Synthesis of Best Seller Drugs Book

Synthesis of Best Seller Drugs


  • Author : Ruben Vardanyan
  • Publisher : Academic Press
  • Release Date : 2016-01-16
  • Genre: Uncategoriezed
  • Pages : 800
  • ISBN 10 : 012411492X

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Synthesis of Best Seller Drugs Excerpt :

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Synthesis of Best Seller Drugs Book

Synthesis of Best Seller Drugs


  • Author : Ruben Vardanyan
  • Publisher : Academic Press
  • Release Date : 2016-01-07
  • Genre: Science
  • Pages : 868
  • ISBN 10 : 9780124115248

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Synthesis of Best Seller Drugs Excerpt :

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

The Art of Drug Synthesis Book

The Art of Drug Synthesis


  • Author : Douglas S. Johnson
  • Publisher : John Wiley & Sons
  • Release Date : 2013-02-26
  • Genre: Science
  • Pages : 350
  • ISBN 10 : 9781118678466

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The Art of Drug Synthesis Excerpt :

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Synthesis of Essential Drugs Book
Score: 3
From 2 Ratings

Synthesis of Essential Drugs


  • Author : Ruben Vardanyan
  • Publisher : Elsevier
  • Release Date : 2006-03-10
  • Genre: Medical
  • Pages : 634
  • ISBN 10 : 008046212X

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Synthesis of Essential Drugs Excerpt :

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references

The Organic Chemistry of Drug Synthesis Book

The Organic Chemistry of Drug Synthesis


  • Author : Daniel Lednicer
  • Publisher : John Wiley & Sons
  • Release Date : 2007-12-14
  • Genre: Science
  • Pages : 288
  • ISBN 10 : 9780470180662

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The Organic Chemistry of Drug Synthesis Excerpt :

The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

An Introduction to Drug Synthesis Book

An Introduction to Drug Synthesis


  • Author : Graham L. Patrick
  • Publisher : Unknown
  • Release Date : 2015
  • Genre: Drugs
  • Pages : null
  • ISBN 10 : 0191073474

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An Introduction to Drug Synthesis Excerpt :

An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Pharmaceutical Process Chemistry for Synthesis Book

Pharmaceutical Process Chemistry for Synthesis


  • Author : Peter J. Harrington
  • Publisher : John Wiley & Sons
  • Release Date : 2011-02-23
  • Genre: Science
  • Pages : 376
  • ISBN 10 : 0470922869

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Pharmaceutical Process Chemistry for Synthesis Excerpt :

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Piperidine Based Drug Discovery Book

Piperidine Based Drug Discovery


  • Author : Ruben Vardanyan
  • Publisher : Elsevier
  • Release Date : 2017-06-12
  • Genre: Science
  • Pages : 358
  • ISBN 10 : 9780128134283

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Piperidine Based Drug Discovery Excerpt :

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Contemporary Drug Synthesis Book
Score: 1.5
From 2 Ratings

Contemporary Drug Synthesis


  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release Date : 2004-12-27
  • Genre: Science
  • Pages : 240
  • ISBN 10 : 9780471686736

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Contemporary Drug Synthesis Excerpt :

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Advances in Heterocyclic Chemistry Book

Advances in Heterocyclic Chemistry


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-05-21
  • Genre: Science
  • Pages : 274
  • ISBN 10 : 9780128155387

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Advances in Heterocyclic Chemistry Excerpt :

Advances in Heterocyclic Chemistry, Volume 126, is the definitive series in the field, one that is of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is used more frequently in explanations. Updates to this release include sections on The Literature of Heterocyclic Chemistry, Part XVI, 2016, The preparation and properties of heteroarylazulenes and hetero-fused azulenes, Recent developments in pyrazole chemistry, Yne, Ene-Yne Synthetic Approaches to Heterocycles, Appel Salt and Heterocycles: A review of Thirty Years of 4,5-Dichloro-1,2,3-dithiazolium Chloride Chemistry, and more. Written by established authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides timely, comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

Modern Drug Synthesis Book

Modern Drug Synthesis


  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release Date : 2013-03-27
  • Genre: Science
  • Pages : 355
  • ISBN 10 : 9781118701249

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Modern Drug Synthesis Excerpt :

Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

Medicinal Chemistry of Anticancer Drugs Book

Medicinal Chemistry of Anticancer Drugs


  • Author : Carmen Avendano
  • Publisher : Elsevier
  • Release Date : 2015-06-11
  • Genre: Science
  • Pages : 768
  • ISBN 10 : 9780444626677

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Medicinal Chemistry of Anticancer Drugs Excerpt :

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Strategies for Organic Drug Synthesis and Design Book
Score: 4
From 2 Ratings

Strategies for Organic Drug Synthesis and Design


  • Author : Daniel Lednicer
  • Publisher : John Wiley & Sons
  • Release Date : 2009-03-04
  • Genre: Science
  • Pages : 700
  • ISBN 10 : 0470399597

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Strategies for Organic Drug Synthesis and Design Excerpt :

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Innovative Drug Synthesis Book

Innovative Drug Synthesis


  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release Date : 2015-12-14
  • Genre: Science
  • Pages : 358
  • ISBN 10 : 9781118820056

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Innovative Drug Synthesis Excerpt :

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery

Chiral Drugs Book

Chiral Drugs


  • Author : Guo-Qiang Lin
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-08
  • Genre: Science
  • Pages : 472
  • ISBN 10 : 1118075633

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Chiral Drugs Excerpt :

An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.