers the history, instrumentation, method development and applications of SFC. The authors provided readers with an overview of analytical and preparative SFC equipment, stationary phases, and mobile phase choices. Topics covered include: Milestones of Supercritical Fluid Chromatography; Physical Properties of Supercritical Fluids; Instrumentation for SFC; Detection in SFC; Achiral SFC Method Development; Chiral SFC Method Development; and Preparative Scale SFC. The book also includes highlights of modern applications of SFC in the final chapters—namely pharmaceuticals, consumer products, foods, polymers, petroleum-related mixtures, and cannabis—and discusses the future of SFC. Provides a clear explanation of the physical and chemical properties of supercritical fluids, which gives the reader a better understanding of the basis for improved performance in SFC compared to HPLC and GC Describes the advantages of SFC as a green alternative to HPLC and GC for the analysis of both polar, water-soluble, and non-polar analytes Details both achiral and chiral SFC method development, including modifiers, additives, the impact of temperature and pressure, and stationary phase choices Details why SFC is the premier modern preparative chromatographic technique used to purify components of mixtures for subsequent uses, both from performance and economic perspective

Practical Supercritical Fluid Chromatography and Extraction Book

Practical Supercritical Fluid Chromatography and Extraction


  • Author : Thomas Caudell
  • Publisher : Routledge
  • Release Date : 2018-05-08
  • Genre: Science
  • Pages : 456
  • ISBN 10 : 9781351422512

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Practical Supercritical Fluid Chromatography and Extraction Excerpt :

An exploration of fundamental as well as practical aspects of supercritical fluid chromatography and extraction. It addresses topics such as: packed columns in SFC; detection in SFC; supercritical fluid chromatography/mass spectroscopy; and evaporative light scattering detection in SFC.

Analysis with Supercritical Fluids  Extraction and Chromatography Book

Analysis with Supercritical Fluids Extraction and Chromatography


  • Author : Bernd Wenclawiak
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 214
  • ISBN 10 : 9783642774744

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Analysis with Supercritical Fluids Extraction and Chromatography Excerpt :

The use of supercritical fluids in analytical chemistry is still grow ing. More and more analysts are discovering the favorable advan tages for a number of applications. Especially supercritical fluid extraction (SFE) has attracted a lot of interest in recent years due to its simplicity. Supercritical fluid chromatography (SFC) has become better established and the development of this technique has been accelerated by the many applications with capillary col umns which have been published in the literature. At first SFC equipment was based on instruments commonly used for liquid chromatography, and the first commercial in struments were derived from this technology. However, capillary columns can be much more easily interfaced to gas chromatogra phy equipment especially to the detectors commonly used for Oc. Many stationary phases both for packed micro columns and capillary columns have been designed for SFC purposes extending this technology to LC and OC. The most common fluid applied in SFC and SFE is carbon dioxide. The advantages of supercritical CO , such as having dif 2 fusivity like a gas and solvating power depending on temperature and pressure, are also valid for other fluids and modified fluids. Both properties are valuable for sample extraction and extraction selectivity.

Supercritical Fluid Chromatography Book

Supercritical Fluid Chromatography


  • Author : Gregory K. Webster
  • Publisher : CRC Press
  • Release Date : 2014-02-04
  • Genre: Medical
  • Pages : 420
  • ISBN 10 : 9789814463003

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Supercritical Fluid Chromatography Excerpt :

Analytical chemists in the pharmaceutical industry are always looking for more-efficient techniques to meet the analytical challenges of today’s pharmaceutical industry. One technique that has made steady advances in pharmaceutical analysis is supercritical fluid chromatography (SFC). SFC is meeting the chromatography needs of the industry by providing efficient and selective testing capabilities on the analytical and preparative scale. The supercritical fluid mobile phase, consisting mainly of CO2, facilitates cost reduction costs and helps the industry in meeting green chemistry standards. This book provides a comprehensive overview of the use of SFC in pharmaceutical analysis. Supercritical Fluid Chromatography reviews the use of SFC in drug-discovery applications and describes its application in drug development. When a drug is developed and brought to market, it is tested many times for impurities and degradants, enantiomeric purity, and analytical and preparative isolations—it is tested during discovery and development and for under-regulated and unregulated methodologies. The book describes the use of SFC for each of these applications and discusses more in-depth topics, such as the use of SFC in mass spectrometric and polarographic detection. The book also sheds light on the role of SFC in drug development from natural products and the advancement of SFC with new technologies and its use in pilot-scale operations as a chromatographic technique.

Supercritical Fluid Chromatography Book

Supercritical Fluid Chromatography


  • Author : Gérard Rossé
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2018-12-17
  • Genre: Science
  • Pages : 213
  • ISBN 10 : 9783110500776

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Supercritical Fluid Chromatography Excerpt :

Supercritical Fluid Chromatography (SFC) provides a timely overview of SFC application areas which were unimaginable just a decade ago. This two-volume series opens with an overview of the history and expectant future of SFC and continues with recent applications in the pharmaceutical industry and other fascinating areas of science. SFC has found its place in the pharmaceutical industry with an increasing body of applications for chiral and achiral molecules in both the research and development phases of the drug discovery process. As illustrated in this two-volume series, the current interest in SFC extends well beyond the pharmaceutical industry. Chapters encompassing applications for polar and non-polar mixtures of importance are covering widely disparate areas in substance abuse, natural products including cannabinoids, bioactive lipids, flavor and fragrance. With its broad balance and coverage, this two-volume book constitutes a unique educational platform to students and scientists for many years to come. The major objective of this book editions is to inspire and stimulate readers to continue exploring the possibilities of exploiting supercritical fluids as a particular media for analysis, purifications and synthesis

Supercritical Fluid Extraction and its Use in Chromatographic Sample Preparation Book

Supercritical Fluid Extraction and its Use in Chromatographic Sample Preparation


  • Author : S.A. Westwood
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 170
  • ISBN 10 : 9789401121644

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Supercritical Fluid Extraction and its Use in Chromatographic Sample Preparation Excerpt :

by Professor D. E. Games, Mass Spectrometry Research Unit, University College of Swansea Sample preparation can be viewed as occupying a Cinderella role in analytical science. However, the quality of sample preparation plays a key role in high In the past decade, there has been quality analysis and deserves higher stature. considerable interest in the use of supercritical fluid extraction (SFE) as an alternative to conventional procedures for the preparation of samples for ana lysis. The driving force for this development is the need for automated, sim pler, faster, non-destructive and selective methods for extraction, preferably using non-toxic extraction media which are easily disposed of. Utilization of supercritical fluids for extraction fulfils these requirements because of their unique physical chemical properties and usually low toxicity. Selectivity can be achieved by suitable selection of pressure (density), temperature and modi fier conditions which enable solvating power to be varied. The high diffusivity of supercritical fluids provides rapid sample penetration and extraction. Use of fluids with low critical temperatures enables extraction to be conducted under mild thermal conditions ensuring that thermally labile compounds do not decompose. The technique can be used off-line, and the extracts analysed by appropriate techniques, or it can be used on-line, by coupling with a variety of chromatographic techniques. These can then, if necessary, be coupled fur ther with spectroscopic techniques, such as Fourier transform infrared, ultra violet or mass spectrometry, to provide specific identification or structural information.

Packed Column SFC Book

Packed Column SFC


  • Author : T A Berger
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007-10-31
  • Genre: Science
  • Pages : 266
  • ISBN 10 : 9781847551603

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Packed Column SFC Excerpt :

Packed Column SFC is the third title to be published in this series and has been produced as a result of the dramatic re-emergence, in the last three years, of packed column instrumentation. This has led to a redefinition of the technique and an urgent need for a practical guide that deals with its subtleties. This book fulfils that need and deals exclusively with packed column SFC. It places the emphasis on understanding the underlying chemistry in order to perform rapid, systematic optimizations and provides many practical tips to help the new user avoid problems unique to SFC. It also proposes a detailed scheme for method development and provides lists of prioritized guidelines. The book clears up some of the confusion that surrounds the analytical use of supercritical fluids and assists the user in understanding the power and utility of this technique. Detailed chapters cover the most promising new application areas for packed column SFC, which are often overlooked in the mainstream chromatography literature. Like the other books in this popular series, Packed Column SFC will prove an invaluable guide and is essential reading for graduates, postgraduates and researchers with interests in pharmaceuticals, agricultural chemistry, small polar drug molecules, chiral analysis, environmental chemistry, and chromatography/instrumentation.

Supercritical Fluids Book

Supercritical Fluids


  • Author : E. Kiran
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 596
  • ISBN 10 : 9789401139298

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Supercritical Fluids Excerpt :

Supercritical fluids are neither gas nor liquid, but can be compressed gradually from low to high density and they are therefore interesting and important as tunable solvents and reaction media in the chemical process industry. By adjusting the density the properties of these fluids can be customised and manipulated for a given process - physical or chemical transformation. Separation and processing using supercritical solvents such as CO2 are currently on-line commercially in the food, essential oils and polymer industries. Many agencies and industries are considering the use of supercritical water for waste remediation. Supercritical fluid chromatography represents another, major analytical application. Significant advances have recently been made in materials processing, ranging from particle formation to the creation of porous materials. The chapters in this book provide tutorial accounts of topical areas centred around: (1) phase equilibria, thermodynamics and equations of state; (2) critical behaviour, crossover effects; (3) transport and interfacial properties; (4) molecular modelling, computer simulation; (5) reactions, spectroscopy; (6) phase separation kinetics; (7) extractions; (8) applications to polymers, pharmaceuticals, natural materials and chromatography; (9) process scale-up.

Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring Book

Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring


  • Author : Melissa N. Dunkle
  • Publisher : John Wiley & Sons
  • Release Date : 2020-09-01
  • Genre: Science
  • Pages : 464
  • ISBN 10 : 9781119523307

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Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring Excerpt :

A thorough introduction to environmental monitoring in the oil and gas industry Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring examines the analytical side of the oil and gas industry as it also provides an overall introduction to the industry. You’ll discover how oil and natural gas are sourced, refined, and processed. You can learn about what’s produced from oil and natural gas, and why evaluating these sourced resources is important. The book discusses the conventional analyses for oil and natural gas feeds, along with their limitations. It offers detailed descriptions of advanced analytical techniques that are commercially available, plus explanations of gas and oil industry equipment and instrumentation. You’ll find technique descriptions supplemented with a list of references as well as with real-life application examples. With this book as a reference, you can prepare to apply specific analytical methods in your organization’s lab environment. Analytical Techniques can also serve as your comprehensive resource on key techniques in the characterization of oil and gas samples, within both refinery and environmental contexts. Understand of the scope of oil and gas industry techniques available Consider the benefits and limitations of each available process Prepare for applying analytical techniques in your lab See real examples and a list of references for each technique Read descriptions of off-line analytics, as well as on-line and process applications As a chemist, engineer, instructor, or student, this book will also expand your awareness of the role these techniques have in environmental monitoring and environmental impact assessments.

Microbore Column Chromatography Book

Microbore Column Chromatography


  • Author : F. J. Yang
  • Publisher : CRC Press
  • Release Date : 2020-08-27
  • Genre: Science
  • Pages : 349
  • ISBN 10 : 9781000147254

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Microbore Column Chromatography Excerpt :

This book describes the various aspects of microbore column chromatography. It provides readers with an in-depth understanding of the supercritical fluid chromatography and microbore high-performance liquid chromatography.

Gradient HPLC for Practitioners Book

Gradient HPLC for Practitioners


  • Author : Stavros Kromidas
  • Publisher : John Wiley & Sons
  • Release Date : 2019-04-16
  • Genre: Science
  • Pages : 260
  • ISBN 10 : 9783527812769

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Gradient HPLC for Practitioners Excerpt :

This practical guide for analytical scientists explains the use of gradients in liquid chromatography. The fundamentals of gradient separations, as well as the most common application scenarios are addressed, from LC-MS coupling to biochromatography to the separation of ionic substances. Throughout, this handy volume provides detailed hands-on information for practitioners, enabling them to use gradient separation methods reliably and efficiently.

Applications of Supercritical Fluids in Industrial Analysis Book

Applications of Supercritical Fluids in Industrial Analysis


  • Author : J.R. Dean
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 224
  • ISBN 10 : 9789401121460

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Applications of Supercritical Fluids in Industrial Analysis Excerpt :

The continued search for rapid, efficient and cost-effective means of analytical measurement has introduced supercritical fluids into the field of analytical chemistry. Two areas are common: supercritical fluid chroma tography and supercritical fluid extraction. Both seek to exploit the unique properties of a gas at temperatures and pressures above the critical point. The most common supercritical fluid is carbon dioxide, employed because of its low critical temperature (31 °C), inertness, purity, non-toxicity and cheapness. Alternative supercritical fluids are also used and often in conjunction with modifiers. The combined gas-like mass transfer and liquid-like solvating characteristics have been used for improved chroma tographic separation and faster sample preparation. Supercritical fluid chromatography (SFC) is complementary to gas chro matography ( GC) and high performance liquid chromatography (HPLC), providing higher efficiency than HPLC, together with the ability to analyse thermally labile and high molecular weight analytes. Both packed and open tubular columns can be employed, providing the capability to analyse a wide range of sample types. In addition, flame ionization detection can be used, thus providing 'universal' detection.

Multidimensional Chromatography Book

Multidimensional Chromatography


  • Author : Hernan J. Cortes
  • Publisher : CRC Press
  • Release Date : 2020-07-24
  • Genre: Science
  • Pages : 424
  • ISBN 10 : 9781000104226

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Multidimensional Chromatography Excerpt :

This book summarizes all the important aspects of multidimensional separations, providing information on gas, liquid and thin-layer chromatography, as well as the techniques and applications of supercritical fluid chromatography in the multidimensional mode.

The Application of Green Solvents in Separation Processes Book

The Application of Green Solvents in Separation Processes


  • Author : Francisco Pena-Pereira
  • Publisher : Elsevier
  • Release Date : 2017-02-28
  • Genre: Science
  • Pages : 560
  • ISBN 10 : 9780128054437

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The Application of Green Solvents in Separation Processes Excerpt :

The Application of Green Solvents in Separation Processes features a logical progression of a wide range of topics and methods, beginning with an overview of green solvents, covering everything from water and organic solvents, to ionic liquids, switchable solvents, eutectic mixtures, supercritical fluids, gas-expanded solvents, and more. In addition, the book outlines green extraction techniques, such as green membrane extraction, ultrasound-assisted extraction, and surfactant-mediated extraction techniques. Green sampling and sample preparation techniques are then explored, followed by green analytical separations, including green gas and liquid capillary chromatography, counter current chromatography, supercritical fluid chromatography, capillary electrophoresis, and other electrical separations. Applications of green chemistry techniques that are relevant for a broad range of scientific and technological areas are covered, including the benefits and challenges associated with their application. Provides insights into recent advances in greener extraction and separation processes Gives an understanding of alternatives to harmful solvents commonly used in extraction and separation processes, as well as advanced techniques for such processes Written by a multidisciplinary group of internationally recognized scientists

Handbook of Food Analysis Instruments Book

Handbook of Food Analysis Instruments


  • Author : Semih Otles
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Science
  • Pages : 544
  • ISBN 10 : 9781420045673

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Handbook of Food Analysis Instruments Excerpt :

Explore the Pros and Cons of Food Analysis InstrumentsThe identification, speciation, and determination of components, additives, and contaminants in raw materials and products will always be a critical task in food processing and manufacturing. With contributions from leading scientists, many of whom actually developed or refined each technique or