The Functional Roles of Glial Cells in Health and Disease Book

The Functional Roles of Glial Cells in Health and Disease


  • Author : Rebecca Matsas
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 389
  • ISBN 10 : 9781461546856

GET BOOK
The Functional Roles of Glial Cells in Health and Disease Excerpt :

Thirty-five years ago, when Stephen Kuffler and his colleagues at Harvard initiated a new era of research on the properties and functions of neuroglial cells, very few neuro scientists were impressed at the time with the hypothesis that neuroglial cells could have another, though more subtle, role to play in the nervous system than to provide static support to neurons. Today, very few neuroscientists are unaware of the fact that multiple interactions between neurons and glial cells have been described, and that they consti tute the basis for understanding the function and the pathology of the nervous system. Glial cells outnumber neurons and make up about one-half of the bulk of the nervous system. They are divided into two major classes: first, the macroglia, which include astrocytes and oligodendrocytes in the central nervous system, and the Schwann cells in the peripheral nervous system; and second, the microglial cells. These different classes of glial cells have different functions and contribute in different ways in the devel opment, function, and the pathology of the nervous system.

Glia in Health and Disease Book

Glia in Health and Disease


  • Author : Margaret S. Ho
  • Publisher : Frontiers Media SA
  • Release Date : 2019-08-16
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889458509

GET BOOK
Glia in Health and Disease Excerpt :

Glial Cells in Health and Disease of the CNS Book

Glial Cells in Health and Disease of the CNS


  • Author : Rommy von Bernhardi
  • Publisher : Springer
  • Release Date : 2016-10-06
  • Genre: Medical
  • Pages : 348
  • ISBN 10 : 9783319407647

GET BOOK
Glial Cells in Health and Disease of the CNS Excerpt :

A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.

The Other Brain Book
Score: 3.5
From 6 Ratings

The Other Brain


  • Author : R. Douglas Fields
  • Publisher : Simon and Schuster
  • Release Date : 2009-12-29
  • Genre: Science
  • Pages : 384
  • ISBN 10 : 1439160430

GET BOOK
The Other Brain Excerpt :

Despite everything that has been written about the brain, a potentially critical part of this vital organ has been overlooked—until now. The Other Brain examines the growing importance of glia, which make up approximately 85 percent of the cells in the brain, and the role they play in how the brain functions, malfunctions, and heals itself. Long neglected as little more than cerebral packing material, glia (meaning “glue”) are now known to regulate the flow of information between neurons and to repair the brain and spinal cord after injury and stroke. But scientists are also discovering that diseased and damaged glia play a significant role in psychiatric illnesses such as schizophrenia and depression, and in neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Diseased glia cause brain cancer and multiple sclerosis and are linked to infectious diseases such as HIV and prion disease (mad cow disease, for example) and to chronic pain. The more we learn about these cells that make up the “other” brain, the more important they seem to be. Written by a neuroscientist who is a leader in glial research, The Other Brain gives readers a much more complete understanding of how the brain works and an intriguing look at potentially revolutionary developments in brain science and medicine.

Glial Neurobiology Book

Glial Neurobiology


  • Author : Alexei Verkhratsky
  • Publisher : John Wiley & Sons
  • Release Date : 2007-08-20
  • Genre: Medical
  • Pages : 230
  • ISBN 10 : 0470513071

GET BOOK
Glial Neurobiology Excerpt :

"This volume is a very valuable and much needed contribution." –Quarterly Review of Biology AT LAST - A comprehensive, accessible textbook on glial neurobiology! Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead, on neurones and neuronal networks because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn’t exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease. Features of this book: an accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain function and nervous system pathology an exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the ACNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels an investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more a wealth of illustrations, including unique images from the authors' own libraries of images, describing the main features of glial cells Written by two leading experts in the field, Glial Neurobiology provides a concise, authoritative introduction to glial physiology and pathology for undergraduate/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology student

Neuroglia Book

Neuroglia


  • Author : Helmut Kettenmann
  • Publisher : Oxford University Press
  • Release Date : 2005
  • Genre: Medical
  • Pages : 601
  • ISBN 10 : 0195152220

GET BOOK
Neuroglia Excerpt :

Graduate students in neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology will find the book indispensable. It is also a vital companion for researchers in these fields as well as clinicians in neurology, neurosurgery, neuropathology, neuro-oncology, physiatry, and psychiatry."--BOOK JACKET.

The Biology of Glial Cells  Recent Advances Book

The Biology of Glial Cells Recent Advances


  • Author : Ishan Patro
  • Publisher : Springer
  • Release Date : 2022-04-10
  • Genre: Medical
  • Pages : 745
  • ISBN 10 : 9811683123

GET BOOK
The Biology of Glial Cells Recent Advances Excerpt :

This book reviews the role of glial cells (astrocytes, microglia, oligodendroglia, satellite cells, and Schwann cells) in neuronal health and diseases. It discusses the latest advances in understanding their origin, differentiation, and hemostasis. The book also examines the role of microglial cells in central nervous system (CNS) development, maintenance, and synaptic plasticity. Further, the book presents the functions of astrocytes in healthy CNS and their critical role in CNS disorders, including Parkinson's and Alzheimer's diseases. Notably, the book describes the pathobiology, molecular pathogenesis, stem cells, and imaging characteristics of gliomas. It defines the role of glial cells in regulating iron homeostasis and their effect on the neurodegeneration of neurons. Lastly, it covers the structure, function, and pathology of oligodendrocytes and their role in neuronal health and disease. ​

Enteric Glia Book

Enteric Glia


  • Author : Brian D. Gulbransen
  • Publisher : Biota Publishing
  • Release Date : 2014-07-01
  • Genre: Medical
  • Pages : 70
  • ISBN 10 : 9781615046614

GET BOOK
Enteric Glia Excerpt :

The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography

The Biology of Glial Cells  Recent Advances Book

The Biology of Glial Cells Recent Advances


  • Author : Ishan Patro
  • Publisher : Springer Nature
  • Release Date : 2022-04-09
  • Genre: Medical
  • Pages : 745
  • ISBN 10 : 9789811683138

GET BOOK
The Biology of Glial Cells Recent Advances Excerpt :

This book reviews the role of glial cells (astrocytes, microglia, oligodendroglia, satellite cells, and Schwann cells) in neuronal health and diseases. It discusses the latest advances in understanding their origin, differentiation, and hemostasis. The book also examines the role of microglial cells in central nervous system (CNS) development, maintenance, and synaptic plasticity. Further, the book presents the functions of astrocytes in healthy CNS and their critical role in CNS disorders, including Parkinson's and Alzheimer's diseases. Notably, the book describes the pathobiology, molecular pathogenesis, stem cells, and imaging characteristics of gliomas. It defines the role of glial cells in regulating iron homeostasis and their effect on the neurodegeneration of neurons. Lastly, it covers the structure, function, and pathology of oligodendrocytes and their role in neuronal health and disease. ​

Glia in Health and Disease Book

Glia in Health and Disease


  • Author : Tania Spohr
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-05-20
  • Genre: Science
  • Pages : 162
  • ISBN 10 : 9781789852530

GET BOOK
Glia in Health and Disease Excerpt :

The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters. Ultimately, we will highlight the influence of astrocytes during the development of a number of neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, focusing on how the serum levels of the astrocytic protein S100B can be used as a biomarker for clinical decisions.

Microglia in Health and Disease  A Unique Immune Cell Population Book

Microglia in Health and Disease A Unique Immune Cell Population


  • Author : Alessandro Michelucci
  • Publisher : Frontiers Media SA
  • Release Date : 2018-10-05
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889456017

GET BOOK
Microglia in Health and Disease A Unique Immune Cell Population Excerpt :

Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.

Introduction to Cell Biology Book

Introduction to Cell Biology


  • Author : John K. Young
  • Publisher : World Scientific
  • Release Date : 2010
  • Genre: Science
  • Pages : 219
  • ISBN 10 : 9789814307321

GET BOOK
Introduction to Cell Biology Excerpt :

This book is intended to be an accessible introduction to the cell biology of mammalian cells for junior or senior undergraduate students who have already had an introduction to biological sciences. This engaging and stimulating text focuses on current controversies in cell biology. To solve these puzzles, the reader will learn how to answer a number of fundamental yet hard-hitting questions in the field. He or she is thus able to approach the subject with the right scientific attitude and build a firm foundation of understanding. Basic features of mammalian cells ? secretion, division, motility, cell-cell interactions ? are described using up-to-date references to the most current scientific literature. The text is well illustrated with clearly understandable diagrams and numerous micrographs of cells. This text will enable non-specialists to acquire a better understanding of current issues in mammalian cell biology.

Introduction to Neuroglia Book

Introduction to Neuroglia


  • Author : Alexei Verkhratsky
  • Publisher : Biota Publishing
  • Release Date : 2014-02-01
  • Genre: Medical
  • Pages : 87
  • ISBN 10 : 9781615046492

GET BOOK
Introduction to Neuroglia Excerpt :

This book is the introduction to a series of e-books dedicated to the physiology and pathophysiology of neuroglia. The topic of neuroglia is generally overlooked in neuroscience curricula across the world, the main attention being focused on the description of excitability of neurons and neuronal networks. The neuroglia, being electrically non-excitable, are universally regarded as supportive cells which do not contribute to information processing. This oversimplified view, however, ignores the tremendous importance of brain homeostasis, which is imperative for the ongoing activity of neuronal networks. It also ignores the truth that specialization of neurons and their ability for rapid propagation and multi-level integration of signals become possible only because of delegation of homeostatic abilities to neuroglia. Furthermore, glial cells contribute to information processing as they can modulate neuronal synaptic transmission. Finally, neuroglia provide the only system of brain defense and as such these cells are intimately involved in all types of neuropathologies, and contribute to both neuroprotection and regeneration of the nervous system. The e-books in this series provide a platform for in-depth learning of all aspects of neuroglial cells function in health and disease.

Glial Cell Function  Paperback  Book

Glial Cell Function Paperback


  • Author : Bernardo Castellano
  • Publisher : Gulf Professional Publishing
  • Release Date : 2003-09-29
  • Genre: Medical
  • Pages : 780
  • ISBN 10 : 0444514864

GET BOOK
Glial Cell Function Paperback Excerpt :

Although knowledge of the development and differentiation of glial cells has significantly increased in recent years, there are still many questions unanswered. The first section of the book is devoted to this very active topic and includes contributions on Schwann cells, oligodendrocytes, astroglia and microglia. The second section of the book covers cellular interactions, the role they play on myelination and remyelination, how these interactions take place and the molecules involved. The third section of this volume focuses on the interactions of neurons with glial cells and their role in brain function. Neuron-glia cross talk appears to be fundamental for synaptic transmission and several chapters in this section address this topic. The topic of how glial cells react to brain injury and how they participate in neuroprotection and brain repair is covered in section four of this book. As our knowledge about the molecules involved in the regenerative properties of glia increases, new avenues are open for the use of genetically modified glia with therapeutic purposes. The final section of the book is devoted to therapeutic approaches to tumours, viral and prion infections. Gene therapy is a promising approach for the treatment of gliomas, one of the most devastating forms of cancer. A chapter on prion diseases and microglia addresses a question of tremendous actuality, since prion diseases in cows is at this moment the major veterinary problem in Europe and has created a considerable social alarm.

Microglia in Health and Disease Book

Microglia in Health and Disease


  • Author : Marie-Ève Tremblay
  • Publisher : Springer
  • Release Date : 2014-09-22
  • Genre: Medical
  • Pages : 486
  • ISBN 10 : 9781493914296

GET BOOK
Microglia in Health and Disease Excerpt :

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.