The Biology of Human Longevity Book

The Biology of Human Longevity


  • Author : Caleb E. Finch
  • Publisher : Elsevier
  • Release Date : 2010-07-28
  • Genre: Medical
  • Pages : 640
  • ISBN 10 : 0080545947

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The Biology of Human Longevity Excerpt :

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

The Biology of Human Longevity Book

The Biology of Human Longevity


  • Author : Caleb Ellicott Finch
  • Publisher : Unknown
  • Release Date : 2007
  • Genre: Medical
  • Pages : 626
  • ISBN 10 : 0123736579

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The Biology of Human Longevity Excerpt :

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. * Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists * Provides a novel synthesis of existing ideas about the biology of longevity and aging * Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

Human Longevity  Individual Life Duration  and the Growth of the Oldest Old Population Book

Human Longevity Individual Life Duration and the Growth of the Oldest Old Population


  • Author : Jean-Marie Robine
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-03-21
  • Genre: Social Science
  • Pages : 442
  • ISBN 10 : 9781402048487

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Human Longevity Individual Life Duration and the Growth of the Oldest Old Population Excerpt :

Old-age survival has considerably improved in the second half of the twentieth century. Why has such a substantial extension of human lifespan occurred? How long can we live? In this book, these fundamental questions are explored by experts from diverse fields. They report on recent cutting-edge studies about essential issues of human longevity and social factors of long survival in old age.

Human Longevity Book

Human Longevity


  • Author : Raymond C. Valentine
  • Publisher : CRC Press
  • Release Date : 2014-09-18
  • Genre: Medical
  • Pages : 259
  • ISBN 10 : 9781466594876

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Human Longevity Excerpt :

More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman’s famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membrane oxidation introduced in this book. This concept is consistent with recent discoveries showing that mitochondria-targeted antioxidants prevent Huntington’s disease, Parkinson’s disease, and traumatic brain disease in animal models of neurodegeneration. This book explores a unified theory of aging based on bioenergetics. It covers a variety of topics including an introduction to the science of human aging, the Darwinian selection of membranes enabling longevity, a revised mitochondrial membrane hypothesis of aging, and various mechanisms that protect human mitochondrial membranes, thereby enabling longevity.

The Longevity Book Book

The Longevity Book


  • Author : Cameron Diaz
  • Publisher : HarperThorsons
  • Release Date : 2016-04-07
  • Genre: Uncategoriezed
  • Pages : 288
  • ISBN 10 : 000813961X

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The Longevity Book Excerpt :

From Cameron Diaz, the #1 New York Times bestselling author of The Body Book, comes a fresh, personal, and authoritative examination of the art and science of growing older and a roadmap for abundant health and resilience as we age.

Handbook of the Biology of Aging Book

Handbook of the Biology of Aging


  • Author : Matt Kaeberlein
  • Publisher : Academic Press
  • Release Date : 2015-08-20
  • Genre: Medical
  • Pages : 576
  • ISBN 10 : 9780124116207

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Handbook of the Biology of Aging Excerpt :

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Biomarkers of Human Aging Book

Biomarkers of Human Aging


  • Author : Alexey Moskalev
  • Publisher : Springer Nature
  • Release Date : 2019-09-13
  • Genre: Science
  • Pages : 421
  • ISBN 10 : 9783030249700

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Biomarkers of Human Aging Excerpt :

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Longevity  Senescence  and the Genome Book

Longevity Senescence and the Genome


  • Author : Caleb E. Finch
  • Publisher : University of Chicago Press
  • Release Date : 1994-05-16
  • Genre: Science
  • Pages : 938
  • ISBN 10 : 0226248895

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Longevity Senescence and the Genome Excerpt :

Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.

Biology of Aging Book

Biology of Aging


  • Author : Robert Arking
  • Publisher : Oxford University Press
  • Release Date : 2006-02-02
  • Genre: FAMILY & RELATIONSHIPS
  • Pages : 604
  • ISBN 10 : 9780195167399

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Biology of Aging Excerpt :

Robert Arking's Biology of Aging is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging.

Human Longevity Book

Human Longevity


  • Author : David W. E. Smith
  • Publisher : Oxford University Press, USA
  • Release Date : 1993
  • Genre: Foreign Language Study
  • Pages : 175
  • ISBN 10 : UOM:39015029855874

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Human Longevity Excerpt :

This absorbing, balanced account of human longevity draws together information from the fields of medicine, biology, demography, epidemiology, gerontology, and sociology. It describes the history and present status of human longevity and deals in logical sequence with the questions this subject raises. The book illustrates how life expectancy has increased in most countries due, in part, to changing causes of death. It examines the biological determinants of longevity and analyzes social and behavioral factors that may reduce longevity. The book covers the reasons why women live longer than men. It asks why the maximum human life span is nearly twice that of any other warm-blooded animal and much longer than required for reproductive success, and it discusses factors that were involved in the evolution of longevity. It presents predictable increases in human life expectancy and explores the possibility that the maximum human life expectancy may become even longer. Accessible, comprehensive, and original, this book provides a multidisciplinary synthesis of ideas and conclusions about human longevity. It will have wide appeal to professionals in the many areas concerned with longevity as well as lay readers.

Aging Book

Aging


  • Author : Stuart Jay Olshansky
  • Publisher : Unknown
  • Release Date : 2015-11-01
  • Genre: MEDICAL
  • Pages : 256
  • ISBN 10 : 1621820807

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Aging Excerpt :

Aging is one of the greatest challenges currently facing society. People are living longer than ever, but many of the later years are fraught with frailty and disease, placing enormous burden on health-care systems. Understanding the biological changes that occur during aging and developing strategies to address them are therefore urgently needed. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of aging, strategies that may extend health span, and the societal implications of delayed aging. Contributors discuss genetic variants that accelerate or protect against aging, biochemical pathways that modulate longevity (e.g., mTOR), biological consequences of aging (e.g., decline in stem cell function), and various animal models used to study aging processes. They emphasize that age-delaying interventions will yield greater health and vitality than disease-specific treatments. Drugs that may promote health span or longevity (e.g., metformin) and efforts to prevent and treat frailty (e.g., through exercise) are explored. The authors consider the socioeconomic benefits and costs of delayed aging and also outline directions for future research and translational efforts. This volume will serve as a vital reference for all involved in the fields of geroscience and geriatric medicine, as well as anyone wishing to understand physiological processes that generate health and disease, regardless of chronological age.

Lifespan Book
Score: 3.5
From 6 Ratings

Lifespan


  • Author : David A. Sinclair
  • Publisher : Atria Books
  • Release Date : 2019-09-10
  • Genre: Science
  • Pages : 432
  • ISBN 10 : 9781501191978

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Lifespan Excerpt :

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Senescence Book

Senescence


  • Author : Jolanta Dorszewska
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-08-30
  • Genre: Medical
  • Pages : 166
  • ISBN 10 : 9789535134619

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Senescence Excerpt :

In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.

Between Zeus and the Salmon Book

Between Zeus and the Salmon


  • Author : National Research Council
  • Publisher : National Academy Press
  • Release Date : 1997-10-29
  • Genre: Science
  • Pages : 304
  • ISBN 10 : NAP:13236

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Between Zeus and the Salmon Excerpt :

Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.