The Mechanics of Inhaled Pharmaceutical Aerosols Book

The Mechanics of Inhaled Pharmaceutical Aerosols


  • Author : Warren H. Finlay
  • Publisher : Academic Press
  • Release Date : 2019-06-01
  • Genre: Technology & Engineering
  • Pages : 302
  • ISBN 10 : 9780081027868

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The Mechanics of Inhaled Pharmaceutical Aerosols Excerpt :

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Pharmaceutical Inhalation Aerosol Technology  Second Edition Book

Pharmaceutical Inhalation Aerosol Technology Second Edition


  • Author : Anthony J. Hickey
  • Publisher : CRC Press
  • Release Date : 2003-09-03
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 9780824756642

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Pharmaceutical Inhalation Aerosol Technology Second Edition Excerpt :

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.

Inhaled Pharmaceutical Product Development Perspectives Book

Inhaled Pharmaceutical Product Development Perspectives


  • Author : Anthony J. Hickey
  • Publisher : Elsevier
  • Release Date : 2017-11-23
  • Genre: Science
  • Pages : 110
  • ISBN 10 : 9780128123362

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Inhaled Pharmaceutical Product Development Perspectives Excerpt :

Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Discusses development strategies and best practices in the context of regulatory requirements Written by a broadly qualified expert drawing on the knowledge and critical opinions of key individuals in the field Includes a foreword by Charles G. Thiel

Pharmaceutical Inhalation Aerosol Technology  Third Edition Book

Pharmaceutical Inhalation Aerosol Technology Third Edition


  • Author : Anthony J. Hickey
  • Publisher : CRC Press
  • Release Date : 2019-03-26
  • Genre: Medical
  • Pages : 730
  • ISBN 10 : 9780429619564

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Pharmaceutical Inhalation Aerosol Technology Third Edition Excerpt :

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Respiratory Drug Delivery  1989  Book

Respiratory Drug Delivery 1989


  • Author : Peter R. Byron
  • Publisher : CRC Press
  • Release Date : 2018-04-20
  • Genre: Medical
  • Pages : 276
  • ISBN 10 : 9781351358019

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Respiratory Drug Delivery 1989 Excerpt :

The focus of this book is on subjects related to drug delivery to the lung. The text spans topics from aerosol deposition through pharmaceutical chemistry and formulation to the final clinical evaluation of pharmaceutical products. Utilizing a multi-disciplinary approach, the chapters consider toxicology from the point of view of drugs and pharmaceutical excipients used in aerosols.

Inhaled Medicines Book

Inhaled Medicines


  • Author : Stavros Kassinos
  • Publisher : Academic Press
  • Release Date : 2021-02-05
  • Genre: Business & Economics
  • Pages : 438
  • ISBN 10 : 9780128149744

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Inhaled Medicines Excerpt :

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources of

Aerosols Handbook Book
Score: 5
From 1 Ratings

Aerosols Handbook


  • Author : Lev S. Ruzer
  • Publisher : CRC Press
  • Release Date : 2004-12-28
  • Genre: Nature
  • Pages : 728
  • ISBN 10 : 9780203493182

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Aerosols Handbook Excerpt :

As more attention is dedicated to understanding the occupational health risks associated with the industrial manufacture and use of nanotechnology, Aerosols Handbook: Measurement, Dosimetry, and Health Effects is a timely presentation of time-tested research in the field of aerosol science. The book covers a multitude of topics in indoor, outdoor,

Good Cascade Impactor Practices  AIM and EDA for Orally Inhaled Products Book

Good Cascade Impactor Practices AIM and EDA for Orally Inhaled Products


  • Author : Terrence P. Tougas
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-10
  • Genre: Medical
  • Pages : 442
  • ISBN 10 : 9781461462965

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Good Cascade Impactor Practices AIM and EDA for Orally Inhaled Products Excerpt :

The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-stage cascade impactor (CI), a process that is demanding for the operator, time consuming, prone to experimental error, and challenging for method transfers from one laboratory to another. Furthermore, we shall show that the current practice of reducing information from mass-weighted aerodynamic particle size distribution (APSD) measurements through the use of CI stage groupings is not the most effective decision-making tool for OIP quality control (QC) in comparison with newly introduced, mutually-independent efficient data analysis (EDA) metrics that can be derived either from full resolution or abbreviated impactor measurements (AIM).

Aerosol Measurement Book

Aerosol Measurement


  • Author : Pramod Kulkarni
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-09
  • Genre: Science
  • Pages : 900
  • ISBN 10 : 1118001672

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Aerosol Measurement Excerpt :

Aerosol Measurement: Principles, Techniques, and Applications Third Edition is the most detailed treatment available of the latest aerosol measurement methods. Drawing on the know-how of numerous expert contributors; it provides a solid grasp of measurement fundamentals and practices a wide variety of aerosol applications. This new edition is updated to address new and developing applications of aerosol measurement, including applications in environmental health, atmospheric science, climate change, air pollution, public health, nanotechnology, particle and powder technology, pharmaceutical research and development, clean room technology (integrated circuit manufacture), and nuclear waste management.

Aerosol Science Book

Aerosol Science


  • Author : Ian Colbeck
  • Publisher : John Wiley & Sons
  • Release Date : 2014-01-30
  • Genre: Science
  • Pages : 496
  • ISBN 10 : 9781118675359

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Aerosol Science Excerpt :

Aerosols influence many areas of our daily life. They are at the core of environmental problems such as global warming, photochemical smog and poor air quality. They can also have diverse effects on human health, where exposure occurs in both outdoor and indoor environments. However, aerosols can have beneficial effects too; the delivery of drugs to the lungs, the delivery of fuels for combustion and the production of nanomaterials all rely on aerosols. Advances in particle measurement technologies have made it possible to take advantage of rapid changes in both particle size and concentration. Likewise, aerosols can now be produced in a controlled fashion. Reviewing many technological applications together with the current scientific status of aerosol modelling and measurements, this book includes: • Satellite aerosol remote sensing • The effects of aerosols on climate change • Air pollution and health • Pharmaceutical aerosols and pulmonary drug delivery • Bioaerosols and hospital infections • Particle emissions from vehicles • The safety of emerging nanomaterials • Radioactive aerosols: tracers of atmospheric processes With the importance of this topic brought to the public’s attention after the eruption of the Icelandic volcano Eyjafjallajökull, this book provides a timely, concise and accessible overview of the many facets of aerosol science.

Public Health Consequences of E Cigarettes Book

Public Health Consequences of E Cigarettes


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2018-05-18
  • Genre: Medical
  • Pages : 774
  • ISBN 10 : 9780309468374

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Public Health Consequences of E Cigarettes Excerpt :

Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.

Aerosol Technology Book
Score: 5
From 1 Ratings

Aerosol Technology


  • Author : William C. Hinds
  • Publisher : John Wiley & Sons
  • Release Date : 2012-12-06
  • Genre: Technology & Engineering
  • Pages : 504
  • ISBN 10 : 9781118591970

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Aerosol Technology Excerpt :

The #1 guide to aerosol science and technology -now better than ever Since 1982, Aerosol Technology has been the text of choice among students and professionals who need to acquire a thorough working knowledge of modern aerosol theory and applications. Now revised to reflect the considerable advances that have been made over the past seventeen years across a broad spectrum of aerosol-related application areas - from occupational hygiene and biomedical technology to microelectronics and pollution control -this new edition includes: * A chapter on bioaerosols * New sections on resuspension, transport losses, respiratory deposition models, and fractal characterization of particles * Expanded coverage of atmospheric aerosols, including background aerosols and urban aerosols * A section on the impact of aerosols on global warming and ozone depletion. Aerosol Technology, Second Edition also features dozens of new, fully worked examples drawn from a wide range of industrial and research settings, plus new chapter-end practice problems to help readers master the material quickly.

Handbook of Lung Targeted Drug Delivery Systems Book

Handbook of Lung Targeted Drug Delivery Systems


  • Author : Yashwant Pathak
  • Publisher : CRC Press
  • Release Date : 2021-10-18
  • Genre: Medical
  • Pages : 690
  • ISBN 10 : 9781000450804

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Handbook of Lung Targeted Drug Delivery Systems Excerpt :

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Recent Advances in Novel Drug Carrier Systems Book

Recent Advances in Novel Drug Carrier Systems


  • Author : Ali Demir Sezer
  • Publisher : BoD – Books on Demand
  • Release Date : 2012-10-31
  • Genre: Medical
  • Pages : 516
  • ISBN 10 : 9789535108108

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Recent Advances in Novel Drug Carrier Systems Excerpt :

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.