Targeting the DNA Damage Response for Anti Cancer Therapy Book

Targeting the DNA Damage Response for Anti Cancer Therapy


  • Author : John Pollard
  • Publisher : Springer
  • Release Date : 2018-05-26
  • Genre: Medical
  • Pages : 401
  • ISBN 10 : 9783319758367

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Targeting the DNA Damage Response for Anti Cancer Therapy Excerpt :

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR. In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.

DNA Repair in Cancer Therapy Book

DNA Repair in Cancer Therapy


  • Author : Mark R. Kelley
  • Publisher : Academic Press
  • Release Date : 2016-06-07
  • Genre: Medical
  • Pages : 464
  • ISBN 10 : 9780128035993

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DNA Repair in Cancer Therapy Excerpt :

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Fragment Based Drug Discovery Book

Fragment Based Drug Discovery


  • Author : Steven Howard
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-07-03
  • Genre: Medical
  • Pages : 264
  • ISBN 10 : 9781849739085

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Fragment Based Drug Discovery Excerpt :

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

The Cancer Handbook Book

The Cancer Handbook


  • Author : Malcolm Alison
  • Publisher : Palgrave Macmillan
  • Release Date : 2002
  • Genre: Medical
  • Pages : 1723
  • ISBN 10 : UOM:39015051550526

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The Cancer Handbook Excerpt :

Provides a comprehensive overview of all major areas of cancer research and oncology. Bridging the gap between the molecular biology of cancer and clinical diagnosis and treatment, this online reference work provides a resource for medical and life sciences students, as well as all scientists, clinicians and researchers working in the cancer field and related biomedical areas.

New Research Directions in DNA Repair Book

New Research Directions in DNA Repair


  • Author : Clark Chen
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-05-22
  • Genre: Medical
  • Pages : 674
  • ISBN 10 : 9789535111146

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New Research Directions in DNA Repair Excerpt :

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Advances in DNA Repair in Cancer Therapy Book

Advances in DNA Repair in Cancer Therapy


  • Author : Lawrence Panasci
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-09
  • Genre: Medical
  • Pages : 312
  • ISBN 10 : 9781461447412

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Advances in DNA Repair in Cancer Therapy Excerpt :

​A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.​

DNA Repair and Cancer Book

DNA Repair and Cancer


  • Author : Srinivasan Madhusudan
  • Publisher : CRC Press
  • Release Date : 2013-01-22
  • Genre: Medical
  • Pages : 718
  • ISBN 10 : 9781466577442

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DNA Repair and Cancer Excerpt :

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

Cell Cycle Regulation Book

Cell Cycle Regulation


  • Author : Philipp Kaldis
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-06-26
  • Genre: Medical
  • Pages : 374
  • ISBN 10 : UVA:X030151344

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Cell Cycle Regulation Excerpt :

This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.

Molecular Therapies of Cancer Book

Molecular Therapies of Cancer


  • Author : Georg F. Weber
  • Publisher : Springer
  • Release Date : 2015-07-22
  • Genre: Medical
  • Pages : 488
  • ISBN 10 : 9783319132785

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Molecular Therapies of Cancer Excerpt :

Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

Characterization of a SUMO Ligase that is Essential for DNA Damage Induced NF Kappa B Activation Book

Characterization of a SUMO Ligase that is Essential for DNA Damage Induced NF Kappa B Activation


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Genre: Uncategoriezed
  • Pages : 39
  • ISBN 10 : OCLC:318694736

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Characterization of a SUMO Ligase that is Essential for DNA Damage Induced NF Kappa B Activation Excerpt :

It has been recently proposed that inhibition of NF-?B may be a therapeutic target for the treatment of ER- breast cancers. As of now, the majority of NF-?B inhibitors focus on the key signal integrating complex known as the I?B kinase (IKK) complex. Since NF-?B plays a major role in many essential physiological processes in the cell, global inhibition of NF-?B at the central IKK complex could allow for increased risk of side effects as well as the desirable effects on cancer cell death. Hence, identification of specific, novel molecular targets in the NF-?B signaling pathway may lead to the identification of more specific NF-?B inhibitors. Our hypothesis is that PIASy, a SUMO ligase, is essential for DNA damage induced NF-?B activation, however is not critical for classical activation of NF-?B, leaving the more physiological pathway intact. We reveal that PIASy is signaling at the level of NEMO SUMOylation, a posttranslational modification that we recently identified being critical for DNA damage induced activation of NF-?B. Reduction of PIASy through siRNA caused inhibition of NF-?B in response to multiple DNA damaging agents commonly used in anti-cancer therapy. We provide strong evidence that PIASy is working at the level of NEMO SUMOylation and propose that PIASy is the SUMO ligase for NEMO. Furthermore, we show that the catalytic activity of PIASy is essential for NF-?B activation and hence suggest that inhibition of PIASy may be used as a more specific inhibitor in anti-cancer therapy to treat ER- breast cancer.

Childhood Cancer in Britain Book

Childhood Cancer in Britain


  • Author : Charles Stiller
  • Publisher : Oxford University Press
  • Release Date : 2007-02-15
  • Genre: Medical
  • Pages : 270
  • ISBN 10 : 9780198520702

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Childhood Cancer in Britain Excerpt :

Cancer is diagnosed in about 140 per million children in Britain each year. There is a 1 in 500 chance that a child will be affected in the first 15 years of life, the most frequently occurring types of cancer being leukaemia and brain tumours. This book covers the descriptive epidemiology of childhood cancer in Britain, based on the unique work of the National Registry of Childhood Tumours, the largest population-based specialist childhood cancer registry in the world. The book provides a detailed account of national incidence and survival rates for childhood cancer in Britain during 1991-2000, and trends during 1966-2000. There is also an account of childhood mortality for the period 1965-2004. The diagnoses are classified throughout according to the International Classification of Childhood Cancer, the first time the third edition of this standard classification has been used for prevalence of incidence, survival and mortality data. The chapter on incidence rates is relevant to planning of health service provision and design of research studies on aetiology, whilst the chapter on trends in incidence is relevant to the possible effects of changes in environmental and other risk factors. In addition to comprehensive tables of rates, age-incidence graphs are provided for all the major types of childhood cancer, and possible artefacts are also discussed. The survival data demonstrates how clinical progress over the past 40 years has led to a major increase in the number of cancer survivors. The role of the Registry, covering history, methodology, current and future uses, is also discussed. This definitive work is the culmination of decades of epidemiological research and is essential reading for anyone involved in paediatric oncology or cancer epidemiology.

PARP Inhibitors for Cancer Therapy Book

PARP Inhibitors for Cancer Therapy


  • Author : Nicola J. Curtin
  • Publisher : Humana Press
  • Release Date : 2015-06-13
  • Genre: Medical
  • Pages : 591
  • ISBN 10 : 9783319141510

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PARP Inhibitors for Cancer Therapy Excerpt :

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

The DNA Damage Response  Implications on Cancer Formation and Treatment Book

The DNA Damage Response Implications on Cancer Formation and Treatment


  • Author : Kum Kum Khanna
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-09-18
  • Genre: Medical
  • Pages : 449
  • ISBN 10 : 9048125618

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The DNA Damage Response Implications on Cancer Formation and Treatment Excerpt :

The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

Handbook of Targeted Cancer Therapy Book

Handbook of Targeted Cancer Therapy


  • Author : Daniel D. Karp
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2014-09-09
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 9781469894584

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Handbook of Targeted Cancer Therapy Excerpt :

Make optimal use of the latest personalized therapeutic strategies with Handbook of Targeted Cancer Therapy! This concise, practical oncology reference examines more than 140 targeted therapy agents for which clinical trial data are available, and explains when and how you can use them to most effectively combat cancer. Approach clinical challenges from any direction with separate sections on Targets by Organ Site, Carcinogenesis from the Perspective of Targeted Therapy, Molecular Targets and Pathways, and Targeted Therapy Agents. Find information easily thanks to a color-coded format and an intuitive organization. Access the complete contents online and on mobile devices, with regular updates to include newly approved treatments. Important state of the art cancer information for caregivers, researchers, other health care professionals, and even patients

Checkpoint Responses in Cancer Therapy Book

Checkpoint Responses in Cancer Therapy


  • Author : Wei Dai
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-05-01
  • Genre: Medical
  • Pages : 314
  • ISBN 10 : 9781597452748

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Checkpoint Responses in Cancer Therapy Excerpt :

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.