Systems Biology and Its Application in TCM Formulas Research Book

Systems Biology and Its Application in TCM Formulas Research


  • Author : Wei-Dong Zhang
  • Publisher : Academic Press
  • Release Date : 2018-02-16
  • Genre: Medical
  • Pages : 380
  • ISBN 10 : 9780128127452

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Systems Biology and Its Application in TCM Formulas Research Excerpt :

Systems Biology and Its Application in TCM Formulas Research presents a theoretical research system formed for Traditional Chinese Medicine (TCM) formulas, along with information on the study of Shexiang Baoxin Pill (SBP), a TCM formula that has shown significant clinical efficacy in the treatment of cardiovascular diseases. The content combines theory and practice, and includes guidance for both theoretical concepts and operable technical routes. This is a valuable source not only for biomedical researchers involved in Systems Biology studies, but also for students and scientists interested in learning more about Traditional Chinese Medicine and its applications in contemporary medicine. Explains, in detail, the Shexiang Baoxin Pill (SBP), a TCM formula efficiently applied in the treatment of cardiovascular diseases Presents TCM formulas from perspectives of systems biology, basic chemical material groups, modern pharmacology and network biology Offers an overview on biology, modern chemistry and information technology as applied in Systems Biology research

Systems Biology for Traditional Chinese Medicine Book

Systems Biology for Traditional Chinese Medicine


  • Author : Guoan Luo
  • Publisher : John Wiley & Sons
  • Release Date : 2012-05-11
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 9781118313350

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Systems Biology for Traditional Chinese Medicine Excerpt :

The application of systems biology methods to TraditionalChinese Medicine Emphasizing the harmony of the human body with the environment,Traditional Chinese Medicine (TCM) has evolved over thousands ofyears. It is a systemic theory derived from clinical experience,the philosophy of holism and systematology, and the belief that manis an integral part of nature. Systems Biology for Traditional Chinese Medicinedescribes how the latest methods in systems biology can be appliedto TCM, providing a comprehensive resource for the modernizationand advancement of TCM as well as general drug discovery efforts.It is the first comprehensive work to propose a system-to-systemresearch methodology to study the interaction between TCM and thehuman body and its applications in drug research anddevelopment. Using three popular traditional Chinesemedicines—Shuanglongfang, Qingkailing, andLiushenwan—as examples, the authors set forth case examplesdemonstrating how to find material groups, perform efficacyscreenings, and conduct safety evaluations of TCM. The bookalso: Describes the mechanisms of TCM at the molecular and systemslevels using chemomics, genomics, proteomics, metabolomics, andbioinformatics Places modern scientific technologies within the context ofTCM, helping drug researchers improve experimental designs andstrategies Illustrates how a systems biology approach is compatible withTCM's traditional, holistic therapeutic strategies and treatmentmodalities Presents topics of current interest, such as integrated globalsystems biology and the application of chemometrics research toherbal medicines This book not only opens a new pathway for the continueddevelopment of TCM, but also for systems biology. In addition, itfosters collaboration and discussion among Eastern and Westernscientists by applying systems biology to TCM.

Systems Biology for Traditional Chinese Medicine Book

Systems Biology for Traditional Chinese Medicine


  • Author : Guoan Luo
  • Publisher : John Wiley & Sons
  • Release Date : 2012-07-03
  • Genre: Science
  • Pages : 518
  • ISBN 10 : 9780470637975

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Systems Biology for Traditional Chinese Medicine Excerpt :

The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.

Network Pharmacology Book

Network Pharmacology


  • Author : Shao Li
  • Publisher : Springer Nature
  • Release Date : 2021-09-29
  • Genre: Medical
  • Pages : 480
  • ISBN 10 : 9789811607530

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Network Pharmacology Excerpt :

This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.

Traditional Chinese Medicine Book

Traditional Chinese Medicine


  • Author : James D Adams
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-10-20
  • Genre: Science
  • Pages : 349
  • ISBN 10 : 9781782624936

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Traditional Chinese Medicine Excerpt :

Traditional Chinese medicine has a strong scientific basis, but the science of these important preparations is often rarely discussed. Western approaches often simplify traditional Chinese medicine to drug discovery in Chinese plants, however, the majority of traditional Chinese medications use complex mixtures of plant extracts, rather than single purified drugs. The combination of different extracts is based on yin, yang and chi theories, which are often poorly understood in the West. Yin and yang are known to be the balance of agonists and antagonists, whereas chi derives from signalling processes in the body and regulates bodily functions. Traditional Chinese medical practitioners understand that yin, yang and chi constantly interact in the body to maintain health. Western medical practitioners understand how to use agonists and antagonists and how to modify signalling processes, but generally do not accept the use of complex plant extracts to perform these functions. Aimed at medical scientists, and including detailed explanations of the theories behind the science, this text may help researchers to understand, and communicate more effectively with, Chinese medical practitioners and will lead to greater acceptance of traditional medications in the West. Presenting a clear rationale for the use of traditional Chinese medications in Western medical facilities, it enables scientists to find new directions in experimental design and encourage examination of these useful, but often poorly understood, preparations in clinical trials.

Traditional Chinese Medicine and Diseases Book

Traditional Chinese Medicine and Diseases


  • Author : Kang Ning
  • Publisher : Springer Nature
  • Release Date : 2022-10-03
  • Genre: Medical
  • Pages : 144
  • ISBN 10 : 9789811947711

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Traditional Chinese Medicine and Diseases Excerpt :

This book focuses on the multi-omics big-data integration, the data-mining techniques and the cutting-edge omics researches in principles and applications for a deep understanding of Traditional Chinese Medicine (TCM) and diseases from the following aspects: (1) Basics about multi-omics data and analytical methods for TCM and diseases. (2) The needs of omics studies in TCM researches, and the basic background of omics research in TCM and disease. (3) Better understanding of the multi-omics big-data integration techniques. (4) Better understanding of the multi-omics big-data mining techniques, as well as with different applications, for most insights from these omics data for TCM and disease researches. (5) TCM preparation quality control for checking both prescribed and unexpected ingredients including biological and chemical ingredients. (6) TCM preparation source tracking. (7) TCM preparation network pharmacology analysis. (8) TCM analysis data resources, web services, and visualizations. (9) TCM geoherbalism examination and authentic TCM identification. Traditional Chinese Medicine has been in existence for several thousands of years, and only in recent tens of years have we realized that the researches on TCM could be profoundly boosted by the omics technologies. Devised as a book on TCM and disease researches in the omics age, this book has put the focus on data integration and data mining methods for multi-omics researches, which will be explained in detail and with supportive examples the “What”, “Why” and “How” of omics on TCM related researches. It is an attempt to bridge the gap between TCM related multi-omics big data, and the data-mining techniques, for best practice of contemporary bioinformatics and in-depth insights on the TCM related questions.

Biotechnology of Anti diabetic Medicinal Plants Book

Biotechnology of Anti diabetic Medicinal Plants


  • Author : Saikat Gantait
  • Publisher : Springer Nature
  • Release Date : 2021-11-13
  • Genre: Medical
  • Pages : 482
  • ISBN 10 : 9789811635298

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Biotechnology of Anti diabetic Medicinal Plants Excerpt :

This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.

The Science and Regulations of Naturally Derived Complex Drugs Book

The Science and Regulations of Naturally Derived Complex Drugs


  • Author : Ram Sasisekharan
  • Publisher : Springer
  • Release Date : 2019-04-23
  • Genre: Medical
  • Pages : 331
  • ISBN 10 : 9783030117511

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The Science and Regulations of Naturally Derived Complex Drugs Excerpt :

This volume in the AAPS Advances series covers various quality, safety and clinical aspects of drug development that are relevant to new and/or generic drugs containing a complex mixture of molecules. Specific topics discussed include: raw materials sourcing; manufacturing controls; characterization; identification of critical product quality components and attributes; identification of impurities, particularly as they bear on toxicity and immunogenicity; clinical trial study design considerations, and the regulatory science applications to development of such complex mixtures. Complex mixtures are challenging to characterize and analyze using standard methods. Further challenges extend throughout the product development cycle from raw material control to clinical study design. The regulatory landscape is rapidly changing as new types of complex mixtures are introduced into clinical trials and to the market (e.g., traditional Chinese medicines and medical marijuana products), while older products are facing generic competition for the first time (e.g., enoxaparin). The future outlook for complex generic drug products, as opposed to the more commonly developed targeted single agent drug products is not clear. The risks pertaining to lack of a full understanding of raw material control, process and controls in manufacture, as well as characterization of a complex mixture were seen vividly during the heparin crisis of 2008. As such powerful lessons have been learned about the regulatory science specific to complex products. The Science and Regulations of Naturally Derived Complex Drugs addresses the interests among industry, academics, and government on the issues surrounding the future development of mixtures for medicinal use.

Intelligent Computing Theories and Application Book

Intelligent Computing Theories and Application


  • Author : De-Shuang Huang
  • Publisher : Springer
  • Release Date : 2019-09-22
  • Genre: Computers
  • Pages : 790
  • ISBN 10 : 9783030269692

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Intelligent Computing Theories and Application Excerpt :

This two-volume set of LNCS 11643 and LNCS 11644 constitutes - in conjunction with the volume LNAI 11645 - the refereed proceedings of the 15th International Conference on Intelligent Computing, ICIC 2019, held in Nanchang, China, in August 2019. The 217 full papers of the three proceedings volumes were carefully reviewed and selected from 609 submissions. The ICIC theme unifies the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in advanced computational intelligence and bridges theoretical research with applications. The theme for this conference is “Advanced Intelligent Computing Methodologies and Applications.” Papers related to this theme are especially solicited, including theories, methodologies, and applications in science and technology.

Veterinary Herbal Medicine Book
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Veterinary Herbal Medicine


  • Author : Susan G. Wynn
  • Publisher : Elsevier Health Sciences
  • Release Date : 2006-11-29
  • Genre: Medical
  • Pages : 736
  • ISBN 10 : 9780323029988

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Veterinary Herbal Medicine Excerpt :

This full-color reference offers practical, evidence-based guidance on using more than 120 medicinal plants, including how to formulate herbal remedies to treat common disease conditions. A body-systems based review explores herbal medicine in context, offering information on toxicology, drug interactions, quality control, and other key topics. More than 120 herbal monographs provide quick access to information on the historical use of the herb in humans and animals, supporting studies, and dosing information. Includes special dosing, pharmacokinetics, and regulatory considerations when using herbs for horses and farm animals. Expanded pharmacology and toxicology chapters provide thorough information on the chemical basis of herbal medicine. Explores the evolutionary relationship between plants and mammals, which is the basis for understanding the unique physiologic effects of herbs. Includes a body systems review of herbal remedies for common disease conditions in both large and small animals. Discusses special considerations for the scientific research of herbs, including complex and individualized interventions that may require special design and nontraditional outcome goals.

Chinmedomics Book

Chinmedomics


  • Author : Xijun Wang
  • Publisher : Academic Press
  • Release Date : 2015-07-15
  • Genre: Medical
  • Pages : 408
  • ISBN 10 : 9780128031186

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Chinmedomics Excerpt :

Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications Edited by the leading experts of research related to Chinmedomics

Neurobiology of Chinese Herb Medicine Book

Neurobiology of Chinese Herb Medicine


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-08-11
  • Genre: Science
  • Pages : 330
  • ISBN 10 : 9780128117804

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Neurobiology of Chinese Herb Medicine Excerpt :

Neurobiology of Chinese Herb Medicine, Volume 135 is a valuable book for anyone interested in alternative medicine or the scientific research surrounding ancient herbal medicine. This updated volume in the series includes chapters that delve into timely topics, including the Effects of Lycium Barbarum on the Visual System, the Effect of Chinese Herbal Medicine on Alzheimer’s Disease, the Effect and Mechanism of Chinese Herbal Medicine on Parkinson’s Disease, the Neurobiology of Chinese Herbal Medicine on Major Depressive Disorder, the Treatment of Insomnia with Traditional Chinese Herbal Medicine, and the Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases. This series is ideal for Chinese herbal medicine practitioners who are working in a clinical environment, although the clinical applications of Chinese medicinal herbs presented provide useful references and guidance for any clinical practice that specializes in the treatment of various conditions. Presents a wealth of information on the use of Chinese herbal medicine and its application to many conditions Provides basic research and clinical studies of Chinese herbal medicines, either as compounds/extracts or formulas Sheds light on possible action mechanisms of many Chinese herbal medicines

Chinese Drugs of Plant Origin Book

Chinese Drugs of Plant Origin


  • Author : Weici Tang
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • Genre: Medical
  • Pages : 1056
  • ISBN 10 : 9783642737398

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Chinese Drugs of Plant Origin Excerpt :

Traditional Chinese medicine has been used for thousands of years by a large population. It is currently still serving many of the health needs of the Chinese people; and still enjoying their confi dence it is practised in China in parallel with modern Western medical treatment. In addition to scientific organisations dedi cated to modern Western medicine, e. g. the Chinese Academy of Medical Sciences and various medical schools, a series of parallel institutions have been established in China to promote traditional Chinese medicine, such as the Academy of Traditional Chinese Medicine and training institutions. Almost all hospitals in China have a department of traditional medicine. Furthermore, a large number of scientific journals are dedicated to traditional Chinese medicine, covering both experimental and clinical investigations. Medicinal materials constitute a key topic in the treatment of disease according to traditional Chinese medicine. The Chinese Pharmacopoeia (1985 edition) is therefore divided into two sepa rate volumes, Volume I containing traditional Chinese medicinal materials and preparations and Volume II containing pharmaceu tics of Western medicine. The oldest Chinese review of medicinal materials, Shennong Bencao Jing (100-200 A. D. ), covered 365 herbal drugs. The clas sic compilation in this field, Bencao Gangmu (Compendium of Materia Medica), was published in 1578 by Li Shi-zhen and recorded as many as 1898 crude drugs of plant, animal and min eral origin.

Model Organisms in Drug Discovery Book

Model Organisms in Drug Discovery


  • Author : Pamela M. Carroll
  • Publisher : John Wiley & Sons
  • Release Date : 2004-04-21
  • Genre: Science
  • Pages : 302
  • ISBN 10 : 9780470871300

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Model Organisms in Drug Discovery Excerpt :

Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

Network Pharmacology and Traditional Medicine Book

Network Pharmacology and Traditional Medicine


  • Author : Shao Li
  • Publisher : Frontiers Media SA
  • Release Date : 2020-10-08
  • Genre: Medical
  • Pages : 438
  • ISBN 10 : 9782889660407

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Network Pharmacology and Traditional Medicine Excerpt :

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.