Surfactants in Biopharmaceutical Development Book

Surfactants in Biopharmaceutical Development

  • Author : Atanas V. Koulov
  • Publisher : Academic Press
  • Release Date : 2021-03-01
  • Genre: Medical
  • Pages : 320
  • ISBN 10 : 9780128125694

Surfactants in Biopharmaceutical Development Excerpt :

Surfactants in Biopharmaceutical Development addresses the progress, challenges and opportunities for surfactant research specific to pharmaceutical development, providing a broad range of important surfactant-related topics as they relate directly to the biopharmaceutical process. Chapters address fundamental topics, like mechanisms of protein stabilization by surfactants, the latest, state-of-the-art technology and methods to illustrate the practical application to biopharmaceutical development, forward-looking chapters on control strategies and novel surfactants, with a special focus on current regulatory aspects of paramount importance for biopharmaceutical companies and regulators. It has been widely recognized that surfactants provide protection to therapeutic proteins against interfacial stresses. Despite the fact that the very mechanism of protein stabilization by surfactants has not been completely understood, surfactants are universally regarded as critical functional excipients by the industry and by regulators. Describes the current state of research on surfactants, drawing upon contributions from international experts across industry and academia Addresses the opportunities and challenges associated with surfactants in drug development and delivery Provides a defining resource for practitioners in the biopharmaceutical industry, regulators and academics Summarizes the latest knowledge of surfactants in biopharmaceutical development in one comprehensive volume

Colloid and Interface Science in Pharmaceutical Research and Development Book

Colloid and Interface Science in Pharmaceutical Research and Development

  • Author : Hiroyuki Ohshima
  • Publisher : Elsevier
  • Release Date : 2014-07-23
  • Genre: Technology & Engineering
  • Pages : 532
  • ISBN 10 : 9780444626080

Colloid and Interface Science in Pharmaceutical Research and Development Excerpt :

Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development Explains the physicochemical/colloidal basis of pharmaceutical science Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail

Biobased Surfactants Book

Biobased Surfactants

  • Author : Douglas G. Hayes
  • Publisher : Elsevier
  • Release Date : 2019-04-30
  • Genre: Science
  • Pages : 541
  • ISBN 10 : 9780128127063

Biobased Surfactants Excerpt :

Biobased Surfactants: Synthesis, Properties, and Applications, Second Edition, covers biosurfactant synthesis and applications and demonstrates how to reduce manufacturing and purification costs, impurities, and by-products. Fully updated, this book covers surfactants in biomedical applications, detergents, personal care, food, pharmaceuticals, cosmetics, and nanotechnology. It reflects on the latest developments in biobased surfactant science and provides case scenarios to guide readers in efficient and effective biobased surfactant application, along with strategies for research into new applications. This book is written from a biorefinery-based perspective by an international team of experts and acts as a key text for researchers and practitioners involved in the synthesis, utilization, and development of biobased surfactants. Describes new and emerging biobased surfactants and their synthesis and development Showcases an interdisciplinary approach to the topic, featuring applications to chemistry, biotechnology, biomedicine, and other areas Presents the entire lifecycle of biobased surfactants in detail

Issues in Pharmacology  Pharmacy  Drug Research  and Drug Innovation  2011 Edition Book

Issues in Pharmacology Pharmacy Drug Research and Drug Innovation 2011 Edition

  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Genre: Medical
  • Pages : 4229
  • ISBN 10 : 9781464963421

Issues in Pharmacology Pharmacy Drug Research and Drug Innovation 2011 Edition Excerpt :

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Challenges in Protein Product Development Book
Score: 2
From 1 Ratings

Challenges in Protein Product Development

  • Author : Nicholas W. Warne
  • Publisher : Springer
  • Release Date : 2018-06-20
  • Genre: Medical
  • Pages : 599
  • ISBN 10 : 9783319906034

Challenges in Protein Product Development Excerpt :

In this volume, the authors discuss the many significant challenges currently faced in biotechnology dosage form development, providing guidance, shared experience and thoughtful reflection on how best to address these potential concerns. As the field of therapeutic recombinant therapeutic proteins enters its fourth decade and the market for biopharmaceuticals becomes increasingly competitive, companies are increasingly dedicating resources to develop innovative biopharmaceuticals to address unmet medical needs. Often, the pharmaceutical development scientist is encountering challenging pharmaceutical properties of a given protein or by the demands placed on the product by stability, manufacturing and preclinical or clinical expectations, as well as the evolving regulatory expectations and landscape. Further, there have been new findings that require close assessment, as for example those related to excipient quality, processing, viscosity and device compatibility and administration, solubility and opalescence and container-closure selection. The literature varies widely in its discussion of these critical elements and consensus does not exist. This topic is receiving a great deal of attention within the biotechnology industry as well as with academic researchers and regulatory agencies globally. Therefore, this book is of interest for business leaders, researchers, formulation and process development scientists, analytical scientists, QA and QC officers, regulatory staff, manufacturing leaders and regulators active in the pharmaceutical and biotech industry, and expert reviewers in regulatory agencies.

Pharmaceutical Product Development Book

Pharmaceutical Product Development

  • Author : Vandana B. Patravale
  • Publisher : CRC Press
  • Release Date : 2016-05-25
  • Genre: Medical
  • Pages : 433
  • ISBN 10 : 9781498730785

Pharmaceutical Product Development Excerpt :

Pharmaceutical product development is a multidisciplinary activity involving extensive efforts in systematic product development and optimization in compliance with regulatory authorities to ensure the quality, efficacy and safety of resulting products. Pharmaceutical Product Development equips the pharmaceutical formulation scientist with extensive and up-to-date knowledge of drug product development and covers all steps from the beginning of product conception to the final packaged form that enters the market and lifecycle management thereof. Applications of core scientific principles for product development are also thoroughly discussed in conjunction with the latest approaches involving design of experiment and quality by design with comprehensive illustrations based on practical case studies of several dosage forms. The book presents pharmaceutical product development information in an easy-to-read mode with simplified theories, case studies and guidelines for students, academicians and professionals in the pharmaceutical industry. It is an invaluable resource and hands-on guide covering managerial, regulatory and practical aspects of pharmaceutical product lifecycle management.

Applied Surfactants Book

Applied Surfactants

  • Author : Tharwat F. Tadros
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-06
  • Genre: Science
  • Pages : 654
  • ISBN 10 : 9783527604531

Applied Surfactants Excerpt :

While currently available titles either focus on the basics or on very specific subtopics, this text meets the need for a comprehensive survey of surfactants and their properties, with a strong emphasis on applications and their correlation to the fundamentals. The author covers their classification, physical properties, phase behavior, adsorption, effects - such as wetting, spreading and adhesion - as well as industrial applications in personal care and cosmetics, pharmaceuticals, agrochemicals and food products. Professor Tadros is a well-known expert on the topic of surfactants, with much experience in colloid science. Here, he uses his industrial experience to close the gap between fundamentals of surfactants and their relevance and applications in practice.

Microbial Surfactants Book

Microbial Surfactants

  • Author : R.Z. Sayyed
  • Publisher : CRC Press
  • Release Date : 2022-06-09
  • Genre: Medical
  • Pages : 262
  • ISBN 10 : 9781000610840

Microbial Surfactants Excerpt :

Biosurfactants are the surface-active biomolecules produced by a wide range of microorganisms. The enormous diversity of biosurfactants make them an interesting group of molecules. Biosurfactants, are less toxic, eco-friendly and possess amphiphatic structure. Due to these and many other useful properties, biosurfactants play a significant role in oil recovery, waste utilization and bioremediation of industrial effluents; hydrocarbons, pesticides and toxic heavy metals and many other hazardous substances. Biosurfactants offer numerous advantages over chemical surfactants. They are environmentally friendly, can be produced from natural sources, less toxic, possess high specificity, have better foaming and emulsifying properties and survive extreme conditions such as high temperatures, extreme pH and salinity. They are cheaper as they can be produced from industrial waste and from by-products as opposed to chemical surfactants. This volume comprises concepts, classification, production and applications of biosurfactants in oil recovery, environment and clean up, etc. It is an excellent literature on fermentation, recovery, genomics and metagenomics of biosurfactant production. It is presented in an easy-to-understand manner, with well-illustrated diagrams, protocols, figures, and recent data on the production, formulation and commercialization and other aspects of biosurfactants. As such, the book will be useful for students, researchers, teachers, and entrepreneurs in the area of PGPR and its allied fields.

Cationic Amphiphiles Book

Cationic Amphiphiles

  • Author : Ferdinand Devinsky
  • Publisher : Unknown
  • Release Date : 2017-06
  • Genre: Uncategoriezed
  • Pages : 195
  • ISBN 10 : 1536119792

Cationic Amphiphiles Excerpt :

Surfactants play an essential role in our daily lives. Their form of usage varies from detergents and cleaning agents through disinfectants and solubilisers up to industrial applications such as paints, oil recovery, anti-corrosion protective coatings, etc. A special distinct class of surfactants is represented by a double-chain, double-head form of surfactant molecules, which are called gemini surfactants. Gemini surfactants show physicochemical and aggregation properties which are superior to those of conventional, single-chain surfactants. From the perspective of applications, an important group of gemini surfactants is represented by cationic gemini surfactants. They have found numerous applications in the various fields such as solubilisation, textile coating, organic and polymer synthesis, electrochemistry, paper industry, etc. One of the most developing areas of cationic gemini surfactants application is the field of pharmaceutical applications. Interaction of cationic surfactants with the oppositely charged cell membrane has been known for a long time. Cationic gemini surfactants turned out to be very efficient bactericidal and antimicrobial agents. Moreover, recent development in this field indicates a cancerostatic effect of cationic geminis through a selective interaction of cationic gemini molecules with cancer cells. Another revolutionary field of cationic gemini surfactants application is their interaction with an oppositely charged electrolyte such as DNA. The interaction of DNA with various positively charged systems such as cationic surfactants, polymers and lipids is of great importance with respect to gene transmission through a biological cell membrane to achieve a therapeutic effect in a cell nucleus. The ambition of this monograph is to provide a complex view of synthesis, structure-aggregation, properties-biological activity relationship and recent applications of cationic gemini surfactants in the pharmaceutical field. Individual chapters in

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals Book

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals

  • Author : Feroz Jameel
  • Publisher : John Wiley & Sons
  • Release Date : 2010-08-09
  • Genre: Science
  • Pages : 984
  • ISBN 10 : 9780470118122

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals Excerpt :

A real-world guide to the production and manufacturing of biopharmaceuticals While much has been written about the science of biopharmaceuticals, there is a need for practical, up-to-date information on key issues at all stages of developing and manufacturing commercially viable biopharmaceutical drug products. This book helps fill the gap in the field, examining all areas of biopharmaceuticals manufacturing, from development and formulation to production and packaging. Written by a group of experts from industry and academia, the book focuses on real-world methods for maintaining product integrity throughout the commercialization process, clearly explaining the fundamentals and essential pathways for all development stages. Coverage includes: Research and early development phase–appropriate approaches for ensuring product stability Development of commercially viable formulations for liquid and lyophilized dosage forms Optimal storage, packaging, and shipping methods Case studies relating to therapeutic monoclonal antibodies, recombinant proteins, and plasma fractions Useful analysis of successful and failed products Formulation and Process Development Strategies for Manufacturing Biopharma-ceuticals is an essential resource for scientists and engineers in the pharmaceutical and biotech industries, for government and regulatory agencies, and for anyone with an interest in the latest developments in the field.

Nanoemulsions Book
Score: 5
From 1 Ratings


  • Author : Seid Mahdi Jafari
  • Publisher : Academic Press
  • Release Date : 2018-02-24
  • Genre: Technology & Engineering
  • Pages : 664
  • ISBN 10 : 9780128118399

Nanoemulsions Excerpt :

Nanoemulsions: Formulation, Applications, and Characterization provides detailed information on the production, application and characterization of food nanoemulsion as presented by experts who share a wealth of experience. Those involved in the nutraceutical, pharmaceutical and cosmetic industries will find this a useful reference as it addresses findings related to different preparation and formulation methods of nanoemulsions and their application in different fields and products. As the last decade has seen a major shift from conventional emulsification processes towards nanoemulsions that both increase the efficiency and stability of emulsions and improve targeted drug and nutraceutical delivery, this book is a timely resource. Summarizes general aspects of food nanoemulsions and their formulation Provides detailed information on the production, application, and characterization of food nanoemulsion Reveals the potential of nanoemulsions, as well as their novel applications in functional foods, nutraceutical products, delivery systems, and cosmetic formulations Explains preparation of nanoemulsions by both low- and high-energy methods

Formulation tools for Pharmaceutical Development Book

Formulation tools for Pharmaceutical Development

  • Author : J E Aguilar
  • Publisher : Elsevier
  • Release Date : 2013-09-30
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9781908818508

Formulation tools for Pharmaceutical Development Excerpt :

A range of new and innovative tools used for preformulation and formulation of medicines help optimize pharmaceutical development projects. Such tools also assist with the performance evaluation of the pharmaceutical process, allowing any potential gaps to be identified. These tools can be applied in both basic research and industrial environment. Formulation tools for pharmaceutical development considers these key research and industrial tools. Nine chapters by leading contributors cover: Artificial neural networks technology to model, understand, and optimize drug formulations; ME_expert 2.0: a heuristic decision support system for microemulsions formulation development; Expert system for the development and formulation of push-pull osmotic pump tablets containing poorly water-soluble drugs; SeDeM Diagram: an expert system for preformulation, characterization and optimization of tables obtained by direct compression; New SeDeM-ODT expert system: an expert system for formulation of orodispersible tablets obtained by direct compression; and 3D-cellular automata in computer-aided design of pharmaceutical formulations: mathematical concept and F-CAD software. Coverage of artificial intelligence tools, new expert systems, understanding of pharmaceutical processes, robust development of medicines, and new ways to develop medicines Development of drugs and medicines using mathematical tools Compilation of expert system developed around the world

Encapsulations Book


  • Author : Alexandru Grumezescu
  • Publisher : Academic Press
  • Release Date : 2016-09-08
  • Genre: Science
  • Pages : 924
  • ISBN 10 : 9780128043783

Encapsulations Excerpt :

Encapsulations, a volume in the Nanotechnology in the Agri-Food Industry series,presents key elements in establishing food quality through the improvement of food flavor and aroma. The major benefits of nanoencapsulation for food ingredients include improvement in bioavailability of flavor and aroma ingredients, improvement in solubility of poor water-soluble ingredients, higher ingredient retention during production process, higher activity levels of encapsulated ingredients, improved shelf life, and controlled release of flavor and aroma. This volume discusses main nanoencapsulation processes such as spray drying, melt injection, extrusion, coacervation, and emulsification. The materials used in nanoencapsulation include lipids, proteins, carbohydrates, cellulose, gums, and food grade polymers. Applications and benefits of nanoencapsulation such as controlled release, protections, and taste masking will be explained in detail. Includes the most up-to-date information on nanoencapsulation and nanocontainer-based delivery of antimicrobials Presents nanomaterials for innovation based on scientific advancements in the field Provides control release strategies to enhance bioactivity, including methods and techniques for research and innovation Provides useful tools to improve the delivery of bioactive molecules and living cells into foods

Water Insoluble Drug Formulation  Third Edition Book

Water Insoluble Drug Formulation Third Edition

  • Author : Ron Liu
  • Publisher : CRC Press
  • Release Date : 2018-03-12
  • Genre: Medical
  • Pages : 736
  • ISBN 10 : 9781351646826

Water Insoluble Drug Formulation Third Edition Excerpt :

Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.