The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders Book

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders


  • Author : David F. Cechetto
  • Publisher : Academic Press
  • Release Date : 2017-02-24
  • Genre: Medical
  • Pages : 340
  • ISBN 10 : 9780128019566

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The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders Excerpt :

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer’s Disease, Parkinson’s, addiction, and cardiovascular dysregulation. Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value. Offers a comprehensive overview on the best available in vivo and in vitro models to study cortical involvement Presents models and specific techniques that help to guide investigators in their choices on how to address research questions experimentally Provides expert commentary and a perspective on future trends at the end of each chapter Addresses translational advances and promising therapeutic options Includes references to key articles for additional detailed study

Molecular Aspects of Neurodegeneration and Neuroprotection Book

Molecular Aspects of Neurodegeneration and Neuroprotection


  • Author : Akhlaq A. Farooqui
  • Publisher : Bentham Science Publishers
  • Release Date : 2011-01-26
  • Genre: Science
  • Pages : 146
  • ISBN 10 : 9781608050925

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Molecular Aspects of Neurodegeneration and Neuroprotection Excerpt :

"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Cognitive deficits in schizophrenia and other neuropsychiatric disorders  Convergence of preclinical and clinical evidence Book

Cognitive deficits in schizophrenia and other neuropsychiatric disorders Convergence of preclinical and clinical evidence


  • Author : Ales Stuchlik
  • Publisher : Frontiers Media SA
  • Release Date : 2015-10-23
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889196791

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Cognitive deficits in schizophrenia and other neuropsychiatric disorders Convergence of preclinical and clinical evidence Excerpt :

Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances.

Glial Man Book

Glial Man


  • Author : Yves Agid
  • Publisher : Oxford University Press
  • Release Date : 2020-11-26
  • Genre: Science
  • Pages : 200
  • ISBN 10 : 9780192587015

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Glial Man Excerpt :

Glial cells play an essential role in initiating and controlling our behaviours, playing a major role in communication between brain cells. They share certain properties with neurons, including the ability to use information from the environment to formulate behaviors. Understanding these cells is key to explaining human movement, emotion, and thoughts. Moreover, glial cells provide a panoply of new therapeutic targets for the treatment of neuropsychiatric disorders. This book is the 'brain' child of two scientist physicians: Pierre Magistretti, a leading expert in cerebral metabolism and glial cell biology, and Yves Agid, an expert in the treatment of nervous system diseases and a researcher in the field of neurodegenerative diseases. This book provides many examples of the decisive role glial cells play in the functioning of the human brain, as well as in neurological and psychiatric pathologies. The result is a revolution in our understanding of the brain and a beacon of hope in the treatment of neuropsychiatric disorders.

Neuropsychiatric Disorders Book
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Neuropsychiatric Disorders


  • Author : Manfred Gerlach
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-28
  • Genre: Medical
  • Pages : 341
  • ISBN 10 : 9783211735749

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Neuropsychiatric Disorders Excerpt :

This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

Make Life Visible Book

Make Life Visible


  • Author : Yoshiaki Toyama
  • Publisher : Springer Nature
  • Release Date : 2019-10-02
  • Genre: Medical
  • Pages : 292
  • ISBN 10 : 9789811379086

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Make Life Visible Excerpt :

This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

                        Book


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1955
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:232938177

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Neurodegenerative Disorders as Systemic Diseases Book

Neurodegenerative Disorders as Systemic Diseases


  • Author : Keiji Wada
  • Publisher : Springer
  • Release Date : 2015-10-21
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9784431545415

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Neurodegenerative Disorders as Systemic Diseases Excerpt :

This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.

Neurogenesis in the Adult Brain II Book

Neurogenesis in the Adult Brain II


  • Author : Tatsunori Seki
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-06-15
  • Genre: Medical
  • Pages : 211
  • ISBN 10 : 9784431539452

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Neurogenesis in the Adult Brain II Excerpt :

The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models Book

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models


  • Author : Sylvie Granon
  • Publisher : Unknown
  • Release Date : 2009-01-01
  • Genre: Uncategoriezed
  • Pages : 358
  • ISBN 10 : 8178954028

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Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models Excerpt :

Psychiatric disorders are uniquely human. Yet we need animal models to test hypotheses about biological mechanisms. Treatment development relies on model systems to evaluate the efficacy of therapeutics. How can such a profound paradox be resolved? Dr. Sylvie Granon of the Institute Pasteur in Paris has successfully assembled a collection of fifteen review chapters that address multiple aspects of rodent models of neuropsychiatric disorders. Outstanding experts describe paradigms relevant to Alzheimer s disease, mental retardation, schizophrenia, autism, attentional deficit hyperactivity disorder, impulsivity, drug addiction, post-traumatic stress disorder, multiple sclerosis, and sudden infant death syndrome. Traditional lesioning and pharmacological methods are contrasted with newer targeted gene mutation strategies for generating rodent models. Strengths and limitations of transgenic and knockout mouse models are discussed by many of the insightful authors. In Alice in Wonderland, the Cheshire Cat speaks English and tell us We re all mad here. Unfortunately, real animals do not talk, and cannot tell us about their abnormal internal emotional or mental states, if any. It is essential to recognize that researchers will never be able to replicate schizophrenia or autism or depression in a mouse. Many psychiatric dysfunctions appear to originate primarily in the human frontal cerebral cortex, a highly developed structure that dramatically eclipses the modest frontal cortex of rodents. Numbers of synapses and available pathways for making neural connections that permit higher executive functions are enormously greater in humans as compared to other species. Expansion of the human prefrontal cortex is an evolutionary recent phenomenon. There has not been enough time for thorough trouble-shooting and beta-testing of its neural circuitry. No wonder so much can go so wrong. Endophenotypes offer a neat solution to our conundrum. Rather than trying to replicate the full hum

Neuropsychiatry  An Issue of Psychiatric Clinics of North America Book

Neuropsychiatry An Issue of Psychiatric Clinics of North America


  • Author : Vassilis E Koliatsos
  • Publisher : Elsevier Health Sciences
  • Release Date : 2020-05-26
  • Genre: Medical
  • Pages : 240
  • ISBN 10 : 9780323789523

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Neuropsychiatry An Issue of Psychiatric Clinics of North America Excerpt :

This issue of Psychiatric Clinics, guest edited by Dr. Vassilis E. Koliatsos will cover Neuropsychiatry. This issue is one of four each year selected by our series consulting editor, Dr. Harsh Trivedi of Sheppard Pratt Health System. Topics in this issue include: The clinical neurobiology of autism spectrum disorders; New developments in impulse control disorders; Schizophrenia as a neurodevelopmental phenotype; Neuropsychiatric Aspects of Epilepsy; New developments in addiction; The clinical neuroscience of acquired brain injury; New developments in frontotemporal dementia; Lewy body degenerations as neuropsychiatric disorders; Neuropsychiatric challenges in Alzheimer’s disease; and New pharmacological approaches in Neuropsychiatry, among others.

Cannabinoids and Neuropsychiatric Disorders Book

Cannabinoids and Neuropsychiatric Disorders


  • Author : Eric Murillo-Rodriguez
  • Publisher : Springer
  • Release Date : 2022-01-01
  • Genre: Science
  • Pages : 153
  • ISBN 10 : 3030573710

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Cannabinoids and Neuropsychiatric Disorders Excerpt :

This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol (Δ9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.

The Human Hypothalamus Book

The Human Hypothalamus


  • Author : Dick F. Swaab
  • Publisher : Elsevier
  • Release Date : 2021-07-07
  • Genre: Science
  • Pages : 516
  • ISBN 10 : 9780128199749

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The Human Hypothalamus Excerpt :

The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more. Summarizes research on how the hypothalamus relates to neurological disorders Contains neuropsychiatric, neurodegenerative, periodic and autonomic disorders Includes the neurobiology of, and treatment for, each disorder Covers depression, anxiety, OCD, PTSD, schizophrenia, autism, aggression, addiction, and more Provides coverage of sleep and pain

Molecular Aspects of Neurodegeneration  Neuroprotection  and Regeneration in Neurological Disorders Book

Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders


  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2020-09-07
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 9780128217016

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Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders Excerpt :

Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders

Inflammation and Oxidative Stress in Neurological Disorders Book

Inflammation and Oxidative Stress in Neurological Disorders


  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-01-27
  • Genre: Medical
  • Pages : 355
  • ISBN 10 : 9783319041117

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Inflammation and Oxidative Stress in Neurological Disorders Excerpt :

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.