The Molecular and Clinical Pathology of Neurodegenerative Disease Book

The Molecular and Clinical Pathology of Neurodegenerative Disease


  • Author : Patrick A. Lewis
  • Publisher : Academic Press
  • Release Date : 2018-11-16
  • Genre: Science
  • Pages : 274
  • ISBN 10 : 9780128110706

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The Molecular and Clinical Pathology of Neurodegenerative Disease Excerpt :

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

The Molecular Pathology of Neurodegenerative Disease Book

The Molecular Pathology of Neurodegenerative Disease


  • Author : Patrick A. Lewis
  • Publisher : Academic Press
  • Release Date : 2018-10-15
  • Genre: Science
  • Pages : 250
  • ISBN 10 : 0128110694

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The Molecular Pathology of Neurodegenerative Disease Excerpt :

The Molecular Pathology of Neurodegenerative Disease brings together the current understanding of the molecular basis of neurodegeneration in humans in a form that is targeted not only for neuroscientists, but also for graduate students in neuroscience and the biomedical and biological sciences. There are a large number of existing books covering this subject that are aimed at a clinical audience (both at undergraduate and higher level), however the increasing interest in neurodegeneration for more basic science courses - neuroscientists, biologists, pharmacists and so forth - highlight the need for a book tailored for this audience. Presents an up-to-date summary on our current understanding of neurodegeneration at a molecular, cellular and tissue level Includes clinical vignettes so that basic science students can relate underlying molecular processes to clinical symptoms Provides background on the history of neurodegeneration Highlights the state-of-the-art treatment options for each disorder

Neurodegeneration Book

Neurodegeneration


  • Author : Dennis Dickson
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-09
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 9781444341232

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Neurodegeneration Excerpt :

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Neurodegenerative Diseases Book

Neurodegenerative Diseases


  • Author : Philip Beart
  • Publisher : Springer
  • Release Date : 2017-07-03
  • Genre: Medical
  • Pages : 542
  • ISBN 10 : 9783319571935

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Neurodegenerative Diseases Excerpt :

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

The Molecular and Cellular Basis of Neurodegenerative Diseases Book

The Molecular and Cellular Basis of Neurodegenerative Diseases


  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2018-03-29
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9780128113059

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The Molecular and Cellular Basis of Neurodegenerative Diseases Excerpt :

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Neuropathology of Neurodegenerative Diseases Book and Online Book

Neuropathology of Neurodegenerative Diseases Book and Online


  • Author : Gabor G. Kovacs
  • Publisher : Cambridge University Press
  • Release Date : 2014-12-04
  • Genre: Medical
  • Pages : 319
  • ISBN 10 : 9781107442429

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Neuropathology of Neurodegenerative Diseases Book and Online Excerpt :

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases Book
Score: 5
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Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases


  • Author : Anil Gupta
  • Publisher : Academic Press
  • Release Date : 2021-12-17
  • Genre: Medical
  • Pages : 242
  • ISBN 10 : 9780128204436

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Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases Excerpt :

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology. Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins Aß peptide, tau protein, a-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases Elucidates neurogenetics of gene APP, gene PSEN1, gene APOE, gene LRRK2, gene DJ1, and others in the pathology of neurodegenerative diseases. Explains caspases-mediated neuronal apoptosis in pathogenesis of Alzheimer’s disease covering amyloidogenesis, caspase-activated DNase, rho-associated coiled coil–containing protein kinase 1, mammalian sterile 20-like kinase 1, role of synaptic loss, microglial TREM2 receptor, microglial LRP1 receptor, microglial advanced glycation end-product receptor, astrocytic glial a 7 subtypes of nAChR, NLRP3 inflammasome, P2X purinoreceptors, miRNAs, and many other factors Demonstrates the role of caspases and apoptosis in Parkinson’s disease covering truncation of a-synuclein, neuroinflammation, parkin protein, activation of microglial cells, extrinsic and intrinsic pathways of apoptosis, ?tau314, and sev

Molecular Biology of Neurodegenerative Diseases Book

Molecular Biology of Neurodegenerative Diseases


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2012-05-22
  • Genre: Science
  • Pages : 498
  • ISBN 10 : 9780123858849

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Molecular Biology of Neurodegenerative Diseases Excerpt :

Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson’s, Alzheimer’s and Huntington’s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field

TDP 43 and Neurodegeneration Book

TDP 43 and Neurodegeneration


  • Author : Vijay Kumar
  • Publisher : Academic Press
  • Release Date : 2021-10-23
  • Genre: Medical
  • Pages : 270
  • ISBN 10 : 9780128204405

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TDP 43 and Neurodegeneration Excerpt :

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside

Imaging in Neurodegenerative Disorders Book

Imaging in Neurodegenerative Disorders


  • Author : Luca Saba
  • Publisher : Oxford University Press, USA
  • Release Date : 2015
  • Genre: Medical
  • Pages : 585
  • ISBN 10 : 9780199671618

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Imaging in Neurodegenerative Disorders Excerpt :

This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.

Molecular Biology of Neurodegenerative Diseases  Visions for the Future Book

Molecular Biology of Neurodegenerative Diseases Visions for the Future


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-11-05
  • Genre: Science
  • Pages : 408
  • ISBN 10 : 9780128178751

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Molecular Biology of Neurodegenerative Diseases Visions for the Future Excerpt :

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Molecular Mechanisms of Neurodegenerative Diseases Book

Molecular Mechanisms of Neurodegenerative Diseases


  • Author : Marie-Francoise Chesselet
  • Publisher : Springer Science & Business Media
  • Release Date : 2000-10-19
  • Genre: Medical
  • Pages : 410
  • ISBN 10 : 9781592590063

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Molecular Mechanisms of Neurodegenerative Diseases Excerpt :

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Neurodegenerative Diseases Book

Neurodegenerative Diseases


  • Author : Philip Beart
  • Publisher : Springer
  • Release Date : 2018-06-12
  • Genre: Medical
  • Pages : 542
  • ISBN 10 : 3319860992

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Neurodegenerative Diseases Excerpt :

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Neurodegenerative Diseases Book

Neurodegenerative Diseases


  • Author : Nagehan Ersoy Tunalı
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-01-20
  • Genre: Science
  • Pages : 180
  • ISBN 10 : 9781838801496

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Neurodegenerative Diseases Excerpt :

Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Molecular Pathology in Clinical Practice Book

Molecular Pathology in Clinical Practice


  • Author : Debra G.B. Leonard
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-11-25
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 9780387332277

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Molecular Pathology in Clinical Practice Excerpt :

This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.