The Molecular and Cellular Basis of Neurodegenerative Diseases Book

The Molecular and Cellular Basis of Neurodegenerative Diseases


  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2018-03-29
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9780128113059

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The Molecular and Cellular Basis of Neurodegenerative Diseases Excerpt :

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Molecular Mechanisms of Neurodegenerative Diseases Book

Molecular Mechanisms of Neurodegenerative Diseases


  • Author : Marie-Francoise Chesselet
  • Publisher : Springer Science & Business Media
  • Release Date : 2000-10-19
  • Genre: Medical
  • Pages : 410
  • ISBN 10 : 9781592590063

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Molecular Mechanisms of Neurodegenerative Diseases Excerpt :

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

The Molecular and Clinical Pathology of Neurodegenerative Disease Book

The Molecular and Clinical Pathology of Neurodegenerative Disease


  • Author : Patrick A. Lewis
  • Publisher : Academic Press
  • Release Date : 2018-11-16
  • Genre: Science
  • Pages : 274
  • ISBN 10 : 9780128110706

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The Molecular and Clinical Pathology of Neurodegenerative Disease Excerpt :

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

The Molecular and Cellular Basis for Parkinson s Disease Book

The Molecular and Cellular Basis for Parkinson s Disease


  • Author : Thomas Müller
  • Publisher : MDPI
  • Release Date : 2019-10-14
  • Genre: Science
  • Pages : 230
  • ISBN 10 : 9783039215485

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The Molecular and Cellular Basis for Parkinson s Disease Excerpt :

The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research.This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included.The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.

Molecular Biology of Neurodegenerative Diseases Book

Molecular Biology of Neurodegenerative Diseases


  • Author : David B. Teplow
  • Publisher : Academic Press
  • Release Date : 2012
  • Genre: Medical
  • Pages : 467
  • ISBN 10 : 9780123858832

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Molecular Biology of Neurodegenerative Diseases Excerpt :

Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson's, Alzheimer's and Huntington's disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Molecular Aspects of Neurodegeneration and Neuroprotection Book

Molecular Aspects of Neurodegeneration and Neuroprotection


  • Author : Akhlaq A. Farooqui
  • Publisher : Bentham Science Publishers
  • Release Date : 2011-01-26
  • Genre: Science
  • Pages : 146
  • ISBN 10 : 9781608050925

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Molecular Aspects of Neurodegeneration and Neuroprotection Excerpt :

"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Molecular and Cellular Therapies for Motor Neuron Diseases Book

Molecular and Cellular Therapies for Motor Neuron Diseases


  • Author : Nicholas M Boulis
  • Publisher : Academic Press
  • Release Date : 2017-01-18
  • Genre: Psychology
  • Pages : 336
  • ISBN 10 : 9780128025246

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Molecular and Cellular Therapies for Motor Neuron Diseases Excerpt :

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Basic Neurochemistry Book
Score: 3.5
From 2 Ratings

Basic Neurochemistry


  • Author : Scott T. Brady
  • Publisher : Academic Press
  • Release Date : 2012
  • Genre: Medical
  • Pages : 1096
  • ISBN 10 : 9780123749475

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Basic Neurochemistry Excerpt :

Includes bibliographical references and index.

Molecular Mechanisms of Dementia Book

Molecular Mechanisms of Dementia


  • Author : Wilma Wasco
  • Publisher : Springer Science & Business Media
  • Release Date : 1996-11-01
  • Genre: Medical
  • Pages : 312
  • ISBN 10 : 9781592594719

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Molecular Mechanisms of Dementia Excerpt :

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Neurodegeneration Book

Neurodegeneration


  • Author : Dennis Dickson
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-09
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 9781444341232

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Neurodegeneration Excerpt :

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Molecular Mechanisms of Dementia Book

Molecular Mechanisms of Dementia


  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2019-04-15
  • Genre: Medical
  • Pages : 386
  • ISBN 10 : 9780128167311

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Molecular Mechanisms of Dementia Excerpt :

Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia Discusses the synthesis, metabolism, and role of lipid mediators in dementia

The Ageing Brain Book

The Ageing Brain


  • Author : Perminder S. Sachdev
  • Publisher : CRC Press
  • Release Date : 2005-09-20
  • Genre: Psychology
  • Pages : 340
  • ISBN 10 : 9780203970973

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The Ageing Brain Excerpt :

When confronted with a neurological or psychiatric disorder in an elderly individual, a clinician or researcher is likely to ask how the processes of ageing have influenced the aetiology and presentation of the disorder, and will impact on its efficient management. There are many urban myths about ageing, and some of these apply to the brain. The reviews included in this book are an attempt to flush out some of these myths, and arm the clinician and general researcher with the empirical facts that can be mustered to substantiate claims about ageing. There are many salient questions: is cognitive change to be expected in an elderly individual? Is this change progressive, relentless and unselective, or is it focal and constrained? Would every person who lived long enough develop Alzheimer’s disease? Do our neurones die as we get old? What happens to the size of the brain and its metabolic activity? How do our hormones change with age? Can anti-oxidants slow or even stop the process of ageing? Are genes important in the ageing brain or is it all in the environment? How much of what we are is due to what we eat? The contributors to this book, each an expert in their field, have addressed some of these questions in a language simple enough for a general reader to understand. The book also deals with some of the most prominent brain disorders of old age - Alzheimer's disease, Parkinson's disease, vascular dementia, and depression. The focus is on the impact of ageing on these disorders. The discussions lay out a broad map for the clinician dealing with neuropsychiatric disorders, and the future researcher of brain ageing. In a field in which the developments are too numerous for any one individual to keep pace with, this book presents up-to-date summaries that can be a useful starting point. The field of brain ageing abounds in tabloid science. This book counters this by providing a strong empirical grounding and considered synthesis of the research.

Parkinson s Disease Book

Parkinson s Disease


  • Author : Patrik Verstreken
  • Publisher : Academic Press
  • Release Date : 2016-12-19
  • Genre: Science
  • Pages : 330
  • ISBN 10 : 9780128038055

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Parkinson s Disease Excerpt :

Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease

Neuropathology of Neurodegenerative Diseases Book and Online Book

Neuropathology of Neurodegenerative Diseases Book and Online


  • Author : Gabor G. Kovacs
  • Publisher : Cambridge University Press
  • Release Date : 2014-12-04
  • Genre: Medical
  • Pages : 316
  • ISBN 10 : 9781107442429

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Neuropathology of Neurodegenerative Diseases Book and Online Excerpt :

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.