The Comprehensive Sourcebook of Bacterial Protein Toxins Book

The Comprehensive Sourcebook of Bacterial Protein Toxins


  • Author : Joseph E. Alouf
  • Publisher : Academic Press
  • Release Date : 2015-05-29
  • Genre: Science
  • Pages : 1200
  • ISBN 10 : 9780128005897

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The Comprehensive Sourcebook of Bacterial Protein Toxins Excerpt :

The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them. Focused chapters on toxin applications and common properties or general features of toxins.

The Comprehensive Sourcebook of Bacterial Protein Toxins Book

The Comprehensive Sourcebook of Bacterial Protein Toxins


  • Author : John H. Freer
  • Publisher : Unknown
  • Release Date : 1999
  • Genre: Medical
  • Pages : 718
  • ISBN 10 : UOM:39015048833282

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The Comprehensive Sourcebook of Bacterial Protein Toxins Excerpt :

The Comprehensive Sourcebook of Bacterial Protein Toxins, Second Edition, provides an up-to-date description of the great advances made in our understanding of the structure, genetics, cellular, and molecular mechanisms of action of bacterial protein toxins over the past decade. This work follows and expands on the first edition (published in 1991), with 70% totally new content and full-color illustrations. Molecular biology, microbiology, immunology, cell biology, protein engineering, structural biochemistry, and clinical research in infectious diseases are brought together to provide a complete overview of the field. Key Features * Most up-to-date and comprehensive reference on the subject * Addresses recent achievements in basic and applied toxin research * Covers use of bacterial toxins in the development of new vaccines, immunodulators, and therapeutics against cancer and various neurological disorders * Written by internationally recognized scientists, including Randall Holmes, a recent candidate for presidency of the American Society for Microbiology

Sourcebook of Bacterial Protein Toxins Book

Sourcebook of Bacterial Protein Toxins


  • Author : Joseph E. Alouf
  • Publisher : Unknown
  • Release Date : 1991
  • Genre: Bacterial protein
  • Pages : 540
  • ISBN 10 : UOM:39015024930649

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Sourcebook of Bacterial Protein Toxins Excerpt :

Written by an international team of leading scientists, this volume draws together a wealth of information on the structure, regulation, and activity of bacterial protein toxins. A comprehensive sourcebook on bacterial toxins, Sourcebook of Bacterial Protein Toxins is the first book designed to draw together current knowledge on these toxins. The 22 chapters of this book have been written by 44 internationally known specialists who have significantly contributed to the progress in the domains covered. This book will appeal to a wide readership, including microbiologists, biochemists, cell biologists, and physicians. It will also arouse the interest of students and scientists in other disciplines who see the power of these fascinating biological agents, either as exquisitely specific probes of cellular processes or as extremely potent agents of infectious disease.

The Comprehensive Sourcebook of Bacterial Protein Toxins Book

The Comprehensive Sourcebook of Bacterial Protein Toxins


  • Author : Joseph E. Alouf
  • Publisher : Elsevier
  • Release Date : 2005-12-20
  • Genre: Science
  • Pages : 1072
  • ISBN 10 : 9780080456980

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The Comprehensive Sourcebook of Bacterial Protein Toxins Excerpt :

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Bacterial Protein Toxins Book

Bacterial Protein Toxins


  • Author : K. Aktories
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-14
  • Genre: Medical
  • Pages : 700
  • ISBN 10 : 9783662059715

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Bacterial Protein Toxins Excerpt :

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Pore Forming Toxins Book

Pore Forming Toxins


  • Author : Gisou van der Goot
  • Publisher : Springer Science & Business Media
  • Release Date : 2001-03-12
  • Genre: Science
  • Pages : 188
  • ISBN 10 : 3540413863

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Pore Forming Toxins Excerpt :

Pore-forming toxins are virulence factors produced by a great variety of pathogenic bacteria ranging from the Gram-positive Staphylococcus aureus to the Gram-negative Helicobacter pylory. The recent studies reviewed in this volume describe the progress that has been made in dissecting the different steps of the mode of action of these proteins which generally include binding to specific cell surface receptors, oligomerization into ring like structures and membrane perforation.

Listeria monocytogenes  Pathogenesis and Host Response Book

Listeria monocytogenes Pathogenesis and Host Response


  • Author : Howard Goldfine
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-06-24
  • Genre: Science
  • Pages : 287
  • ISBN 10 : 9780387493763

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Listeria monocytogenes Pathogenesis and Host Response Excerpt :

During the past twenty years Listeria monocytogenes has emerged as one of the most intensely studied bacterial pathogens. New windows are constantly being opened into the complexity of host cell biology and the interplay of the signals connecting the various cells and organs involved in the host response. This volume includes research from studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections.

Clostridium Difficile Book

Clostridium Difficile


  • Author : Shymaa Enany
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-09-27
  • Genre: Science
  • Pages : 162
  • ISBN 10 : 9789535134275

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Clostridium Difficile Excerpt :

Clostridium difficile bacteria could be found everywhere around us: in the air, water, and soil and in the feces of humans and animals. You can easily become infected with C. difficile if you touch contaminated clothing, sheets, or other objects and then touch your mouth. Many people have the bacteria in their intestines and never have any symptoms. Still, it can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. The chance of developing a C. difficile infection increases with the usage of high doses of antibiotics over a prolonged period; thus, it is most often spread in the healthcare facilities between workers, patients, and residents. Each year in the United States, almost a half million people get sick from C. difficile, and approximately 29,000 patients died within 30 days of its initial diagnosis. Nowadays, C. difficile infections have become more frequent, severe, and difficult to treat. Therefore, the early diagnosis and the suitable treatment have become a real demand. In this book, we present the experience of worldwide specialists on the diagnosis and the treatment of C. difficile infections along with its lights and shadows.

Concepts in Bacterial Virulence Book

Concepts in Bacterial Virulence


  • Author : Wayne Russell
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2005-01-01
  • Genre: Medical
  • Pages : 287
  • ISBN 10 : 9783805577861

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Concepts in Bacterial Virulence Excerpt :

Over the past few decades the increase in bacterial resistance has led to the search for novel antibacterial therapies and a better understanding of virulence mechanisms used by pathogens. It has been shown that the interplay between pathogenic bacteria and the host is complex and finely balanced. Successful pathogens can manipulate host homeostasis and normal cell functions using a variety of molecular strategies. This volume of the Karger book series Contributions to Microbiology summarizes some of the most important bacterial virulence mechanisms. Eminent scientists provide an update on recent findings in their fields. This state-of-the-art account will not only attract the interest of clinical and preclinical researchers, but will also be of great value to students with an interest in medicine, biology, chemistry, and infectious diseases.

Pore Forming Toxins Book

Pore Forming Toxins


  • Author : Gisou van der Goot
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 168
  • ISBN 10 : 9783642565083

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Pore Forming Toxins Excerpt :

Pore-forming toxins are virulence factors produced by a great variety of pathogenic bacteria ranging from the Gram-positive Staphylococcus aureus to the Gram-negative Helicobacter pylory. The recent studies reviewed in this volume describe the progress that has been made in dissecting the different steps of the mode of action of these proteins which generally include binding to specific cell surface receptors, oligomerization into ring like structures and membrane perforation.

Essentials of Genomic and Personalized Medicine Book

Essentials of Genomic and Personalized Medicine


  • Author : Geoffrey S. Ginsburg
  • Publisher : Academic Press
  • Release Date : 2009-10-02
  • Genre: Science
  • Pages : 850
  • ISBN 10 : 0080958117

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Essentials of Genomic and Personalized Medicine Excerpt :

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. * Full color throughout * Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice * Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Neonatal Nutrition for Inflammatory Disorders and Necrotizing Enterocolitis Book

Neonatal Nutrition for Inflammatory Disorders and Necrotizing Enterocolitis


  • Author : Misty Good
  • Publisher : MDPI
  • Release Date : 2020-11-19
  • Genre: Medical
  • Pages : 232
  • ISBN 10 : 9783039434817

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Neonatal Nutrition for Inflammatory Disorders and Necrotizing Enterocolitis Excerpt :

This Nutrients Special Issue focuses on neonatal nutritional advances for inflammatory disorders affecting infants such as necrotizing enterocolitis (NEC). Nutrition can significantly impact the development of certain diseases that afflict infants. This Special Issue aims to bring together the latest research on the role of nutrition in preventing or impacting neonatal disorders. Specifically, this Special Issue focuses on the role of breast milk or donor breast milk and the various components in milk that have been demonstrated to protect against NEC and other inflammatory diseases. This issue provides a comprehensive composite of the advances in nutritional strategies that can modulate or prevent neonatal intestinal disorders.

Microbiology of Urinary Tract Infections Book

Microbiology of Urinary Tract Infections


  • Author : Payam Behzadi
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-02-13
  • Genre: Medical
  • Pages : 112
  • ISBN 10 : 9781789849554

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Microbiology of Urinary Tract Infections Excerpt :

Generally, in accordance with anatomical characteristics, urinary tract infections (UTIs) and in particular recurrent UTIs occur in women; in contrast, UTIs normally occur in men with different predisposing factors. There are several types of UTIs, including asymptomatic and symptomatic, complicated and uncomplicated, acute and chronic with a diversity of microbial pathogens. In pathogens, virulence factors and genes determine the type and severity of the UTIs. Obviously, UTIs are a huge problem in global public healthcare systems with a wide range of predisposing factors, including gender, microbial agent, the host's immune deficiencies, genetic diseases, catheterization, etc. The recent items determine the microbiology of UTIs. Accurate diagnosis and definitive treatment are the key to UTI reduction.

Uptake and Trafficking of Protein Toxins Book

Uptake and Trafficking of Protein Toxins


  • Author : Holger Barth
  • Publisher : Springer
  • Release Date : 2017-12-01
  • Genre: Medical
  • Pages : 256
  • ISBN 10 : 9783319588933

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Uptake and Trafficking of Protein Toxins Excerpt :

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.