The Handbook of Metabolic Phenotyping Book

The Handbook of Metabolic Phenotyping


  • Author : John C. Lindon
  • Publisher : Elsevier
  • Release Date : 2018-10-04
  • Genre: Science
  • Pages : 619
  • ISBN 10 : 9780128122945

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The Handbook of Metabolic Phenotyping Excerpt :

The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics. Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping Explores, in detail, the many diverse statistical approaches used in the field Offers practical tips for successfully conducting metabolic phenotyping studies Features reviews of all of the various fields of activity relating to human studies

The Handbook of Metabonomics and Metabolomics Book
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The Handbook of Metabonomics and Metabolomics


  • Author : John C. Lindon
  • Publisher : Elsevier
  • Release Date : 2011-08-11
  • Genre: Science
  • Pages : 572
  • ISBN 10 : 0080468004

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The Handbook of Metabonomics and Metabolomics Excerpt :

Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies * aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification * covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

Encyclopedia of Analytical Science Book

Encyclopedia of Analytical Science


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2019-04-02
  • Genre: Science
  • Pages : 5109
  • ISBN 10 : 9780081019849

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Encyclopedia of Analytical Science Excerpt :

The third edition of the Encyclopedia of Analytical Science is a definitive collection of articles covering the latest technologies in application areas such as medicine, environmental science, food science and geology. Meticulously organized, clearly written and fully interdisciplinary, the Encyclopedia of Analytical Science provides foundational knowledge across the scope of modern analytical chemistry, linking fundamental topics with the latest methodologies. Articles will cover three broad areas: analytical techniques (e.g., mass spectrometry, liquid chromatography, atomic spectrometry); areas of application (e.g., forensic, environmental and clinical); and analytes (e.g., arsenic, nucleic acids and polycyclic aromatic hydrocarbons), providing a one-stop resource for analytical scientists. Offers readers a one-stop resource with access to information across the entire scope of modern analytical science Presents articles split into three broad areas: analytical techniques, areas of application and and analytes, creating an ideal resource for students, researchers and professionals Provides concise and accessible information that is ideal for non-specialists and readers from undergraduate levels and higher

Drug Metabolism Handbook Book

Drug Metabolism Handbook


  • Author : Ala F. Nassar
  • Publisher : John Wiley & Sons
  • Release Date : 2009-01-28
  • Genre: Medical
  • Pages : 800
  • ISBN 10 : 0470439254

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Drug Metabolism Handbook Excerpt :

A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.

Handbook of Neurobehavioral Genetics and Phenotyping Book

Handbook of Neurobehavioral Genetics and Phenotyping


  • Author : Valter Tucci
  • Publisher : John Wiley & Sons
  • Release Date : 2017-03-06
  • Genre: Medical
  • Pages : 648
  • ISBN 10 : 9781118540718

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Handbook of Neurobehavioral Genetics and Phenotyping Excerpt :

The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour. Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., “systems biology” approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.

Measuring Metabolic Rates Book

Measuring Metabolic Rates


  • Author : John R. B. Lighton
  • Publisher : Oxford University Press
  • Release Date : 2018-12-06
  • Genre: Science
  • Pages : 304
  • ISBN 10 : 9780192566096

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Measuring Metabolic Rates Excerpt :

The measurement of metabolic rates is central to important questions in many areas of physiological research. Unfortunately these measurements are anything but straightforward, with numerous pitfalls awaiting both the novice and even the experienced investigator. The original edition of this work, published in 2008, quickly became the principle "how to" manual for the field. It successfully de-mystified the topic, explaining every common variation of metabolic rate measurement. Background information on different analyzer and equipment types allowed users to choose the best instruments for their application. Respirometry equations, normally a topic of terror and confusion to researchers, were derived and described in sufficient detail to facilitate their selection and use. In this new edition, the content has been thoroughly updated and a decade of new literature incorporated. New chapters on room calorimetry, human metabolic measurement, and metabolic phenotyping have also been added. Measuring Metabolic Rates is aimed at experimental biologists, physiologists, and any professional scientist involved with metabolic measurement. This practical handbook will also be of relevance and use to graduate students.

Metabolic Phenotyping in Personalized and Public Healthcare Book

Metabolic Phenotyping in Personalized and Public Healthcare


  • Author : Jeremy Nicholson
  • Publisher : Academic Press
  • Release Date : 2016-02-11
  • Genre: Science
  • Pages : 428
  • ISBN 10 : 9780128004142

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Metabolic Phenotyping in Personalized and Public Healthcare Excerpt :

Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream. Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making Discusses longitudinal sampling from individual patients for stratified medicine Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England

Concepts and Principles of Pharmacology Book

Concepts and Principles of Pharmacology


  • Author : James E. Barrett
  • Publisher : Springer Nature
  • Release Date : 2019-12-24
  • Genre: Medical
  • Pages : 466
  • ISBN 10 : 9783030353629

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Concepts and Principles of Pharmacology Excerpt :

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Comprehensive Foodomics Book

Comprehensive Foodomics


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2020-11-12
  • Genre: Science
  • Pages : 2330
  • ISBN 10 : 9780128163962

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Comprehensive Foodomics Excerpt :

Comprehensive Foodomics offers a definitive collection of over 150 articles that provide researchers with innovative answers to crucial questions relating to food quality, safety and its vital and complex links to our health. Topics covered include transcriptomics, proteomics, metabolomics, genomics, green foodomics, epigenetics and noncoding RNA, food safety, food bioactivity and health, food quality and traceability, data treatment and systems biology. Logically structured into 10 focused sections, each article is authored by world leading scientists who cover the whole breadth of Omics and related technologies, including the latest advances and applications. By bringing all this information together in an easily navigable reference, food scientists and nutritionists in both academia and industry will find it the perfect, modern day compendium for frequent reference. List of sections and Section Editors: Genomics - Olivia McAuliffe, Dept of Food Biosciences, Moorepark, Fermoy, Co. Cork, Ireland Epigenetics & Noncoding RNA - Juan Cui, Department of Computer Science & Engineering, University of Nebraska-Lincoln, Lincoln, NE Transcriptomics - Robert Henry, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Australia Proteomics - Jens Brockmeyer, Institute of Biochemistry and Technical Biochemistry, University Stuttgart, Germany Metabolomics - Philippe Schmitt-Kopplin, Research Unit Analytical BioGeoChemistry, Neuherberg, Germany Omics data treatment, System Biology and Foodomics - Carlos Leon Canseco, Visiting Professor, Biomedical Engineering, Universidad Carlos III de Madrid Green Foodomics - Elena Ibanez, Foodomics Lab, CIAL, CSIC, Madrid, Spain Food safety and Foodomics - Djuro Josić, Professor Medicine (Research) Warren Alpert Medical School, Brown University, Providence, RI, USA & Sandra Kraljević Pavelić, University of Rijeka, Department of Biotechnology, Rijeka, Croatia Food Quality, Traceability and Foodomics

Metabolic Profiling Book

Metabolic Profiling


  • Author : Georgios A. Theodoridis
  • Publisher : Humana
  • Release Date : 2019-04-30
  • Genre: Science
  • Pages : 291
  • ISBN 10 : 149399252X

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Metabolic Profiling Excerpt :

This volume explores the different approaches and techniques used by researchers to study the recent challenges and developments in metabolic profiling. This book is divided into IV parts. Part I contains chapters that highlight basic concepts, such as experimental design, data treatment, metabolite identification, and harmonization. Part II describes experimental protocols for both targeted and untargeted metabolomics covering the basic analytical technologies: LC-MS, GC-MS, NMR and CE-MS. In addition the protocols describe methods for the study of tissues, feces, blood and other types of biological samples as well as the application of chemical derivatization for GC-MS. Parts III and IV present the use of metabolomics in the study of food, plants and the life sciences, with examples from the quest for the discovery of disease biomarkers, physical exercise omics and metabolic profiling of food, fruit and wine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Metabolic Profiling: Methods and Protocols is a valuable resource for researchers who are interested in expanding their knowledge of this rapidly developing field.

The Handbook of Plant Metabolomics Book

The Handbook of Plant Metabolomics


  • Author : Wolfram Weckwerth
  • Publisher : John Wiley & Sons
  • Release Date : 2013-02-28
  • Genre: Science
  • Pages : 448
  • ISBN 10 : 9783527669905

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The Handbook of Plant Metabolomics Excerpt :

This is the newest title in the successful Molecular Plant Biology Handbook Series. Just like the other titles in the series this new book presents an excellent overview of different approaches and techniques in Metabolomics. Contributors are either from ivy-league research institutions or from companies developing new technologies in this dynamic and fast-growing field. With its approach to introduce current techniques in plant metabolomics to a wider audience and with many labs and companies considering to introduce metabolomics for their research, the title meets a growing market. The Kahl books are in addition a trusted brand for the plant science community and have always sold above expectations.

Encyclopedia of Bioinformatics and Computational Biology Book

Encyclopedia of Bioinformatics and Computational Biology


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2018-08-21
  • Genre: Medical
  • Pages : 3284
  • ISBN 10 : 9780128114322

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Encyclopedia of Bioinformatics and Computational Biology Excerpt :

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

The Disruptive Fourth Industrial Revolution Book

The Disruptive Fourth Industrial Revolution


  • Author : Wesley Doorsamy
  • Publisher : Springer Nature
  • Release Date : 2020-07-13
  • Genre: Technology & Engineering
  • Pages : 285
  • ISBN 10 : 9783030482305

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The Disruptive Fourth Industrial Revolution Excerpt :

The book explores technological advances in the fourth industrial revolution (4IR), which is based on a variety of technologies such as artificial intelligence, Internet of Things, machine learning, big data, additive printing, cloud computing, and virtual and augmented reality. Critically analyzing the impacts and effects of these disruptive technologies on various areas, including economics, society, business, government, labor, law, and environment, the book also provides a broad overview of 4IR, with a focus on technologies, to allow readers to gain a deeper understanding of the recent advances and future trajectories. It is intended for researchers, practitioners, policy-makers and industry leaders.

Bioactive Compounds in Fermented Foods Book

Bioactive Compounds in Fermented Foods


  • Author : Amit Kumar Rai
  • Publisher : CRC Press
  • Release Date : 2021-11-29
  • Genre: Technology & Engineering
  • Pages : 414
  • ISBN 10 : 9780429651212

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Bioactive Compounds in Fermented Foods Excerpt :

The volume reviews different types of bioactive components associated with food fermentation and their impact on human health. The diversity of microorganism responsible for the production of different types of fermented foods and beverages includes bacteria, yeasts, and fungi. Biotransformation of food constituent by microorganisms occurs during fermentation processes for the production of fermented food and in the gastrointestinal tract by gut microorganisms. This biotransformation results in production of specific bioactive compounds that are responsible for a wide range of health benefits. The bioactive compounds discussed in this book includes polyphenols, bioactive peptides, fibrinolytic enzymes, gama-amino butyric acids (GABA) exopolysaccharides, probiotic, prebiotic, symbiotic and antinutritional factors. These bioactive compounds are responsible for health benefits such as antioxidant, antihypertension, antimicrobial, cholesterol lowering, anticancer, obesity and antithrombotic properties. Advanced research in the field of food fermentation and their health benefits have resulted in commercialization of some of the fermented foods as functional foods. The traditional fermented foods consumed in different parts of the world and their health benefits are discussed in detail and the book concludes with recent advances in microbial transformation during gut fermentation and their impact on human health. There has been increasing interest among researchers on the proposed title in the last decade and the book brings updated information on research and advances in different types of health benefits exhibited by bioactive compounds in a wide range of fermented foods.

Epigenetics and Metabolomics Book

Epigenetics and Metabolomics


  • Author : Paban K. Agrawala
  • Publisher : Elsevier
  • Release Date : 2021-08-25
  • Genre: Medical
  • Pages : 476
  • ISBN 10 : 9780323856539

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Epigenetics and Metabolomics Excerpt :

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare. Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others Provides guidance in epigenomics and metabolomic research methodology