The Vasculome Book

The Vasculome


  • Author : Zorina S. Galis
  • Publisher : Academic Press
  • Release Date : 2022-06-24
  • Genre: Medical
  • Pages : 526
  • ISBN 10 : 9780128225479

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The Vasculome Excerpt :

The Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section. Brings together leading experts who present the latest biomedical thinking about the vasculature from the integrative perspective of the Vasculome Challenges traditional real and perceived boundaries within vascular research areas and stimulates new fundamental thinking and medical explorations Creates the bases for translating the integrative Vasculome concept into improved fundamental and clinical assessment and management of local and systemic contributions of the vasculature in health and disease

Stroke E Book Book

Stroke E Book


  • Author : James C. Grotta
  • Publisher : Elsevier Health Sciences
  • Release Date : 2021-02-06
  • Genre: Medical
  • Pages : 1518
  • ISBN 10 : 9780323694254

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Stroke E Book Excerpt :

Authored by the world’s foremost stroke experts, this classic text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. Stroke: Pathophysiology, Diagnosis, and Management, 7th Edition, covers every aspect of this fast-moving field, and is an ideal resource for stroke specialists, general neurologists, and other medical professionals with an interest in stroke. You’ll find expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, advances in diagnostic tests, full-color CT images, pathology slides, and much more, for a complete picture of today’s stroke medicine. Helps you recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Keeps you abreast of the overwhelming volume of studies and guidelines in this dynamic field, providing clear summaries and practical evaluations of all relevant data. Contains updates throughout, including the latest clinical trials (thrombectomy, DAWN, DEFUSE), genetics research, prevention research, new therapies, and the new guidelines from the ASA. Includes new slides for lectures, covering basic science, case studies, and interventional treatment overviews. Features a Key Points summary at the beginning of each chapter so you can quickly find important information. Provides abundant full-color CT images and pathology slides that help you make efficient and accurate diagnoses.

Central Nervous System Diseases  New Insights for the Healthcare Professional  2013 Edition Book

Central Nervous System Diseases New Insights for the Healthcare Professional 2013 Edition


  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-07-22
  • Genre: Medical
  • Pages : 734
  • ISBN 10 : 9781481657563

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Central Nervous System Diseases New Insights for the Healthcare Professional 2013 Edition Excerpt :

Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Vasculome Book

The Vasculome


  • Author : Zorina Galis
  • Publisher : Elsevier
  • Release Date : 2022-07-08
  • Genre: Medical
  • Pages : 530
  • ISBN 10 : 9780128225462

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The Vasculome Excerpt :

The Vasculome: From Many, One highlights the unique integrative nature of the body-wide distributed vascular system. The book introduces the fundamental bases of the "unity in diversity” of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section. Recognized experts are invited to contribute to this shared perspective of the Vasculome: from classic names and other outstanding researchers challenging the boundaries of fundamental understanding, to academic physicians ready to translate the latest scientific and technological advancements to holistically assess the contribution of the Vasculome to human health and disease, with the ultimate goal to improve prevention and treatment of a wide variety of medical conditions, and combining traditional and state of the art knowledge presented in a novel way.

Physiology  Pharmacology and Pathology of the Blood Brain Barrier Book

Physiology Pharmacology and Pathology of the Blood Brain Barrier


  • Author : Zameel Cader
  • Publisher : Springer Nature
  • Release Date : 2022-06-13
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9783030996543

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Physiology Pharmacology and Pathology of the Blood Brain Barrier Excerpt :

This book presents a comprehensive collection of current knowledge and leading research about the blood-brain barrier. The chapters are organized in four main parts providing basic information and novel insights about the physiology of the blood-brain barrier, the challenges related to finding and developing drugs crossing the blood-brain barrier, experimental methods to study the blood-brain barrier and the role of the blood-brain barrier in disease mechanisms and its consequences for drug development. In the first part the readers will discover the structure, function and developmental aspects of the blood-brain barrier and gain novel insights into the complexity and functionality of the neurovascular unit and energy metabolism of brain endothelial cells. Chapters of the second part focus on translational challenges from the bench to the bedside in CNS drug development, shed light on the importance to understand the brain distribution of drugs related to their efficacy, elaborate on general pharmacokinetic considerations for CNS drugs and introduce current and novel drug delivery strategies to overcome the blood-brain barrier. The experimental part of the book covers mathematical and in vitro models as well as animal and human methods in blood-brain barrier research. Specific emphasis is set on the description of the methods, the role of species differences for data interpretation, novel human models based on stem cells with the potential for personalized medicine and technical considerations and tips helpful for readers interested in working with these models. In the fourth part particular attentions is given to the blood-brain barrier, its changes and participation during disease progression. Chapters summarize alterations of the blood-brain barrier that are present in common disorders such as Alzheimer’s disease, multiple sclerosis, stroke, traumatic brain injury, epilepsy and brain tumors. Present therapies will be discussed and the consequences for novel tr

Molecular  Genetic  And Cellular Advances In Cerebrovascular Diseases Book

Molecular Genetic And Cellular Advances In Cerebrovascular Diseases


  • Author : Su Hua
  • Publisher : World Scientific
  • Release Date : 2017-12-26
  • Genre: Science
  • Pages : 320
  • ISBN 10 : 9789814723312

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Molecular Genetic And Cellular Advances In Cerebrovascular Diseases Excerpt :

This book will cover recent advances in genetics and molecular biology of cerebrovascular diseases, including ischemic stroke, brain arteriovenous malformation, brain aneurysms, and cavernous malformation. Developments in diagnostics, imaging and treatment will also be discussed. Much progress has been made in recent years in these fields, but not been summarized in one comprehensive text. This volume fills the gap in the literature by compiling them in one convenient, handy volume for neuroscience researchers and medical professionals. Contents: Imaging in Cerebrovascular Disease (Christopher P Hess)Cell Mechanisms and Clinical Targets in Stroke (Jing Lan, Elga Esposito, MingMing Ning, Xunming Ji, and Eng H Lo)Neural Repair for Cerebrovascular Diseases (Steven C Cramer)Brain AVM: Current Treatments and Challenges (W Caleb Rutledge and Michael T Lawton)Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation (Wan Zhu, Rui Zhang, Li Ma, and Hua Su)Biology of Brain Aneurysms (W Caleb Rutledge and Tomoki Hashimoto)Intracranial Aneurysms: Imaging, Hemodynamics, and Remodeling (David Saloner)Recent Advances in CADASIL Research (Suning Ping and Li-Ru Zhao)Dural Fistula (Daniel L Cooke, Matthew R Amans, and Van V Halbach)Interventional Therapies for Cerebrovascular Diseases (Fabio Settecase and Steven W Hetts)Stem Cell-mediated Biobridge: Crossing the Great Divide Between Bench and Clinic in Translating Cell Therapy for Stroke (Trenton Lippert, Marci Crowley, M Grant Liska, and Cesar V Borlongan) Readership: Neurologists, neurobiologists, neuroscientists. Keywords: Ischemic Stroke;Brain Arteriovenous Malformation;Brain Aneurism;Cerebral Cavernous Malformation;Dural Fistula;Brain ImageReview:0

The ESC Textbook of Cardiovascular Development Book

The ESC Textbook of Cardiovascular Development


  • Author : José M. Pérez-Pomares
  • Publisher : Oxford University Press
  • Release Date : 2018-08-23
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9780191074523

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The ESC Textbook of Cardiovascular Development Excerpt :

This highly illustrated textbook has been prepared by the Working Group on Development, Anatomy and Pathology of the European Society of Cardiology (ESC). The ESC Textbook of Cardiovascular Development is the authority on cardiovascular development from a perspective of both basic scientists and clinicians. The embryonic origin of congenital heart diseases and their pathology has been analysed in depth. Modern concepts pivotal to the understanding of cardiovascular morphogenesis, including those still subject to controversy, have been highlighted and the content covers the ESC Core Curriculum. The textbook will appeal to researchers and clinicians from a wide spectrum of disciplines including molecular and developmental biologists working on mechanisms of heart development in a range of model organisms as well as pathologists, morphologists, geneticists, and cardiologists.

Glial Amino Acid Transporters Book

Glial Amino Acid Transporters


  • Author : Arturo Ortega
  • Publisher : Springer
  • Release Date : 2017-08-21
  • Genre: Medical
  • Pages : 341
  • ISBN 10 : 9783319557694

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Glial Amino Acid Transporters Excerpt :

This ambitious compendium provides an extensive overview on the "supporting cells" of the vertebrate central nervous system, these being glial cells which far outnumber neurons but are much less understood. Covering multiple aspects of this family of transporters-- from structural properties, to their involvement in signaling and gene expression regulation, this volume presents the most recent research on the roles of glial amino acid transporters as key molecules of brain metabolism and signaling.

The Vasculome Book

The Vasculome


  • Author : Zorina Galis
  • Publisher : Elsevier
  • Release Date : 2022-07-08
  • Genre: Medical
  • Pages : 530
  • ISBN 10 : 9780128225462

GET BOOK
The Vasculome Excerpt :

The Vasculome: From Many, One highlights the unique integrative nature of the body-wide distributed vascular system. The book introduces the fundamental bases of the "unity in diversity” of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section. Recognized experts are invited to contribute to this shared perspective of the Vasculome: from classic names and other outstanding researchers challenging the boundaries of fundamental understanding, to academic physicians ready to translate the latest scientific and technological advancements to holistically assess the contribution of the Vasculome to human health and disease, with the ultimate goal to improve prevention and treatment of a wide variety of medical conditions, and combining traditional and state of the art knowledge presented in a novel way.

Primer on Cerebrovascular Diseases Book

Primer on Cerebrovascular Diseases


  • Author : Louis R. Caplan
  • Publisher : Academic Press
  • Release Date : 2017-02-10
  • Genre: Science
  • Pages : 968
  • ISBN 10 : 9780128030592

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Primer on Cerebrovascular Diseases Excerpt :

Primer on Cerebrovascular Diseases, Second Edition, is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, presenting the information in a comprehensive and easily accessible manner. Numerous changes have occurred in the field since the publication of the first edition in 1997, particularly our understanding of the genetic aspects of cerebrovascular disease. This updated edition reflects the advances made over the last two decades, not only demonstrating the promise for therapy, but also for a molecular understanding of cerebrovascular diseases. The new edition includes new and expanded topics, including carotid stenting, Iatrogenic causes of stroke, axonal transport and injury, RNAIs, proteomics, and more. Provides concise chapters on topics in cerebral blood flow and metabolism, pathogenesis of cerebrovascular disorders, diagnostic testing, and management in a comprehensive and accessible format Written by international leading authorities on cerebral vasculature Provides up-to-date information on practical applications of basic research and the main clinical issues facing the community, such as axonal transport and proteomics

Biologics and Biosimilars Book

Biologics and Biosimilars


  • Author : Xiaodong Feng
  • Publisher : CRC Press
  • Release Date : 2022-06-14
  • Genre: Medical
  • Pages : 528
  • ISBN 10 : 9780429939280

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Biologics and Biosimilars Excerpt :

Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases. This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines. Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.

Plant derived Bioactives Book

Plant derived Bioactives


  • Author : Mallappa Kumara Swamy
  • Publisher : Springer Nature
  • Release Date : 2020-06-27
  • Genre: Science
  • Pages : 589
  • ISBN 10 : 9789811523618

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Plant derived Bioactives Excerpt :

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, “Plant-derived Bioactives: Chemistry and Mode of Action” discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of new drugs.

Brain Repair Book

Brain Repair


  • Author : Mathias Bähr
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-03-06
  • Genre: Medical
  • Pages : 252
  • ISBN 10 : 9780387301280

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Brain Repair Excerpt :

Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics. Thus, this book is unique in bridging the gap between basic and clinical research. It will be a valuable tool for all students, researchers and clinicians interested in understanding the brain's capacity to cope with lesions and interested in learning about emerging new therapy concepts.

The Art of Cistercian Persuasion in the Middle Ages and Beyond Book

The Art of Cistercian Persuasion in the Middle Ages and Beyond


  • Author : Anonim
  • Publisher : BRILL
  • Release Date : 2015-10-12
  • Genre: History
  • Pages : 316
  • ISBN 10 : 9789004305304

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The Art of Cistercian Persuasion in the Middle Ages and Beyond Excerpt :

The articles in this collection offer an in-depth analysis of the Dialogus Miraculorum by the Cistercian Caesarius of Heisterbach (thirteenth century) and provide an insight into the theory and practice of Cistercian persuasion and Caesarius’s narrative theology.