The Epigenome and Developmental Origins of Health and Disease Book

The Epigenome and Developmental Origins of Health and Disease

  • Author : Cheryl S Rosenfeld
  • Publisher : Academic Press
  • Release Date : 2015-10-10
  • Genre: Science
  • Pages : 560
  • ISBN 10 : 9780128016725
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The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Developmental Origins of Health and Disease Book

Developmental Origins of Health and Disease

  • Author : Peter Gluckman
  • Publisher : Cambridge University Press
  • Release Date : 2006-04-20
  • Genre: Medical
  • Pages : 542
  • ISBN 10 : 0521847435
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This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Developmental Origins of Health and Disease DOHaD Book

Developmental Origins of Health and Disease DOHaD

  • Author : Takeo Kubota
  • Publisher : Springer
  • Release Date : 2018-06-28
  • Genre: Medical
  • Pages : 95
  • ISBN 10 : 9789811055263
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This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

Epigenetics Book

Epigenetics

  • Author : Joel D. Wallach
  • Publisher : SelectBooks, Inc.
  • Release Date : 2014-05
  • Genre: Health & Fitness
  • Pages : 443
  • ISBN 10 : 9781590792551
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WHAT IS EPIGENETICS? Epigenetics is an emerging field of science that studies alterations in gene expression caused by factors other than changes in the DNA sequence. Epigenetics: The Death of the Genetic Theory of Disease Transmission is the result of decades of research and its findings that could be as critical to our understanding of human health as Pasteur’s research in bacteriology. Dr. Joel “Doc” Wallach has dedicated his life work to identifying connections between certain nutritional deficiencies and a range of maladies, formerly thought to be hereditary, including Cystic Fibrosis and Muscular Dystrophy. This nexus between nutrition and so-called genetic disease has been observed in both humans and primates, and it is the central theme of Epigenetics. To bring us Epigenetics, Wallach has teamed with noted scholars Dr. Ma Lan and Dr. Gerhard N. Schrauzer. Their collective expertise gives this book its far reaching perspective. Epigenetics is of vital importance to anyone who wants real knowledge about how the human body functions, and it provides a path for better health. Epigentics dispels the dogma and misinformation propagated by medical institutions and doctors resistant to change. Epigenetics is the beginning of a new era of well-being on this planet.

Environmental Epigenetics Book

Environmental Epigenetics

  • Author : L. Joseph Su
  • Publisher : Springer
  • Release Date : 2015-05-18
  • Genre: Medical
  • Pages : 321
  • ISBN 10 : 9781447166788
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This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Epigenetic Epidemiology Book

Epigenetic Epidemiology

  • Author : Karin B. Michels
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-01-02
  • Genre: Medical
  • Pages : 448
  • ISBN 10 : 9789400724952
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The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

The Routledge Handbook of Anthropology and Reproduction Book

The Routledge Handbook of Anthropology and Reproduction

  • Author : Sallie Han
  • Publisher : Routledge
  • Release Date : 2021-11-09
  • Genre: Social Science
  • Pages : 676
  • ISBN 10 : 9781000455984
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The Routledge Handbook of Anthropology and Reproduction is a comprehensive overview of the topics, approaches, and trajectories in the anthropological study of human reproduction. The book brings together work from across the discipline of anthropology, with contributions by established and emerging scholars in archaeological, biological, linguistic, and sociocultural anthropology. Across these areas of research, consideration is given to the contexts, conditions, and contingencies that mark and shape the experiences of reproduction as always gendered, classed, and racialized. Over 39 chapters, a diverse range of international scholars cover topics including: Reproductive governance, stratification, justice, and freedom. Fertility and infertility. Technologies and imaginations. Queering reproduction. Pregnancy, childbirth, and reproductive loss. Postpartum and infant care. Care, kinship, and alloparenting. This is a valuable reference for scholars and upper-level students in anthropology and related disciplines associated with reproduction, including sociology, gender studies, science and technology studies, human development and family studies, global health, public health, medicine, medical humanities, and midwifery and nursing.

Pre emptive Medicine Public Health Aspects of Developmental Origins of Health and Disease Book

Pre emptive Medicine Public Health Aspects of Developmental Origins of Health and Disease

  • Author : Fumihiro Sata
  • Publisher : Springer
  • Release Date : 2018-12-11
  • Genre: Medical
  • Pages : 217
  • ISBN 10 : 9789811321948
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This book reviews public health activities such as awareness campaigns, health education, and strategies for health policy based on recent epidemiological studies that provide insights into epigenetic processes caused by environmental factors and developmental plasticity. It provides the latest concepts and findings on the public health aspects of Developmental Origins of Health and Disease (DOHaD) research regarding early prevention of non-communicable diseases (NCDs). Attention is especially paid to key issues, including strategies for the effective prevention of NCDs in developmental stages of life and younger generations rather than in adults and the elderly. Public Health Aspects in Developmental Origins of Health and Disease (DOHaD) is structured in two parts; the first focuses on general remarks reviewing specific recommendations, practical methods and protocols, and future goals regarding public health aspects, while the second presents brief profiles of individual cohorts and consortia studies. This collection will benefit both new and established researchers, as well as students in the fields of epidemiology, clinical medicine, nutrition, education, and public health who are seeking comprehensive information on DOHaD and preemptive medicine.

Early Life Origins of Ageing and Longevity Book

Early Life Origins of Ageing and Longevity

  • Author : Alexander Vaiserman
  • Publisher : Springer
  • Release Date : 2019-07-29
  • Genre: Science
  • Pages : 310
  • ISBN 10 : 9783030249588
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This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process. Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns. Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.

Epigenetic Epidemiology Book

Epigenetic Epidemiology

  • Author : Karin B. Michels
  • Publisher : Springer Nature
  • Release Date : 2022-04-14
  • Genre: Science
  • Pages : 516
  • ISBN 10 : 9783030944759
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Now in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. Unlike our genetic inheritance, our epigenome is malleable throughout the lifecourse and is shaped by our environmental experiences. Population-based epidemiologic studies increasingly incorporate epigenetic components. These so called epigenome-wide association studies (EWAS) contribute substantially to our understanding of the relevance of epigenetic marks, such as DNA methylation, histone modification, and non-coding RNAs for disease causation. Written by leading experts in the field, the book opens with a comprehensive introduction of the principles of epigenetic epidemiology and discusses challenges in study design, analysis, and interpretation. It summarizes the latest advances in epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the epigenetic clock, and the role of epigenetics in the developmental origins hypothesis. The final part focuses on epigenetic epidemiology of various health conditions such as imprinting disorders, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, metabolic disorder and vascular disease, as well as neurodevelopmental and psychiatric disorders. Given its scope, Epigenetic Epidemiology is an indispensable resource for researchers working in the field of human epigenetics.

Handbook of Life Course Health Development Book

Handbook of Life Course Health Development

  • Author : Neal Halfon
  • Publisher : Springer
  • Release Date : 2017-11-20
  • Genre: Medical
  • Pages : 664
  • ISBN 10 : 9783319471433
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This book is open access under a CC BY 4.0 license. ​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.

Epigenetics of Aging and Longevity Book

Epigenetics of Aging and Longevity

  • Author : Alexey Moskalev
  • Publisher : Academic Press
  • Release Date : 2017-11-17
  • Genre: Medical
  • Pages : 544
  • ISBN 10 : 9780128110836
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Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Environmental Epigenomics in Health and Disease Book

Environmental Epigenomics in Health and Disease

  • Author : Randy L Jirtle
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-05-16
  • Genre: Medical
  • Pages : 309
  • ISBN 10 : 9783642233807
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There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.