The Common Marmoset in Captivity and Biomedical Research Book

The Common Marmoset in Captivity and Biomedical Research


  • Author : Robert P. Marini
  • Publisher : Academic Press
  • Release Date : 2018-11-19
  • Genre: Science
  • Pages : 570
  • ISBN 10 : 9780128118306

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The Common Marmoset in Captivity and Biomedical Research Excerpt :

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

The Common Marmoset in Captivity and Biomedical Research Book

The Common Marmoset in Captivity and Biomedical Research


  • Author : Robert P. Marini
  • Publisher : Academic Press
  • Release Date : 2018-11
  • Genre: Science
  • Pages : 925
  • ISBN 10 : 0128118296

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The Common Marmoset in Captivity and Biomedical Research Excerpt :

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species, filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its Blue Book series, the book covers the biology and management, diseases and clinical applications, and research. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced, small, prolific and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model with which to study a number of disorders, like autism, which have yet to be substantively understood. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research and applications Includes contributions from world-renowned editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Care  Use  and Welfare of Marmosets as Animal Models for Gene Editing Based Biomedical Research Book

Care Use and Welfare of Marmosets as Animal Models for Gene Editing Based Biomedical Research


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2019-08-26
  • Genre: Science
  • Pages : 123
  • ISBN 10 : 9780309488518

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Care Use and Welfare of Marmosets as Animal Models for Gene Editing Based Biomedical Research Excerpt :

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

Reproduction in New World Primates Book

Reproduction in New World Primates


  • Author : J.P. Hearn
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 224
  • ISBN 10 : 9789400973220

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Reproduction in New World Primates Excerpt :

The New World primates are becoming widely used in scientific and medical work in fields from anthropology to zoology, behaviour to urology. They have unique attributes for studies in cancer, infectious diseases, genetics, virology and reproduction. However, it is only now that their reproductive physiology is being clarified in any depth and this book is a first synthesis of that knowledge. The nine authors involved in this project have presented an up to date account of the major New World species used in biological and medical science. In addition to their distribution and conservation in the wild, essential biological data from laboratory studies are presented on reproductive cycles, gestation length, seasonal breeding, puberty and other factors. The major applications of these species in research are explored. Whenever possible, research workers should steer away from using endangered species in their studies. The New World monkeys used in research in any numbers are still fairly common ~n the wild, yet their greatest advantages are ~n their smalle size and high fecundity. This makes possible the establishment of self sustaining captive breeding colonies at a fraction of the time and cost necessary for the more conventional Old World laboratory primates. Consequently the drain on wild stocks need not be extensive as only breeding nuclei should be necessary.

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment Book

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment


  • Author : Joerg Bluemel
  • Publisher : Academic Press
  • Release Date : 2015-03-13
  • Genre: Medical
  • Pages : 716
  • ISBN 10 : 9780124171466

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The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment Excerpt :

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Behavioral Biology of Laboratory Animals Book

Behavioral Biology of Laboratory Animals


  • Author : Kristine Coleman
  • Publisher : CRC Press
  • Release Date : 2021-09-01
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9780429671296

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Behavioral Biology of Laboratory Animals Excerpt :

This 30-chapter volume informs students and professionals about the behavioral biology of animals commonly housed in laboratory and other captive settings. Each species evolved under specific environmental conditions, resulting in unique behavioral patterns, many of which are maintained in captivity even after generations of breeding. Understanding natural behavior is therefore a critical part of modern animal care practices. The descriptions, data, guidance, resources, and recommendations in this book will help the reader understand their animals better, refine the care and treatment that they receive, and improve the well-being, welfare, and wellness of their animals. The book is divided into three sections, all focusing on aspects of the behavioral biology of animals found in laboratories and related research settings. After five introductory chapters, 25 chapters are dedicated to specific taxonomic groups (including mice, zebrafish, zebra finches, reptiles, macaques) while a concluding section of ethograms provides a centralized resource for those interested in understanding, and potentially quantifying, animal behavior. The Behaviorial Biology of Laboratory Animals will provide anyone working in maintenance, care, and/or research programs that involve laboratory animals with information about the way the animals live in the wild, and the way that they should live in captive research settings. Many of the guidelines and recommendations will also be valuable to those managing and working with animals in other environments, including zoological parks, aquaria, and sanctuaries.

Comparative Biology of Aging Book

Comparative Biology of Aging


  • Author : Norman S. Wolf
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-01-08
  • Genre: Medical
  • Pages : 391
  • ISBN 10 : 9789048134656

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Comparative Biology of Aging Excerpt :

determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].

Nursery Rearing of Nonhuman Primates in the 21st Century Book

Nursery Rearing of Nonhuman Primates in the 21st Century


  • Author : Gene P. Sackett
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-05-10
  • Genre: Medical
  • Pages : 602
  • ISBN 10 : 9780387256405

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Nursery Rearing of Nonhuman Primates in the 21st Century Excerpt :

Nursery Rearing of Nonhuman Primates in the 21st Century describes how and why nursery rearing of primates can produce adaptable juveniles and adults for research, conservation, and display-educational purposes. The volume details the history of nursery rearing since the mid-19th century, the outcomes of varied nursery rearing methods, the contemporary goals of nursery rearing as well as reference data derived from species commonly reared in nursery or hand-feeding situations. Examples of the changing goals of nursery rearing covered in this volume are the need for biological containment in disease research, the production of specific pathogen-free colonies by removal of neonates from the mother, the production of phenotypes for genetic and molecular biology studies, and the breeding of endangered species for conservation or research purposes.

Management of Animal Care and Use Programs in Research  Education  and Testing Book

Management of Animal Care and Use Programs in Research Education and Testing


  • Author : Robert H. Weichbrod
  • Publisher : CRC Press
  • Release Date : 2017-09-07
  • Genre: Medical
  • Pages : 872
  • ISBN 10 : 9781498748452

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Management of Animal Care and Use Programs in Research Education and Testing Excerpt :

AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how

Nonhuman Primates in Biomedical Research Book

Nonhuman Primates in Biomedical Research


  • Author : Christian R. Abee
  • Publisher : Academic Press
  • Release Date : 2012-06-07
  • Genre: Medical
  • Pages : 868
  • ISBN 10 : 9780123978387

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Nonhuman Primates in Biomedical Research Excerpt :

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

Scientific Foundations of Zoos and Aquariums Book

Scientific Foundations of Zoos and Aquariums


  • Author : Allison B. Kaufman
  • Publisher : Cambridge University Press
  • Release Date : 2019-01-03
  • Genre: Law
  • Pages : 697
  • ISBN 10 : 9781107199194

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Scientific Foundations of Zoos and Aquariums Excerpt :

Using first-person stories and approachable scientific reviews, this volume explores how zoos conduct and support science around the world.

The Biology of Animal Stress Book
Score: 4
From 3 Ratings

The Biology of Animal Stress


  • Author : Gary P. Moberg
  • Publisher : CABI
  • Release Date : 2000
  • Genre: Animal behavior
  • Pages : 396
  • ISBN 10 : 0851999301

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The Biology of Animal Stress Excerpt :

The subjects of stress and animal welfare are currently attracting immense interest. This book brings together a range of perspectives from biomedical research (including human health and animal models of human stress) on stress and welfare, and assesses new approaches to conceptualising and alleviating stress.

Raptors in Captivity Book

Raptors in Captivity


  • Author : Lori R Arent
  • Publisher : Unknown
  • Release Date : 2018-05
  • Genre: Science
  • Pages : 306
  • ISBN 10 : 0888391099

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Raptors in Captivity Excerpt :

A first-of-its-kind resource, Raptors in Captivity is designed as a reader-friendly reference tool covering a wide range of topics from choosing a suitable species, to housing and transportation, diet, medical care, equipment, training. Raptors in Captivity is the recommended US Fish & Wildlife Service 'bible' for the care and keeping of raptors in captivity -- an incredible endorsement! If you're a zoo, rehab center or a falconer, here are the guidelines for safely caring for raptors -- and complying with permits. Covers a range of topics from making the decision to keep raptors and choosing suitable species, to housing and transportation, diet, medical care, equipment, training, and recovering a lost bird.

The Mammalian Preimplantation Embryo Book

The Mammalian Preimplantation Embryo


  • Author : Barry D. Bavister
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 398
  • ISBN 10 : 9781468453324

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The Mammalian Preimplantation Embryo Excerpt :

With a few notable exceptions, mammalian preimplantation embryos grown in vitro are likely to exhibit sub-optimal or retarded development. This may be manifested in different ways, depending on the species and on the stage(s) of embryonic development that are being examined. For example, bovine embryos often experience difficulty in cleaving under in vitro conditions, and usually cease development at about the 8-cell stage (Wright and Bondioli, 1981). The block to development is stage-dependent; embryos cultured for 24 hr from the I-cell stage are much more capable of developing into viable blastocysts after transfer to oviducts than embryos cultured for 24 hr from the 4-cell stage prior to transfer (Eyestone et oZ. , 1985). Similar problems with in vitro embryo development are encountered in other species. Pig embryos can be grown up to the 4-cell stage in vitro but usually no further (Davis and Day, 1978). In the golden hamster, in the rat and in many outbred strains of mice, development of zygotes in vitro is blocked at the 2-cell stage (Yanagimachi and Chang, 1964; Whittingham, 1975). Even with some inbred mouse strains, embryo development is reduced if very early cleavage stages are used as the starting point for in vitro culture (Spielmann et oZ. , 1980). A common finding is that embryos grown in vitro have reduced cell counts (Harlow and Quinn, 1982; Kane, 1985) and their viability is reduced (Bowman and McLaren, 1970; Papaioannou and Ebert, 1986) compared to equivalent developmental stages recovered from mated animals.