The Cellular Secretome and Organ Crosstalk Book

The Cellular Secretome and Organ Crosstalk


  • Author : Jurgen Eckel
  • Publisher : Academic Press
  • Release Date : 2018-06
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 0128095180

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The Cellular Secretome and Organ Crosstalk Excerpt :

The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease. Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development. Summarizes our current knowledge on the secretome of different cells and tissues Dissects auto-, para- and endocrine functions of major secreted peptides and proteins Analyzes the secretory malfunction of different cells and its impact for disease development Authored by a leader in the field, presenting a coherent view on this very complex topic

The Cellular Secretome and Organ Crosstalk Book

The Cellular Secretome and Organ Crosstalk


  • Author : Juergen Eckel
  • Publisher : Academic Press
  • Release Date : 2018-06-12
  • Genre: Science
  • Pages : 240
  • ISBN 10 : 9780128097199

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The Cellular Secretome and Organ Crosstalk Excerpt :

The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease. Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development. Summarizes our current knowledge on the secretome of different cells and tissues Dissects auto-, para- and endocrine functions of major secreted peptides and proteins Analyzes the secretory malfunction of different cells and its impact for disease development Authored by a leader in the field, presenting a coherent view on this very complex topic

Scientific Principles of Adipose Stem Cells Book

Scientific Principles of Adipose Stem Cells


  • Author : Lauren Kokai
  • Publisher : Academic Press
  • Release Date : 2021-09-01
  • Genre: Science
  • Pages : 484
  • ISBN 10 : 9780128193778

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Scientific Principles of Adipose Stem Cells Excerpt :

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications

Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity Book

Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity


  • Author : Takeshi Yoneshiro
  • Publisher : Frontiers Media SA
  • Release Date : 2020-12-28
  • Genre: Science
  • Pages : 187
  • ISBN 10 : 9782889662821

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Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity Excerpt :

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

The Biology and Therapeutic Application of Mesenchymal Cells  2 Volume Set Book

The Biology and Therapeutic Application of Mesenchymal Cells 2 Volume Set


  • Author : Kerry Atkinson
  • Publisher : John Wiley & Sons
  • Release Date : 2017-01-17
  • Genre: Science
  • Pages : 1080
  • ISBN 10 : 9781118907511

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The Biology and Therapeutic Application of Mesenchymal Cells 2 Volume Set Excerpt :

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.

Dental Stem Cells  Regenerative Potential Book

Dental Stem Cells Regenerative Potential


  • Author : Barbara Zavan
  • Publisher : Humana Press
  • Release Date : 2016-07-25
  • Genre: Science
  • Pages : 287
  • ISBN 10 : 9783319332994

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Dental Stem Cells Regenerative Potential Excerpt :

This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.

Crosstalk between the osteogenic and neurogenic stem cell niches  how far are they from each other  Book

Crosstalk between the osteogenic and neurogenic stem cell niches how far are they from each other


  • Author : Wanda Lattanzi
  • Publisher : Frontiers Media SA
  • Release Date : 2016-03-14
  • Genre: Electronic book
  • Pages : 104
  • ISBN 10 : 9782889197774

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Crosstalk between the osteogenic and neurogenic stem cell niches how far are they from each other Excerpt :

Somatic stem cells reside in definite compartments, known as "niches", within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organism, including brain and heart. (HSCs) and mesenchymal stem cells (MSCs), that intensely interacts. HSCs represent the common precursors of all mature blood cells. (Bone, cartilage, blood vessels, adipose tissue, and.), And in the case of the skeletal muscle Supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal linesages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors' lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreak of the disease is the most important cause of neurodegeneration and neurological disorders, including the development of neurological disorders. Based on this research, the research group is interested in the development of new technologies, and in the field of research and development. The results of the study are summarized in the following sections: In vivo transplantation, has been covered.

Pericyte Biology in Different Organs Book

Pericyte Biology in Different Organs


  • Author : Alexander Birbrair
  • Publisher : Springer
  • Release Date : 2019-04-01
  • Genre: Science
  • Pages : 277
  • ISBN 10 : 9783030110932

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Pericyte Biology in Different Organs Excerpt :

The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.

Extracellular Matrix Degradation Book

Extracellular Matrix Degradation


  • Author : William C. Parks
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-07
  • Genre: Science
  • Pages : 255
  • ISBN 10 : 9783642168611

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Extracellular Matrix Degradation Excerpt :

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Muscle and Exercise Physiology Book

Muscle and Exercise Physiology


  • Author : Jerzy A. Zoladz
  • Publisher : Academic Press
  • Release Date : 2018-11-05
  • Genre: Science
  • Pages : 618
  • ISBN 10 : 9780128145944

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Muscle and Exercise Physiology Excerpt :

Muscle and Exercise Physiology is a comprehensive reference covering muscle and exercise physiology, from basic science to advanced knowledge, including muscle power generating capabilities, muscle energetics, fatigue, aging and the cardio-respiratory system in exercise performance. Topics presented include the clinical importance of body responses to physical exercise, including its impact on oxygen species production, body immune system, lipid and carbohydrate metabolism, cardiac energetics and its functional reserves, and the health-related effects of physical activity and inactivity. Novel topics like critical power, ROS and muscle, and heart muscle physiology are explored. This book is ideal for researchers and scientists interested in muscle and exercise physiology, as well as students in the biological sciences, including medicine, human movements and sport sciences. Contains basic and state-of-the-art knowledge on the most important issues of muscle and exercise physiology, including muscle and body adaptation to physical training, the impact of aging and physical activity/inactivity Provides both the basic and advanced knowledge required to understand mechanisms that limit physical capacity in both untrained people and top class athletes Covers advanced content on muscle power generating capabilities, muscle energetics, fatigue and aging

Nutrition and Enhanced Sports Performance Book

Nutrition and Enhanced Sports Performance


  • Author : Debasis Bagchi
  • Publisher : Academic Press
  • Release Date : 2013-07-26
  • Genre: Technology & Engineering
  • Pages : 568
  • ISBN 10 : 9780123964779

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Nutrition and Enhanced Sports Performance Excerpt :

Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength provides a comprehensive overview to understanding the integrated impact of nutrition on performance. The book is divided into five main themes: An introductory overview of the role of nutrition in human health Various types of physical exercises, including cardiovascular training, resistance training, aerobic and anaerobic exercise, bioenergetics, and energy balance. This section also covers the nutritional requirements associated with various fitness programs, as well as exercise and nutritional requirements in special populations, including the pre-pubertal, young, elderly, and disabled. Sports and nutritional requirements. The molecular mechanisms involved in muscle building A thorough review of various food, minerals, supplements, phytochemicals, amino acids, transition metals, small molecules and other ergogenic agents that have been implicated in muscle building and human performance This book is an ideal resource for nutritionists, dietitians, exercise physiologists, health practitioners, researchers, students, athletes, trainers, and all those who wish to broaden their knowledge of nutrition and its role in human performance. Discusses the impact of nutrition, including food, minerals, vitamins, hormones, trace elements, etc., that can significantly attenuate/improve human performance and sports Addresses the molecular and cellular pathways involved in the physiology of muscle growth and the mechanisms by which nutrients affect muscle health, growth and maintenance Encompasses multiple forms of sports/performance and the salient contribution of appropriate nutrition on special populations, including nutritional guidelines and recommendations to athletes Strong focus on muscle building

Hormones  Metabolism and the Benefits of Exercise Book

Hormones Metabolism and the Benefits of Exercise


  • Author : Bruce Spiegelman
  • Publisher : Springer
  • Release Date : 2018-03-07
  • Genre: Science
  • Pages : 102
  • ISBN 10 : 9783319727905

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Hormones Metabolism and the Benefits of Exercise Excerpt :

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

The Plasticity of Skeletal Muscle Book

The Plasticity of Skeletal Muscle


  • Author : Kunihiro Sakuma
  • Publisher : Springer
  • Release Date : 2017-03-01
  • Genre: Medical
  • Pages : 292
  • ISBN 10 : 9789811032929

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The Plasticity of Skeletal Muscle Excerpt :

This book discusses recent advances and various topics in plasticity of skeletal muscle from the perspectives of morphology, biological function, and clinical applications. Skeletal muscle is a highly plastic organ to adapt to environmental various demands, appears to endocrine various myokines, which flow into blood to protect the recognizing function of brain and inhibit the appearance of several cancer tumorigenesis. The book deals with current stem-cell based, pharmacological, and nutritional therapies for muscle wasting (sarcopenia, cachexia, and muscular dystrophy). It also explains the roles of biological mediators such as PGC-1, transient receptor potential cation channels (TRPC), and AMPK in modulating muscle function. The functional roles of ubiquitin-proteasome system, autophagy-dependent signaling in muscle homeostasis, ribosome biogenesis, and redox regulation of mechanotransduction to modulate skeletal muscle mass are also covered. It is an essential resource for physicians, researchers, post-docs as well as graduate students in the field of sports science including rehabilitation therapy, exercise physiology, exercise biochemistry, and molecular biology dealing with skeletal muscle.

From Obesity to Diabetes Book

From Obesity to Diabetes


  • Author : Juergen Eckel
  • Publisher : Springer Nature
  • Release Date : 2022-08-22
  • Genre: Medical
  • Pages : 508
  • ISBN 10 : 9783030999957

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From Obesity to Diabetes Excerpt :

Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.